DE69840878D1 - Massenspektrometrischer Nachweis von Polypeptiden - Google Patents

Massenspektrometrischer Nachweis von Polypeptiden

Info

Publication number
DE69840878D1
DE69840878D1 DE69840878T DE69840878T DE69840878D1 DE 69840878 D1 DE69840878 D1 DE 69840878D1 DE 69840878 T DE69840878 T DE 69840878T DE 69840878 T DE69840878 T DE 69840878T DE 69840878 D1 DE69840878 D1 DE 69840878D1
Authority
DE
Germany
Prior art keywords
polypeptides
mass spectrometric
spectrometric detection
identity
target polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69840878T
Other languages
English (en)
Inventor
Scott Higgins
Hubert Koester
Daniel P Little
David Lough
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sequenom Inc
Original Assignee
Sequenom Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequenom Inc filed Critical Sequenom Inc
Application granted granted Critical
Publication of DE69840878D1 publication Critical patent/DE69840878D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
DE69840878T 1997-09-02 1998-09-02 Massenspektrometrischer Nachweis von Polypeptiden Expired - Lifetime DE69840878D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/922,201 US6207370B1 (en) 1997-09-02 1997-09-02 Diagnostics based on mass spectrometric detection of translated target polypeptides

Publications (1)

Publication Number Publication Date
DE69840878D1 true DE69840878D1 (de) 2009-07-16

Family

ID=25446684

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69836488T Expired - Lifetime DE69836488D1 (de) 1997-09-02 1998-09-02 Massenspektrometrischer nachweis von polypeptiden
DE19882657T Expired - Fee Related DE19882657C2 (de) 1997-09-02 1998-09-02 Massenspektrometrischer Nachweis von Polypeptiden
DE69840878T Expired - Lifetime DE69840878D1 (de) 1997-09-02 1998-09-02 Massenspektrometrischer Nachweis von Polypeptiden

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69836488T Expired - Lifetime DE69836488D1 (de) 1997-09-02 1998-09-02 Massenspektrometrischer nachweis von polypeptiden
DE19882657T Expired - Fee Related DE19882657C2 (de) 1997-09-02 1998-09-02 Massenspektrometrischer Nachweis von Polypeptiden

Country Status (9)

Country Link
US (4) US6207370B1 (de)
EP (2) EP1296143B1 (de)
JP (1) JP2001515209A (de)
AT (2) ATE433112T1 (de)
AU (1) AU744266B2 (de)
CA (1) CA2300356A1 (de)
DE (3) DE69836488D1 (de)
NO (1) NO20001043L (de)
WO (1) WO1999012040A2 (de)

Families Citing this family (197)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
AU2069597A (en) 1996-03-04 1997-09-22 Genetrace Systems, Inc. Methods of screening nucleic acids using mass spectrometry
US6329180B1 (en) 1996-09-13 2001-12-11 Alex M. Garvin Genetic analysis using peptide tagged in-vitro synthesized proteins
US5965363A (en) 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
US5777324A (en) 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
EP1164203B1 (de) * 1996-11-06 2007-10-10 Sequenom, Inc. DNA-Diagnostik mittels Massenspektrometrie
US7285422B1 (en) * 1997-01-23 2007-10-23 Sequenom, Inc. Systems and methods for preparing and analyzing low volume analyte array elements
DE69735445T2 (de) * 1996-12-10 2006-08-10 Sequenom, Inc., San Diego Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
CA2243230A1 (en) * 1998-07-15 2000-01-15 Aled Edwards A device and method for the determination of protein domain boundaries
US7300753B2 (en) * 1998-09-04 2007-11-27 John Rush Immunoaffinity isolation of modified peptides from complex mixtures
US7198896B2 (en) * 1998-09-04 2007-04-03 Cell Signaling Technology, Inc. Immunoaffinity isolation of modified peptides from complex mixtures
US20120244594A9 (en) 1998-09-04 2012-09-27 Cell Signaling Technology, Inc. Immunoaffinity isolation of modified peptides from complex mixtures
US20030194700A1 (en) * 1998-12-01 2003-10-16 Toshiaki Ito Biochip and method for producing the same
CA2355134A1 (en) * 1998-12-16 2000-06-22 Sequel Genetics, Incorporated Methods and products for peptide-based dna sequence characterization and analysis
US7384387B1 (en) * 1999-02-11 2008-06-10 Maxygen, Inc. High throughput mass spectrometry
US7166475B2 (en) * 1999-02-26 2007-01-23 Cyclacel Ltd. Compositions and methods for monitoring the modification state of a pair of polypeptides
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
US6994969B1 (en) * 1999-04-30 2006-02-07 Methexis Genomics, N.V. Diagnostic sequencing by a combination of specific cleavage and mass spectrometry
US6306628B1 (en) * 1999-08-25 2001-10-23 Ambergen, Incorporated Methods for the detection, analysis and isolation of Nascent proteins
DE19943743C2 (de) * 1999-09-03 2002-02-07 Jerini Biotools Gmbh Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays
ATE350662T1 (de) * 1999-10-07 2007-01-15 Ciphergen Biosystems Inc Markerproteine für prostatakrebs
US7332275B2 (en) 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
US20030207297A1 (en) * 1999-10-13 2003-11-06 Hubert Koster Methods for generating databases and databases for identifying polymorphic genetic markers
US7917301B1 (en) 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
US20020155445A1 (en) * 1999-12-16 2002-10-24 Jarvik Jonathan W. Methods and products for peptide based DNA sequence identification and analysis
US7816098B2 (en) * 2000-01-31 2010-10-19 Sense Proteomic Limited Methods of making and using a protein array
US7060506B2 (en) 2000-01-31 2006-06-13 Cyclacel, Ltd. Compositions and methods for monitoring the modification of modification dependent binding partner polypeptides
CA2396755A1 (en) 2000-02-03 2001-08-09 Nanoscale Combinatorial Synthesis, Inc. Structure identification methods using mass measurements
US6569383B1 (en) * 2000-03-11 2003-05-27 Intrinsic Bioprobes, Inc. Bioactive chip mass spectrometry
ATE423221T1 (de) * 2000-06-13 2009-03-15 Univ Boston Verwendung von mass-matched nukleotide in der analyse von oligonukleotidmischungen sowie in der hoch-multiplexen nukleinsäuresequenzierung
US7244701B2 (en) * 2000-06-16 2007-07-17 Zealand Phama A/S Diuretic peptide conjugate
US7550425B2 (en) * 2000-06-16 2009-06-23 Zealand Pharma A/S Diuretic peptide conjugates
US6680203B2 (en) * 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
AU7861301A (en) * 2000-08-15 2002-02-25 Discerna Ltd Functional protein arrays
EP1330654B1 (de) * 2000-10-23 2006-03-08 Genetics Institute, LLC Säureempfindliches isotop-codiertes extrahiermittel (alice) in massenspectrometrieanalyse
US20020142483A1 (en) 2000-10-30 2002-10-03 Sequenom, Inc. Method and apparatus for delivery of submicroliter volumes onto a substrate
US6649419B1 (en) * 2000-11-28 2003-11-18 Large Scale Proteomics Corp. Method and apparatus for protein manipulation
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
EP1356281B1 (de) * 2000-12-26 2006-05-10 The Institute for Systems Biology Schnelle und quantitative proteomanalyse und damit zusammenhängende verfahren
JP4880188B2 (ja) 2001-01-23 2012-02-22 プレジデント アンド フェロウズ オブ ハーバード カレッジ 核酸プログラム型タンパク質アレイ
US6969757B2 (en) 2001-01-26 2005-11-29 Syngenta Participations Ag Differential labeling for quantitative analysis of complex protein mixtures
US7166436B2 (en) 2001-01-26 2007-01-23 Syngenta Participations, Ag Differential labeling for quantitative analysis of complex protein mixtures
JP2005504263A (ja) * 2001-02-01 2005-02-10 シファーゲン バイオシステムズ， インコーポレイテッド タンデム質量分析によるタンパク質同定、特徴付けおよび配列決定のための改良された方法
DE10106339A1 (de) * 2001-02-09 2002-08-22 Hans-Joachim Mueller Verfahren zum Hochdurchsatz-Screening von Kandidaten-Verbindungen über die Hochdurchsatz-Direktsynthese von rekombinanten Polypeptiden
AU2002240423B2 (en) 2001-02-14 2006-03-09 Picoliter Inc. Acoustic sample introduction for analysis and/or processing
US6855925B2 (en) * 2001-02-14 2005-02-15 Picoliter Inc. Methods, devices, and systems using acoustic ejection for depositing fluid droplets on a sample surface for analysis
US6707038B2 (en) 2001-02-14 2004-03-16 Picoliter Inc. Method and system using acoustic ejection for selective fluid deposition on a nonuniform sample surface
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
WO2004060278A2 (en) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Methods for rapid identification of pathogens in humans and animals
US20040121313A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in organs for transplantation
US7718354B2 (en) 2001-03-02 2010-05-18 Ibis Biosciences, Inc. Methods for rapid identification of pathogens in humans and animals
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
ATE476654T1 (de) * 2001-03-02 2010-08-15 Activx Biosciences Inc Plattform für protein-profiling
US20020137106A1 (en) * 2001-03-09 2002-09-26 Ciphergen Biosystems, Inc. Detection of biological pathway components
US20030036057A1 (en) * 2001-03-09 2003-02-20 Andreas Braun Genes and polymorphisms associated with cardiovascular disease and their use
CN1273615C (zh) * 2001-04-03 2006-09-06 塞莫费尼根股份有限公司 用于简化复合肽混合物的方法和试剂盒
EP1415137A4 (de) * 2001-04-17 2007-04-25 Ista S P A Massenspektrometrische verfahren zum nachweis und zur quantifizierung spezifischer zielproteine in komplexen biologischen proben
WO2002086168A1 (en) * 2001-04-19 2002-10-31 Ciphergen Biosystems, Inc. Biomolecule characterization using mass spectrometry and affinity tags
AU2002338428A1 (en) * 2001-04-20 2002-11-05 Carnegie Mellon University Methods and systems for identifying proteins
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
US6627606B2 (en) * 2001-04-30 2003-09-30 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1465 daltons
US6677303B2 (en) * 2001-04-30 2004-01-13 Syn X Pharma Biopolymer marker indicative of disease state having a molecular weight of 1097 daltons
US6620786B2 (en) * 2001-04-30 2003-09-16 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having molecular weight of 2937 daltons
US6627608B2 (en) * 2001-04-30 2003-09-30 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1206 daltons
US6593298B2 (en) * 2001-04-30 2003-07-15 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1690 daltons
US6617308B2 (en) * 2001-04-30 2003-09-09 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1865 daltons
US6627607B2 (en) * 2001-04-30 2003-09-30 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1845 daltons
US6703366B2 (en) * 2001-04-30 2004-03-09 George Jackowski Biopolymer marker indicative of disease state having a molecular weight of 1,896 daltons
US6693080B2 (en) * 2001-04-30 2004-02-17 Syn X Pharma Biopolymer marker indicative of disease state having a molecular weight of 1521 daltons
US7074570B2 (en) * 2001-05-23 2006-07-11 Ge Healthcare Bio-Sciences Ab Peptide fragmentation
WO2002097392A2 (en) * 2001-05-25 2002-12-05 Waters Investments Limited Sample concentration maldi plates for maldi mass spectrometry
JP2002372517A (ja) * 2001-05-31 2002-12-26 Inst Of Physical & Chemical Res 質量分析法によるタンパク質の構造解析方法
US7074558B2 (en) * 2001-06-07 2006-07-11 Pbi Technology, Inc. Nucleic acid amplification using an RNA polymerase and DNA/RNA mixed polymer intermediate products
US20110111424A1 (en) * 2001-06-21 2011-05-12 Cell Signaling Technology, Inc. Analysis of ubiquitinated polypeptides
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US8073627B2 (en) * 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
US6800449B1 (en) * 2001-07-13 2004-10-05 Syngenta Participations Ag High throughput functional proteomics
WO2003092581A2 (en) * 2001-07-16 2003-11-13 Hk Pharmaceuticals, Inc. Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US20030143576A1 (en) * 2001-08-22 2003-07-31 Heman Chao Method and device for integrated protein expression, purification and detection
US7133864B2 (en) 2001-08-23 2006-11-07 Syngenta Participations Ag System and method for accessing biological data
JP2005507877A (ja) * 2001-08-31 2005-03-24 ファーマシア コーポレイション ペプチド生体マーカー及び同定方法
US7148343B2 (en) * 2001-10-12 2006-12-12 Gentra Systems, Inc. Compositions and methods for using a solid support to purify RNA
WO2003036263A2 (en) * 2001-10-26 2003-05-01 Sequenom, Inc. Method and apparatus for parallel dispensing of defined volumes of solid particles
US20030091976A1 (en) * 2001-11-14 2003-05-15 Ciphergen Biosystems, Inc. Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry
US20040053356A1 (en) * 2001-12-28 2004-03-18 Mds Proteomics Inc. Enzyme/chemical reactor based protein processing method for proteomics analysis by mass spectrometry
US20030153729A1 (en) * 2001-12-28 2003-08-14 Duewel Henry S. Enzyme/chemical reactor based protein processing method for proteomics analysis by mass spectrometry
US20040009567A1 (en) * 2001-12-28 2004-01-15 Mds Proteomics Inc. Enzyme/chemical reactor based protein processing method for proteomics analysis by mass spectrometry
DK1502102T3 (da) * 2002-03-11 2009-05-04 Caprotec Bioanalytics Gmbh Forbindelser og fremgangsmåder til analysering af proteomet
EP1501863A4 (de) * 2002-05-03 2007-01-24 Sequenom Inc Kinaseankerproteinmuteine, peptide davon und damit im zusammenhang stehende verfahren
US20040171070A1 (en) * 2002-05-20 2004-09-02 Ramagauri Bhikhabhai Peptide analysis using a solid support
US6770871B1 (en) 2002-05-31 2004-08-03 Michrom Bioresources, Inc. Two-dimensional tandem mass spectrometry
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US6624409B1 (en) 2002-07-30 2003-09-23 Agilent Technologies, Inc. Matrix assisted laser desorption substrates for biological and reactive samples
US7632686B2 (en) * 2002-10-03 2009-12-15 Anderson Forschung Group High sensitivity quantitation of peptides by mass spectrometry
WO2004035169A2 (en) * 2002-10-15 2004-04-29 The Regents Of The University Of Michigan Multidimensional protein separation system
WO2004050839A2 (en) * 2002-11-27 2004-06-17 Sequenom, Inc. Fragmentation-based methods and systems for sequence variation detection and discovery
WO2004053370A1 (en) * 2002-12-09 2004-06-24 Waters Investments Limited Peltier based freeze-thaw valves and method of use
US20040248162A1 (en) * 2002-12-17 2004-12-09 Affymetrix, Inc. Releasable polymer arrays
US20040185473A1 (en) * 2002-12-17 2004-09-23 Affymetrix, Inc. Releasable polymer arrays
AU2003300168A1 (en) * 2002-12-31 2004-07-29 Rodi Pharma, Inc. Bindingzyme arrays and high-throughput proteomic methods
US7422865B2 (en) * 2003-01-13 2008-09-09 Agilent Technologies, Inc. Method of identifying peptides in a proteomic sample
WO2004064972A2 (en) * 2003-01-16 2004-08-05 Hk Pharmaceuticals, Inc. Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US20070141570A1 (en) * 2003-03-07 2007-06-21 Sequenom, Inc. Association of polymorphic kinase anchor proteins with cardiac phenotypes and related methods
US8046171B2 (en) 2003-04-18 2011-10-25 Ibis Biosciences, Inc. Methods and apparatus for genetic evaluation
EP1618216A2 (de) * 2003-04-25 2006-01-25 Sequenom, Inc. Auf fragmentierung beruhende verfahren und systeme zur de-novo-sequenzierung
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
US7368290B2 (en) * 2003-05-12 2008-05-06 Sandia National Laboratories Structural determination of intact proteins using mass spectrometry
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7425700B2 (en) * 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
DK1660680T3 (da) 2003-07-31 2009-06-22 Sequenom Inc Fremgangsmåde til multipleks-polymerasekædereaktioner på höjt niveau og homogene masseforlængelsesreaktioner til genotypebestemmelse af polymorfismer
US20050277204A1 (en) * 2003-08-12 2005-12-15 Massachusetts Institute Of Technology Sample preparation methods and devices
BRPI0413476A (pt) * 2003-08-12 2006-10-17 Massachusetts Inst Technology métodos e disositivos para preparação de amostras
US9394565B2 (en) * 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
US20120122096A1 (en) 2003-09-11 2012-05-17 Rangarajan Sampath Compositions for use in identification of bacteria
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8163895B2 (en) 2003-12-05 2012-04-24 Ibis Biosciences, Inc. Compositions for use in identification of orthopoxviruses
US20070087448A1 (en) * 2004-02-16 2007-04-19 Nelsestuen Gary L Biological profiles and methods of use
US20050181513A1 (en) * 2004-02-18 2005-08-18 Viorica Lopez-Avila Methods and compositions for assessing a sample by MAILDI mass spectrometry
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
US8119336B2 (en) 2004-03-03 2012-02-21 Ibis Biosciences, Inc. Compositions for use in identification of alphaviruses
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
AU2005230936B2 (en) * 2004-03-26 2010-08-05 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
WO2006073436A2 (en) * 2004-04-29 2006-07-13 The Trustees Of Columbia University In The City Of New York Mass tag pcr for multiplex diagnostics
US20050244973A1 (en) * 2004-04-29 2005-11-03 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
EP2458619B1 (de) 2004-05-24 2017-08-02 Ibis Biosciences, Inc. Massenspektrometrie mit selektivem Ionfilter durch digitale Schwelle
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7785843B2 (en) 2004-06-23 2010-08-31 Sequenom, Inc. Target-specific compomers and methods of use
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
US7563598B2 (en) * 2004-07-30 2009-07-21 Ambergen, Inc. Detection of truncation mutations by mass spectrometry
US7786261B2 (en) * 2004-09-02 2010-08-31 National Research Council Of Canada Coiled-coil fusion proteins comprising cell receptor domains
DE102004042530B4 (de) * 2004-09-02 2006-10-19 Mosaiques Diagnostics And Therapeutics Ag Verfahren zur Diagnose von Arteriosklerose
US20060073501A1 (en) * 2004-09-10 2006-04-06 Van Den Boom Dirk J Methods for long-range sequence analysis of nucleic acids
US20060073534A1 (en) * 2004-10-05 2006-04-06 The University Of Georgia Research Foundation, Inc Method for cleaving and deglycosylating antibodies to promote ligand binding
US20060105372A1 (en) 2004-11-05 2006-05-18 Bair Robert J Compositions and methods for purifying nucleic acids from stabilization reagents
US7547775B2 (en) * 2004-12-31 2009-06-16 Affymetrix, Inc. Parallel preparation of high fidelity probes in an array format
WO2006094238A2 (en) 2005-03-03 2006-09-08 Isis Pharmaceuticals, Inc. Compositions for use in identification of adventitious viruses
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
US9180196B2 (en) 2005-03-11 2015-11-10 The Regents Of The University Of Colorado, A Body Corporate Photodegradable groups for tunable polymeric materials
US8343710B1 (en) * 2005-03-11 2013-01-01 The Regents Of The University Of Colorado, A Body Corporate Photodegradable groups for tunable polymeric materials
CA2616281C (en) 2005-07-21 2014-04-22 Isis Pharmaceuticals, Inc. Methods for rapid identification and quantitation of mitochondrial dna variants
WO2007035864A2 (en) * 2005-09-20 2007-03-29 Cell Biosciences, Inc. Electrophoresis standards, methods and kits
JP2007108015A (ja) * 2005-10-13 2007-04-26 Biologica:Kk 分析用の保持体及びその利用
CA2627966A1 (en) 2005-11-16 2007-05-24 Novartis Ag Biomarkers for anti-nogo-a antibody treatment in spinal cord injury
US7889347B2 (en) 2005-11-21 2011-02-15 Plexera Llc Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism
US7463358B2 (en) 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
US8088582B2 (en) 2006-04-06 2012-01-03 Ibis Biosciences, Inc. Compositions for the use in identification of fungi
CA2653671A1 (en) * 2006-05-30 2007-12-06 Synergenz Bioscience Limited Methods and compositions for assessment of pulmonary function and disorders
US8178316B2 (en) 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
US20150232540A1 (en) 2006-07-11 2015-08-20 Cell Signaling Technology, Inc. Analysis of ubiquitnated polypeptides
AU2007353877B2 (en) 2006-09-14 2012-07-19 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
US8871471B2 (en) 2007-02-23 2014-10-28 Ibis Biosciences, Inc. Methods for rapid forensic DNA analysis
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
US20090180931A1 (en) 2007-09-17 2009-07-16 Sequenom, Inc. Integrated robotic sample transfer device
CA2706763C (en) * 2007-11-27 2013-07-30 Laboratory Corporation Of America Holdings Enhanced method for detecting and/or quantifying an analyte in a sample
EP2232258A4 (de) 2007-12-05 2011-01-05 Govt Of The U S A As Represented By The Secretary Of The Dept Of Health & Human Services Verbesserte virale proteinquantifizierung und impfstoffqualitätskontrolle damit
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
WO2009117785A1 (en) * 2008-03-28 2009-10-01 Newsouth Innovations Pty Limited Method of hla tissue typing
WO2009131909A2 (en) * 2008-04-21 2009-10-29 Bio-Rad Laboratories, Inc. Recombinant deamidated gliadin antigen
WO2009155103A2 (en) * 2008-05-30 2009-12-23 Ibis Biosciences, Inc. Compositions for use in identification of tick-borne pathogens
WO2009148995A2 (en) * 2008-06-02 2009-12-10 Ibis Biosciences, Inc. Compositions for use in identification of adventitious viruses
ES2845203T3 (es) 2008-07-01 2021-07-26 Genocea Biosciences Inc Sistema de análisis de antígenos
WO2010012002A1 (en) * 2008-07-25 2010-01-28 Saryna Medical Corporation Methods and systems for genetic analysis of fetal nucleated red blood cells
EP2851433B1 (de) * 2008-08-01 2017-10-11 Brown University System und Verfahren zur Bestimmung von Molekülen anhand von Massenspektrometrie sowie entsprechende Verfahren
US8148163B2 (en) 2008-09-16 2012-04-03 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
EP2344893B1 (de) 2008-09-16 2014-10-15 Ibis Biosciences, Inc. Mikroplatten-handhabungssysteme und verfahren
WO2010033599A2 (en) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, systems, and methods
WO2010039870A1 (en) * 2008-10-03 2010-04-08 Ibis Biosciences, Inc. Compositions for use in identification of neisseria, chlamydia, and/or chlamydophila bacteria
WO2010039848A2 (en) * 2008-10-03 2010-04-08 Ibis Biosciences, Inc. Compositions for use in identification of streptococcus pneumoniae
EP2396803A4 (de) 2009-02-12 2016-10-26 Ibis Biosciences Inc Ionisationssondenanordnungen
EP2226637A1 (de) * 2009-03-04 2010-09-08 Centre National de la Recherche Scientifique (CNRS) Vernetzungsmittel auf solidem Träger
WO2010104798A1 (en) 2009-03-08 2010-09-16 Ibis Biosciences, Inc. Bioagent detection methods
WO2010114842A1 (en) 2009-03-30 2010-10-07 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
US8945511B2 (en) 2009-06-25 2015-02-03 Paul Weinberger Sensitive methods for detecting the presence of cancer associated with the over-expression of galectin-3 using biomarkers derived from galectin-3
US9194877B2 (en) 2009-07-17 2015-11-24 Ibis Biosciences, Inc. Systems for bioagent indentification
WO2011008971A1 (en) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Lift and mount apparatus
US9416409B2 (en) 2009-07-31 2016-08-16 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
EP2462244B1 (de) 2009-08-06 2016-07-20 Ibis Biosciences, Inc. Basiszusammensetzungen ohne massebestimmung zur nukleinsäureerkennung
US20110065111A1 (en) * 2009-08-31 2011-03-17 Ibis Biosciences, Inc. Compositions For Use In Genotyping Of Klebsiella Pneumoniae
EP2957641B1 (de) 2009-10-15 2017-05-17 Ibis Biosciences, Inc. Multiple-displacement-amplifikation
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
US9758840B2 (en) 2010-03-14 2017-09-12 Ibis Biosciences, Inc. Parasite detection via endosymbiont detection
RU2445000C2 (ru) * 2010-03-22 2012-03-20 Общество с ограниченной ответственностью "ЭкоБиоФарм" Способ диагностики онкологических заболеваний предстательной железы на основе ацилкарнитина и арахидоноил амина
US9291597B2 (en) 2010-07-02 2016-03-22 Ventana Medical Systems, Inc. Detecting targets using mass tags and mass spectrometry
US8629093B2 (en) 2010-09-01 2014-01-14 The Procter & Gamble Company Detergent composition comprising mixture of chelants
JP6775827B2 (ja) * 2015-08-07 2020-10-28 国立大学法人愛媛大学 質量分析を用いたｂ型肝炎ウイルスの測定方法
CN105699476B (zh) * 2016-03-29 2018-03-13 武汉大学 一种多肽化衍生方法及其在maldi‑tof‑ms检测小分子化合物中的应用
KR101953800B1 (ko) * 2016-10-12 2019-03-04 주식회사 엘지화학 초고온용 에어로겔 블랭킷, 이의 제조방법 및 이의 시공방법
JP2022505162A (ja) * 2018-10-18 2022-01-14 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 質量分析システムとの使用のための試料採取要素の官能化
WO2021026172A1 (en) 2019-08-05 2021-02-11 Seer, Inc. Systems and methods for sample preparation, data generation, and protein corona analysis
JP2022543668A (ja) 2019-08-09 2022-10-13 ナットクラッカー セラピューティクス， インコーポレイテッド マイクロ流体装置およびその使用方法
US20230151406A1 (en) * 2020-02-19 2023-05-18 Chan Zuckerberg Biohub, Inc. Nucleic acid sequence detection by endonuclease digestion and mass spectrometry
CN116773840B (zh) * 2023-08-25 2023-10-27 四川徕伯益自动化技术有限公司 一种样本溶液的溯源方法及介质

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2739829C2 (de) 1977-09-03 1986-04-10 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Anordnung zur Analyse einer Probenschicht durch Beschuß mit elektromagnetischer Strahlung
US4356270A (en) 1977-11-08 1982-10-26 Genentech, Inc. Recombinant DNA cloning vehicle
US4442354A (en) 1982-01-22 1984-04-10 Atom Sciences, Inc. Sputter initiated resonance ionization spectrometry
DE3329892A1 (de) 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur herstellung von oligonucleotiden
US4983521A (en) 1983-10-26 1991-01-08 The Regents Of The University Of California Transmembrane integrator sequences
US4683194A (en) 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US5118605A (en) 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
GB2168478A (en) 1984-11-26 1986-06-18 Scan Limited M Analysis of protein etc using mass spectrometry
JPS61200524A (ja) 1985-03-01 1986-09-05 Fuji Photo Film Co Ltd 光走査装置
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4766072A (en) 1985-07-17 1988-08-23 Promega Corporation Vectors for in vitro production of RNA copies of either strand of a cloned DNA sequence
US5604099A (en) 1986-03-13 1997-02-18 Hoffmann-La Roche Inc. Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
JP2640812B2 (ja) 1986-10-21 1997-08-13 協和醗酵工業株式会社 粉粒体の高濃度気力輸送方法及びその装置
GB8626075D0 (en) 1986-10-31 1986-12-03 Vg Instr Group Time-of-flight mass spectrometer
US5670381A (en) 1988-01-29 1997-09-23 Abbott Laboratories Devices for performing ion-capture binding assays
DE3809504C1 (de) 1988-03-22 1989-09-21 Bruker - Franzen Analytik Gmbh, 2800 Bremen, De
EP0347365B1 (de) 1988-06-14 1996-08-28 QIAGEN GmbH HIV-2-Virusvarianten
US5237016A (en) 1989-01-05 1993-08-17 Siska Diagnostics, Inc. End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
US4920264A (en) 1989-01-17 1990-04-24 Sri International Method for preparing samples for mass analysis by desorption from a frozen solution
JPH04501468A (ja) 1989-05-19 1992-03-12 フェン，ジョン，ビー 多重帯電イオンおよび大分子の分子量の決定方法
GB2236186B (en) 1989-08-22 1994-01-05 Finnigan Mat Gmbh Process and device for laser desorption of analyte molecular ions, especially of biomolecules
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US5410068A (en) 1989-10-23 1995-04-25 Perseptive Biosystems, Inc. Succinimidyl trityl compounds and a process for preparing same
US5288644A (en) 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5135870A (en) 1990-06-01 1992-08-04 Arizona Board Of Regents Laser ablation/ionizaton and mass spectrometric analysis of massive polymers
DE4019005C2 (de) 1990-06-13 2000-03-09 Finnigan Mat Gmbh Vorrichtungen zur Analyse von Ionen hoher Masse
ES2155822T3 (es) 1990-12-06 2001-06-01 Affymetrix Inc Compuestos y su utilizacion en una estrategia de sintesis binaria.
WO1992013629A1 (en) 1991-01-31 1992-08-20 Wayne State University A method for analyzing an organic sample
US5210412A (en) 1991-01-31 1993-05-11 Wayne State University Method for analyzing an organic sample
US5198531A (en) 1991-06-14 1993-03-30 Research Diagnostic Antibodies Polymeric resin for peptide synthesis
US5492817A (en) 1993-11-09 1996-02-20 Promega Corporation Coupled transcription and translation in eukaryotic cell-free extract
ES2097363T3 (es) 1991-10-11 1997-04-01 Promega Corp Transcripcion y traduccion acopladas en un extracto exento de celulas eucariotas.
IL103674A0 (en) 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
AU675054B2 (en) 1991-11-22 1997-01-23 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
DE4202123C2 (de) 1992-01-27 1995-04-06 Bruker Franzen Analytik Gmbh Vorrichtung für die massenspektrometrische Untersuchung schneller organischer Ionen
US5382793A (en) 1992-03-06 1995-01-17 Hewlett-Packard Company Laser desorption ionization mass monitor (LDIM)
EP0664884A4 (de) 1992-05-29 1997-05-02 Univ Rockefeller Methode und produkt für die bestimmung der folge von peptiden unter verwendung eines massenspektrometers.
US5792664A (en) 1992-05-29 1998-08-11 The Rockefeller University Methods for producing and analyzing biopolymer ladders
WO1994000562A1 (en) 1992-06-24 1994-01-06 The Mt. Sinai School Of Medicine Of The City University Of New York A novel human immunodeficiency virus
US5795714A (en) 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US5503980A (en) 1992-11-06 1996-04-02 Trustees Of Boston University Positional sequencing by hybridization
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
CA2153387A1 (en) 1993-01-07 1994-07-21 Hubert Koester Dna sequencing by mass spectrometry
US6194144B1 (en) 1993-01-07 2001-02-27 Sequenom, Inc. DNA sequencing by mass spectrometry
US5750349A (en) 1993-01-25 1998-05-12 Takeda Chemical Industries Ltd. Antibodies to β-amyloids or their derivatives and use thereof
US5628184A (en) 1993-02-03 1997-05-13 Santos; Rolando R. Apparatus for reducing the production of NOx in a gas turbine
JPH08507926A (ja) 1993-03-19 1996-08-27 シーケノム・インコーポレーテツド エキソヌクレアーゼ分解を介した質量分析法によるｄｎａ配列決定
US6074823A (en) 1993-03-19 2000-06-13 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
US5381008A (en) 1993-05-11 1995-01-10 Mds Health Group Ltd. Method of plasma mass analysis with reduced space charge effects
US5376788A (en) 1993-05-26 1994-12-27 University Of Manitoba Apparatus and method for matrix-assisted laser desorption mass spectrometry
ES2201077T3 (es) 1993-05-28 2004-03-16 Baylor College Of Medicine Metodo y espectrometro de masas para la desorcion e ionizacion de analitos.
FR2709761B1 (fr) 1993-09-10 1995-11-24 Pasteur Institut Procédé de détection de molécules contenant des mésappariements nucléotidiques et de localisation de ces mésappariements, et application à la détection de substitutions ou de délétions de bases .
JPH07150956A (ja) 1993-11-26 1995-06-13 Mitsubishi Heavy Ind Ltd ターボクーリングエンジン
US5622829A (en) 1993-12-08 1997-04-22 The Regents Of The University Of California Genetic markers for breast, ovarian, and prostatic cancer
US5538897A (en) * 1994-03-14 1996-07-23 University Of Washington Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases
DK0751950T3 (da) 1994-03-23 2001-01-29 Penn State Res Found Fremgangsmåde til identifikation af elementer af kombinatoriske biblioteker
US5643722A (en) 1994-05-11 1997-07-01 Trustees Of Boston University Methods for the detection and isolation of proteins
US5986076A (en) 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
US5612474A (en) 1994-06-30 1997-03-18 Eli Lilly And Company Acid labile immunoconjugate intermediates
US5545539A (en) 1994-10-18 1996-08-13 Genzyme Corporation Method for nucleotide sequence amplification
US5504326A (en) 1994-10-24 1996-04-02 Indiana University Foundation Spatial-velocity correlation focusing in time-of-flight mass spectrometry
CA2218188A1 (en) 1995-04-11 1996-10-17 Trustees Of Boston University Solid phase sequencing of biopolymers
WO1996033731A1 (en) 1995-04-26 1996-10-31 Regeneron Pharmaceuticals, Inc. Methods of using neurotrophic factors to enhance neuronal grafts
US5753439A (en) 1995-05-19 1998-05-19 Trustees Of Boston University Nucleic acid detection methods
WO1996036986A1 (en) * 1995-05-19 1996-11-21 Perseptive Biosystems, Inc. Methods and apparatus for sequencing polymers with a statistical certainty using mass spectrometry
US5625184A (en) 1995-05-19 1997-04-29 Perseptive Biosystems, Inc. Time-of-flight mass spectrometry analysis of biomolecules
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US5700642A (en) 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers
US5654150A (en) * 1995-06-07 1997-08-05 President And Fellows Of Harvard College Method of expression cloning
US6146854A (en) 1995-08-31 2000-11-14 Sequenom, Inc. Filtration processes, kits and devices for isolating plasmids
US5869242A (en) 1995-09-18 1999-02-09 Myriad Genetics, Inc. Mass spectrometry to assess DNA sequence polymorphisms
US5654545A (en) 1995-09-19 1997-08-05 Bruker-Franzen Analytik Gmbh Mass resolution in time-of-flight mass spectrometers with reflectors
AU7016896A (en) 1995-10-30 1997-05-22 Trustees Of Boston University Piezoelectric force sensing apparatus and methods for biopolymer sequencing
DE69631540T2 (de) 1995-11-23 2005-01-27 Cancer Research Technology Ltd. Materialien und methoden mit bezug zur identifizierung und sequenzierung des krebs-suszeptilitaetsgens brca2 und dessen anwendungen
US5742049A (en) 1995-12-21 1998-04-21 Bruker-Franzen Analytik Gmbh Method of improving mass resolution in time-of-flight mass spectrometry
US5641959A (en) 1995-12-21 1997-06-24 Bruker-Franzen Analytik Gmbh Method for improved mass resolution with a TOF-LD source
AU2217597A (en) 1996-03-18 1997-10-22 Sequenom, Inc. Dna sequencing by mass spectrometry
US5777325A (en) 1996-05-06 1998-07-07 Hewlett-Packard Company Device for time lag focusing time-of-flight mass spectrometry
US5928906A (en) 1996-05-09 1999-07-27 Sequenom, Inc. Process for direct sequencing during template amplification
US6022688A (en) 1996-05-13 2000-02-08 Sequenom, Inc. Method for dissociating biotin complexes
DE19624802A1 (de) 1996-06-21 1998-01-02 Forssmann Wolf Georg Verfahren zum direkten diagnostischen Nachweis von pathogenen, genetisch bedingten Punktmutationen in Proteinen bei Herzerkrankungen durch chemische und physikalische Methoden, besonders der direkten und indirekten Kopplung der Hochdruck-Flüssigkeitschromatographie und der Massenspektrometrie
WO1998011249A1 (en) 1996-09-13 1998-03-19 Garvin Alex M Mutation detection using peptide tagged in vitro synthesized proteins
US5777324A (en) 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
US5864137A (en) 1996-10-01 1999-01-26 Genetrace Systems, Inc. Mass spectrometer
DE69727489T2 (de) 1996-11-06 2004-11-25 Sequenom, Inc., San Diego Verfahren zur massenspektrometrie
AU746737B2 (en) 1996-11-06 2002-05-02 Sequenom, Inc. Compositions and methods for immobilizing nucleic acids to solid supports
EP1164203B1 (de) 1996-11-06 2007-10-10 Sequenom, Inc. DNA-Diagnostik mittels Massenspektrometrie
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US6024925A (en) 1997-01-23 2000-02-15 Sequenom, Inc. Systems and methods for preparing low volume analyte array elements
US6140053A (en) 1996-11-06 2000-10-31 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
CN1118580C (zh) * 1997-01-23 2003-08-20 布拉克斯集团有限公司 对多肽的特性分析

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US6387628B1 (en) 2002-05-14
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