DE69838485D1 - Verfahren und vorrichtung zur transdermalen verabreichung von lithium - Google Patents
Verfahren und vorrichtung zur transdermalen verabreichung von lithiumInfo
- Publication number
- DE69838485D1 DE69838485D1 DE69838485T DE69838485T DE69838485D1 DE 69838485 D1 DE69838485 D1 DE 69838485D1 DE 69838485 T DE69838485 T DE 69838485T DE 69838485 T DE69838485 T DE 69838485T DE 69838485 D1 DE69838485 D1 DE 69838485D1
- Authority
- DE
- Germany
- Prior art keywords
- lithium
- transdermal administration
- disclosed
- substantially constant
- constant rate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6214897P | 1997-10-09 | 1997-10-09 | |
US62148P | 1997-10-09 | ||
PCT/US1998/021320 WO1999018797A1 (en) | 1997-10-09 | 1998-10-09 | Method and devices for transdermal delivery of lithium |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69838485D1 true DE69838485D1 (de) | 2007-11-08 |
DE69838485T2 DE69838485T2 (de) | 2008-06-26 |
Family
ID=22040523
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69838485T Expired - Lifetime DE69838485T2 (de) | 1997-10-09 | 1998-10-09 | Verfahren und vorrichtung zur transdermalen verabreichung von lithium |
Country Status (7)
Country | Link |
---|---|
US (2) | US6375990B1 (de) |
EP (1) | EP1030560B1 (de) |
AT (1) | ATE373957T1 (de) |
AU (1) | AU9794798A (de) |
CA (1) | CA2308489A1 (de) |
DE (1) | DE69838485T2 (de) |
WO (1) | WO1999018797A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69838485T2 (de) * | 1997-10-09 | 2008-06-26 | Emory University | Verfahren und vorrichtung zur transdermalen verabreichung von lithium |
US6792306B2 (en) * | 2000-03-10 | 2004-09-14 | Biophoretic Therapeutic Systems, Llc | Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor |
US20030044413A1 (en) * | 2000-08-15 | 2003-03-06 | Regents Of The University Of Minnesota | Methods of limiting apoptosis of cells |
US20020141970A1 (en) * | 2001-03-05 | 2002-10-03 | Pettit Dean K. | Stable aqueous solutions of granulocyte macrophage colony-stimulating factor |
US7378111B2 (en) * | 2002-02-20 | 2008-05-27 | The Trustees Of The University Of Pennsylvania | Regulation of GSK-3α activity for the treatment or prevention of Alzheimer's disease |
GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
US8332028B2 (en) * | 2006-11-28 | 2012-12-11 | Polyplus Battery Company | Protected lithium electrodes for electro-transport drug delivery |
US20090005824A1 (en) * | 2007-06-29 | 2009-01-01 | Polyplus Battery Company | Electrotransport devices, methods and drug electrode assemblies |
US20090069740A1 (en) * | 2007-09-07 | 2009-03-12 | Polyplus Battery Company | Protected donor electrodes for electro-transport drug delivery |
RU2499583C2 (ru) * | 2007-10-15 | 2013-11-27 | Алза Корпорейшн | Заместительное трансдермальное введение фентанила один раз в день |
US8275441B2 (en) * | 2007-11-02 | 2012-09-25 | Tyco Healthcare Group Lp | Electrodes possessing change indicator |
WO2012007387A1 (en) | 2010-07-13 | 2012-01-19 | Medesis Pharma | Low- dose lithium for the treatment of neurodegenerative disorders |
US9114258B2 (en) | 2011-01-04 | 2015-08-25 | Kato Medical Systems Llc | Electrokinetic nerve stimulator |
US20120270860A1 (en) | 2011-04-19 | 2012-10-25 | Gihyun Yoon | Methods for treating or preventing alcohol-related disorders or craving-related disorders |
GB2524777A (en) * | 2014-04-02 | 2015-10-07 | Microarray Ltd | Dressing comprising electrodes |
Family Cites Families (85)
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US5135477A (en) | 1984-10-29 | 1992-08-04 | Medtronic, Inc. | Iontophoretic drug delivery |
US4747819A (en) | 1984-10-29 | 1988-05-31 | Medtronic, Inc. | Iontophoretic drug delivery |
US4744787A (en) | 1984-10-29 | 1988-05-17 | Medtronic, Inc. | Iontophoresis apparatus and methods of producing same |
US4624847A (en) | 1985-04-22 | 1986-11-25 | Alza Corporation | Drug delivery device for programmed delivery of beneficial drug |
EP0289204B1 (de) | 1987-04-27 | 1991-07-17 | Efamol Holdings Plc | Lithiumsalze enthaltende pharmazeutische Zubereitungen |
US5252333A (en) | 1987-04-27 | 1993-10-12 | Scotia Holdings Plc | Lithium salt-containing pharmaceutical compositions |
US5162042A (en) | 1988-07-05 | 1992-11-10 | Alza Corporation | Electrotransport transdermal system |
US5612059A (en) | 1988-08-30 | 1997-03-18 | Pfizer Inc. | Use of asymmetric membranes in delivery devices |
US5496266A (en) | 1990-04-30 | 1996-03-05 | Alza Corporation | Device and method of iontophoretic drug delivery |
CA2001444C (en) | 1988-10-28 | 2000-07-25 | Darrel F. Untereker | Iontophoresis electrode |
US5057072A (en) | 1988-10-28 | 1991-10-15 | Medtronic, Inc. | Iontophoresis electrode |
US5252334A (en) | 1989-09-08 | 1993-10-12 | Cygnus Therapeutic Systems | Solid matrix system for transdermal drug delivery |
US4950229A (en) | 1989-09-25 | 1990-08-21 | Becton, Dickinson And Company | Apparatus for an electrode used for iontophoresis |
US5320597A (en) | 1991-02-08 | 1994-06-14 | Becton, Dickinson And Company | Device and method for renewing electrodes during iontophoresis |
US5167616A (en) | 1989-12-14 | 1992-12-01 | Alza Corporation | Iontophoretic delivery method |
US5334138A (en) | 1990-03-15 | 1994-08-02 | North Carolina State University | Method and composition for increased skin concentration of active agents by iontophoresis |
US5213568A (en) | 1990-03-30 | 1993-05-25 | Medtronic Inc. | Activity controlled electrotransport drug delivery device |
US5162043A (en) | 1990-03-30 | 1992-11-10 | Alza Corporation | Iontophoretic delivery device |
DK0522043T3 (da) | 1990-03-30 | 2004-02-23 | Alza Corp | Iontoforetisk indgivelsesindretning |
US5084006A (en) | 1990-03-30 | 1992-01-28 | Alza Corporation | Iontopheretic delivery device |
AU657681B2 (en) | 1990-03-30 | 1995-03-23 | Alza Corporation | Device and method for iontophoretic drug delivery |
US5147297A (en) | 1990-05-07 | 1992-09-15 | Alza Corporation | Iontophoretic delivery device |
US5037381A (en) | 1990-07-27 | 1991-08-06 | Bock C Randolph | Electrically assisted transdermal transport device and method for renewing the device |
WO1992007618A1 (en) | 1990-10-29 | 1992-05-14 | Alza Corporation | Iontophoretic drug delivery electrode and method of hydrating the same |
US5158537A (en) | 1990-10-29 | 1992-10-27 | Alza Corporation | Iontophoretic delivery device and method of hydrating same |
GB9023701D0 (en) * | 1990-10-31 | 1990-12-12 | Efamol Holdings | Medical treatment |
ES2065181T3 (es) | 1991-03-11 | 1995-02-01 | Alza Corp | Dispositivo de suministro iontoforetico y procedimiento para su fabricacion. |
US5405317A (en) | 1991-05-03 | 1995-04-11 | Alza Corporation | Iontophoretic delivery device |
US5131403A (en) | 1991-06-05 | 1992-07-21 | Becton Dickinson And Company | Method for obtaining blood using iontophoresis |
US5464387A (en) | 1991-07-24 | 1995-11-07 | Alza Corporation | Transdermal delivery device |
US5203768A (en) | 1991-07-24 | 1993-04-20 | Alza Corporation | Transdermal delivery device |
CA2076574A1 (en) | 1991-10-01 | 1993-04-02 | John Lenneis Haynes | Extended-life drug filled patch |
US5411737A (en) | 1991-10-15 | 1995-05-02 | Merck & Co., Inc. | Slow release syneresing polymeric drug delivery device |
WO1993010854A1 (en) | 1991-12-03 | 1993-06-10 | Alza Corporation | Iontophoretic delivery device and power supply therefor |
US5256137A (en) | 1992-03-10 | 1993-10-26 | Becton Dickinson And Company | Biphasic power source for use in an iontophoretic drug delivery system |
US5246418A (en) | 1991-12-17 | 1993-09-21 | Becton Dickinson And Company | Iontophresis system having features for reducing skin irritation |
US5260066A (en) * | 1992-01-16 | 1993-11-09 | Srchem Incorporated | Cryogel bandage containing therapeutic agent |
CA2087087C (en) | 1992-01-22 | 2000-07-18 | Burton H. Sage, Jr. | Molecules for iontophoretic delivery |
HUT65957A (en) | 1992-03-17 | 1994-08-29 | Becton Dickinson Co | User operated iontophoretical device and method for manufacturing it |
US5310403A (en) | 1992-05-18 | 1994-05-10 | Becton, Dickinson And Company | Iontophoretic drug delivery device and circuit therefor |
US5310404A (en) | 1992-06-01 | 1994-05-10 | Alza Corporation | Iontophoretic delivery device and method of hydrating same |
US5312326A (en) | 1992-06-02 | 1994-05-17 | Alza Corporation | Iontophoretic drug delivery apparatus |
EP0751801B1 (de) | 1992-06-02 | 1997-11-26 | Alza Corporation | Abgabevorrichtung zur elektrischen übertragung von arzneimitteln |
US5264219A (en) | 1992-08-07 | 1993-11-23 | Minnesota Mining And Manufacturing Company | Transdermal drug delivery backing |
US5306235A (en) | 1992-09-30 | 1994-04-26 | Becton Dickinson And Company | Failsafe iontophoresis drug delivery system |
AU6100194A (en) | 1993-02-02 | 1994-08-29 | Becton Dickinson & Company | Active drug delivery device, electrode, and method for making same |
US5427585A (en) | 1993-03-29 | 1995-06-27 | Bettinger; David S. | On-demand iontophoretic system |
WO1994027649A1 (en) | 1993-05-26 | 1994-12-08 | Becton Dickinson And Company | Patch, with system and apparatus for manufacture |
US5458569A (en) | 1993-06-08 | 1995-10-17 | Becton Dickinson And Company | Wearable iontophoresis system |
US5645854A (en) | 1993-06-23 | 1997-07-08 | Masiz; John J. | Molecular transdermal transport system |
US5460821A (en) | 1993-06-23 | 1995-10-24 | Masiz; John J. | Molecular transdermal transport system |
USD352113S (en) | 1993-08-05 | 1994-11-01 | Becton Dickinson And Company | Iontophoretic drug delivery system |
USD352357S (en) | 1993-08-06 | 1994-11-08 | Becton Dickinson And Company | Iontophoretic drug delivery system |
US5744155A (en) | 1993-08-13 | 1998-04-28 | Friedman; Doron | Bioadhesive emulsion preparations for enhanced drug delivery |
USD366702S (en) | 1993-08-30 | 1996-01-30 | Becton Dickinson And Company | Iontophoretic drug delivery controller |
USD352782S (en) | 1993-08-30 | 1994-11-22 | Becton Dickinson And Company | Iontophoretic drug delivery system |
US5723145A (en) | 1993-09-30 | 1998-03-03 | Takiron Co., Ltd. | Transdermal absorption preparation |
AU7845494A (en) | 1993-09-30 | 1995-04-18 | Becton Dickinson & Company | Iontophoretic device, reservoir and method of making |
US5540669A (en) | 1993-09-30 | 1996-07-30 | Becton, Dickinson And Company | Iontophoretic drug delivery system and method for using same |
JPH07129875A (ja) | 1993-11-04 | 1995-05-19 | Nippon Signal Co Ltd:The | 警報装置 |
US5387189A (en) | 1993-12-02 | 1995-02-07 | Alza Corporation | Electrotransport delivery device and method of making same |
US5635204A (en) | 1994-03-04 | 1997-06-03 | Montefiore Medical Center | Method for transdermal induction of anesthesia, analgesia or sedation |
US5567439A (en) | 1994-06-14 | 1996-10-22 | Fuisz Technologies Ltd. | Delivery of controlled-release systems(s) |
US5603955A (en) | 1994-07-18 | 1997-02-18 | University Of Cincinnati | Enhanced loading of solutes into polymer gels |
US5554380A (en) | 1994-08-04 | 1996-09-10 | Kv Pharmaceutical Company | Bioadhesive pharmaceutical delivery system |
WO1996009851A1 (en) | 1994-09-29 | 1996-04-04 | Becton Dickinson And Company | Method of preparing silver chloride electrodes for iontophoretic drug delivery devices |
US5645526A (en) | 1994-09-30 | 1997-07-08 | Becton Dickinson And Company | Apparatus and method for ensuring compatibility of a reusable iontophoretic controller with an iontophoretic patch |
EP0783344B1 (de) | 1994-09-30 | 1999-05-19 | Becton, Dickinson and Company | Vorrichtung zur iontophoretischen verabreichung von medikamenten mit verbesserter steuereinrichtung und kissenelektrode |
DK0783301T3 (da) | 1994-09-30 | 1999-08-02 | Becton Dickinson Co | Fremgangsmåde til udformning og pakning af iontoforetiske medikamentleveringsplastre og lignende med henblik på forøgelse a |
US5498235A (en) | 1994-09-30 | 1996-03-12 | Becton Dickinson And Company | Iontophoresis assembly including patch/controller attachment |
EP0783345A1 (de) | 1994-09-30 | 1997-07-16 | Vyteris, Inc. | Vorrichtung zur iontophoretischen verabreichung von medikamenten und entsprechende wegwerfbare kissenelektrode und auswechselbare mehrwegsteuereinrichtung |
US5688231A (en) | 1994-09-30 | 1997-11-18 | Becton Dickinson And Company | Iontophoresis assembly including cleanable electrical contacts |
US5736580A (en) | 1994-11-14 | 1998-04-07 | Alza Croporation | Composition, device, and method for electrotransport agent delivery |
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US5651979A (en) | 1995-03-30 | 1997-07-29 | Gel Sciences, Inc. | Apparatus and method for delivering a biologically active compound into a biological environment |
US5626786A (en) | 1995-04-17 | 1997-05-06 | Huntington; John H. | Labile bromine fire suppressants |
US6167301A (en) | 1995-08-29 | 2000-12-26 | Flower; Ronald J. | Iontophoretic drug delivery device having high-efficiency DC-to-DC energy conversion circuit |
CA2233068A1 (en) | 1995-09-28 | 1997-04-03 | Vyteris, Inc. | Iontophoretic drug delivery system, including disposable patch |
US5688232A (en) | 1995-09-28 | 1997-11-18 | Becton Dickinson And Company | Iontophoretic drug delivery device having an improved controller |
WO1997012644A1 (en) | 1995-09-29 | 1997-04-10 | Becton Dickinson And Company | Improved iontophoretic reservoir apparatus |
EP0957979B1 (de) | 1995-09-29 | 2007-05-23 | Vyteris, Inc. | Kostengünstige elektroden für eine iontophoretische vorrichtung |
US6060638A (en) | 1995-12-22 | 2000-05-09 | Kimberly-Clark Worldwide, Inc. | Matched permeability liner/absorbent structure system for absorbent articles and the like |
IT1284849B1 (it) * | 1996-06-10 | 1998-05-22 | Ist Farmacoterapico It Spa | Cerotto a rilascio controllato di litio. |
US5693024A (en) | 1996-09-27 | 1997-12-02 | Becton Dickinson And Company | Iontophoretic drug delivery system, including method for determining hydration of patch |
DE69838485T2 (de) | 1997-10-09 | 2008-06-26 | Emory University | Verfahren und vorrichtung zur transdermalen verabreichung von lithium |
-
1998
- 1998-10-09 DE DE69838485T patent/DE69838485T2/de not_active Expired - Lifetime
- 1998-10-09 EP EP98952191A patent/EP1030560B1/de not_active Expired - Lifetime
- 1998-10-09 AT AT98952191T patent/ATE373957T1/de not_active IP Right Cessation
- 1998-10-09 WO PCT/US1998/021320 patent/WO1999018797A1/en active IP Right Grant
- 1998-10-09 AU AU97947/98A patent/AU9794798A/en not_active Abandoned
- 1998-10-09 CA CA002308489A patent/CA2308489A1/en not_active Abandoned
- 1998-10-09 US US09/529,248 patent/US6375990B1/en not_active Expired - Lifetime
-
2002
- 2002-04-22 US US10/127,257 patent/US20020160056A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1030560A1 (de) | 2000-08-30 |
DE69838485T2 (de) | 2008-06-26 |
US20020160056A1 (en) | 2002-10-31 |
WO1999018797A1 (en) | 1999-04-22 |
EP1030560B1 (de) | 2007-09-26 |
AU9794798A (en) | 1999-05-03 |
ATE373957T1 (de) | 2007-10-15 |
US6375990B1 (en) | 2002-04-23 |
EP1030560A4 (de) | 2004-11-17 |
CA2308489A1 (en) | 1999-04-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |