DE69834527D1 - Verfahren zur Geschlechtsbestimmung von Säuger-Nachkommenschaft - Google Patents

Verfahren zur Geschlechtsbestimmung von Säuger-Nachkommenschaft

Info

Publication number
DE69834527D1
DE69834527D1 DE69834527T DE69834527T DE69834527D1 DE 69834527 D1 DE69834527 D1 DE 69834527D1 DE 69834527 T DE69834527 T DE 69834527T DE 69834527 T DE69834527 T DE 69834527T DE 69834527 D1 DE69834527 D1 DE 69834527D1
Authority
DE
Germany
Prior art keywords
sex
mammalian offspring
spermatozoa
sexing mammalian
sexing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69834527T
Other languages
English (en)
Other versions
DE69834527T2 (de
Inventor
Thomas L Benjamin
Barbara Kohn
Christopher J Basker
Susan George
David Livingston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vlp Watertown Watertown Us LP
Original Assignee
Vicam LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vicam LP filed Critical Vicam LP
Application granted granted Critical
Publication of DE69834527D1 publication Critical patent/DE69834527D1/de
Publication of DE69834527T2 publication Critical patent/DE69834527T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/0612—Germ cells sorting of gametes, e.g. according to sex or motility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/85—Reproductive organs or embryos
    • Y10S530/852—Sperm
DE69834527T 1997-07-01 1998-07-01 Verfahren zur Geschlechtsbestimmung von Säuger-Nachkommenschaft Expired - Fee Related DE69834527T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88620397A 1997-07-01 1997-07-01
US886203 1997-07-01

Publications (2)

Publication Number Publication Date
DE69834527D1 true DE69834527D1 (de) 2006-06-22
DE69834527T2 DE69834527T2 (de) 2007-05-10

Family

ID=25388608

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69834527T Expired - Fee Related DE69834527T2 (de) 1997-07-01 1998-07-01 Verfahren zur Geschlechtsbestimmung von Säuger-Nachkommenschaft

Country Status (6)

Country Link
US (3) US6153373A (de)
EP (1) EP0894498B1 (de)
AT (1) ATE326228T1 (de)
DE (1) DE69834527T2 (de)
DK (1) DK0894498T3 (de)
ES (1) ES2260809T3 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2264428B1 (de) 1997-01-31 2017-05-03 Xy, Llc Optisches Gerät mit fokussierendem Reflektor zur Konvergenz von Strahlung auf einen Partikelfluss
EP0894498B1 (de) 1997-07-01 2006-05-17 Vicam, L.P. Verfahren zur Geschlechtsbestimmung von Säuger-Nachkommenschaft
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
NZ527659A (en) 1998-07-30 2006-02-24 Colorado State University Thro Equine artificial insemination when there has been sex selection of the sperm to produce an equine of the desired sex
GB9817795D0 (en) * 1998-08-14 1998-10-14 Genosis Inc A method and device for separation and detection of spermatozoa in a sample
US7071005B1 (en) 1998-08-24 2006-07-04 Centrus International, Inc. Method and device for concentrating selected groups of microorganisms
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
AR034121A1 (es) 2000-05-09 2004-02-04 Xy Inc Metodo para aislar celulas de esperma que contienen cromosoma x de celulas de esperma que contienen cromosoma y
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
AU2002220018A1 (en) * 2000-11-29 2002-06-11 Colorado State University System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
AU2003265362B2 (en) 2002-08-01 2009-11-05 Xy, Llc. Low pressure sperm cell separation system
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
BRPI0313476B1 (pt) 2002-08-15 2015-06-23 Xy Llc Citômetro de fluxo de alta resolução
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US20040142384A1 (en) * 2003-01-16 2004-07-22 Cohen Barb Ariel Magnetic separator
DE602004024874D1 (de) 2003-03-28 2010-02-11 Inguran Llc Eschlechts-sortierten tierspermien
AU2004242121B2 (en) 2003-05-15 2010-06-24 Xy, Llc. Efficient haploid cell sorting for flow cytometer systems
US20050114915A1 (en) * 2003-11-26 2005-05-26 Vicam L.P. Method for sex biasing spermatozoa
ES2397678T3 (es) 2004-03-29 2013-03-08 Inguran, Llc Suspensiones de espermatozoides para clasificación en poblaciones enriquecidas portadoras del cromosoma X o Y
BRPI0401765C1 (pt) 2004-05-17 2011-03-15 Hy Biotecnologica Ltda método de enriquecimento de espermatozoides de mamìferos portadores de cromossomo x ou de cromossomo y
MX2007000888A (es) 2004-07-22 2007-04-02 Monsanto Technology Llc Procedimiento para enriquecer una poblacion de celulas de esperma.
CA2598805A1 (en) * 2005-02-24 2006-08-31 Biocern, Inc. Sperm cell separation methods and compositions
WO2008028081A2 (en) * 2006-08-30 2008-03-06 Biocern, Inc. Sperm cell separation methods and compositions containing aptamers or nucleic acid sequences for use therein
US8669418B2 (en) 2005-12-22 2014-03-11 Vib Vzw Means and methods for mediating protein interference
EP2345417A1 (de) 2005-12-22 2011-07-20 Vib Vzw Mittel und Verfahren zur Interferenz mit Proteinen
EP1870423A1 (de) * 2006-06-22 2007-12-26 Genes Diffusion Y-Chromosom assoziierte Antigene oberflächen Struktur von Spermienzellen
CA2568512A1 (en) * 2006-12-04 2008-06-04 Ab Biotech Inc. Gender selection with the use of antibodies
WO2008088601A2 (en) * 2007-01-16 2008-07-24 Texas Tech University System Method and apparatus for gender selection based on ph
AU2008279893A1 (en) * 2007-07-23 2009-01-29 Androgenix Ltd Materials and methods for sperm sex selection
CA2701170A1 (en) 2007-09-29 2009-08-27 Timothy James Williams Composition and method to modify sperm function and increase male gender ratio in mammals
CA2793945A1 (en) * 2009-04-01 2011-10-21 Biocern, Inc. Sperm cell separation methods and compositions containing sperm cell targeting ligands for use therein
NZ600737A (en) * 2009-11-24 2013-05-31 Biassex Pty Ltd Method for influencing sex selection in artificial insemination and apparatus for same
WO2012123419A1 (en) 2011-03-11 2012-09-20 Vib Vzw Molecules and methods for inhibition and detection of proteins
US10379026B2 (en) 2012-08-29 2019-08-13 Inguran, Llc Cell processing using magnetic particles
NZ705665A (en) 2012-08-29 2017-08-25 Inguran Llc Magnetic removal or identification of damaged or compromised cells or cellular structures
US10527607B2 (en) * 2013-03-15 2020-01-07 Arex Life Sciences, Llc Rapid real time multipoint procedure for optimizing sperm state for use in assisted reproductive technologies
KR101497614B1 (ko) * 2013-12-06 2015-03-03 손중호 마그네틱 비드를 이용한 정자 성 분리방법
EP2955521A1 (de) * 2014-06-11 2015-12-16 Centre Hospitalier Universitaire Vaudois (CHUV) Verfahren zur Trennung von Zellen
BR112018013224A2 (pt) * 2016-01-04 2018-12-11 Univ Tennessee Res Found métodos para melhorar a qualidade de sêmen
CA3058848A1 (en) 2017-05-09 2018-11-15 Vib Vzw Means and methods for treating bacterial infections

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474875A (en) * 1969-04-10 1984-10-02 Wallace Shrimpton Method and means for controlling the sex of mammalian offspring and product therefor
US3692897A (en) 1969-11-04 1972-09-19 Gustaaf J Van Den Bovenkamp Immunological method and composition for controlling the sex of mammalian offspring
US3687806A (en) 1969-11-04 1972-08-29 Bio Controls Inc Method for controlling sex of mammalian offspring
US4526716A (en) * 1981-11-20 1985-07-02 The Ohio State University Antigenic modification of polypeptides
US3906929A (en) * 1973-11-23 1975-09-23 Lynn Lawrence Augspurger Processes for reproduction of cellular bodies
US4083957A (en) * 1974-07-26 1978-04-11 Lang John L Process for the alteration of the sex-ratio of mammals
US3970518A (en) 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
AU2154077A (en) * 1976-01-27 1978-07-27 Univ Edinburgh Control of sex ratio in mammalian offspring
US4191749A (en) * 1977-10-11 1980-03-04 Bryant Bernard J Method and material for increasing the percentage of mammalian offspring of either sex
US4448767A (en) * 1977-10-11 1984-05-15 Sumar Corporation Preparation of monospecific male-specific antibody and the use thereof for increasing the percentage of mammalian offspring of either sex
US4230685A (en) * 1979-02-28 1980-10-28 Northwestern University Method of magnetic separation of cells and the like, and microspheres for use therein
GB2070641A (en) 1980-02-29 1981-09-09 Bryant B J Preparation of monospecific male-specific antibody and the use thereof for increasing the percentage of mammalian offspring of either sex
US4362246A (en) * 1980-07-14 1982-12-07 Adair Edwin Lloyd Method of treating collected mammal semen and separating sperm into X Y components
US4680258A (en) * 1981-03-24 1987-07-14 Sloan-Kettering Institute For Cancer Research Process for sex determination in man by use of monoclonal antibodies to the H-Y antigen
US4659655A (en) * 1981-11-25 1987-04-21 Bio-Response, Inc. Method for isolating product-producing cells
WO1984001265A1 (en) * 1982-10-05 1984-04-12 Genetic Engineering Inc Method of treating collected mammal semen and separating sperm into x and y components
US4508625A (en) 1982-10-18 1985-04-02 Graham Marshall D Magnetic separation using chelated magnetic ions
US4912201A (en) 1983-03-15 1990-03-27 University Of Southern California Monoclonal antibodies and antisera to intragonadal regulatory protein
US4554088A (en) 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4643967A (en) 1983-07-07 1987-02-17 Bryant Bernard J Antibody method for lowering risk of susceptibility to HLA-associated diseases in future human generations
WO1985000503A1 (en) 1983-07-22 1985-02-14 Wachtel Stephen S Monoclonal antibodies to the h-y antigen, methods of production, applications, and products of manufacture
US4769319A (en) 1985-05-31 1988-09-06 Salk Institute Biotechnology Industrial Associates, Inc. Nucleic acid probes for prenatal sexing
US4904391A (en) 1985-10-09 1990-02-27 Freeman Richard B Method and apparatus for removal of cells from bone marrow
US4770992A (en) * 1985-11-27 1988-09-13 Den Engh Gerrit J Van Detection of specific DNA sequences by flow cytometry
US4999283A (en) * 1986-01-10 1991-03-12 University Of Kentucky Research Foundation Method for x and y spermatozoa separation
AU7453287A (en) * 1986-06-26 1988-01-07 Bio Science Laboratory Antibody to middle piece of y chromosome bearing spermatozoon
US5418133A (en) 1986-08-12 1995-05-23 The Australian National University Sex determination in cattle, sheep and goats using y-chromosome polynucleotides
US4722887A (en) * 1986-12-19 1988-02-02 Biosyne Corporation Phase partition separation of sperm based on seminolipid expression
US5238812A (en) 1987-03-13 1993-08-24 Coulter Corporation Method and apparatus for rapid mixing of small volumes for enhancing biological reactions
US5346990A (en) 1987-04-08 1994-09-13 Cytogam, Inc. Sex-associated membrane proteins and methods for increasing the probability that offspring will be of a desired sex
US5021244A (en) * 1988-12-06 1991-06-04 Cytogam, Inc. Sex-associated membrane antibodies and their use for increasing the probability that offspring will be of a desired sex
US5215884A (en) 1988-01-21 1993-06-01 University Of Georgia Research Foundation, Inc. Sex-specific DNA probes
EP0348174A3 (de) 1988-06-23 1991-05-22 Bio-Rad Laboratories, Inc. Sperma-Antikörper-Test
US5108933A (en) * 1988-09-16 1992-04-28 Immunicon Corporation Manipulation of colloids for facilitating magnetic separations
DE68900926D1 (de) 1988-09-28 1992-04-09 Sigma Tau Ind Farmaceuti Pharmazeutische zubereitung, die zidovudin und inosiplex oder bestandteile davon enthaelt, fuer die behandlung von aids-verwandten syndromen.
US5536475A (en) 1988-10-11 1996-07-16 Baxter International Inc. Apparatus for magnetic cell separation
US5081030A (en) * 1989-04-25 1992-01-14 The Johns Hopkins University Release of cells from affinity matrices
ES2091823T3 (es) 1989-05-10 1996-11-16 Us Agriculture Metodo para preseleccionar el sexo de la progenie.
EP0658345A1 (de) 1989-05-12 1995-06-21 Cytogam, Inc. Mit dem Geschlecht assoziierte Membranproteine und Methoden zur Erhöhung der Wahrscheinlichkeit, dass die Nachkommenschaft das Gewünschte Geschlecht Besitzt
DE68924275T2 (de) 1989-05-12 1996-05-02 Cytogam Inc Mit dem geschlecht assoziierte membranproteine und methoden zur erhöhung der wahrscheinlichkeit, dass die nachkommenschaft das gewünschte geschlecht besitzt.
US5389377A (en) * 1989-12-22 1995-02-14 Molecular Bioquest, Inc. Solid care therapeutic compositions and methods for making same
US5648468A (en) 1990-03-09 1997-07-15 Spaulding; Glenn F. Process for identifying sex associated egg proteins and methods for increasing the probability that the avian offspring will be the desired sex
WO1991017188A1 (en) * 1990-05-08 1991-11-14 A.B. Technolody Pty. Limited Separation of mammalian semen into fractions enriched either for spermatozoa containing an x chromosome or for spermatozoa contai ning a y chromosome
EP0536213A1 (de) 1990-06-28 1993-04-14 Imperial Cancer Research Technology Limited Gen, dass das geschlecht entscheidet
US5200084A (en) * 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
US5466574A (en) * 1991-03-25 1995-11-14 Immunivest Corporation Apparatus and methods for magnetic separation featuring external magnetic means
US5186827A (en) * 1991-03-25 1993-02-16 Immunicon Corporation Apparatus for magnetic separation featuring external magnetic means
US5225282A (en) * 1991-12-13 1993-07-06 Molecular Bioquest, Inc. Biodegradable magnetic microcluster comprising non-magnetic metal or metal oxide particles coated with a functionalized polymer
JP2593021B2 (ja) 1991-12-13 1997-03-19 伊藤ハム株式会社 ウシ胚の性の識別方法
US5200284A (en) 1992-05-28 1993-04-06 Eastman Kodak Company Melamine-cured polyester-amide coated articles useful as toner fusing members
US5759772A (en) 1992-07-23 1998-06-02 Wisconsin Alumni Research Foundation Method for determining the sex of an embryo
US5679513A (en) 1992-12-31 1997-10-21 Texas Tech University Method for diagnosing ratites
US5679514A (en) 1992-12-31 1997-10-21 Texas Tech University Method for determining the sex of birds
US5514537A (en) 1994-11-28 1996-05-07 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Process and apparatus for sorting spermatozoa
WO1996022302A1 (en) 1995-01-20 1996-07-25 Florida State University Sex-specific dna probe for parrots, methods and kits
JPH11511252A (ja) 1995-08-11 1999-09-28 ユニバーシティ・オブ・グエルフ 性特異的および種特異的分子の同定方法、該方法を用いて同定した分子、および該分子の使用
AUPO060996A0 (en) 1996-06-21 1996-07-18 University Of Melbourne, The Sexing gene
EP0972183A4 (de) 1997-04-04 2006-12-06 Biosite Inc Verfahren zur verwendung magnetischer partikeln zur konzentration von liganden
EP0894498B1 (de) 1997-07-01 2006-05-17 Vicam, L.P. Verfahren zur Geschlechtsbestimmung von Säuger-Nachkommenschaft
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6221857B1 (en) 1998-06-10 2001-04-24 North Carolina State University Altering sex ratio of offspring in mammals
US6485972B1 (en) 1998-10-15 2002-11-26 President And Fellows Of Harvard College WNT signalling in reproductive organs
US6493566B1 (en) 1999-01-22 2002-12-10 Instrumentation Metrics, Inc. Classification system for sex determination and tissue characterization
WO2001042283A2 (en) 1999-12-07 2001-06-14 University Of Guelph Sex-chromosome-specific proteins, species specific and sperm specific proteins and methods for their identification and isolation
BR0016816A (pt) 1999-12-27 2002-12-24 Chengyu Liu Controle da proporção sexual da prole através do direcionamento de trangenes para os cromossomos sexuais

Also Published As

Publication number Publication date
EP0894498B1 (de) 2006-05-17
EP0894498A3 (de) 2002-05-02
US6489092B1 (en) 2002-12-03
ES2260809T3 (es) 2006-11-01
EP0894498A2 (de) 1999-02-03
DE69834527T2 (de) 2007-05-10
US6153373A (en) 2000-11-28
US20030068654A1 (en) 2003-04-10
ATE326228T1 (de) 2006-06-15
DK0894498T3 (da) 2006-08-28

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: VLP WATERTOWN LIMITED PARTNERSHIP, WATERTOWN, , US

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee