DE69825040D1 - Bioabbaubare polymere mit phosphat-endgruppen, zusammensetzungen, gegenstände und verfahren zu ihren herstelling und verwendung - Google Patents

Bioabbaubare polymere mit phosphat-endgruppen, zusammensetzungen, gegenstände und verfahren zu ihren herstelling und verwendung

Info

Publication number
DE69825040D1
DE69825040D1 DE69825040T DE69825040T DE69825040D1 DE 69825040 D1 DE69825040 D1 DE 69825040D1 DE 69825040 T DE69825040 T DE 69825040T DE 69825040 T DE69825040 T DE 69825040T DE 69825040 D1 DE69825040 D1 DE 69825040D1
Authority
DE
Germany
Prior art keywords
polymers
compositions
branched
alkyl
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69825040T
Other languages
English (en)
Other versions
DE69825040T2 (de
Inventor
Hai-Quan Mao
Zhong Zhao
P English
W Leong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Inc
School of Medicine of Johns Hopkins University
Original Assignee
Guilford Pharmaceuticals Inc
Johns Hopkins University
School of Medicine of Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharmaceuticals Inc, Johns Hopkins University, School of Medicine of Johns Hopkins University filed Critical Guilford Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69825040D1 publication Critical patent/DE69825040D1/de
Publication of DE69825040T2 publication Critical patent/DE69825040T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/692—Polyesters containing atoms other than carbon, hydrogen and oxygen containing phosphorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/692—Polyesters containing atoms other than carbon, hydrogen and oxygen containing phosphorus
    • C08G63/6922—Polyesters containing atoms other than carbon, hydrogen and oxygen containing phosphorus derived from hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/912—Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L85/00—Compositions of macromolecular compounds obtained by reactions forming a linkage in the main chain of the macromolecule containing atoms other than silicon, sulfur, nitrogen, oxygen and carbon; Compositions of derivatives of such polymers
    • C08L85/02—Compositions of macromolecular compounds obtained by reactions forming a linkage in the main chain of the macromolecule containing atoms other than silicon, sulfur, nitrogen, oxygen and carbon; Compositions of derivatives of such polymers containing phosphorus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/924—Material characteristic
DE69825040T 1997-04-03 1998-04-02 Bioabbaubare polymere mit phosphat-endgruppen, zusammensetzungen, gegenstände und verfahren zu ihren herstelling und verwendung Expired - Lifetime DE69825040T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83221797A 1997-04-03 1997-04-03
US832217 1997-04-03
PCT/US1998/006380 WO1998044020A1 (en) 1997-04-03 1998-04-02 Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same

Publications (2)

Publication Number Publication Date
DE69825040D1 true DE69825040D1 (de) 2004-08-19
DE69825040T2 DE69825040T2 (de) 2005-09-08

Family

ID=25261018

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69825040T Expired - Lifetime DE69825040T2 (de) 1997-04-03 1998-04-02 Bioabbaubare polymere mit phosphat-endgruppen, zusammensetzungen, gegenstände und verfahren zu ihren herstelling und verwendung

Country Status (18)

Country Link
US (3) US6166173A (de)
EP (1) EP0971969B1 (de)
JP (1) JP4170399B2 (de)
KR (1) KR20010006041A (de)
CN (1) CN1107687C (de)
AT (1) ATE271084T1 (de)
AU (1) AU742110B2 (de)
BR (1) BR9809390A (de)
CA (1) CA2285909C (de)
DE (1) DE69825040T2 (de)
HK (1) HK1027366A1 (de)
HU (1) HUP0001412A2 (de)
IL (1) IL132122A0 (de)
NO (1) NO994803L (de)
NZ (1) NZ500674A (de)
RU (1) RU2207350C2 (de)
UA (1) UA54505C2 (de)
WO (1) WO1998044020A1 (de)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US6713527B2 (en) 1997-02-07 2004-03-30 Queen's University At Kingston Anaesthetic bone cement
US6355705B1 (en) * 1997-02-07 2002-03-12 Queen's University At Kingston Anaesthetic bone cement
UA54505C2 (uk) * 1997-04-03 2003-03-17 Гілфорд Фармасьютікалз Інк. Полімери, що біологічно розкладаються, зшиті фосфатами, композиції, вироби і способи для їх виготовлення і використання
KR20010020432A (ko) 1997-04-30 2001-03-15 토마스 씨. 서 폴리(고리지방족 포스포에스테르) 화합물로 이루어진 생분해성 조성물, 약품 및 그의 이용방법
US6548302B1 (en) 1998-06-18 2003-04-15 Johns Hopkins University School Of Medicine Polymers for delivery of nucleic acids
US6419709B1 (en) 1998-10-02 2002-07-16 Guilford Pharmaceuticals, Inc. Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
US6350464B1 (en) * 1999-01-11 2002-02-26 Guilford Pharmaceuticals, Inc. Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same
US6348042B1 (en) * 1999-02-02 2002-02-19 W. Lee Warren, Jr. Bioactive shunt
US6537585B1 (en) * 1999-03-26 2003-03-25 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors
US6461631B1 (en) * 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
US6805876B2 (en) 2000-03-10 2004-10-19 Johns Hopkins University Phosphate based biodegradable polymers
AU2001269961A1 (en) * 2000-07-06 2002-01-21 Guilford Pharmaceuticals Improved polymers and polymerization processes
AU2001270310A1 (en) * 2000-07-07 2002-01-21 Guilford Pharmaceuticals Inc. Compositions for sustained release of antineoplastic taxanes, and methods of making and using the same
US20020045668A1 (en) * 2000-07-17 2002-04-18 Wenbin Dang Compositions for sustained release of analgesic agents, and methods of making and using the same
US7666445B2 (en) * 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
US20020141966A1 (en) * 2000-11-16 2002-10-03 Wenbin Dang Compositions for treatment of malignant effusions, and methods of making and using the same
US6527693B2 (en) 2001-01-30 2003-03-04 Implant Sciences Corporation Methods and implants for providing radiation to a patient
US6590059B2 (en) 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
WO2003000776A1 (en) * 2001-05-14 2003-01-03 Johns Hopkins Singapore Pte Ltd Biodegradable polyphosphoramidates for controlled release of bioactive substances
WO2002092667A1 (en) * 2001-05-14 2002-11-21 Johns Hopkins Singapore Pte Ltd. Biodegradable polyphosphates for controlled release of bioactive substances
WO2003007915A2 (en) * 2001-07-19 2003-01-30 Guilford Pharmaceuticals, Inc. Compositions for treatment of head and neck cancers, and methods of making and using the same
AU2002354957A1 (en) * 2001-07-19 2003-03-03 Guilford Pharmaceuticals, Inc. Biocompatible polymer containing composition for treatment of prostate cancers
AUPR951501A0 (en) * 2001-12-14 2002-01-24 Smart Drug Systems Inc Modified sustained release pharmaceutical system
WO2003060799A2 (en) * 2002-01-09 2003-07-24 Guilford Pharmaceuticals, Inc. Compositions for treatment of central nervous system neoplasms, and methods of making and using the same
US7479535B2 (en) 2002-02-25 2009-01-20 Guilford Pharmaceuticals, Inc. Phosphorous-containing compounds with polymeric chains, and methods of making and using the same
US20050129776A1 (en) 2002-05-03 2005-06-16 Inserm Microparticles supporting cells and active substances
FR2839260B1 (fr) * 2002-05-03 2005-02-25 Inst Nat Sante Rech Med Microparticules a base d'un materiau bicompatible et biodegradable, supportant des cellules et des substances biologiquement actives
US20090004741A1 (en) * 2002-05-14 2009-01-01 Jun Wang Biodegradable polyphosphoramidates for controlled release of bioactive substances
US8313760B2 (en) 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
CN100341589C (zh) 2002-05-24 2007-10-10 血管技术国际股份公司 用于涂覆医用植入物的组合物和方法
US7041309B2 (en) * 2002-06-13 2006-05-09 Neuropro Technologies, Inc. Spinal fusion using an HMG-CoA reductase inhibitor
SE0202619D0 (sv) * 2002-09-05 2002-09-05 Fredrik Nederberg New Polymers and Applications
US20040197301A1 (en) * 2003-02-18 2004-10-07 Zhong Zhao Hybrid polymers and methods of making the same
CA2536242A1 (en) * 2003-11-20 2005-06-09 Angiotech International Ag Implantable sensors and implantable pumps and anti-scarring agents
US20050209664A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Electrical devices and anti-scarring agents
US8329203B2 (en) * 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
AU2005206143B2 (en) * 2004-01-12 2010-12-16 The Trustees Of The University Of Pennsylvania Long-term delivery formulations and methods of use thereof
US8119153B2 (en) * 2004-08-26 2012-02-21 Boston Scientific Scimed, Inc. Stents with drug eluting coatings
DE602005012551D1 (de) * 2004-12-22 2009-03-12 California Inst Of Techn Abbaubare polymere und herstellungsverfahren dafür
JP2008527199A (ja) * 2005-01-13 2008-07-24 カードモンロー コーポレイション 交換可能なフックモジュール
WO2006078903A1 (en) * 2005-01-21 2006-07-27 Matthews Richard H Radiosensitizer formulations comprising nitrohistidine derivatives
AU2005100176A4 (en) * 2005-03-01 2005-04-07 Gym Tv Pty Ltd Garbage bin clip
US7669732B2 (en) * 2005-10-25 2010-03-02 Imi Cornelius Inc. Cup lid dispenser
EP1808380A1 (de) * 2006-01-13 2007-07-18 Pepup S.A. Flexibler Beutel für eine Flüssigkeit und Verfahren zu dessen Herstellung
EP3061791B1 (de) 2006-07-20 2019-01-16 OrbusNeich Medical, Inc. Bioresorbierbare polymerzusammensetzung für eine medizinische vorrichtung
US20090169628A1 (en) * 2006-10-17 2009-07-02 Armark Authentication Technologies, Llc Article and method for focused delivery of therapeutic and/or diagnostic materials
CN101631513B (zh) 2006-10-20 2013-06-05 奥巴斯尼茨医学公司 可生物吸收的聚合物组合物和医疗设备
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
JP2008138051A (ja) * 2006-11-30 2008-06-19 Terumo Corp α−ヒドロキシ酸重合体組成物およびそれを用いた成形品の製造方法
WO2008098220A1 (en) * 2007-02-08 2008-08-14 University Of Washington Biocompatile amino acid anhydride polymers
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
CN101125916B (zh) * 2007-06-26 2010-06-23 天大药业（珠海）有限公司 一种生物降解聚合物及其制备方法和应用
US8608049B2 (en) 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
JP2009096720A (ja) * 2007-10-12 2009-05-07 Idemitsu Kosan Co Ltd 生分解性液状エステル化合物
WO2009088777A1 (en) * 2007-12-31 2009-07-16 Armark Authentication Technologies, Llc Article and method for focused delivery of therapeutic and/or diagnostic materials
WO2009143236A1 (en) * 2008-05-20 2009-11-26 Albert Einstein Healthcare Network Compositions and methods for the treatment of skeletal metastatic lesions and fractures
US20110086998A1 (en) * 2008-07-24 2011-04-14 Tomokazu Kusunoki An aliphatic polyester resin and a process for producing it
WO2010037021A2 (en) * 2008-09-29 2010-04-01 Armark Authentication Technologies, Llc Spinneret and method of spinning fiber
US20100291214A1 (en) * 2008-12-23 2010-11-18 Armark Authentication Technologies, Llc Three-dimensional microfiber extrudate structure and process for forming three-dimensional microfiber extrudate structure
US9078712B2 (en) 2009-04-15 2015-07-14 Warsaw Orthopedic, Inc. Preformed drug-eluting device to be affixed to an anterior spinal plate
US9414864B2 (en) 2009-04-15 2016-08-16 Warsaw Orthopedic, Inc. Anterior spinal plate with preformed drug-eluting device affixed thereto
WO2010132763A1 (en) * 2009-05-15 2010-11-18 Armark Authentication Technologies, Llc Fiber having non-uniform composition and method for making same
US9636109B2 (en) * 2009-07-22 2017-05-02 Wisconsin Alumni Research Foundation Biologically active sutures for regenerative medicine
US9199032B2 (en) 2010-03-03 2015-12-01 Novabone Products, Llc System and kit for delivering collagen bioglass composite bone grafting materials for regenerating hard tissues
US9144629B2 (en) 2010-03-03 2015-09-29 Novabone Products, Llc Ionically crosslinked materials and methods for production
AU2011223652B2 (en) 2010-03-03 2015-01-29 Novabone Products, Llc Devices and methods for the regeneration of bony defects
CN103371857A (zh) * 2012-04-12 2013-10-30 北京汇福康医疗技术有限公司 复合型生物套管及其制备方法和应用
US8907050B2 (en) * 2012-05-11 2014-12-09 University Of South Carolina Polymeric additive for strength, deformability, and toughness enhancement of cemetitious materials and composites
US10066204B2 (en) 2013-03-15 2018-09-04 Wisconsin Alumni Research Foundation Chemically labile peptide-presenting surfaces for cellular self-assembly

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3442982A (en) * 1965-10-15 1969-05-06 Weston Chemical Corp Polyphosphites of 2,2-dimethyl-3-hydroxypropyl - 2 - dimethyl - 3-hydroxypropionate
US4746462A (en) * 1985-02-21 1988-05-24 Dainichiseika Color & Chemicals Mfg. Co., Ltd. Phosphoric ester compound
US5194581A (en) * 1989-03-09 1993-03-16 Leong Kam W Biodegradable poly(phosphoesters)
US5256765A (en) * 1989-03-09 1993-10-26 The Johns Hopkins University School Of Medicine Biodegradable poly(phosphate esters)
DE4404365A1 (de) * 1994-02-11 1995-08-17 Cassella Ag Phosphin- und phosphonsäuregruppenhaltige Polykondensate
ES2234014T3 (es) 1996-04-23 2005-06-16 Ipsen Manufacturing Ireland Limited Polimeros polilacticos acidos.
UA54505C2 (uk) * 1997-04-03 2003-03-17 Гілфорд Фармасьютікалз Інк. Полімери, що біологічно розкладаються, зшиті фосфатами, композиції, вироби і способи для їх виготовлення і використання
EP0991699B1 (de) 1997-06-18 2002-04-24 Guilford Pharmaceuticals Inc. Zweistufige lösungspolymerisation von hochmolekularen poly(phosphorestern)
US6028163A (en) 1997-06-27 2000-02-22 Guilford Pharmaceuticals Inc. Solution polymerization of high molecular weight poly(phosphoesters) in toluene

Also Published As

Publication number Publication date
CA2285909A1 (en) 1998-10-08
JP4170399B2 (ja) 2008-10-22
US20020151617A1 (en) 2002-10-17
AU742110B2 (en) 2001-12-20
NZ500674A (en) 2002-02-01
RU2207350C2 (ru) 2003-06-27
US6376644B1 (en) 2002-04-23
CN1107687C (zh) 2003-05-07
DE69825040T2 (de) 2005-09-08
WO1998044020A1 (en) 1998-10-08
HK1027366A1 (en) 2001-01-12
ATE271084T1 (de) 2004-07-15
BR9809390A (pt) 2000-06-13
CA2285909C (en) 2008-07-29
IL132122A0 (en) 2001-03-19
NO994803D0 (no) 1999-10-01
CN1256701A (zh) 2000-06-14
US6166173A (en) 2000-12-26
HUP0001412A2 (hu) 2000-08-28
EP0971969B1 (de) 2004-07-14
AU6944998A (en) 1998-10-22
UA54505C2 (uk) 2003-03-17
JP2001521561A (ja) 2001-11-06
NO994803L (no) 1999-12-03
KR20010006041A (ko) 2001-01-15
EP0971969A1 (de) 2000-01-19

Similar Documents

Publication Publication Date Title
DE69825040D1 (de) Bioabbaubare polymere mit phosphat-endgruppen, zusammensetzungen, gegenstände und verfahren zu ihren herstelling und verwendung
DE69826994D1 (de) Bioabbaubare terephthalat polyester-polyphosphat polymere, zusammensetzungen, gegenstände und verfahren für ihre herstellung und verwendung
HUP0001299A2 (hu) Poli(cikloalifás foszfoészter) vegyületeket tartalmazó, biológiailag lebontható kompozíciók és eszközök
DE69624475T2 (de) Heterotelechelische blockcopolymere und verfahren zu deren herstellung
NO921421D0 (no) Kopolymermateriale med lav molekylvekt omfattende polymermonoalkylfosfinat og monoalkylfosfonat samt fremgangsmaatetil fremstilling derav
DK0547126T3 (da) Polymere indeholdende diesterenheder
TW369617B (en) Plastic articles for medical use
IL117750A0 (en) Cell growth substrate polymer
EP0295055A3 (de) Biodegradierbare polymere Materialien auf der Basis von Polyetherglycolen, Verfahren zu ihrer Herstellung und chirurgische Gegenstände daraus
ATE145340T1 (de) Methode zur verbesserung der okuläre, blut- und biokompatibilität synthetischer polymeren
DE69825618D1 (de) Biologisch-abbaubare anionische polymere, die sich von der aminosäure l-tyrosin herleiten
DE68912691D1 (de) Verfahren zur Herstellung von Copolymeren von Diallyldimethylammoniumchlorid und Acrylamid mit hohem Molekulargewicht in Lösungsmitteln.
MY117816A (en) Inherently light-and heat-stabilized polyamides of improved wetfastness
FR2695800B1 (fr) Compose antiseptique.
TR199801196T2 (xx) Biyolojik aktif benzotiyazolon etanaminler.
WO2000019976A3 (en) Biodegradable terephthalate polyester-poly(phosphonate) and polyester-poly(phosphite) compositions, articles, and methods of using them
ES2008311A6 (es) Procedimiento para controlar la morfologia de peliculas polimericas conductoras.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: MEISSNER, BOLTE & PARTNER GBR, 80538 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: MGI GP, INC. (N.D.GES.D. STAATES DELAWARE), BA, US

Owner name: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICIN, US

8327 Change in the person/name/address of the patent owner

Owner name: EISAI CORPORATION OF NORTH AMERICA, WOODCLIFF , US

Owner name: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICIN, US

8327 Change in the person/name/address of the patent owner

Owner name: EISAI INC., WOODCLIFF LAKE, N.J., US

Owner name: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICIN, US