DE69906254D1 - Verfahren zur gerfriertrocknung von präparaten mit verzörgerter wirkstoffabgabe - Google Patents
Verfahren zur gerfriertrocknung von präparaten mit verzörgerter wirkstoffabgabeInfo
- Publication number
- DE69906254D1 DE69906254D1 DE69906254T DE69906254T DE69906254D1 DE 69906254 D1 DE69906254 D1 DE 69906254D1 DE 69906254 T DE69906254 T DE 69906254T DE 69906254 T DE69906254 T DE 69906254T DE 69906254 D1 DE69906254 D1 DE 69906254D1
- Authority
- DE
- Germany
- Prior art keywords
- active substance
- delayed delivery
- freezing drying
- sustained
- release preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP991198 | 1998-01-21 | ||
| PCT/JP1999/000175 WO1999037288A1 (en) | 1998-01-21 | 1999-01-20 | Lyophilization method for sustained-release preparations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69906254D1 true DE69906254D1 (de) | 2003-04-30 |
| DE69906254T2 DE69906254T2 (de) | 2003-11-13 |
Family
ID=11733300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69906254T Expired - Lifetime DE69906254T2 (de) | 1998-01-21 | 1999-01-20 | Verfahren zur gerfriertrocknung von präparaten mit verzörgerter wirkstoffabgabe |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20050100604A1 (de) |
| EP (1) | EP1049458B1 (de) |
| KR (1) | KR100595340B1 (de) |
| CN (1) | CN1180768C (de) |
| AT (1) | ATE235231T1 (de) |
| AU (1) | AU1982599A (de) |
| CA (1) | CA2317039C (de) |
| DE (1) | DE69906254T2 (de) |
| NO (1) | NO20003527L (de) |
| WO (1) | WO1999037288A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002005787A1 (fr) * | 2000-07-17 | 2002-01-24 | Takeda Chemical Industries, Ltd. | Fabrication pour produits lyophilises |
| WO2002078673A1 (fr) * | 2001-03-29 | 2002-10-10 | Takeda Chemical Industries, Ltd. | Procede de production d'un medicament sous forme de granules fins |
| PT1532985T (pt) * | 2002-06-25 | 2017-01-20 | Takeda Pharmaceuticals Co | Processo de produção de uma composição de libertação sustentada |
| EP1870649A1 (de) * | 2006-06-20 | 2007-12-26 | Octapharma AG | Gefriertocknung zum Erzielen einer bestimmte Restfeuchte durch beschränkte Desorptionsenergiepegeln. |
| US20100186252A1 (en) * | 2009-01-29 | 2010-07-29 | Morimoto-Pharma Co., Ltd. | Freeze-drying method and apparatus |
| CN108571862A (zh) * | 2017-03-07 | 2018-09-25 | 成都青山利康药业有限公司 | 一种薄膜的冻干剥离方法 |
| CN111840758A (zh) * | 2020-07-03 | 2020-10-30 | 广州曼翔医药有限公司 | 一种咽鼓管球囊导管 |
| US11287185B1 (en) | 2020-09-09 | 2022-03-29 | Stay Fresh Technology, LLC | Freeze drying with constant-pressure and constant-temperature phases |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3928566A (en) * | 1970-08-14 | 1975-12-23 | Du Pont | Lyophilized biological products |
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| ATE61935T1 (de) | 1985-02-07 | 1991-04-15 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von mikrokapseln. |
| JPS6349683A (ja) | 1986-08-19 | 1988-03-02 | 共和真空技術株式会社 | 凍結乾燥方法と装置 |
| US4722943A (en) | 1987-03-19 | 1988-02-02 | Pierce & Stevens Corporation | Composition and process for drying and expanding microspheres |
| CA1334379C (en) | 1987-11-24 | 1995-02-14 | James William Mcginity | Method for preparing a solid sustained release form of a functionally active composition |
| US4878597A (en) * | 1988-03-24 | 1989-11-07 | Haast William E | Lyophilization containers |
| JPH07116022B2 (ja) * | 1989-04-18 | 1995-12-13 | 三共株式会社 | 凍結乾燥製剤の製法 |
| JP2533174Y2 (ja) * | 1989-04-24 | 1997-04-23 | 日東電工株式会社 | オムツ用粘着テ−プ |
| JP2653255B2 (ja) | 1990-02-13 | 1997-09-17 | 武田薬品工業株式会社 | 長期徐放型マイクロカプセル |
| DE4004620C1 (en) | 1990-02-15 | 1991-09-05 | Du Pont De Nemours (Deutschland) Gmbh, 6380 Bad Homburg, De | Photo-structured layer of three=dimensional object prodn. - by using fusible plastisol or organosol contg. unsatd. monomer, photoinitiator and thermally reactive cpd. |
| JP2551881B2 (ja) | 1991-06-26 | 1996-11-06 | 株式会社大塚製薬工場 | 凍結乾燥用容器および充填容器入り凍結乾燥薬剤の製造方法 |
| ATE154241T1 (de) | 1991-10-01 | 1997-06-15 | Takeda Chemical Industries Ltd | Mikropartikeln-zusammenfassung zur verlängerten freigabe und herstellung derselbe |
| DE69316101T2 (de) | 1992-08-07 | 1998-10-22 | Takeda Chemical Industries Ltd | Herstellung von Mikrokapseln, die wasserlösliche Arzneimittel enthalten |
| JP3277342B2 (ja) | 1992-09-02 | 2002-04-22 | 武田薬品工業株式会社 | 徐放性マイクロカプセルの製造法 |
| NZ260909A (en) | 1993-07-05 | 1995-04-27 | Takeda Chemical Industries Ltd | Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution |
| US5514670A (en) | 1993-08-13 | 1996-05-07 | Pharmos Corporation | Submicron emulsions for delivery of peptides |
| EP0668073B1 (de) * | 1994-02-21 | 1999-04-14 | Takeda Chemical Industries, Ltd. | Polyester Matrix für eine pharmazeutische Zusammensetzung mit verzögerter Freigabe |
| JP3790567B2 (ja) | 1994-09-30 | 2006-06-28 | 武田薬品工業株式会社 | 徐放剤 |
| US6117455A (en) | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
| US6294202B1 (en) | 1994-10-06 | 2001-09-25 | Genzyme Corporation | Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers |
| CA2180206A1 (en) | 1995-06-30 | 1996-12-31 | Motoya Ohshika | Freeze-dried preparation for pharmaceutical use |
| TW448055B (en) | 1995-09-04 | 2001-08-01 | Takeda Chemical Industries Ltd | Method of production of sustained-release preparation |
| JPH0995440A (ja) | 1995-09-29 | 1997-04-08 | Roussel Morishita Kk | 徐放性製剤およびその製造方法 |
| US5665428A (en) | 1995-10-25 | 1997-09-09 | Macromed, Inc. | Preparation of peptide containing biodegradable microspheres by melt process |
| JP3765338B2 (ja) | 1995-12-15 | 2006-04-12 | 武田薬品工業株式会社 | 注射用徐放性製剤の製造法 |
| CA2192773C (en) | 1995-12-15 | 2008-09-23 | Hiroaki Okada | Production of sustained-release preparation for injection |
| WO1997035563A2 (en) | 1996-03-28 | 1997-10-02 | Takeda Chemical Industries, Ltd. | Sustained-release preparation and its production |
| US6287587B2 (en) | 1997-07-15 | 2001-09-11 | Takeda Chemical Industries, Ltd. | Process for producing sustained-release preparation by in-water drying |
| JP3639783B2 (ja) * | 2000-10-30 | 2005-04-20 | 共和真空技術株式会社 | 食品・薬品等の凍結乾燥方法および凍結乾燥装置 |
| JP3653239B2 (ja) * | 2001-06-14 | 2005-05-25 | 共和真空技術株式会社 | 食品・薬品等の凍結乾燥装置 |
-
1999
- 1999-01-20 DE DE69906254T patent/DE69906254T2/de not_active Expired - Lifetime
- 1999-01-20 WO PCT/JP1999/000175 patent/WO1999037288A1/en active IP Right Grant
- 1999-01-20 CN CNB998023191A patent/CN1180768C/zh not_active Expired - Lifetime
- 1999-01-20 AT AT99900642T patent/ATE235231T1/de not_active IP Right Cessation
- 1999-01-20 CA CA002317039A patent/CA2317039C/en not_active Expired - Lifetime
- 1999-01-20 AU AU19825/99A patent/AU1982599A/en not_active Abandoned
- 1999-01-20 KR KR1020007007972A patent/KR100595340B1/ko not_active IP Right Cessation
- 1999-01-20 EP EP99900642A patent/EP1049458B1/de not_active Expired - Lifetime
-
2000
- 2000-07-07 NO NO20003527A patent/NO20003527L/no not_active Application Discontinuation
-
2004
- 2004-12-02 US US11/001,889 patent/US20050100604A1/en not_active Abandoned
-
2010
- 2010-11-23 US US12/926,520 patent/US8927016B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2317039A1 (en) | 1999-07-29 |
| NO20003527L (no) | 2000-09-05 |
| KR20010034271A (ko) | 2001-04-25 |
| AU1982599A (en) | 1999-08-09 |
| CA2317039C (en) | 2009-09-29 |
| CN1180768C (zh) | 2004-12-22 |
| US20050100604A1 (en) | 2005-05-12 |
| DE69906254T2 (de) | 2003-11-13 |
| EP1049458B1 (de) | 2003-03-26 |
| WO1999037288A1 (en) | 1999-07-29 |
| US20110070311A1 (en) | 2011-03-24 |
| US8927016B2 (en) | 2015-01-06 |
| CN1288374A (zh) | 2001-03-21 |
| KR100595340B1 (ko) | 2006-07-03 |
| ATE235231T1 (de) | 2003-04-15 |
| EP1049458A1 (de) | 2000-11-08 |
| NO20003527D0 (no) | 2000-07-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP |
|
| 8364 | No opposition during term of opposition |