DE69920284D1 - Detektor für laser-induzierte fluoreszenz und anwendungsverfahren für dieses gerät - Google Patents

Detektor für laser-induzierte fluoreszenz und anwendungsverfahren für dieses gerät

Info

Publication number
DE69920284D1
DE69920284D1 DE69920284T DE69920284T DE69920284D1 DE 69920284 D1 DE69920284 D1 DE 69920284D1 DE 69920284 T DE69920284 T DE 69920284T DE 69920284 T DE69920284 T DE 69920284T DE 69920284 D1 DE69920284 D1 DE 69920284D1
Authority
DE
Germany
Prior art keywords
laser
application
fluorescence detector
induced fluorescence
induced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69920284T
Other languages
English (en)
Other versions
DE69920284T2 (de
Inventor
Francois Couderc
Michel Nertz
Georges Nouadje
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PICOMETRICS RAMONVILLE SAINT A
Original Assignee
PICOMETRICS RAMONVILLE SAINT A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PICOMETRICS RAMONVILLE SAINT A filed Critical PICOMETRICS RAMONVILLE SAINT A
Application granted granted Critical
Publication of DE69920284D1 publication Critical patent/DE69920284D1/de
Publication of DE69920284T2 publication Critical patent/DE69920284T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6402—Atomic fluorescence; Laser induced fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6467—Axial flow and illumination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6478—Special lenses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6482—Sample cells, cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/063—Illuminating optical parts
    • G01N2201/0638—Refractive parts
    • G01N2201/0639—Sphere lens
DE69920284T 1999-04-07 1999-04-07 Detektor für laser-induzierte fluoreszenz und anwendungsverfahren für dieses gerät Expired - Lifetime DE69920284T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/FR1999/000800 WO2000060342A1 (fr) 1999-04-07 1999-04-07 Detecteur de fluorescence induite par laser et procede de mise en oeuvre dudit dispositif

Publications (2)

Publication Number Publication Date
DE69920284D1 true DE69920284D1 (de) 2004-10-21
DE69920284T2 DE69920284T2 (de) 2005-11-24

Family

ID=9541207

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69920284T Expired - Lifetime DE69920284T2 (de) 1999-04-07 1999-04-07 Detektor für laser-induzierte fluoreszenz und anwendungsverfahren für dieses gerät

Country Status (6)

Country Link
US (1) US5926271A (de)
EP (1) EP1166099B1 (de)
JP (1) JP2002541454A (de)
AU (1) AU3041799A (de)
DE (1) DE69920284T2 (de)
WO (1) WO2000060342A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69321110T2 (de) * 1993-07-12 1999-03-04 Hewlett Packard Gmbh Verfahren zur Herstellung einer Kapillarrohres, Kapillarrohr für eine Elektrophoresevorrichtung und Elektrophoresevorrichtung mit einem solchen Kapillarrohr
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
JP2003524754A (ja) * 1998-05-16 2003-08-19 ピーイー コーポレイション （エヌワイ） Ｄｎａのポリメラーゼ連鎖反応をモニタする装置
US6818437B1 (en) * 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
US7387891B2 (en) * 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
US7423750B2 (en) * 2001-11-29 2008-09-09 Applera Corporation Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion
US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
US20050279949A1 (en) * 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US6239871B1 (en) 1999-08-24 2001-05-29 Waters Investments Limited Laser induced fluorescence capillary interface
US6839375B1 (en) * 2001-09-06 2005-01-04 Lambda Physik Ag On-line quality control of the key optical components in lithography lasers using laser induced fluorescence
US7635588B2 (en) * 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
ATE537438T1 (de) * 2002-05-17 2011-12-15 Life Technologies Corp Vorrichtung und verfahren zur unterscheidung mehrerer fluoreszenzsignale anhand ihrer anregungswellenlänge
US6970492B2 (en) * 2002-05-17 2005-11-29 Lambda Physik Ag DUV and VUV laser with on-line pulse energy monitor
FR2869686B1 (fr) * 2003-12-11 2009-06-05 Flowgene Sa Detecteur de lumiere a chambre elliptique
US7177023B2 (en) * 2004-03-19 2007-02-13 Applera Corporation Fluorescent light detection
CN100498297C (zh) * 2004-07-02 2009-06-10 中国科学院大连化学物理研究所 一种集成式微流控芯片控制与分析平台
RU2400733C2 (ru) * 2004-12-13 2010-09-27 Байер Хелткэр Ллк Система для спектроскопии пропускания для использования при определении анализируемых веществ в жидкости организма
WO2006089089A2 (en) * 2005-02-16 2006-08-24 Applera Corporation Refractive index matching in capillary illumination
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
EP1928304B1 (de) 2005-09-30 2012-10-24 Intuity Medical, Inc. Katalysatoren für körperflüssigkeitsprobennahme
US20080018894A1 (en) * 2006-05-07 2008-01-24 Zu Jianping Lily Optical ball lens light scattering apparatus and method for use thereof
US20080248581A1 (en) * 2007-04-06 2008-10-09 Bayer Healthcare Llc Method for performing correction of blood glucose assay bias using blood hemoglobin concentration
DE102007020610A1 (de) * 2007-04-30 2008-11-20 Thomas Dr. Ruckstuhl Behälter und Verfahren zum Nachweis von Fluoreszenz
WO2009145920A1 (en) 2008-05-30 2009-12-03 Intuity Medical, Inc. Body fluid sampling device -- sampling site interface
US9636051B2 (en) 2008-06-06 2017-05-02 Intuity Medical, Inc. Detection meter and mode of operation
EP3106871B1 (de) 2009-11-30 2021-10-27 Intuity Medical, Inc. Verfahren zum verifizieren der genauigkeit des betriebs einer analyt-überwachungsvorrichtung
JP2011191175A (ja) * 2010-03-15 2011-09-29 Mitsutoyo Corp レーザ反射体
EP3407064B1 (de) 2011-08-03 2020-04-22 Intuity Medical, Inc. Vorrichtung zur entnahme von körperflüssigkeiten
CN104956193B (zh) * 2013-01-30 2017-10-24 台湾超微光学股份有限公司 光感测模块、光谱仪的光机构及光谱仪
CN103257128B (zh) * 2013-05-13 2015-10-07 上海通微分析技术有限公司 串行双光路激光诱导荧光光谱仪
CN104034709A (zh) * 2014-06-06 2014-09-10 中国科学院长春光学精密机械与物理研究所 一种荧光分析仪光学系统
WO2016020831A1 (en) * 2014-08-06 2016-02-11 Ecole Polytechnique Federale De Lausanne (Epfl) System for optical detection and imaging of sub-diffraction-limited nano-objects
CN104483297B (zh) * 2014-12-08 2017-03-08 上海通微分析技术有限公司 可视化校准激光诱导荧光检测设备
US10613029B2 (en) * 2015-04-14 2020-04-07 Honeywell International Inc. Apparatus and method for forming an alignment cell
WO2020190969A1 (en) * 2019-03-18 2020-09-24 Life Technologies Corporation Multi-capillary optical detection system
CN113063759B (zh) * 2021-03-15 2023-05-05 国科大杭州高等研究院 基于半球空间类复眼结构的体细胞激光诱导荧光探测方法
CN113063762B (zh) * 2021-03-15 2023-05-05 国科大杭州高等研究院 半球空间类复眼体细胞激光诱导荧光探测仪

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348107A (en) * 1980-07-18 1982-09-07 Coulter Electronics, Inc. Orifice inside optical element
SE8102772L (sv) * 1981-05-04 1982-11-05 Sven Staffan Folestad Forfarande for laserinducerad fluoriscensdetektering och anordning for genomforande av forfarandet
DE3424108A1 (de) * 1984-06-29 1986-01-09 Bernhard Prof. Dr.-Ing. 4300 Essen Schrader Probenanordnung zur spektrometrie, verfahren zur messung von lumineszenz und streuung und verwendung der probenanordnung
US5037199A (en) * 1989-02-22 1991-08-06 Linear Instruments Corporation Ball lens micro-cell
US5061361A (en) * 1989-03-06 1991-10-29 Hewlett-Packard Company Capillary zone electrophoresis cell system
EP0416234A3 (en) * 1989-09-05 1991-07-03 Hewlett-Packard Company Electrophoresis apparatus
DE69321110T2 (de) * 1993-07-12 1999-03-04 Hewlett Packard Gmbh Verfahren zur Herstellung einer Kapillarrohres, Kapillarrohr für eine Elektrophoresevorrichtung und Elektrophoresevorrichtung mit einem solchen Kapillarrohr
US5658446A (en) * 1996-01-22 1997-08-19 Hewlett-Packard Company Preparative capillary electrophoresis with wide-bore capillary

Also Published As

Publication number Publication date
AU3041799A (en) 2000-10-23
EP1166099B1 (de) 2004-09-15
US5926271A (en) 1999-07-20
DE69920284T2 (de) 2005-11-24
EP1166099A1 (de) 2002-01-02
WO2000060342A1 (fr) 2000-10-12
JP2002541454A (ja) 2002-12-03

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Legal Events

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