DE69901743D1 - Biosensor, iontophoretischen Probenahmesystem, und Verfahren zur seiner Anwendung - Google Patents

Biosensor, iontophoretischen Probenahmesystem, und Verfahren zur seiner Anwendung

Info

Publication number
DE69901743D1
DE69901743D1 DE69901743T DE69901743T DE69901743D1 DE 69901743 D1 DE69901743 D1 DE 69901743D1 DE 69901743 T DE69901743 T DE 69901743T DE 69901743 T DE69901743 T DE 69901743T DE 69901743 D1 DE69901743 D1 DE 69901743D1
Authority
DE
Germany
Prior art keywords
biosensor
sampling system
iontophoretic sampling
analytes
transdermal extraction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69901743T
Other languages
English (en)
Other versions
DE69901743T2 (de
Inventor
Lynn Kim
Norman A Parris
Russell O Potts
Janet A Tamada
Michael J Tierney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Animas Technologies LLC
Original Assignee
Cygnus Therapeutic Systems
Cygnus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cygnus Therapeutic Systems, Cygnus Inc filed Critical Cygnus Therapeutic Systems
Application granted granted Critical
Publication of DE69901743D1 publication Critical patent/DE69901743D1/de
Publication of DE69901743T2 publication Critical patent/DE69901743T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1495Calibrating or testing of in-vivo probes
DE69901743T 1998-03-13 1999-03-12 Biosensor, iontophoretischen Probenahmesystem, und Verfahren zur seiner Anwendung Expired - Lifetime DE69901743T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7799398P 1998-03-13 1998-03-13
US8059198P 1998-04-03 1998-04-03
US17490298A 1998-10-19 1998-10-19

Publications (2)

Publication Number Publication Date
DE69901743D1 true DE69901743D1 (de) 2002-07-18
DE69901743T2 DE69901743T2 (de) 2003-01-30

Family

ID=27373197

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69901743T Expired - Lifetime DE69901743T2 (de) 1998-03-13 1999-03-12 Biosensor, iontophoretischen Probenahmesystem, und Verfahren zur seiner Anwendung

Country Status (11)

Country Link
US (4) US6587705B1 (de)
EP (1) EP0942278B1 (de)
JP (1) JP3155523B2 (de)
KR (1) KR100328654B1 (de)
AT (1) ATE219245T1 (de)
CA (1) CA2265119C (de)
DE (1) DE69901743T2 (de)
DK (1) DK0942278T3 (de)
ES (1) ES2178349T3 (de)
GB (1) GB2335278B (de)
PT (1) PT942278E (de)

Families Citing this family (283)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9700384D0 (sv) * 1997-02-04 1997-02-04 Biacore Ab Analytical method and apparatus
US7192450B2 (en) 2003-05-21 2007-03-20 Dexcom, Inc. Porous membranes for use with implantable devices
US7657297B2 (en) 2004-05-03 2010-02-02 Dexcom, Inc. Implantable analyte sensor
US8527026B2 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
US6862465B2 (en) 1997-03-04 2005-03-01 Dexcom, Inc. Device and method for determining analyte levels
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US8071384B2 (en) 1997-12-22 2011-12-06 Roche Diagnostics Operations, Inc. Control and calibration solutions and methods for their use
US7470547B2 (en) 2003-07-31 2008-12-30 Biodot, Inc. Methods and systems for dispensing sub-microfluidic drops
US20020159919A1 (en) * 1998-01-09 2002-10-31 Carl Churchill Method and apparatus for high-speed microfluidic dispensing using text file control
CA2265119C (en) 1998-03-13 2002-12-03 Cygnus, Inc. Biosensor, iontophoretic sampling system, and methods of use thereof
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US6599408B1 (en) 1998-09-17 2003-07-29 E. I. Du Pont De Nemours And Company Thick film conductor composition for use in biosensors
US6391643B1 (en) 1998-10-28 2002-05-21 Cygnus, Inc. Kit and method for quality control testing of an iontophoretic sampling system
US6561978B1 (en) 1999-02-12 2003-05-13 Cygnus, Inc. Devices and methods for frequent measurement of an analyte present in a biological system
EP1064046A1 (de) 1999-04-22 2001-01-03 Cygnus, Inc. Verfahren und vorrichtung zum trennen von interferenden spezies
WO2001038873A2 (en) * 1999-11-24 2001-05-31 Biotronic Technologies, Inc. Devices and methods for detecting analytes using electrosensor having capture reagent
US6733655B1 (en) 2000-03-08 2004-05-11 Oliver W. H. Davies Measurement of substances in liquids
EP1225831A2 (de) * 2000-03-17 2002-07-31 Sontra Medical, Inc. Nichtinvasive körperflussentnahme und -analyse
CA2407973C (en) * 2000-05-03 2011-06-07 Jen-Jr Gau Biological identification system with integrated sensor chip
AU2014200664B2 (en) * 2000-06-01 2015-05-14 Georgetown University Systems and methods for monitoring health and delivering drugs transdermally
AU2012201079B2 (en) * 2000-06-01 2013-03-28 Georgetown University Systems and methods for monitoring health and delivering drugs transdermally
US6887202B2 (en) 2000-06-01 2005-05-03 Science Applications International Corporation Systems and methods for monitoring health and delivering drugs transdermally
AU2000276114A1 (en) * 2000-09-25 2002-04-08 Transmedica International, Inc. Irradiation enhanced permeation and collection
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US6627058B1 (en) 2001-01-17 2003-09-30 E. I. Du Pont De Nemours And Company Thick film conductor composition for use in biosensors
WO2002078512A2 (en) 2001-04-02 2002-10-10 Therasense, Inc. Blood glucose tracking apparatus and methods
US7699791B2 (en) 2001-06-12 2010-04-20 Pelikan Technologies, Inc. Method and apparatus for improving success rate of blood yield from a fingerstick
EP1404232B1 (de) 2001-06-12 2009-12-02 Pelikan Technologies Inc. Gerät und verfahren zur entnahme von blutproben
DE60238119D1 (de) 2001-06-12 2010-12-09 Pelikan Technologies Inc Elektrisches betätigungselement für eine lanzette
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7749174B2 (en) 2001-06-12 2010-07-06 Pelikan Technologies, Inc. Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7316700B2 (en) 2001-06-12 2008-01-08 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US7011630B2 (en) * 2001-06-22 2006-03-14 Animas Technologies, Llc Methods for computing rolling analyte measurement values, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods
US6702857B2 (en) 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
KR100453483B1 (ko) * 2001-10-26 2004-10-20 케이엠에이치 주식회사 글루코스 추출장치용 패치 및 그 제작방법
WO2003054070A2 (en) * 2001-12-20 2003-07-03 Cygnus, Inc. Highly catalytic screen-printing ink
DE60337038D1 (de) 2002-03-22 2011-06-16 Animas Technologies Llc Leistungsverbesserung einer Analytenüberwachungsvorrichtung
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7150975B2 (en) * 2002-08-19 2006-12-19 Animas Technologies, Llc Hydrogel composition for measuring glucose flux
US7727181B2 (en) 2002-10-09 2010-06-01 Abbott Diabetes Care Inc. Fluid delivery device with autocalibration
US7993108B2 (en) 2002-10-09 2011-08-09 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
EP2386758A1 (de) 2002-10-09 2011-11-16 Abbott Diabetes Care Inc. Verfahren zur Abgabe einer vorbestimmten Menge eines medizinischen Fluids
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US7811231B2 (en) 2002-12-31 2010-10-12 Abbott Diabetes Care Inc. Continuous glucose monitoring system and methods of use
EP1447665B1 (de) * 2003-02-11 2016-06-29 Bayer HealthCare LLC Methode zur Verringerung des Einflusses von Hämatokrit auf die Analytbestimmung in Vollblut
JP4381705B2 (ja) * 2003-03-26 2009-12-09 シスメックス株式会社 経皮的分析物抽出システムと分析システムおよび経皮的分析物抽出方法と分析方法
US7134999B2 (en) 2003-04-04 2006-11-14 Dexcom, Inc. Optimized sensor geometry for an implantable glucose sensor
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
US7679407B2 (en) 2003-04-28 2010-03-16 Abbott Diabetes Care Inc. Method and apparatus for providing peak detection circuitry for data communication systems
US7875293B2 (en) * 2003-05-21 2011-01-25 Dexcom, Inc. Biointerface membranes incorporating bioactive agents
US8262614B2 (en) 2003-05-30 2012-09-11 Pelikan Technologies, Inc. Method and apparatus for fluid injection
US7258673B2 (en) * 2003-06-06 2007-08-21 Lifescan, Inc Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8066639B2 (en) 2003-06-10 2011-11-29 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US8058077B2 (en) 2003-06-20 2011-11-15 Roche Diagnostics Operations, Inc. Method for coding information on a biosensor test strip
US7645421B2 (en) 2003-06-20 2010-01-12 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US8148164B2 (en) 2003-06-20 2012-04-03 Roche Diagnostics Operations, Inc. System and method for determining the concentration of an analyte in a sample fluid
US7488601B2 (en) 2003-06-20 2009-02-10 Roche Diagnostic Operations, Inc. System and method for determining an abused sensor during analyte measurement
US7452457B2 (en) 2003-06-20 2008-11-18 Roche Diagnostics Operations, Inc. System and method for analyte measurement using dose sufficiency electrodes
US7718439B2 (en) 2003-06-20 2010-05-18 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7645373B2 (en) 2003-06-20 2010-01-12 Roche Diagnostic Operations, Inc. System and method for coding information on a biosensor test strip
US8206565B2 (en) 2003-06-20 2012-06-26 Roche Diagnostics Operation, Inc. System and method for coding information on a biosensor test strip
US7467003B2 (en) * 2003-12-05 2008-12-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7424318B2 (en) 2003-12-05 2008-09-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7460898B2 (en) * 2003-12-05 2008-12-02 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7761130B2 (en) 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7366556B2 (en) 2003-12-05 2008-04-29 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US20080119703A1 (en) 2006-10-04 2008-05-22 Mark Brister Analyte sensor
KR20110041579A (ko) 2003-08-15 2011-04-21 애니머스 테크놀로지스 엘엘씨 생리적 분석물의 모니터링용 마이크로프로세서, 장치, 및 방법
US7189341B2 (en) * 2003-08-15 2007-03-13 Animas Technologies, Llc Electrochemical sensor ink compositions, electrodes, and uses thereof
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
WO2005033659A2 (en) 2003-09-29 2005-04-14 Pelikan Technologies, Inc. Method and apparatus for an improved sample capture device
EP1680014A4 (de) 2003-10-14 2009-01-21 Pelikan Technologies Inc Verfahren und gerät für eine variable anwenderschnittstelle
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
WO2005057168A2 (en) 2003-12-05 2005-06-23 Dexcom, Inc. Calibration techniques for a continuous analyte sensor
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
US8668656B2 (en) 2003-12-31 2014-03-11 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
CN1636505B (zh) * 2004-01-09 2011-11-09 希森美康株式会社 提取器具、提取装置和血糖值测量装置
JP2005218855A (ja) * 2004-01-09 2005-08-18 Sysmex Corp 経皮的分析物抽出キット、経皮的分析物抽出装置、血糖値測定装置、経皮的分析物抽出方法及び血糖値測定方法
CA2553632A1 (en) 2004-02-06 2005-08-25 Bayer Healthcare Llc Oxidizable species as an internal reference for biosensors and method of use
WO2005089103A2 (en) 2004-02-17 2005-09-29 Therasense, Inc. Method and system for providing data communication in continuous glucose monitoring and management system
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
JP4599872B2 (ja) * 2004-03-31 2010-12-15 パナソニック電工株式会社 血糖計測装置
US20050245799A1 (en) * 2004-05-03 2005-11-03 Dexcom, Inc. Implantable analyte sensor
US8792955B2 (en) 2004-05-03 2014-07-29 Dexcom, Inc. Transcutaneous analyte sensor
WO2006011062A2 (en) 2004-05-20 2006-02-02 Albatros Technologies Gmbh & Co. Kg Printable hydrogel for biosensors
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
EP1765194A4 (de) 2004-06-03 2010-09-29 Pelikan Technologies Inc Verfahren und gerät für eine flüssigkeitsentnahmenvorrichtung
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
US20060020192A1 (en) 2004-07-13 2006-01-26 Dexcom, Inc. Transcutaneous analyte sensor
US8886272B2 (en) 2004-07-13 2014-11-11 Dexcom, Inc. Analyte sensor
US20060270922A1 (en) 2004-07-13 2006-11-30 Brauker James H Analyte sensor
US8224414B2 (en) 2004-10-28 2012-07-17 Echo Therapeutics, Inc. System and method for analyte sampling and analysis with hydrogel
EP1819283A4 (de) * 2004-10-28 2011-08-10 Sontra Medical Corp System und verfahren für die analyten-entnahme und analyse mit hydrogel
JP2006167428A (ja) * 2004-11-16 2006-06-29 Sysmex Corp 分析物抽出装置、分析装置、分析物抽出方法および分析方法
ES2255861B1 (es) * 2004-12-23 2007-11-01 Intecsa-Inarsa S.A. Dispositivos y procedimientos para la medida del contenido de etanol en sangre.
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
KR100624458B1 (ko) * 2005-01-17 2006-09-19 삼성전자주식회사 휴대용 원심분리기
JPWO2006077750A1 (ja) * 2005-01-19 2008-06-19 シスメックス株式会社 分析装置および分析物抽出カートリッジ
US7545272B2 (en) 2005-02-08 2009-06-09 Therasense, Inc. RF tag on test strips, test strip vials and boxes
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
CN101180093B (zh) 2005-03-21 2012-07-18 雅培糖尿病护理公司 用于提供结合的药剂输液以及分析物监测系统的方法和系统
EP1869414A4 (de) * 2005-03-29 2010-07-28 Arkal Medical Inc Vorrichtungen, systeme, verfahren und werkzeuge zur kontinuierlichen glucoseüberwachung
WO2006113618A1 (en) * 2005-04-15 2006-10-26 Dexcom, Inc. Analyte sensing biointerface
US8060174B2 (en) 2005-04-15 2011-11-15 Dexcom, Inc. Analyte sensing biointerface
US8112240B2 (en) 2005-04-29 2012-02-07 Abbott Diabetes Care Inc. Method and apparatus for providing leak detection in data monitoring and management systems
US7768408B2 (en) 2005-05-17 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
US7620437B2 (en) 2005-06-03 2009-11-17 Abbott Diabetes Care Inc. Method and apparatus for providing rechargeable power in data monitoring and management systems
FR2887425A1 (fr) * 2005-06-22 2006-12-29 Annick Nicole Lydie Tournefier Systeme d'analyse electrophysiologique
KR100692783B1 (ko) * 2005-07-19 2007-03-12 케이엠에이치 주식회사 글루코스 추출용 패치
BRPI0613592A2 (pt) 2005-07-20 2011-01-18 Bayer Healthcare Llc amperometria conectada por porta
EP3483598A1 (de) 2005-09-30 2019-05-15 Ascensia Diabetes Care Holdings AG Gesteuerte voltammetrie
US7756561B2 (en) 2005-09-30 2010-07-13 Abbott Diabetes Care Inc. Method and apparatus for providing rechargeable power in data monitoring and management systems
US7583190B2 (en) 2005-10-31 2009-09-01 Abbott Diabetes Care Inc. Method and apparatus for providing data communication in data monitoring and management systems
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
US7729737B2 (en) * 2005-11-22 2010-06-01 Isense Corporation Method and apparatus for background current arrangements for a biosensor
US7963917B2 (en) * 2005-12-05 2011-06-21 Echo Therapeutics, Inc. System and method for continuous non-invasive glucose monitoring
JP2009520187A (ja) 2005-12-16 2009-05-21 バイエル・ヘルスケア・エルエルシー 経皮アナライトセンサアセンブリおよびその使用方法
JP2009519758A (ja) * 2005-12-16 2009-05-21 バイエル・ヘルスケア・エルエルシー デュアル経皮アナライトセンサアセンブリおよびその使用方法
BRPI0620735A2 (pt) 2005-12-27 2011-11-22 Bayer Healthcare Llc sistema de sensor eletroquìmico usando um substrato com pelo menos uma abertura e método de fabricação do mesmo
CN100403018C (zh) * 2006-01-20 2008-07-16 南京剑桥医疗器械有限公司 虹吸纳米生物传感芯片及其制备方法
US8344966B2 (en) 2006-01-31 2013-01-01 Abbott Diabetes Care Inc. Method and system for providing a fault tolerant display unit in an electronic device
DE602007013718D1 (de) * 2006-02-27 2011-05-19 Edwards Lifesciences Corp Wassergel für intravenösen amperometrischen biosensor
JP2007244736A (ja) 2006-03-17 2007-09-27 Toshiba Corp 生体成分測定装置及び生体成分測定方法
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
JP4916748B2 (ja) * 2006-03-30 2012-04-18 シスメックス株式会社 分析装置および分析方法
US7620438B2 (en) 2006-03-31 2009-11-17 Abbott Diabetes Care Inc. Method and system for powering an electronic device
US8226891B2 (en) 2006-03-31 2012-07-24 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
US20080071158A1 (en) 2006-06-07 2008-03-20 Abbott Diabetes Care, Inc. Analyte monitoring system and method
KR100832242B1 (ko) * 2006-09-30 2008-05-28 케이엠에이치 주식회사 포도당 추출용 패치 및 그를 포함하는 무채혈 혈당 측정장치
US7831287B2 (en) 2006-10-04 2010-11-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8579853B2 (en) 2006-10-31 2013-11-12 Abbott Diabetes Care Inc. Infusion devices and methods
EP2133692B1 (de) * 2006-11-06 2013-10-09 Yokohama City University Diagnoseverfahren für fettleberkrankheit, diagnosevorrichtung, diagnoseprogramm, diagnosemittel und verfahren zur suche nach einem therapeutischen mittel gegen fettleberkrankheit
WO2008089449A2 (en) 2007-01-19 2008-07-24 Biodot, Inc. Systems and methods for high speed array printing and hybridization
US8930203B2 (en) 2007-02-18 2015-01-06 Abbott Diabetes Care Inc. Multi-function analyte test device and methods therefor
US8732188B2 (en) 2007-02-18 2014-05-20 Abbott Diabetes Care Inc. Method and system for providing contextual based medication dosage determination
US8123686B2 (en) 2007-03-01 2012-02-28 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
RU2444980C2 (ru) 2007-03-07 2012-03-20 Эко Терапьютикс, Инк. Трансдермальная система мониторинга аналита и способы детекции аналита
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
KR100868566B1 (ko) 2007-03-29 2008-11-13 케이엠에이치 주식회사 포도당 농도 측정 장치 및 그를 이용한 포도당 농도를측정하는 방법
US8456301B2 (en) 2007-05-08 2013-06-04 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US7928850B2 (en) 2007-05-08 2011-04-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8461985B2 (en) 2007-05-08 2013-06-11 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8665091B2 (en) 2007-05-08 2014-03-04 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US20080306444A1 (en) 2007-06-08 2008-12-11 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
US8414846B2 (en) 2007-09-11 2013-04-09 University Of Florida Research Foundation, Inc. Devices and methods for the collection and detection of substances
US9360398B2 (en) 2007-09-11 2016-06-07 University Of Florida Research Foundation, Inc. Devices and methods for the collection and detection of substances
EP2227132B1 (de) 2007-10-09 2023-03-08 DexCom, Inc. Integriertes insulin-abgabesystem mit kontinuierlichem glucosesensor
WO2009076302A1 (en) 2007-12-10 2009-06-18 Bayer Healthcare Llc Control markers for auto-detection of control solution and methods of use
JP5088148B2 (ja) * 2008-01-16 2012-12-05 Tdk株式会社 代謝物濃度を測定する方法及びこれに用いられる電気化学センサ
CA2715628A1 (en) 2008-02-21 2009-08-27 Dexcom, Inc. Systems and methods for processing, transmitting and displaying sensor data
EP2265324B1 (de) 2008-04-11 2015-01-28 Sanofi-Aventis Deutschland GmbH Integriertes System zur Messung von Analyten
US8620398B2 (en) * 2008-06-02 2013-12-31 Abbott Diabetes Care Inc. Reference electrodes having an extended lifetime for use in long term amperometric sensors
US20110223204A1 (en) * 2008-06-04 2011-09-15 Bradford J Duft Treatment of pain with gap junction modulation compounds
US20100004522A1 (en) * 2008-07-02 2010-01-07 Eddie Varela Continuously Wearable Compact Blood Glucose Measuring Device
US8650937B2 (en) 2008-09-19 2014-02-18 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
US8103456B2 (en) 2009-01-29 2012-01-24 Abbott Diabetes Care Inc. Method and device for early signal attenuation detection using blood glucose measurements
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US8560082B2 (en) 2009-01-30 2013-10-15 Abbott Diabetes Care Inc. Computerized determination of insulin pump therapy parameters using real time and retrospective data processing
WO2010127050A1 (en) 2009-04-28 2010-11-04 Abbott Diabetes Care Inc. Error detection in critical repeating data in a wireless sensor system
US8467972B2 (en) 2009-04-28 2013-06-18 Abbott Diabetes Care Inc. Closed loop blood glucose control algorithm analysis
ES2349841B1 (es) * 2009-05-11 2011-11-04 Consejo Superior De Investigaciones Científicas (Csic) Dispositivo no invasivo par la deteccion de metabolitos en el sudor.
WO2010138856A1 (en) 2009-05-29 2010-12-02 Abbott Diabetes Care Inc. Medical device antenna systems having external antenna configurations
WO2011011739A2 (en) 2009-07-23 2011-01-27 Abbott Diabetes Care Inc. Real time management of data relating to physiological control of glucose levels
EP3284494A1 (de) 2009-07-30 2018-02-21 Tandem Diabetes Care, Inc. Tragbares infusionspumpensystem
EP2473099A4 (de) 2009-08-31 2015-01-14 Abbott Diabetes Care Inc Analytüberwachungssystem und -verfahren zur leistungs- und rauschverwaltung
US9314195B2 (en) 2009-08-31 2016-04-19 Abbott Diabetes Care Inc. Analyte signal processing device and methods
WO2011041469A1 (en) 2009-09-29 2011-04-07 Abbott Diabetes Care Inc. Method and apparatus for providing notification function in analyte monitoring systems
WO2011068846A2 (en) 2009-12-01 2011-06-09 Bridgestone Corporation Modified rubber compositions and methods of preparation
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8235897B2 (en) 2010-04-27 2012-08-07 A.D. Integrity Applications Ltd. Device for non-invasively measuring glucose
US9125625B2 (en) 2010-06-10 2015-09-08 The Regents Of The University Of California Textile-based printable electrodes for electrochemical sensing
CN103339498B (zh) * 2011-01-05 2015-02-18 密克罗奇普技术公司 使用电流源的葡萄糖测量
US9068566B2 (en) 2011-01-21 2015-06-30 Biodot, Inc. Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube
DK3575796T3 (da) 2011-04-15 2021-01-18 Dexcom Inc Avanceret analytsensorkalibrering og fejldetektion
WO2013070794A2 (en) 2011-11-07 2013-05-16 Abbott Diabetes Care Inc. Analyte monitoring device and methods
CA2868534A1 (en) 2012-03-27 2013-10-03 Coda Therapeutics, Inc. Compositions and treatments based on cadherin modulation
EP2834007B1 (de) 2012-04-04 2019-06-26 University of Cincinnati Vorrichtung und verfahren zur schweissentnahme
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
CN104768567B (zh) 2012-05-18 2017-07-11 奥塔哥创业有限公司 用于伤口愈合的联合治疗和组合物
GB2502287B (en) * 2012-05-21 2016-11-23 Dermal Diagnostics Ltd Cumulative measurement of an analyte
US9238100B2 (en) 2012-06-07 2016-01-19 Tandem Diabetes Care, Inc. Device and method for training users of ambulatory medical devices
US9968306B2 (en) 2012-09-17 2018-05-15 Abbott Diabetes Care Inc. Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
JP2016502116A (ja) 2012-12-27 2016-01-21 セノバ システムズ インコーポレイテッド pHメータ
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US10888244B2 (en) 2013-10-18 2021-01-12 University Of Cincinnati Sweat sensing with chronological assurance
AU2014337142A1 (en) 2013-10-18 2016-05-05 University Of Cincinnati Devices for integrated, repeated, prolonged, and/or reliable sweat stimulation and biosensing
CN110477861B (zh) 2013-10-18 2023-02-03 辛辛那提大学 以确保时间顺序方式的汗液感测
US20150221974A1 (en) * 2014-02-04 2015-08-06 Kalptree Energy, Inc. Battery reinforced polymer composite smart structure
WO2015184097A2 (en) 2014-05-28 2015-12-03 University Of Cincinnati Devices with reduced sweat volumes between sensors and sweat glands
US10932761B2 (en) 2014-05-28 2021-03-02 University Of Cincinnati Advanced sweat sensor adhesion, sealing, and fluidic strategies
WO2015184084A2 (en) 2014-05-28 2015-12-03 University Of Cincinnati Sweat monitoring and control of drug delivery
WO2016049019A1 (en) 2014-09-22 2016-03-31 University Of Cincinnati Sweat sensing with analytical assurance
US10722160B2 (en) 2014-12-03 2020-07-28 The Regents Of The University Of California Non-invasive and wearable chemical sensors and biosensors
KR102335739B1 (ko) 2014-12-19 2021-12-06 삼성전자주식회사 비 침습적 혈당 측정 방법 및 이를 위한 장치
EP3256049A4 (de) 2015-02-13 2018-07-25 University of Cincinnati Vorrichtungen zur integrierten indirekten schweissstimulation und -messung
US10335043B2 (en) 2015-04-06 2019-07-02 Thomas Jefferson University Implantable vital sign sensor
US11000195B2 (en) 2015-04-06 2021-05-11 Thomas Jefferson University Implantable vital sign sensor
US11330987B2 (en) 2015-04-06 2022-05-17 Thomas Jefferson University Implantable vital sign sensor
EP3280315B1 (de) 2015-04-06 2020-11-18 Thomas Jefferson University Implantierbarer vitalzeichensensor
GB2538731B (en) 2015-05-26 2019-05-22 Imperial Innovations Ltd Methods
US10646142B2 (en) 2015-06-29 2020-05-12 Eccrine Systems, Inc. Smart sweat stimulation and sensing devices
US10413182B2 (en) 2015-07-24 2019-09-17 Johnson & Johnson Vision Care, Inc. Biomedical devices for biometric based information communication
US11219390B2 (en) 2015-08-03 2022-01-11 Georgetown University Apparatus and method for delivery of antimicrobial during a transdermal sampling and delivery process
CN108348156B (zh) * 2015-09-09 2021-05-04 辛辛那提大学 机械地共置汗液刺激和感测
KR20170040918A (ko) * 2015-10-06 2017-04-14 삼성전자주식회사 바이오 센서 및 그의 센싱 방법
EP3364862A4 (de) 2015-10-23 2019-10-23 Eccrine Systems, Inc. Vorrichtungen zur konzentration von proben für die erweiterte messung von schweissanalyten
FR3043332B1 (fr) * 2015-11-06 2019-05-10 Seb S.A. Dispositif d'application d'un produit a distribuer sur la peau d'un utilisateur par iontophorese
FR3043333B1 (fr) * 2015-11-06 2017-12-22 Seb Sa Dispositif d'application d'un produit a distribuer sur la peau d'un utilisateur par iontophorese comprenant des moyens de mesure d'absence de produit et procede correspondant
US10674946B2 (en) 2015-12-18 2020-06-09 Eccrine Systems, Inc. Sweat sensing devices with sensor abrasion protection
WO2017173462A1 (en) * 2016-04-01 2017-10-05 The Regents Of The University Of California Flexible epidermal multimodal health monitor
US10471249B2 (en) 2016-06-08 2019-11-12 University Of Cincinnati Enhanced analyte access through epithelial tissue
WO2018006087A1 (en) 2016-07-01 2018-01-04 University Of Cincinnati Devices with reduced microfluidic volume between sensors and sweat glands
US10405794B2 (en) 2016-07-19 2019-09-10 Eccrine Systems, Inc. Sweat conductivity, volumetric sweat rate, and galvanic skin response devices and applications
US10736565B2 (en) 2016-10-14 2020-08-11 Eccrine Systems, Inc. Sweat electrolyte loss monitoring devices
CN107064266A (zh) * 2017-06-07 2017-08-18 杭州暖芯迦电子科技有限公司 一种多工作电极葡萄糖传感器及其制造方法
US11874249B2 (en) 2017-08-23 2024-01-16 Mayo Foundation For Medical Education And Research Graphite biosensor and circuit structure and method of manufacture
US20200205721A1 (en) * 2017-09-07 2020-07-02 The Regents Of The University Of California Multiplexed sweat extraction and sensing wearable device for normalized and time-sequential sweat analysis
AU2018354120A1 (en) 2017-10-24 2020-04-23 Dexcom, Inc. Pre-connected analyte sensors
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
US20200337641A1 (en) * 2017-11-02 2020-10-29 The Regents Of The University Of California Flexible systems, devices and methods for epidermal monitoring of analytes and biomarkers in fluids on skin
US11154225B2 (en) 2018-06-22 2021-10-26 The Regents Of The University Of Colorado Transdermal biosensor
US20200352450A1 (en) * 2019-02-12 2020-11-12 Medtronic Minimed, Inc. Miniaturized noninvasive glucose sensor and continuous glucose monitoring system
KR102140817B1 (ko) 2019-04-04 2020-08-03 재단법인 아산사회복지재단 미소유체 rfid 센서를 이용한 메디컬 케어용 칫솔 및 메디컬 케어 시스템
EP3771411A1 (de) * 2019-08-02 2021-02-03 Bionime Corporation Verfahren zur verminderung der messinterferenz eines mikrobiosensors
US10758329B1 (en) 2019-08-20 2020-09-01 Raymond L. Wright, III Hydrating mouth guard
US11331020B2 (en) 2020-02-06 2022-05-17 Trustees Of Boston University Enzyme-based electrochemical nicotine biosensor
US11536685B2 (en) 2020-02-06 2022-12-27 Trustees Of Boston University High throughput assay for identifying microbial redox enzymes
EP4048152B1 (de) 2020-07-29 2023-12-20 Biolinq Incorporated System zur kontinuierlichen analytüberwachung mit einer mikronadelanordnung
US20240049994A1 (en) * 2021-02-05 2024-02-15 The Regents Of The University Of California One-touch fingertip sweat sensor and personalized data processing for reliable prediction of blood biomarker concentrations
WO2022232670A1 (en) 2021-04-30 2022-11-03 Trustees Of Boston University Hormone electrochemical biosensor
CN116113454A (zh) 2021-05-08 2023-05-12 比奥林股份有限公司 基于微针阵列的连续分析物监测装置的故障检测
WO2022271131A1 (en) * 2021-06-22 2022-12-29 Ege Üni̇versi̇tesi̇ Wearable biomedical devices for diagnosis, identification, monitoring and prediction of major cardiac events and acute coronary syndrome cases

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3173885A (en) 1962-07-11 1965-03-16 Du Pont Resistor composition
GB8612861D0 (en) 1986-05-27 1986-07-02 Cambridge Life Sciences Immobilised enzyme biosensors
US5540828A (en) * 1987-06-08 1996-07-30 Yacynych; Alexander Method for making electrochemical sensors and biosensors having a polymer modified surface
GB8724446D0 (en) 1987-10-19 1987-11-25 Cambridge Life Sciences Immobilised enzyme electrodes
WO1989006989A1 (en) 1988-01-29 1989-08-10 The Regents Of The University Of California Iontophoretic non-invasive sampling or delivery device
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
GB8817997D0 (en) 1988-07-28 1988-09-01 Cambridge Life Sciences Enzyme electrodes & improvements in manufacture thereof
US5076273A (en) 1988-09-08 1991-12-31 Sudor Partners Method and apparatus for determination of chemical species in body fluid
US5086229A (en) 1989-01-19 1992-02-04 Futrex, Inc. Non-invasive measurement of blood glucose
US4933062A (en) 1989-03-07 1990-06-12 University Of Connecticut Modified composite electrodes with renewable surface for electrochemical applications and method of making same
US5139023A (en) 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
US4975581A (en) 1989-06-21 1990-12-04 University Of New Mexico Method of and apparatus for determining the similarity of a biological analyte from a model constructed from known biological fluids
US5262035A (en) * 1989-08-02 1993-11-16 E. Heller And Company Enzyme electrodes
CA2028261C (en) 1989-10-28 1995-01-17 Won Suck Yang Non-invasive method and apparatus for measuring blood glucose concentration
US5140985A (en) 1989-12-11 1992-08-25 Schroeder Jon M Noninvasive blood glucose measuring device
US5036861A (en) 1990-01-11 1991-08-06 Sembrowich Walter L Method and apparatus for non-invasively monitoring plasma glucose levels
US5115805A (en) 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
AU7107394A (en) 1993-07-16 1995-02-13 Cygnus Therapeutic Systems Noninvasive glucose monitor
US5885211A (en) * 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
JP3328290B2 (ja) 1994-06-24 2002-09-24 シグナス, インコーポレイテッド イオン導入サンプリング装置および方法
US5771890A (en) 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
EP0745571B1 (de) 1995-05-29 2000-08-09 Nisshinbo Industries, Inc. Kohlenstoffverbundmaterial und Verfahren zu seiner Herstellung
CA2226176C (en) 1995-07-12 2003-09-16 Cygnus, Inc. Hydrogel patch
US5626035A (en) * 1995-07-24 1997-05-06 Russian American Technology Alliance Apparatus and method for separation of helium and neon
EP0781150B1 (de) 1995-07-25 2002-11-06 Massachusetts Institute Of Technology Verbesserter transdermaler transport unter verwendung von ultraschall
US5989409A (en) 1995-09-11 1999-11-23 Cygnus, Inc. Method for glucose sensing
US5735273A (en) 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
DE69631735T2 (de) 1995-11-27 2005-01-20 Greatbatch-Sierra, Inc., Carson City Zusammenbau von Durchführungskondensatoren
WO1997024059A1 (en) 1995-12-28 1997-07-10 Cygnus, Inc. Continuous monitoring of physiological analyte
US5653918A (en) 1996-01-11 1997-08-05 E. I. Du Pont De Nemours And Company Flexible thick film conductor composition
US5795453A (en) 1996-01-23 1998-08-18 Gilmartin; Markas A. T. Electrodes and metallo isoindole ringed compounds
US5954685A (en) 1996-05-24 1999-09-21 Cygnus, Inc. Electrochemical sensor with dual purpose electrode
ATE275723T1 (de) 1996-11-07 2004-09-15 Cambridge Sensors Ltd Elektroden und ihre verwendung in assays
US6139718A (en) 1997-03-25 2000-10-31 Cygnus, Inc. Electrode with improved signal to noise ratio
US5851438A (en) 1997-08-29 1998-12-22 E. I. Du Pont De Nemours And Company Thick film compositions for making medical electrodes
CA2265119C (en) 1998-03-13 2002-12-03 Cygnus, Inc. Biosensor, iontophoretic sampling system, and methods of use thereof
US6272364B1 (en) 1998-05-13 2001-08-07 Cygnus, Inc. Method and device for predicting physiological values
JP2002514452A (ja) 1998-05-13 2002-05-21 シグナス, インコーポレイテッド 生理学的検体の測定のための信号処理
PT1077634E (pt) 1998-05-13 2003-12-31 Cygnus Therapeutic Systems Monitorizacao de substancias fisiologicas a analisar
DK1053043T3 (da) 1998-05-13 2002-11-18 Cygnus Therapeutic Systems Opsamlingsenheder til transdermale prøveudtagningssystemer
US6599408B1 (en) 1998-09-17 2003-07-29 E. I. Du Pont De Nemours And Company Thick film conductor composition for use in biosensors
US6042751A (en) 1998-09-17 2000-03-28 E. I. Du Pont De Nemours And Company Thick film conductor composition for use in biosensors
JP3537136B2 (ja) * 1998-09-30 2004-06-14 シグナス, インコーポレイテッド 生理的数値を予測する方法および装置
US6391643B1 (en) * 1998-10-28 2002-05-21 Cygnus, Inc. Kit and method for quality control testing of an iontophoretic sampling system
US6627058B1 (en) 2001-01-17 2003-09-30 E. I. Du Pont De Nemours And Company Thick film conductor composition for use in biosensors

Also Published As

Publication number Publication date
JP3155523B2 (ja) 2001-04-09
US20040167383A1 (en) 2004-08-26
CA2265119A1 (en) 1999-09-13
EP0942278A3 (de) 2000-06-14
EP0942278A2 (de) 1999-09-15
US20050027179A1 (en) 2005-02-03
GB2335278B (en) 2000-02-16
KR100328654B1 (ko) 2002-03-14
US20030135100A1 (en) 2003-07-17
GB2335278A (en) 1999-09-15
KR19990077833A (ko) 1999-10-25
JP2000000227A (ja) 2000-01-07
DK0942278T3 (da) 2002-10-07
US6587705B1 (en) 2003-07-01
ATE219245T1 (de) 2002-06-15
DE69901743T2 (de) 2003-01-30
US6999810B2 (en) 2006-02-14
US6736777B2 (en) 2004-05-18
US6816742B2 (en) 2004-11-09
CA2265119C (en) 2002-12-03
EP0942278B1 (de) 2002-06-12
GB9905831D0 (en) 1999-05-05
PT942278E (pt) 2002-11-29
ES2178349T3 (es) 2002-12-16

Similar Documents

Publication Publication Date Title
DE69901743T2 (de) Biosensor, iontophoretischen Probenahmesystem, und Verfahren zur seiner Anwendung
ATE231017T1 (de) Testsatz und verfahren zur qualitätsprüfung von einem iontophoretischen probenahmesystem
ATE129868T1 (de) Vorrichtung und verfahren zum nachweis von chemischen spezies.
DE69917258D1 (de) Methode und vorrichtung zum elektrochemischen immunoassay mehrerer analyten
PT1077634E (pt) Monitorizacao de substancias fisiologicas a analisar
ATE137583T1 (de) Verfahren und vorrichtung zur bestimmung von chemischen spezies in körperflüssigkeit
DE60315373D1 (de) Vorrichtung und Verfahren zur Bestimmung der Konzentration von Analyten
ATE332667T1 (de) Verfahren und vorrichtung zur sammlung von physiologischen proben
WO2001038873A3 (en) Devices and methods for detecting analytes using electrosensor having capture reagent
DE68928266D1 (de) Verfahren und vorrichtung zur amperometrischen diagnostischen analyse
RU2002116217A (ru) Электрохимический способ и устройства, предназначенные для применения при определении концентраций исследуемых веществ с поправкой на гематокритное число
DE69910007D1 (de) Vorrichtung zum vorhersagen von physiologischen messwerten
ATA114789A (de) Verfahren und vorrichtung zur feststellung biologischer aktivitaeten in einer probe
ATE360090T1 (de) Vorrichtung und verfahren zum bestimmen der koagulation in flüssigproben
DE60121547D1 (de) Electrochemisches verfahren zum nachweis von nukleinsäuren
DE3669888D1 (de) Nachweis von salicylat und geraet zur durchfuehrung desselben.
CA2450965A1 (en) Method for non-invasively determining the relative levels of two substances present in a biological system
AU2003219060A1 (en) Use of capturing probes for identifying nucleic acids
DE60143227D1 (de) Vorrichtung und verfahren zur bestimmung des eintretens und vorhandenseins septischer bedingungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ANIMAS TECHNOLOGIES LLC, WEST CHESTER, PA., US