DE69918389D1 - Verfahren und vorrichtung zur erkennung von molekül-bindungsreaktionen - Google Patents
Verfahren und vorrichtung zur erkennung von molekül-bindungsreaktionenInfo
- Publication number
- DE69918389D1 DE69918389D1 DE69918389T DE69918389T DE69918389D1 DE 69918389 D1 DE69918389 D1 DE 69918389D1 DE 69918389 T DE69918389 T DE 69918389T DE 69918389 T DE69918389 T DE 69918389T DE 69918389 D1 DE69918389 D1 DE 69918389D1
- Authority
- DE
- Germany
- Prior art keywords
- molecular binding
- binding reactions
- detecting molecular
- signal
- response
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
- G11C13/0002—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
- G11C13/0009—RRAM elements whose operation depends upon chemical change
- G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/806—Electrical property or magnetic property
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7344598P | 1998-02-02 | 1998-02-02 | |
| US73445P | 1998-02-02 | ||
| PCT/US1999/002147 WO1999039190A1 (en) | 1998-02-02 | 1999-02-01 | Method and apparatus for detecting molecular binding events |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69918389D1 true DE69918389D1 (de) | 2004-08-05 |
| DE69918389T2 DE69918389T2 (de) | 2005-10-06 |
Family
ID=22113726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69918389T Expired - Lifetime DE69918389T2 (de) | 1998-02-02 | 1999-02-01 | Verfahren und Vorrichtung zur Erkennung von Molekülbindungsreaktionen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6368795B1 (de) |
| EP (1) | EP0991938B1 (de) |
| JP (2) | JP2002502028A (de) |
| KR (1) | KR20010040559A (de) |
| CN (1) | CN1292087A (de) |
| AT (1) | ATE270429T1 (de) |
| AU (1) | AU745416B2 (de) |
| CA (1) | CA2318191C (de) |
| DE (1) | DE69918389T2 (de) |
| GB (1) | GB2342176B (de) |
| IL (1) | IL137260A0 (de) |
| NO (1) | NO20003911L (de) |
| WO (1) | WO1999039190A1 (de) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6287874B1 (en) | 1998-02-02 | 2001-09-11 | Signature Bioscience, Inc. | Methods for analyzing protein binding events |
| US6395480B1 (en) | 1999-02-01 | 2002-05-28 | Signature Bioscience, Inc. | Computer program and database structure for detecting molecular binding events |
| AU769226B2 (en) * | 1998-02-02 | 2004-01-22 | Signature Bioscience Inc. | Test systems and sensors for detecting molecular binding events |
| US20020177175A1 (en) * | 1998-02-02 | 2002-11-28 | Hefti John J. | Coplanar waveguide biosensor for detecting molecular or cellular events |
| US6485905B2 (en) * | 1998-02-02 | 2002-11-26 | Signature Bioscience, Inc. | Bio-assay device |
| US6287776B1 (en) | 1998-02-02 | 2001-09-11 | Signature Bioscience, Inc. | Method for detecting and classifying nucleic acid hybridization |
| US6368795B1 (en) | 1998-02-02 | 2002-04-09 | Signature Bioscience, Inc. | Bio-assay device and test system for detecting molecular binding events |
| EP1087777B1 (de) * | 1998-05-22 | 2003-02-19 | Inspire Pharmaceuticals, Inc. | Therapeutische dinucleotide und deren derivate |
| AU5251299A (en) * | 1999-02-01 | 2000-08-18 | Signature Bioscience Inc. | Method and apparatus for detecting molecular binding events |
| CA2386193A1 (en) * | 1999-10-13 | 2001-04-19 | Signature Bioscience, Inc. | System and method for detecting and identifying molecular events in a test sample |
| DE10002597A1 (de) * | 2000-01-21 | 2001-08-02 | Infineon Technologies Ag | Verfahren und Vorrichtung zur Identifikation von in einer Trägerflüssigkeit vorhandenen Molekülen |
| CA2412394A1 (en) | 2000-08-02 | 2002-02-07 | Walter Ausserer | High throughput separations based analysis systems |
| JP4860841B2 (ja) * | 2000-08-25 | 2012-01-25 | シスメックス株式会社 | 分析データ提供方法、分析データ提供装置及び分析データ提供プログラム |
| US6586946B2 (en) | 2000-11-13 | 2003-07-01 | Signature Bioscience, Inc. | System and method for detecting and identifying molecular events in a test sample using a resonant test structure |
| US8900811B2 (en) | 2000-11-16 | 2014-12-02 | Caliper Life Sciences, Inc. | Method and apparatus for generating thermal melting curves in a microfluidic device |
| US6778724B2 (en) | 2000-11-28 | 2004-08-17 | The Regents Of The University Of California | Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices |
| AU2002238100A1 (en) * | 2001-02-12 | 2002-08-28 | Signature Bioscience, Inc. | A system and method for characterizing the permittivity of molecular events |
| WO2002077605A2 (en) * | 2001-03-21 | 2002-10-03 | Signature Bioscience, Inc. | Reentrant cavity bioassay for detecting molecular or cellular events |
| US6627461B2 (en) * | 2001-04-18 | 2003-09-30 | Signature Bioscience, Inc. | Method and apparatus for detection of molecular events using temperature control of detection environment |
| WO2002099386A2 (en) * | 2001-06-07 | 2002-12-12 | Proligo Llc | Microcalorimetric detection of analytes and binding events |
| US20040166593A1 (en) * | 2001-06-22 | 2004-08-26 | Nolte David D. | Adaptive interferometric multi-analyte high-speed biosensor |
| US20030032000A1 (en) * | 2001-08-13 | 2003-02-13 | Signature Bioscience Inc. | Method for analyzing cellular events |
| AU2002359263A1 (en) * | 2001-10-12 | 2003-04-22 | Wisconsin Alumni Research Foundation | Microwave dielectric spectroscopy method and apparatus for assays of proteins and other biological molecules |
| CA2477702A1 (en) | 2002-03-05 | 2003-09-18 | Caliper Life Sciences, Inc. | Mixed mode microfluidic systems abstract of the disclosure |
| US7419784B2 (en) | 2002-04-02 | 2008-09-02 | Dubrow Robert S | Methods, systems and apparatus for separation and isolation of one or more sample components of a sample biological material |
| US7470533B2 (en) * | 2002-12-20 | 2008-12-30 | Acea Biosciences | Impedance based devices and methods for use in assays |
| US8206903B2 (en) | 2002-12-20 | 2012-06-26 | Acea Biosciences | Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses |
| US7732127B2 (en) * | 2002-12-20 | 2010-06-08 | Acea Biosciences, Inc. | Dynamic monitoring of cell adhesion and spreading using the RT-CES system |
| US7560269B2 (en) | 2002-12-20 | 2009-07-14 | Acea Biosciences, Inc. | Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays |
| US7468255B2 (en) * | 2002-12-20 | 2008-12-23 | Acea Biosciences | Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology |
| US8263375B2 (en) | 2002-12-20 | 2012-09-11 | Acea Biosciences | Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology |
| CN100577811C (zh) * | 2002-07-20 | 2010-01-06 | 美国艾森生物科学公司 | 基于阻抗分析细胞和颗粒的装置和方法 |
| US11346797B2 (en) | 2002-12-20 | 2022-05-31 | Agilent Technologies, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties |
| US10215748B2 (en) | 2002-12-20 | 2019-02-26 | Acea Biosciences, Inc. | Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways |
| US10551371B2 (en) | 2003-11-10 | 2020-02-04 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function |
| US10539523B2 (en) | 2002-12-20 | 2020-01-21 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties |
| US9612234B2 (en) | 2008-05-05 | 2017-04-04 | Acea Biosciences, Inc. | Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments |
| WO2005022147A1 (en) | 2003-08-28 | 2005-03-10 | Celula, Inc. | Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network |
| US20070072286A1 (en) * | 2003-09-29 | 2007-03-29 | Koninkljke Philips Electronics N.V. | Label-free detection of biomolecules |
| CA2550274A1 (en) | 2003-11-12 | 2005-05-26 | Acea Biosciences, Inc. | Real time electronic cell sensing systems and applications for cell-based assays |
| US7514938B2 (en) * | 2004-05-11 | 2009-04-07 | Board Of Regents Of The University And College System Of Nevada, On Behalf Of The University Of Nevada, Reno | Dielectric relaxation spectroscopy apparatus and methods of use |
| JP4546326B2 (ja) * | 2004-07-30 | 2010-09-15 | キヤノン株式会社 | センシング装置 |
| KR100667305B1 (ko) * | 2005-01-03 | 2007-01-12 | 삼성전자주식회사 | 생분자결합 검출장치 및 그 방법 |
| US7910356B2 (en) * | 2005-02-01 | 2011-03-22 | Purdue Research Foundation | Multiplexed biological analyzer planar array apparatus and methods |
| US7405831B2 (en) * | 2005-02-01 | 2008-07-29 | Purdue Research Foundation | Laser scanning interferometric surface metrology |
| US20070023643A1 (en) * | 2005-02-01 | 2007-02-01 | Nolte David D | Differentially encoded biological analyzer planar array apparatus and methods |
| WO2007131103A2 (en) * | 2006-05-03 | 2007-11-15 | Quadraspec, Inc. | Direct printing of patterned hydrophobic wells |
| US8041515B2 (en) * | 2006-09-20 | 2011-10-18 | Acea Biosciences, Inc. | Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents |
| US20080230605A1 (en) * | 2006-11-30 | 2008-09-25 | Brian Weichel | Process and apparatus for maintaining data integrity |
| US7522282B2 (en) * | 2006-11-30 | 2009-04-21 | Purdue Research Foundation | Molecular interferometric imaging process and apparatus |
| US20080144899A1 (en) * | 2006-11-30 | 2008-06-19 | Manoj Varma | Process for extracting periodic features from images by template matching |
| JP4928249B2 (ja) * | 2006-12-20 | 2012-05-09 | キヤノン株式会社 | 検出装置 |
| US7659968B2 (en) * | 2007-01-19 | 2010-02-09 | Purdue Research Foundation | System with extended range of molecular sensing through integrated multi-modal data acquisition |
| WO2008118934A1 (en) * | 2007-03-26 | 2008-10-02 | Purdue Research Foundation | Method and apparatus for conjugate quadrature interferometric detection of an immunoassay |
| WO2009039298A2 (en) * | 2007-09-18 | 2009-03-26 | University Of Florida Research Foundation, Inc. | Sensors using aigan/gan high electron mobility transistors |
| CA2723223C (en) | 2008-05-05 | 2017-06-06 | Acea Biosciences, Inc. | Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution |
| US8836351B2 (en) * | 2008-06-10 | 2014-09-16 | University Of Florida Research Foundation, Inc. | Chloride detection |
| US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
| US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
| US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
| US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
| US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
| US8741591B2 (en) | 2009-10-09 | 2014-06-03 | The Research Foundation For The State University Of New York | pH-insensitive glucose indicator protein |
| US9949679B2 (en) * | 2012-12-07 | 2018-04-24 | Ascilion Ab | Microfabricated sensor and a method of sensing the level of a component in bodily fluid |
| EP3071965A1 (de) | 2013-11-21 | 2016-09-28 | Avails Medical, Inc. | Elektrischer biosensor zum nachweis einer substanz in einer körperflüssigkeit sowie verfahren und system dafür |
| US9702847B2 (en) | 2014-12-30 | 2017-07-11 | Avails Medical, Inc. | Systems and methods for detecting a substance in bodily fluid |
| CA2996417A1 (en) | 2015-08-25 | 2017-03-02 | Avails Medical, Inc. | Devices, systems and methods for detecting viable microorganisms in a fluid sample |
| AT517604B1 (de) * | 2015-10-06 | 2017-03-15 | Siemens Ag Oesterreich | Messfühler |
| WO2017132095A1 (en) | 2016-01-25 | 2017-08-03 | Avails Medical, Inc. | Devices, systems and methods for detecting viable infectious agents in a fluid sample using an electrolyte-insulator-semiconductor sensor |
| US10174356B2 (en) | 2016-05-31 | 2019-01-08 | Avails Medical, Inc. | Devices, systems and methods to detect viable infectious agents in a fluid sample and susceptibility of infectious agents to anti-infectives |
| CN108241056A (zh) * | 2016-12-23 | 2018-07-03 | 财团法人金属工业研究发展中心 | 生物检测装置 |
| CN110582569B (zh) | 2017-03-03 | 2024-04-02 | 安捷伦科技有限公司 | 用于iPSC和ESC衍生的心肌细胞的功能成熟的方法和系统 |
| WO2019005296A1 (en) | 2017-06-27 | 2019-01-03 | Avails Medical, Inc. | APPARATUS, SYSTEMS AND METHODS FOR DETERMINING THE SENSITIVITY OF MICROORGANISMS TO ANTI-INFECTIOUS |
| GB201711543D0 (en) | 2017-07-18 | 2017-08-30 | Univ Oxford Innovation Ltd | Sensor, sensing system and sensing method |
| US10775422B2 (en) * | 2017-09-05 | 2020-09-15 | Texas Instruments Incorporated | Molecular spectroscopy cell with resonant cavity |
| JP7209701B2 (ja) | 2017-10-03 | 2023-01-20 | アベイルズ メディカル，インコーポレイテッド | レドックス反応に基づいて微生物の濃度及び抗感染剤に対する微生物の感受性を決定する装置、システム、及び方法 |
| USD941488S1 (en) | 2020-02-07 | 2022-01-18 | Agilent Technologies, Inc. | Instrument for analyzing biological cells |
| CN113218968B (zh) * | 2021-05-26 | 2022-07-15 | 江南大学 | 酵母菌测试用高灵敏度微波生物传感器及其应用 |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4288229A (en) | 1980-03-07 | 1981-09-08 | Envirotech Corporation | Determination of total organic carbon in a plurality of aqueous samples containing halide ion |
| US4407290A (en) | 1981-04-01 | 1983-10-04 | Biox Technology, Inc. | Blood constituent measuring device and method |
| US4767717A (en) | 1985-05-02 | 1988-08-30 | Baisden C Robert | Method of detecting and quantitating cell malignancy in biological tissue |
| EP0213825A3 (de) | 1985-08-22 | 1989-04-26 | Molecular Devices Corporation | Chemisch-modulierte Mehrfachkapazitanz |
| US4765179A (en) | 1985-09-09 | 1988-08-23 | Solid State Farms, Inc. | Radio frequency spectroscopy apparatus and method using multiple frequency waveforms |
| US4679426A (en) | 1985-09-09 | 1987-07-14 | Fuller Milton E | Wave shape chemical analysis apparatus and method |
| US4822566A (en) * | 1985-11-19 | 1989-04-18 | The Johns Hopkins University | Optimized capacitive sensor for chemical analysis and measurement |
| GB8612221D0 (en) | 1986-05-20 | 1986-06-25 | Amersham Int Plc | Assaying species in sample |
| GB8801807D0 (en) | 1988-01-27 | 1988-02-24 | Amersham Int Plc | Biological sensors |
| DE68907519T2 (de) | 1988-05-10 | 1993-10-21 | Amersham Int Plc | Biosensoren. |
| GB8811919D0 (en) | 1988-05-20 | 1988-06-22 | Amersham Int Plc | Biological sensors |
| US5120648A (en) | 1988-05-26 | 1992-06-09 | Lim Technology Laboratories, Inc. | Chemical analyzer using rf radiation attenuation measurements |
| GB8813307D0 (en) | 1988-06-06 | 1988-07-13 | Amersham Int Plc | Biological sensors |
| US5478755A (en) * | 1988-07-25 | 1995-12-26 | Ares Serono Research & Development Ltd. | Long range surface plasma resonance immunoassay |
| WO1990002327A1 (en) * | 1988-08-18 | 1990-03-08 | AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INSTITUTE LTD., Commonwealth Scientific and Industrial Research Organization | Improvements in sensitivity and selectivity of ion channel membrane biosensors |
| US5156810A (en) * | 1989-06-15 | 1992-10-20 | Biocircuits Corporation | Biosensors employing electrical, optical and mechanical signals |
| US5025222A (en) | 1989-07-07 | 1991-06-18 | Phase Dynamics, Inc. | System and method for monitoring substances and reactions |
| US5434084A (en) | 1989-09-06 | 1995-07-18 | The Washington Research Foundation | Flow optrode having separate reaction and detection chambers |
| US5082629A (en) | 1989-12-29 | 1992-01-21 | The Board Of The University Of Washington | Thin-film spectroscopic sensor |
| US5082630A (en) * | 1990-04-30 | 1992-01-21 | The United States Of America As Represented By The United States Department Of Energy | Fiber optic detector for immuno-testing |
| WO1991019187A1 (en) | 1990-06-04 | 1991-12-12 | Pb Diagnostic Systems, Inc. | Analytical assay |
| GB9019123D0 (en) | 1990-09-01 | 1990-10-17 | Fisons Plc | Analytical device |
| US5212099A (en) | 1991-01-18 | 1993-05-18 | Eastman Kodak Company | Method and apparatus for optically measuring concentration of an analyte |
| US5233306A (en) | 1991-02-13 | 1993-08-03 | The Board Of Regents Of The University Of Wisconsin System | Method and apparatus for measuring the permittivity of materials |
| GB9111912D0 (en) | 1991-06-04 | 1991-07-24 | Fisons Plc | Analytical methods |
| US5340715A (en) * | 1991-06-07 | 1994-08-23 | Ciba Corning Diagnostics Corp. | Multiple surface evanescent wave sensor with a reference |
| CA2069537A1 (en) * | 1991-06-07 | 1992-12-08 | Thomas A. Cook | Multiple output referencing system for evanescent wave sensor |
| DE69110032T2 (de) * | 1991-06-08 | 1995-12-21 | Hewlett Packard Gmbh | Verfahren und Gerät zur Feststellung und/oder Konzentrationsbestimmung von Biomolekülen. |
| US5218814A (en) * | 1991-06-14 | 1993-06-15 | Deere & Company | Engine and transaxle module |
| AU2907092A (en) | 1991-10-21 | 1993-05-21 | James W. Holm-Kennedy | Method and device for biochemical sensing |
| US5846708A (en) | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
| IL103674A0 (en) * | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
| US5403747A (en) | 1992-04-01 | 1995-04-04 | Thomas Jefferson University | Protein assay using microwave energy |
| US5478748A (en) | 1992-04-01 | 1995-12-26 | Thomas Jefferson University | Protein assay using microwave energy |
| GB9212416D0 (en) * | 1992-06-11 | 1992-07-22 | Medical Res Council | Reversible binding substances |
| US5504366A (en) | 1992-07-17 | 1996-04-02 | Biotechnology Research And Development Corp. | System for analyzing surfaces of samples |
| US5397896A (en) | 1992-07-17 | 1995-03-14 | Penn State Research Foundation And Biotechnology Research And Development Corporation | Multiple source and detection frequencies in detecting threshold phenomena associated with and/or atomic or molecular spectra |
| US5268573A (en) | 1992-07-17 | 1993-12-07 | The Penn State Research Foundation | System for detecting threshold phenomena associated with and/or atomic or molecular spectra of a substance |
| US5348003A (en) | 1992-09-03 | 1994-09-20 | Sirraya, Inc. | Method and apparatus for chemical analysis |
| US5543329A (en) | 1992-11-03 | 1996-08-06 | Intelligent Monitoring Systems And Advanced Global Technologies | Sensor for antigen-antibody reactions |
| US5359681A (en) * | 1993-01-11 | 1994-10-25 | University Of Washington | Fiber optic sensor and methods and apparatus relating thereto |
| US5327225A (en) * | 1993-01-28 | 1994-07-05 | The Center For Innovative Technology | Surface plasmon resonance sensor |
| US5363052A (en) | 1993-02-16 | 1994-11-08 | Solid State Farms, Inc. | Permittivity spectroscopy apparatus and method |
| US5512492A (en) * | 1993-05-18 | 1996-04-30 | University Of Utah Research Foundation | Waveguide immunosensor with coating chemistry providing enhanced sensitivity |
| US5919712A (en) * | 1993-05-18 | 1999-07-06 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
| JPH08511096A (ja) | 1993-06-01 | 1996-11-19 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | 被検体−応答性ｋｔｐ組成物及び方法 |
| AU7552194A (en) | 1993-07-26 | 1995-02-20 | Phase Dynamics, Inc. | System and method for monitoring substances and reactions |
| US5508203A (en) | 1993-08-06 | 1996-04-16 | Fuller; Milton E. | Apparatus and method for radio frequency spectroscopy using spectral analysis |
| US5792668A (en) | 1993-08-06 | 1998-08-11 | Solid State Farms, Inc. | Radio frequency spectral analysis for in-vitro or in-vivo environments |
| JPH0763760A (ja) * | 1993-08-31 | 1995-03-10 | Daikin Ind Ltd | 光学的免疫測定方法およびその装置 |
| US5432096A (en) | 1993-12-20 | 1995-07-11 | Cetac Technologies Inc. | Simultaneous multiple, single wavelength electromagnetic wave energy absorbtion detection and quantifying spectrophotometric system, and method of use |
| GB9401170D0 (en) * | 1994-01-21 | 1994-03-16 | Lynxvale Limited . | Optical sensor |
| CA2152756A1 (en) * | 1994-06-28 | 1995-12-29 | Tadakazu Yamauchi | Method and device for specific binding assay |
| US5485277A (en) * | 1994-07-26 | 1996-01-16 | Physical Optics Corporation | Surface plasmon resonance sensor and methods for the utilization thereof |
| US5656428A (en) | 1994-09-08 | 1997-08-12 | Biode, Inc. | Homogeneous bioassay using acoustic emission spectroscopy |
| GB9418981D0 (en) | 1994-09-21 | 1994-11-09 | Univ Glasgow | Apparatus and method for carrying out analysis of samples |
| US5599668A (en) * | 1994-09-22 | 1997-02-04 | Abbott Laboratories | Light scattering optical waveguide method for detecting specific binding events |
| US5620850A (en) * | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
| US6035246A (en) | 1994-11-04 | 2000-03-07 | Sandia Corporation | Method for identifying known materials within a mixture of unknowns |
| US5814565A (en) * | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
| US5629213A (en) * | 1995-03-03 | 1997-05-13 | Kornguth; Steven E. | Analytical biosensor |
| EP0871871B1 (de) | 1995-05-17 | 2004-05-06 | Ambri Limited | Verbesserung eines ionenreservoirs durch die verwendung eines elektrischen potentials |
| GB9518429D0 (en) * | 1995-09-08 | 1995-11-08 | Pharmacia Biosensor | A rapid method for providing kinetic and structural data in molecular interaction analysis |
| US5815278A (en) * | 1995-10-25 | 1998-09-29 | University Of Washington | Surface plasmon resonance light pipe sensing probe and related interface optics |
| AU7526496A (en) * | 1995-10-25 | 1997-05-15 | University Of Washington | Surface plasmon resonance electrode as chemical sensor |
| US5661301A (en) | 1996-02-07 | 1997-08-26 | The Penn State Research Foundation | Spectroscopy and mapping of atoms, molecules and surface features via difference frequency generation with a scanning tunneling microscope or related instruments |
| US5671303A (en) | 1996-04-17 | 1997-09-23 | Motorola, Inc. | Molecular detection apparatus and method using optical waveguide detection |
| ATE234462T1 (de) * | 1996-04-25 | 2003-03-15 | Pence Inc | Biosensor-vorrichtung und verfahren |
| US5827482A (en) | 1996-08-20 | 1998-10-27 | Motorola Corporation | Transistor-based apparatus and method for molecular detection and field enhancement |
| US5832165A (en) * | 1996-08-28 | 1998-11-03 | University Of Utah Research Foundation | Composite waveguide for solid phase binding assays |
| US5858666A (en) * | 1996-08-29 | 1999-01-12 | Biotechnology Research And Development Corporation | Apparatus and method of detection employing an AC frequency sensor array |
| US5846843A (en) | 1996-11-18 | 1998-12-08 | The University Of Toledo | Sensor using long range surface plasmon resonance with diffraction double-grating |
| US6306584B1 (en) | 1997-01-21 | 2001-10-23 | President And Fellows Of Harvard College | Electronic-property probing of biological molecules at surfaces |
| US6048692A (en) | 1997-10-07 | 2000-04-11 | Motorola, Inc. | Sensors for electrically sensing binding events for supported molecular receptors |
| US6368795B1 (en) | 1998-02-02 | 2002-04-09 | Signature Bioscience, Inc. | Bio-assay device and test system for detecting molecular binding events |
| US6395480B1 (en) | 1999-02-01 | 2002-05-28 | Signature Bioscience, Inc. | Computer program and database structure for detecting molecular binding events |
-
1999
- 1999-02-01 US US09/243,194 patent/US6368795B1/en not_active Expired - Lifetime
- 1999-02-01 AU AU24906/99A patent/AU745416B2/en not_active Ceased
- 1999-02-01 CN CN99803583A patent/CN1292087A/zh active Pending
- 1999-02-01 EP EP99904525A patent/EP0991938B1/de not_active Expired - Lifetime
- 1999-02-01 WO PCT/US1999/002147 patent/WO1999039190A1/en not_active Application Discontinuation
- 1999-02-01 CA CA002318191A patent/CA2318191C/en not_active Expired - Fee Related
- 1999-02-01 DE DE69918389T patent/DE69918389T2/de not_active Expired - Lifetime
- 1999-02-01 AT AT99904525T patent/ATE270429T1/de not_active IP Right Cessation
- 1999-02-01 IL IL13726099A patent/IL137260A0/xx unknown
- 1999-02-01 KR KR1020007008428A patent/KR20010040559A/ko not_active Application Discontinuation
- 1999-02-01 JP JP2000529595A patent/JP2002502028A/ja not_active Withdrawn
- 1999-02-01 GB GB9923039A patent/GB2342176B/en not_active Expired - Fee Related
-
2000
- 2000-08-01 NO NO20003911A patent/NO20003911L/no not_active Application Discontinuation
-
2005
- 2005-06-01 JP JP2005162003A patent/JP2005308761A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0991938B1 (de) | 2004-06-30 |
| EP0991938A1 (de) | 2000-04-12 |
| ATE270429T1 (de) | 2004-07-15 |
| CN1292087A (zh) | 2001-04-18 |
| DE69918389T2 (de) | 2005-10-06 |
| AU2490699A (en) | 1999-08-16 |
| US6368795B1 (en) | 2002-04-09 |
| JP2002502028A (ja) | 2002-01-22 |
| CA2318191C (en) | 2009-05-05 |
| GB2342176A (en) | 2000-04-05 |
| CA2318191A1 (en) | 1999-08-05 |
| NO20003911L (no) | 2000-09-29 |
| JP2005308761A (ja) | 2005-11-04 |
| AU745416B2 (en) | 2002-03-21 |
| GB9923039D0 (en) | 1999-12-01 |
| KR20010040559A (ko) | 2001-05-15 |
| IL137260A0 (en) | 2001-07-24 |
| WO1999039190A1 (en) | 1999-08-05 |
| GB2342176B (en) | 2001-05-02 |
| NO20003911D0 (no) | 2000-08-01 |
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