DE69924369D1 - Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers - Google Patents

Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers

Info

Publication number
DE69924369D1
DE69924369D1 DE69924369T DE69924369T DE69924369D1 DE 69924369 D1 DE69924369 D1 DE 69924369D1 DE 69924369 T DE69924369 T DE 69924369T DE 69924369 T DE69924369 T DE 69924369T DE 69924369 D1 DE69924369 D1 DE 69924369D1
Authority
DE
Germany
Prior art keywords
fumarate
propylene
produced
propylene glycol
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69924369T
Other languages
English (en)
Inventor
J Peter
J Suggs
Paul S Engel
Antonios G Mikos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
William Marsh Rice University
Original Assignee
William Marsh Rice University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William Marsh Rice University filed Critical William Marsh Rice University
Application granted granted Critical
Publication of DE69924369D1 publication Critical patent/DE69924369D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/52—Polycarboxylic acids or polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation
    • C08G63/56—Polyesters derived from ester-forming derivatives of polycarboxylic acids or of polyhydroxy compounds other than from esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/52—Polycarboxylic acids or polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation
DE69924369T 1998-04-10 1999-04-09 Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers Expired - Fee Related DE69924369D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8130898P 1998-04-10 1998-04-10
US8140598P 1998-04-10 1998-04-10
US8218298P 1998-04-16 1998-04-16
PCT/US1999/007912 WO1999052469A1 (en) 1998-04-10 1999-04-09 Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger

Publications (1)

Publication Number Publication Date
DE69924369D1 true DE69924369D1 (de) 2005-04-28

Family

ID=27373944

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69924369T Expired - Fee Related DE69924369D1 (de) 1998-04-10 1999-04-09 Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers

Country Status (7)

Country Link
US (2) US6124373A (de)
EP (1) EP1079869B1 (de)
JP (1) JP2002539275A (de)
AT (1) ATE291444T1 (de)
CA (1) CA2327730A1 (de)
DE (1) DE69924369D1 (de)
WO (1) WO1999052469A1 (de)

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CA2369758C (en) 1999-04-16 2007-04-03 Wm. Marsh Rice University Functionalized poly(propylene fumarate) and poly(propylene fumarate-co-ethylene glycol)
US6884778B2 (en) * 2000-04-14 2005-04-26 William Marsh Rice University Biocompatible macromers
DE10032220A1 (de) * 2000-07-03 2002-01-24 Sanatis Gmbh Magnesium-ammonium-phosphat-Zemente, deren Herstellung und Verwendung
WO2002085246A2 (en) * 2001-04-19 2002-10-31 Case Western Reserve University Fabrication of a polymeric prosthetic implant
JP2004536909A (ja) * 2001-06-28 2004-12-09 ダブリューエム・マーシュ・ライス・ユニバーシティー フマル酸ジエチル／ポリ（フマル酸プロピレン）生体材料の光架橋
US7629388B2 (en) 2001-11-20 2009-12-08 William Marsh Rice University Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion
WO2003065996A2 (en) 2002-02-05 2003-08-14 Cambridge Scientific, Inc. Bioresorbable osteoconductive compositions for bone regeneration
US6884432B2 (en) * 2002-04-25 2005-04-26 Mayo Foundation For Medical Education And Research Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery
US7273523B2 (en) * 2002-06-07 2007-09-25 Kyphon Inc. Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof
EP1608292A4 (de) * 2003-03-13 2007-10-31 Univ Rice William M Injizierbares und vorgefertigtes verbundmaterial als knochenersatz und verfahren zur herstellung eines derartigen knochenersatzmaterials
DE60335037D1 (de) 2003-03-14 2010-12-30 Depuy Spine Inc Hydraulische vorrichtung zur knochenzementeinspritzung bei perkutaner vertebroplastie
US8066713B2 (en) 2003-03-31 2011-11-29 Depuy Spine, Inc. Remotely-activated vertebroplasty injection device
US8415407B2 (en) 2004-03-21 2013-04-09 Depuy Spine, Inc. Methods, materials, and apparatus for treating bone and other tissue
AU2004255225A1 (en) * 2003-07-01 2005-01-20 Mayo Foundation For Medical Education And Research Self-crosslinkable poly(caprolactone fumarate)
US7252686B2 (en) * 2003-08-13 2007-08-07 Boston Scientific Scimed Methods for reducing bone compression fractures using wedges
WO2005030034A2 (en) 2003-09-26 2005-04-07 Depuy Spine, Inc. Device for delivering viscous material
US20060018949A1 (en) * 2004-04-07 2006-01-26 Bausch & Lomb Incorporated Injectable biodegradable drug delivery system
US8168692B2 (en) 2004-04-27 2012-05-01 Kyphon Sarl Bone substitute compositions and method of use
CN106963464B (zh) * 2004-07-30 2019-11-05 德普伊新特斯产品有限责任公司 外科用具
CA2587308A1 (en) * 2004-11-12 2006-05-18 Mayo Foundation For Medical Education And Research Photocrosslinkable poly(caprolactone fumarate)
AU2005306295B2 (en) * 2004-11-18 2011-06-16 Mayo Foundation For Medical Education And Research Block copolymers of polycaprolactone and poly (propylene fumarate)
ATE511439T1 (de) * 2005-04-29 2011-06-15 Mayo Foundation Hydrophile/hydrophobe polymernetze auf der basis von poly(caprolactonfumarat), poly(ethylenglycolfumarat) und copolymere davon
US9381024B2 (en) 2005-07-31 2016-07-05 DePuy Synthes Products, Inc. Marked tools
US9918767B2 (en) 2005-08-01 2018-03-20 DePuy Synthes Products, Inc. Temperature control system
US7651701B2 (en) * 2005-08-29 2010-01-26 Sanatis Gmbh Bone cement composition and method of making the same
US8360629B2 (en) 2005-11-22 2013-01-29 Depuy Spine, Inc. Mixing apparatus having central and planetary mixing elements
US7754005B2 (en) * 2006-05-02 2010-07-13 Kyphon Sarl Bone cement compositions comprising an indicator agent and related methods thereof
US7507286B2 (en) * 2006-06-08 2009-03-24 Sanatis Gmbh Self-foaming cement for void filling and/or delivery systems
EP2032191B1 (de) * 2006-06-29 2015-08-12 Depuy Spine Inc. Integriertes knochenbiopsie- und therapiegerät
AU2007297097A1 (en) 2006-09-14 2008-03-20 Depuy Spine, Inc. Bone cement and methods of use thereof
AU2007300585A1 (en) * 2006-09-21 2008-04-03 Kyphon Sarl Diammonium phosphate and other ammonium salts and their use in preventing clotting
EP3095511A1 (de) 2006-10-19 2016-11-23 Depuy Spine Inc. Versiegelter behälter
WO2008073190A2 (en) * 2006-11-03 2008-06-19 Kyphon Sarl Materials and methods and systems for delivering localized medical treatments
DK2022446T3 (da) * 2007-07-30 2012-07-23 Purzer Pharmaceutical Co Ltd Biologisk nedbrydeligt knoglecement og fremgangsmåde til fremstilling deraf
US20090286907A1 (en) * 2008-01-23 2009-11-19 Beltz Mark W Fumaric Acid/Diol Polyesters and Their Manufacture and Use
US7968616B2 (en) * 2008-04-22 2011-06-28 Kyphon Sarl Bone cement composition and method
EP2590605A1 (de) 2010-07-09 2013-05-15 Board of Regents of the University of Texas System Biologisch abbaubare gerüste
US11865785B2 (en) * 2010-08-20 2024-01-09 H. David Dean Continuous digital light processing additive manufacturing of implants
KR101879438B1 (ko) 2010-08-20 2018-08-17 케이스 웨스턴 리저브 유니버시티 이식물의 ｃＤＬＰ 첨삭 가공
AU2015257289B2 (en) 2014-05-05 2020-10-01 Advanced Medical Solutions Israel (Sealantis) Ltd Biological adhesives and sealants and methods of using the same
CA2967949C (en) * 2014-11-18 2023-04-04 The University Of Akron Well-defined degradable poly(propylene fumarate) polymers and scalable methods for the synthesis thereof
AU2018214596A1 (en) 2017-02-02 2019-08-08 The University Of Akron Functionalized poly(propylene fumarate) polymers made by ring opening polymerization using magnesium catalysts
GB2594243A (en) * 2020-04-15 2021-10-27 Arterius Ltd A bone cement
WO2022015989A1 (en) * 2020-07-15 2022-01-20 The University Of Akron Synthesis of poly (propylene maleate-co-succinate) by the time-dependent reduction of poly (propylene maleate) double bonds mediated by zinc and acetic acid

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Also Published As

Publication number Publication date
ATE291444T1 (de) 2005-04-15
US6355755B1 (en) 2002-03-12
WO1999052469A9 (en) 2000-03-23
EP1079869B1 (de) 2005-03-23
JP2002539275A (ja) 2002-11-19
EP1079869A1 (de) 2001-03-07
WO1999052469A1 (en) 1999-10-21
EP1079869A4 (de) 2002-08-07
CA2327730A1 (en) 1999-10-21
US6124373A (en) 2000-09-26

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8339 Ceased/non-payment of the annual fee