DE69830927D1 - Bewertung von humaner papillomvirus verwandter krankheit - Google Patents

Bewertung von humaner papillomvirus verwandter krankheit

Info

Publication number
DE69830927D1
DE69830927D1 DE69830927T DE69830927T DE69830927D1 DE 69830927 D1 DE69830927 D1 DE 69830927D1 DE 69830927 T DE69830927 T DE 69830927T DE 69830927 T DE69830927 T DE 69830927T DE 69830927 D1 DE69830927 D1 DE 69830927D1
Authority
DE
Germany
Prior art keywords
evaluation
related disease
papillomvirus
human
human papillomvirus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69830927T
Other languages
English (en)
Other versions
DE69830927T2 (de
Inventor
T Lorincz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qiagen Gaithersburg LLC
Original Assignee
Qiagen Gaithersburg LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27371534&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69830927(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Qiagen Gaithersburg LLC filed Critical Qiagen Gaithersburg LLC
Application granted granted Critical
Publication of DE69830927D1 publication Critical patent/DE69830927D1/de
Publication of DE69830927T2 publication Critical patent/DE69830927T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/708—Specific hybridization probes for papilloma
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
DE69830927T 1997-12-12 1998-12-11 Bewertung von humaner papillomvirus verwandter krankheit Expired - Lifetime DE69830927T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US6942697P 1997-12-12 1997-12-12
US69426P 1997-12-12
US7048698P 1998-01-05 1998-01-05
US70486P 1998-01-05
US8216798P 1998-04-17 1998-04-17
US82167P 1998-04-17
PCT/US1998/026447 WO1999029890A2 (en) 1997-12-12 1998-12-11 Assessment of human papilloma virus-related disease

Publications (2)

Publication Number Publication Date
DE69830927D1 true DE69830927D1 (de) 2005-08-25
DE69830927T2 DE69830927T2 (de) 2006-05-24

Family

ID=27371534

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69830927T Expired - Lifetime DE69830927T2 (de) 1997-12-12 1998-12-11 Bewertung von humaner papillomvirus verwandter krankheit

Country Status (13)

Country Link
US (5) US6969585B2 (de)
EP (2) EP1038029A2 (de)
JP (3) JP2002508190A (de)
AT (1) ATE299946T1 (de)
AU (2) AU748022B2 (de)
BR (2) BR9814272A (de)
CA (2) CA2313483C (de)
DE (1) DE69830927T2 (de)
DK (1) DK1038022T3 (de)
ES (1) ES2246546T3 (de)
NO (2) NO330906B1 (de)
PT (1) PT1038022E (de)
WO (2) WO1999029890A2 (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029890A2 (en) * 1997-12-12 1999-06-17 Digene Corporation Assessment of human papilloma virus-related disease
KR20020064298A (ko) 1999-10-13 2002-08-07 시쿼넘, 인코포레이티드 다형성 유전 마커를 동정하기 위한 데이타베이스 및 이의제조 방법
KR100382703B1 (ko) * 2000-03-15 2003-05-09 주식회사 바이오메드랩 인유두종바이러스의 유전형 진단키트 및 상기 진단키트의제조방법
AU2001249526A1 (en) * 2000-03-28 2001-10-08 Biosearch International Pty Ltd Approaches for hpv detection and staging by targeting the e6 gene region of the viral genome
US20040115692A1 (en) * 2000-04-03 2004-06-17 Cytyc Corporation Methods, compositions and apparatuses for detecting a target in a preservative solution
ATE456668T1 (de) * 2000-04-03 2010-02-15 Cytyc Corp Nachweis und typisierung des papillomavirus mittels pna-sonden
IT1316070B1 (it) * 2000-05-05 2003-03-28 Bioanalisi Ct Sud Snc Di Perse Metodo e mezzi per l'identificazione di virus hpv
US7439016B1 (en) * 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
US7601497B2 (en) * 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
BR0112385A (pt) 2000-06-21 2003-06-17 Digene Corp Meio de coleta universal
GB0018140D0 (en) * 2000-07-24 2000-09-13 Medical Res Council Screening for abnormalities
US20040229298A1 (en) * 2000-11-11 2004-11-18 Lu Peter S. Methods and compositions for treating cervical cancer
US20040121310A1 (en) * 2002-12-18 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in forensic studies
KR100437626B1 (ko) * 2001-06-21 2004-06-26 주식회사 마이진 인간 유두종바이러스 유전자형 검사 방법과 이를 위한검사 키트
EP1463839B1 (de) 2002-01-07 2007-02-21 Norchip A/S Detektionsverfahren für papillomavirus mrna
EP1556513B1 (de) 2002-10-21 2010-04-28 Eisai Inc. Zusammensetzungen und verfahren zurbehandlung von krankheiten, die durch das humane papillomavirus vermitteltwerden
EP1464709B1 (de) * 2003-03-31 2007-12-26 Stichting Researchfonds Pathologie Nachweis von invasivem Krebs induziert von HPV und dessen Vorläufer Läsionen mit Invasionspotential
US20040203004A1 (en) * 2003-04-10 2004-10-14 Bernard Hans Ulrich Diagnostic apparatus and method
US7361460B2 (en) 2003-04-11 2008-04-22 Digene Corporation Approach to molecular diagnosis of human papillomavirus-related diseases
WO2005008248A2 (en) * 2003-07-18 2005-01-27 Georgetown University Diagnosis and treatment of cervical cancer
DE60300339T2 (de) * 2003-08-25 2006-04-13 Mtm Laboratories Ag Verfahren zum Nachweis von Karzinomen in solubilisierten zervikalen Körperproben
EP1510820B1 (de) * 2003-08-25 2010-03-17 MTM Laboratories AG Verfahren zum Nachweis von medizinisch relevanten Zuständen in gelösten LBC-Proben
US7482142B1 (en) 2004-05-07 2009-01-27 Roche Molecular Systems, Inc. High-risk human papillomavirus detection
US7316904B1 (en) 2004-06-30 2008-01-08 Chromodynamics, Inc. Automated pap screening using optical detection of HPV with or without multispectral imaging
KR100572721B1 (ko) * 2004-07-26 2006-04-24 이미영 환원전리수를 포함하는 ｒｎａ 보존액 및 그를 이용한ｒｎａ 보존방법
US7354719B2 (en) 2004-12-08 2008-04-08 Gen-Probe Incorporated Detection of nucleic acids from multiple types of human papillomaviruses
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
GB0500996D0 (en) * 2005-01-18 2005-02-23 Delfts Diagnostic Labaratory B Detection method and materials therefor
US7524631B2 (en) * 2005-02-02 2009-04-28 Patterson Bruce K HPV E6, E7 mRNA assay and methods of use thereof
US20070111960A1 (en) * 2005-03-04 2007-05-17 Advandx, Inc. High affinity probes for analysis of human papillomavirus expression
DE102005015005A1 (de) * 2005-04-01 2006-10-05 Qiagen Gmbh Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe
US7972776B2 (en) * 2005-11-15 2011-07-05 Oncohealth Corporation Protein chips for HPV detection
US7732166B2 (en) * 2005-11-15 2010-06-08 Oncohealth Corporation Detection method for human pappilomavirus (HPV) and its application in cervical cancer
EP2041315B1 (de) * 2006-06-19 2010-08-25 Becton, Dickinson and Company Verfahren und zusammensetzungen für den erhalt amplifizierbarer nukleinsäuren aus transportmedien ausgesetzten geweben, zellen oder viren
JP2009545317A (ja) * 2006-08-01 2009-12-24 アプライド バイオシステムズ， エルエルシー 分析物および核酸の検出
US8865162B2 (en) * 2008-06-13 2014-10-21 Oncohealth Corp. Monoclonal antibodies against HPV proteins
WO2010129821A1 (en) 2009-05-07 2010-11-11 Oncohealth Corporation Identification of high grade or ≥cin2 for early stages and late stages detection, screening, and diagnosis of human papillomavirus (hpv) and hpv-associated cancers
US8968995B2 (en) * 2008-11-12 2015-03-03 Oncohealth Corp. Detection, screening, and diagnosis of HPV-associated cancers
WO2008071998A2 (en) * 2006-12-15 2008-06-19 Oncomethylome Sciences Sa Diagnostic methods for diseases caused by a hpv infection comprising determining the methylation status of the hpv genome
JP5241100B2 (ja) * 2006-12-28 2013-07-17 シスメックス株式会社 抗原賦活化液、抗原賦活化方法及び細胞の検出方法
US20090311392A1 (en) * 2007-09-20 2009-12-17 Paul Bernard Newman Novel approach to the controlled decontamination and or detoxification of nuts, grains, fruits and vegetables
WO2009092017A1 (en) * 2008-01-16 2009-07-23 Medical College Of Georgia Research Institute, Inc. Biomarkers for hpv-induced cancer
EP2262911B1 (de) * 2008-04-17 2016-10-12 QIAGEN Gaithersburg, Inc. Zusammensetzungen, verfahren und kits mit synthetischen sonden zum nachweis der anwesenheit einer target-nukleinsäure
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
WO2010062546A1 (en) 2008-10-27 2010-06-03 Qiagen Gaithersburg Inc. Fast results hybrid capture assay on an automated platform
EP2184368A1 (de) 2008-11-07 2010-05-12 DKFZ Deutsches Krebsforschungszentrum Diagnosetranskript- und Spleißmuster von HPV16 bei verschiedenen Halsverletzungen
GB0820822D0 (en) * 2008-11-13 2008-12-24 Inst Catala D Oncologia Novel product and processes
WO2010064628A1 (ja) * 2008-12-05 2010-06-10 オリンパス株式会社 核酸含有試料の調製方法、試料調製用溶液、及び核酸の解析方法
SG173140A1 (en) 2009-01-27 2011-08-29 Genetic Technologies Ltd Biological sampling device
WO2010088292A1 (en) * 2009-01-28 2010-08-05 Qiagen Gaithersburg, Inc. Sequence-specific large volume sample preparation method and assay
US9797000B2 (en) 2009-05-01 2017-10-24 Qiagen Gaithersburg Inc. Non-target amplification method for detection of RNA splice-forms in a sample
EP2473596B1 (de) 2009-09-03 2017-12-13 Becton, Dickinson and Company Verfahren und zusammensetzung für direkte chemische lyse
EP2478087B1 (de) 2009-09-14 2017-01-18 QIAGEN Gaithersburg, Inc. Zusammensetzungen und verfahren zur rückgewinnung von nukleinsäuren oder proteinen aus in zytologischen medien fixierten gewebeproben
WO2011082415A2 (en) * 2010-01-04 2011-07-07 Qiagen Gaithersburg, Inc. Methods, compositions, and kits for recovery of nucleic acids or proteins from fixed tissue samples
US9128094B2 (en) 2010-01-08 2015-09-08 Oncohealth Corp. High throughput cell-based HPV immunoassays for diagnosis and screening of HPV-associated cancers
US9605303B2 (en) 2010-01-29 2017-03-28 Qiagen Gaithersburg, Inc. Method of determining and confirming the presence of an HPV in a sample
US9689047B2 (en) * 2010-01-29 2017-06-27 Qiagen Gaithersburg Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
AU2011255638B2 (en) 2010-05-19 2016-08-25 Qiagen Gaithersburg, Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
US9376727B2 (en) 2010-05-25 2016-06-28 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically truncated probes
WO2012116220A2 (en) 2011-02-24 2012-08-30 Qiagen Gaithersburg, Inc. Materials and methods for detection of hpv nucleic acid
US20140127745A1 (en) * 2011-06-24 2014-05-08 Biotechnology Developers, S.A. Method, compositions and device for preparing cytological specimens
EP2773745B1 (de) 2011-11-03 2019-04-10 QIAGEN Gaithersburg, Inc. Materialien und verfahren zur immobilisierung, isolierung und konzentration von zellen mittels carboxylierter oberflächen
JP5960421B2 (ja) * 2011-12-05 2016-08-02 株式会社日立ハイテクノロジーズ 細胞の測定方法及び細胞の測定用試薬
CN104394774B (zh) 2012-04-28 2018-03-09 塞托克尔公司 用于生物样本自收集的方法、包装和装置
US8734364B1 (en) 2013-11-07 2014-05-27 Genetic Technologies Limited Device and method for obtaining a biological sample
WO2016005789A1 (en) * 2014-07-07 2016-01-14 Institut Pasteur Broad range gene and genotype papillomavirus transcriptome as a biomarker of papillomavirus- associated cancer stages
CN107250346B (zh) 2015-06-30 2019-11-15 希森美康株式会社 细胞保存液及其利用、以及细胞保存液的制造方法
US11072660B2 (en) 2016-10-03 2021-07-27 Juno Therapeutics, Inc. HPV-specific binding molecules
EP3692063A1 (de) 2017-10-03 2020-08-12 Juno Therapeutics, Inc. Hpv-spezifische bindungsmoleküle
SG11202009284TA (en) 2018-04-05 2020-10-29 Juno Therapeutics Inc T cell receptors and engineered cells expressing same
PL240016B1 (pl) * 2019-09-09 2022-02-07 Genomtec Spolka Akcyjna Zestaw starterów do wykrywania wirusa brodawczaka ludzkiego typ 16 (HPV16 Human papillomavirus type 16), sposób wykrywania infekcji HPV16, zastosowanie zestawu starterów do wykrywania infekcji HPV16
WO2021156404A2 (en) * 2020-02-07 2021-08-12 Isa Pharmaceuticals Treatment of hpv-related diseases
WO2023081900A1 (en) 2021-11-08 2023-05-11 Juno Therapeutics, Inc. Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732847A (en) 1981-06-09 1988-03-22 University Of Hawaii Monoclonal antibodies for DNA-RNA hybrid complexes and their uses
FI63596C (fi) 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4578282A (en) * 1982-02-04 1986-03-25 Harrison James S Composition for diagnostic reagents
US4465078A (en) * 1982-09-30 1984-08-14 Medtest Corporation Method for cell sampling in a body cavity
US4865980A (en) 1982-12-29 1989-09-12 University Of Hawaii Monoclonal antibodies for DNA-RNA hybrid complexes and their uses
CA1215904A (en) 1983-01-10 1986-12-30 David E. Kohne Method for detection identification and quantitation of non-viral organisms
US5288611A (en) 1983-01-10 1994-02-22 Gen-Probe Incorporated Method for detecting, identifying, and quantitating organisms and viruses
US5200313A (en) 1983-08-05 1993-04-06 Miles Inc. Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
US4743535A (en) 1984-11-07 1988-05-10 Miles Inc. Hybridization assay employing labeled probe and anti-hybrid
EP0144914A3 (de) 1983-12-12 1986-08-13 Miles Inc. Hybridisierungstest mittels markierter Paare von hybridbindenden Reagenzien
AU3844485A (en) 1984-02-09 1985-08-15 Enzo Biochem Inc. Heterologous detection of cabeled dna
FI71768C (fi) 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
CA1260372A (en) * 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
US6221581B1 (en) 1984-04-27 2001-04-24 Enzo Diagnostics, Inc. Processes for detecting polynucleotides, determining genetic mutations or defects in genetic material, separating or isolating nucleic acid of interest from samples, and useful compositions of matter and multihybrid complex compositions
ZA853756B (en) 1984-06-01 1986-01-29 Miles Lab Nucleic acid hybridization assay employing immobilized rna probes
CA1253777A (en) 1984-06-01 1989-05-09 Robert J. Carrico Nucleic acid hybridization assay employing immobilized rna probes
US4563417A (en) 1984-08-31 1986-01-07 Miles Laboratories, Inc. Nucleic acid hybridization assay employing antibodies to intercalation complexes
US4775619A (en) 1984-10-16 1988-10-04 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US5641630A (en) 1985-06-13 1997-06-24 Amgen Inc. Method and kit for performing nucleic acid hybridization assays
US4751177A (en) 1985-06-13 1988-06-14 Amgen Methods and kits for performing nucleic acid hybridization assays
US4888278A (en) * 1985-10-22 1989-12-19 University Of Massachusetts Medical Center In-situ hybridization to detect nucleic acid sequences in morphologically intact cells
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US5750338A (en) 1986-10-23 1998-05-12 Amoco Corporation Target and background capture methods with amplification for affinity assays
IL85551A0 (en) 1987-04-01 1988-08-31 Miles Inc Rapid hybridization assay and reagent system used therein
GB8717169D0 (en) * 1987-07-21 1987-08-26 Ti Interlock Ltd Pneumatic control system
US5656731A (en) 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5082830A (en) 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
US6326136B1 (en) 1988-04-01 2001-12-04 Digene Corporation Macromolecular conjugate made using unsaturated aldehydes
US5374524A (en) 1988-05-10 1994-12-20 E. I. Du Pont De Nemours And Company Solution sandwich hybridization, capture and detection of amplified nucleic acids
US5639871A (en) * 1988-09-09 1997-06-17 Roche Molecular Systems, Inc. Detection of human papillomavirus by the polymerase chain reaction
WO1990010716A1 (en) 1989-03-10 1990-09-20 Gene-Trak Systems Immobilized oligonucleotide probes and uses therefor
US5106727A (en) 1989-04-27 1992-04-21 Life Technologies, Inc. Amplification of nucleic acid sequences using oligonucleotides of random sequences as primers
EP0405913B1 (de) 1989-06-30 1998-12-23 Chiron Corporation Hydrophobe Nukleinsäure-Sonde
US5116734A (en) 1989-09-01 1992-05-26 Digene Diagnostics, Inc. Highly sensitive method for detecting peroxidase
US5580970A (en) 1989-12-01 1996-12-03 Amoco Corporation Detection of HPV transcripts
JPH05501650A (ja) 1989-12-01 1993-04-02 バイシス・インコーポレーテツド Ｈｐｖ転写物の検出
US5629153A (en) 1990-01-10 1997-05-13 Chiron Corporation Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays
US5792606A (en) 1990-02-26 1998-08-11 Boehringer Mannheim Gmbh Nucleic acid hybridization based assay for determining a substance of interest
CA2039517C (en) 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
US5695926A (en) 1990-06-11 1997-12-09 Bio Merieux Sandwich hybridization assays using very short capture probes noncovalently bound to a hydrophobic support
US5484699A (en) 1990-09-28 1996-01-16 Abbott Laboratories Nucleotide sequences useful as type specific probes, PCR primers and LCR probes for the amplification and detection of human papilloma virus, and related kits and methods
US5474895A (en) 1990-11-14 1995-12-12 Siska Diagnostics Inc. Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
US5256571A (en) 1991-05-01 1993-10-26 Cytyc Corporation Cell preservative solution
US5543294A (en) * 1991-07-19 1996-08-06 The Trustees Of Columbia University In The City Of New York Polymerase chain reaction/restriction fragment length polymorphism method for the detection and typing of myobacteria
US5556748A (en) 1991-07-30 1996-09-17 Xenopore Corporation Methods of sandwich hybridization for the quantitative analysis of oligonucleotides
WO1993010263A1 (en) 1991-11-14 1993-05-27 Digene Diagnostics, Inc. Non-radioactive hybridization assay and kit
US5981179A (en) 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
CA2124928C (en) 1991-12-23 2003-06-17 Bruce D. Irvine Hbv amplifier probes for use in solution phase sandwich hybridization assays
US5747244A (en) 1991-12-23 1998-05-05 Chiron Corporation Nucleic acid probes immobilized on polystyrene surfaces
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
IL106273A0 (en) 1992-07-17 1993-11-15 Res Dev Foundation Rapid detection of biopolymers in stained specimens
JPH08503606A (ja) 1992-10-09 1996-04-23 アモコ・コーポレーション 検定法
AU6031094A (en) 1993-01-15 1994-08-15 Public Health Research Institute Of The City Of New York, Inc., The Sensitive nucleic acid sandwich hybridization assays and kits
US5357977A (en) * 1993-04-23 1994-10-25 St. Mary's Hospital And Medical Center, Inc. Cytological sampling method and device
WO1994028156A1 (en) 1993-05-20 1994-12-08 Dana-Farber Cancer Institute Compositions and methods for treatment of herpesvirus infections
WO1995003430A1 (en) 1993-07-23 1995-02-02 Gen-Probe Incorporated Methods for enhancing nucleic acid amplification
DE4331012A1 (de) 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
US5370128A (en) 1993-12-02 1994-12-06 Wainwright; Sharon R. Pap brush and pap unit container systems
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
EP0754241B1 (de) 1994-04-04 1998-12-02 Ciba Corning Diagnostics Corp. Hybridisation-ligitation-verfahren zum nachweis von spezifischen dns sequenzen
CA2126952C (en) 1994-06-28 2010-12-14 Sithian Pandian Probe, kit, and method of amplification for increasing the sensitivity of nucleic acid hybridization assays
US5681702A (en) 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
JP3093116B2 (ja) 1994-09-30 2000-10-03 株式会社豊田中央研究所 核酸検出方法
US6057099A (en) 1994-12-02 2000-05-02 Intelligene Ltd. Detection of nucleic acid sequences
US5747248A (en) 1994-12-05 1998-05-05 Chiron Corporation Discontinuous probe design using hybritope mapping
DE4445769C1 (de) * 1994-12-21 1995-11-09 Biochrom Kg Protektionsmedium zum Aufbewahren vitaler Gewebe, insbesondere von Zähnen
CA2139070C (en) 1994-12-23 2010-03-30 Burton W. Blais Method for enhancing detection ability of nucleic acid assays employing polymerase chain reaction
US5731153A (en) 1996-08-26 1998-03-24 The Regents Of The University Of California Identification of random nucleic acid sequence aberrations using dual capture probes which hybridize to different chromosome regions
US5888724A (en) 1995-02-17 1999-03-30 The Trustees Of Columbia University In The City Of New York Detection of high oncogenic-risk papilloma virus in high grade cervical lesions and cancers by a PCR/ELISA assay
US6083925A (en) 1995-06-07 2000-07-04 Connaught Laboratories Limited Nucleic acid respiratory syncytial virus vaccines
JP2000500342A (ja) 1995-11-15 2000-01-18 ジェン−プローブ・インコーポレーテッド ヒトパピローマウイルス核酸に相補的な核酸プローブおよび関連する方法およびキット
US5853993A (en) 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
US5679333A (en) * 1996-10-25 1997-10-21 Dunphy; Brian William Formaldehyde-free tissue preservative compositions
US6110676A (en) 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
US20020034737A1 (en) 1997-03-04 2002-03-21 Hyseq, Inc. Methods and compositions for detection or quantification of nucleic acid species
US6043038A (en) 1998-03-31 2000-03-28 Tularik, Inc. High-throughput screening assays for modulators of primase activity
JP2002509694A (ja) 1997-11-04 2002-04-02 ロシュ ダイアグノスティックス ゲーエムベーハー 特異的かつ高感度な核酸検出方法
WO1999029890A2 (en) * 1997-12-12 1999-06-17 Digene Corporation Assessment of human papilloma virus-related disease
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US7399589B2 (en) 1998-02-06 2008-07-15 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
US5994079A (en) 1998-02-06 1999-11-30 Digene Corporation Direct detection of RNA mediated by reverse transcriptase lacking RNAse H function
US6686151B1 (en) 1998-02-06 2004-02-03 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
US20010055766A1 (en) 1999-04-02 2001-12-27 Alexander Aristarkhov Immunosorbant assay using branched bis-biotin/avidin/multiple label complex as a detection reagent
US7019822B1 (en) 1999-04-29 2006-03-28 Mss, Inc. Multi-grade object sorting system and method
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US6893819B1 (en) 2000-11-21 2005-05-17 Stratagene California Methods for detection of a nucleic acid by sequential amplification
US6436662B1 (en) 2000-04-04 2002-08-20 Digene Corporation Device and method for cytology slide preparation
US6521190B1 (en) 2000-05-19 2003-02-18 Digene Corporation Cell collection apparatus
AU2001274869A1 (en) 2000-05-20 2001-12-03 The Regents Of The University Of Michigan Method of producing a dna library using positional amplification
US7439016B1 (en) 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
US7601497B2 (en) 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
BR0112385A (pt) 2000-06-21 2003-06-17 Digene Corp Meio de coleta universal
US6977148B2 (en) 2001-10-15 2005-12-20 Qiagen Gmbh Multiple displacement amplification
WO2006075245A2 (en) 2005-01-14 2006-07-20 The Regents Of The University Of Michigan Systems, methods, and compositions for detection of human papilloma virus in biological samples
US7972776B2 (en) 2005-11-15 2011-07-05 Oncohealth Corporation Protein chips for HPV detection
US20080206777A1 (en) 2007-02-27 2008-08-28 Nuclea Biomarkers, Llc Gene and protein expression profiles associated with the therapeutic efficacy of EGFR-TK inhibitors
US7985375B2 (en) 2007-04-06 2011-07-26 Qiagen Gaithersburg, Inc. Sample preparation system and method for processing clinical specimens
EP2262911B1 (de) 2008-04-17 2016-10-12 QIAGEN Gaithersburg, Inc. Zusammensetzungen, verfahren und kits mit synthetischen sonden zum nachweis der anwesenheit einer target-nukleinsäure
US9090948B2 (en) 2008-09-30 2015-07-28 Abbott Molecular Inc. Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples

Also Published As

Publication number Publication date
JP2002508190A (ja) 2002-03-19
NO20002980D0 (no) 2000-06-09
BR9814272A (pt) 2000-10-03
JP2010136729A (ja) 2010-06-24
WO1999029890A3 (en) 1999-09-10
PT1038022E (pt) 2005-11-30
EP1038029A2 (de) 2000-09-27
US20110097708A1 (en) 2011-04-28
AU746061B2 (en) 2002-04-11
NO20002980L (no) 2000-08-08
WO1999031273A2 (en) 1999-06-24
DK1038022T3 (da) 2005-10-24
NO20002979D0 (no) 2000-06-09
WO1999029890A2 (en) 1999-06-17
ATE299946T1 (de) 2005-08-15
CA2313641A1 (en) 1999-06-24
US7291455B2 (en) 2007-11-06
US20030091992A1 (en) 2003-05-15
CA2313483C (en) 2017-12-05
AU1723299A (en) 1999-07-05
EP1038022B1 (de) 2005-07-20
EP1038022A2 (de) 2000-09-27
ES2246546T3 (es) 2006-02-16
BR9814271A (pt) 2001-03-20
WO1999031273A3 (en) 1999-10-07
US6969585B2 (en) 2005-11-29
AU748022B2 (en) 2002-05-30
DE69830927T2 (de) 2006-05-24
NO20002979L (no) 2000-08-09
JP2001526045A (ja) 2001-12-18
CA2313483A1 (en) 1999-06-17
NO330906B1 (no) 2011-08-15
AU1911799A (en) 1999-06-28
US7879546B2 (en) 2011-02-01
US6355424B1 (en) 2002-03-12
US20020127545A1 (en) 2002-09-12
US20070154884A1 (en) 2007-07-05

Similar Documents

Publication Publication Date Title
DE69830927D1 (de) Bewertung von humaner papillomvirus verwandter krankheit
DE69604298D1 (de) Varianten des grünen fluoreszenzproteins, gfp
ATE470723T1 (de) Genexpressionsmarker für die prognose von brustkrebs
EA200000298A1 (ru) Агонисты простагландинов и их применение для лечения заболеваний костей
DE69905476D1 (en) Phosphonsaürederivate als ptp-1b-inhibitoren
ATE274348T1 (de) Überbrückte indenopyrrolocarbazole
TR200100885T2 (tr) 2-Metil-tieno-benzodiazepin formülasyonu
HK1056692A1 (en) Proteins
BR9710919A (pt) Proteina purificada sr-p70
ATE469169T1 (de) Erythrovirus und ihre verwendung
BR0012921A (pt) Compostos calcilìticos
ATE306668T1 (de) Diagnose von brustkrebs unter verwendung von bcmp-7 als marker
EA200000522A1 (ru) 5-htагонисты
DE69636041D1 (de) Nachweis von brusttumorvirus-artigen sequenzen in brustkrebs bei menschen
ATE323505T1 (de) Verwendung von rekombinantem lungensurfactant zur frühbehandlung von akuten lungenerkrankungen
DE69839846D1 (de) Bestimmung der vorhandenen mengen an cyclin-abhängr bei krebspatienten
TR200000435T2 (tr) Bulaşıcı akdeniz humması geni.
SE0002417D0 (sv) Promoter sequences
ATE442383T1 (de) Mutierte bcl-2 proteine und verwendung davon
DE69821102D1 (de) Verwendung von calculus
ID27964A (id) Turuna-azabisikloheptana n-tersubstitusi, pembuatan dan penggunaannya
IT1303825B1 (it) Corredo di strumenti per microchirurgia oftalmica.

Legal Events

Date Code Title Description
8363 Opposition against the patent
8328 Change in the person/name/address of the agent

Representative=s name: KOENIG SZYNKA TILMANN VON RENESSE, 40549 DUESSELDO

8327 Change in the person/name/address of the patent owner

Owner name: QIAGEN GAITHERSBURG, INC. (N. D. GES. D. STAAT, US