DE69824191D1 - Denatonium capsaicinat und verfahren zu ihrer herstellung - Google Patents

Denatonium capsaicinat und verfahren zu ihrer herstellung

Info

Publication number
DE69824191D1
DE69824191D1 DE69824191T DE69824191T DE69824191D1 DE 69824191 D1 DE69824191 D1 DE 69824191D1 DE 69824191 T DE69824191 T DE 69824191T DE 69824191 T DE69824191 T DE 69824191T DE 69824191 D1 DE69824191 D1 DE 69824191D1
Authority
DE
Germany
Prior art keywords
denatonium
production
capsaicinate
denatonium capsaicinate
lidocaine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69824191T
Other languages
English (en)
Other versions
DE69824191T2 (de
Inventor
Melvin Blum
Michael Roitberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Burlington Bio Medical and Scientific Corp
Original Assignee
Burlington Bio Medical and Scientific Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Burlington Bio Medical and Scientific Corp filed Critical Burlington Bio Medical and Scientific Corp
Application granted granted Critical
Publication of DE69824191D1 publication Critical patent/DE69824191D1/de
Publication of DE69824191T2 publication Critical patent/DE69824191T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D5/00Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
    • C09D5/14Paints containing biocides, e.g. fungicides, insecticides or pesticides
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02Amines; Quaternary ammonium compounds
    • A01N33/12Quaternary ammonium compounds
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/20Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D5/00Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
    • C09D5/16Antifouling paints; Underwater paints
    • C09D5/1606Antifouling paints; Underwater paints characterised by the anti-fouling agent
    • C09D5/1612Non-macromolecular compounds
    • C09D5/1625Non-macromolecular compounds organic
DE69824191T 1997-09-19 1998-07-31 Denatonium capsaicinat und verfahren zu ihrer herstellung Expired - Fee Related DE69824191T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/929,621 US5891919A (en) 1997-09-19 1997-09-19 Denatonium capsaicinate and methods of producing the same
US929621 1997-09-19
PCT/US1998/015836 WO1999015495A1 (en) 1997-09-19 1998-07-31 Denatonium capsaicinate and methods of producing the same

Publications (2)

Publication Number Publication Date
DE69824191D1 true DE69824191D1 (de) 2004-07-01
DE69824191T2 DE69824191T2 (de) 2005-05-04

Family

ID=25458174

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69824191T Expired - Fee Related DE69824191T2 (de) 1997-09-19 1998-07-31 Denatonium capsaicinat und verfahren zu ihrer herstellung

Country Status (6)

Country Link
US (1) US5891919A (de)
EP (1) EP1015418B1 (de)
AT (1) ATE267802T1 (de)
AU (1) AU8603598A (de)
DE (1) DE69824191T2 (de)
WO (1) WO1999015495A1 (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7011843B2 (en) * 1997-10-01 2006-03-14 Lts Lohmann-Therapie Systeme Ag Method for protecting a human being against health impairment by ingestion of a transdermal therapeutic system
US20010041694A1 (en) * 1999-12-27 2001-11-15 Larry Clark Identification of snake repellents
GB0026137D0 (en) * 2000-10-25 2000-12-13 Euro Celtique Sa Transdermal dosage form
US7332182B2 (en) 2001-08-06 2008-02-19 Purdue Pharma L.P. Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant
US20030068375A1 (en) 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
US20030044458A1 (en) * 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
US7141250B2 (en) * 2001-08-06 2006-11-28 Euro-Celtique S.A. Pharmaceutical formulation containing bittering agent
US7157103B2 (en) 2001-08-06 2007-01-02 Euro-Celtique S.A. Pharmaceutical formulation containing irritant
US7842307B2 (en) 2001-08-06 2010-11-30 Purdue Pharma L.P. Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent
US7144587B2 (en) * 2001-08-06 2006-12-05 Euro-Celtique S.A. Pharmaceutical formulation containing opioid agonist, opioid antagonist and bittering agent
US7632321B2 (en) * 2001-11-01 2009-12-15 Idatech, Llc Fuel processing systems, fuel cell systems, and improved feedstocks therefor
US20040076671A1 (en) * 2002-10-21 2004-04-22 Aletha Tippett Methods and compositions for topical wound treatment
JP2006522815A (ja) * 2003-04-08 2006-10-05 アルゴルクス ファーマスーティカルズ,インク 合成カプサイシンの製造および精製
WO2005027642A1 (en) * 2003-09-25 2005-03-31 Darren Wayne Eade Repellent preparations
EP3326617A1 (de) 2004-06-12 2018-05-30 Collegium Pharmaceutical, Inc. Missbrauchsverhindernde arzneimittelformulierungen
JP2008521815A (ja) * 2004-11-24 2008-06-26 アルゴルクス ファーマスーティカルズ,インク カプシノイドゲル製剤及びその使用
US20090306429A1 (en) * 2004-12-06 2009-12-10 Henk Pluim Preparation of a quaternary ammonium hydroxide and use thereof for the preparation of a quaternary ammonium salt
EP1824814A2 (de) * 2004-12-06 2007-08-29 Disham Pharmaceuticals and Chemicals Ltd. Herstelung eines quaternären ammoniumhydroxids und dessen verwendung zur herstellung eines quaternären ammoniumsalzes
ES2273588B1 (es) * 2005-07-29 2008-04-01 Relats, S.A. Metodo para la fabricacion de fundas protectoras de cables, tubos y similares.
US7707961B2 (en) * 2005-08-12 2010-05-04 Tmc-Ip, Llc Apparatus for applying chemical coatings
US20070036902A1 (en) * 2005-08-12 2007-02-15 O'neal Hubert R Method for applying chemical coatings
WO2007041272A2 (en) * 2005-09-30 2007-04-12 Maxam Industries, Inc. Long lasting natural anti-pest additive
MX348214B (es) * 2006-03-10 2017-06-05 Archer Daniels Midland Co Metodos y composiciones para productividad aumentada en animales.
US7582783B2 (en) * 2006-03-23 2009-09-01 White Flower Associates Llp Analgesics, anaesthetics, antifoulants, aversants, irritants, incapacitants and compositions containing the same
CA2666077C (en) * 2006-10-17 2016-06-28 Labtec Gesellschaft Fuer Technologische Forschung Und Entwicklung Mbh Adhesive label with bittering agent and fluidifying agents for natural airway secretions
WO2008080980A1 (de) * 2006-12-29 2008-07-10 Patrick Franke Medicinal composition
US7754096B2 (en) * 2007-02-01 2010-07-13 E.I. Du Pont De Nemours And Company Liquefied-gas aerosol dusting composition containing denatonium benzoate
GB0712142D0 (en) * 2007-06-24 2007-08-01 Drew Anthony N Beach Wax
DE202008014092U1 (de) * 2008-10-23 2010-03-11 Rehau Ag + Co Rohr
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
CN104873455B (zh) 2010-12-22 2023-09-12 普渡制药公司 包覆的抗篡改控制释放剂型
US9233073B2 (en) 2010-12-23 2016-01-12 Purdue Pharma L.P. Tamper resistant solid oral dosage forms
EA039943B1 (ru) 2011-01-07 2022-03-30 Анджи Фарма (Юс) Элэлси Способ снижения уровней глюкозы в крови у субъекта
US9795792B2 (en) 2011-02-25 2017-10-24 Medtronic, Inc. Emergency mode switching for non-pacing modes
CA2835595C (en) 2011-05-10 2019-02-12 Itochu Chemical Frontier Corporation Non-aqueous patch
US11786455B2 (en) 2011-05-10 2023-10-17 Itochu Chemical Frontier Corporation Non-aqueous patch
US9925264B2 (en) 2011-05-10 2018-03-27 Itochu Chemical Frontier Corporation Non-aqueous patch
ES2683006T3 (es) 2011-09-27 2018-09-24 Itochu Chemical Frontier Corporation Parche no acuoso
CN104349773A (zh) 2012-01-06 2015-02-11 埃尔舍利克斯治疗公司 用于治疗代谢性病症的组合物和方法
ES2832773T3 (es) 2012-01-06 2021-06-11 Anji Pharma Us Llc Composiciones de biguanida y métodos de tratamiento de trastornos metabólicos
WO2013139706A1 (en) * 2012-03-23 2013-09-26 Roblon Aktieselskab Pest-repellent dielectric cable
AR091739A1 (es) 2012-07-11 2015-02-25 Elcelyx Therapeutics Inc Composiciones y metodos para reducir el riesgo cardiometabolico
CN110051638B (zh) 2013-01-05 2022-02-01 安济药业(美国)有限责任公司 包含双胍的延迟释放组合物
EA201500742A1 (ru) 2013-02-05 2015-12-30 Пердью Фарма Л.П. Защищенные от нецелевого использования фармацевтические композиции
US10751287B2 (en) 2013-03-15 2020-08-25 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
US20150252306A1 (en) 2014-03-07 2015-09-10 The Procter & Gamble Company Compositions comprising a pungent agent
WO2017222575A1 (en) 2016-06-23 2017-12-28 Collegium Pharmaceutical, Inc. Process of making more stable abuse-deterrent oral formulations
DE102016009766A1 (de) 2016-08-11 2018-02-15 Julius-Maximilians-Universität Würzburg Herstellung von Bitterstoffderivaten
CA3090224A1 (en) 2018-02-21 2019-08-29 Julius-Maximilians-Universitaet Wuerzburg Aminomethyl-functionalized denatonium derivatives, their preparation and use
EP3818102A4 (de) * 2018-07-05 2022-03-30 UPL Ltd Neue zusammensetzungen für bitterstoffe
SG11202108243SA (en) * 2019-02-20 2021-09-29 Upl Ltd Spray composition of aversive agent
AR118158A1 (es) * 2019-02-20 2021-09-22 Upl Ltd Un método y composición para repeler insectos usando un agente repelente
CA3129111A1 (en) 2019-03-11 2020-09-17 Bridget M. Cole Charged ion channel blockers and methods for use
AU2020237474A1 (en) 2019-03-11 2021-09-30 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10927096B2 (en) 2019-03-11 2021-02-23 Nocion Therapeutics, Inc. Ester substituted ion channel blockers and methods for use
US10828287B2 (en) 2019-03-11 2020-11-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP2023500890A (ja) 2019-11-06 2023-01-11 ノシオン セラピューティクス,インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
EP4054559A4 (de) 2019-11-06 2023-11-29 Nocion Therapeutics, Inc. Geladene ionenkanalblocker und verfahren zur verwendung
KR20230022830A (ko) 2020-03-11 2023-02-16 녹시온 테라퓨틱스 인코포레이티드 하전된 이온 채널 차단제 및 사용 방법
WO2022187436A1 (en) * 2021-03-05 2022-09-09 Corning Research & Development Corporation Porous ceramic polymer composites for preventing rodent damage
US20230172187A1 (en) * 2021-12-02 2023-06-08 Max A Different Breed L.L.C. Predator reactive multi-layer repellant device

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3080327A (en) * 1959-11-20 1963-03-05 T & H Smith Ltd Quaternary salts as denaturants for organic substances
US3268577A (en) * 1960-11-15 1966-08-23 Edinburgh Pharmaceutical Ind L Quaternary organic salts of omega-dialkylamino-2, 6-dimethylacetanilides
US4005038A (en) * 1974-04-15 1977-01-25 Peerless Paint And Varnish Corporation Paint composition containing denatonium benzoate or lignocaine benzyl octanoate with a latex resin binder for application over old paint films to prevent ingestion of poisons therefrom
DE3215987A1 (de) * 1981-04-30 1982-12-02 Glaxo Group Ltd., London Lignocainbenzylbenzoat und verfahren zu seiner herstellung
US4652577A (en) * 1984-11-02 1987-03-24 Atomergic Chemetals Corporation Denatonium saccharide, compositions and method of use
US4661504A (en) * 1984-11-02 1987-04-28 Atomergic Chemetals Corporation Denatonium saccharide compositions and method of use
US5008289A (en) * 1988-12-02 1991-04-16 Galenpharma, Inc. Composition for treating nasal disorders and headaches
US4997853A (en) * 1988-12-02 1991-03-05 Galenpharma, Inc. Method and compositions utilizing capsaicin as an external analgesic
US5403868A (en) * 1988-12-23 1995-04-04 Sandoz Ltd. Capsaicin derivatives
EP0458177B1 (de) * 1990-05-22 1997-07-16 Nippon Kayaku Kabushiki Kaisha Harzformmasse zum Schutz gegen Beschädigung durch Tierverbiss
US5322862A (en) * 1990-05-22 1994-06-21 Nippon Kayaku Kabushiki Kaisha Resin molding composition for preventing gnawing damage by animals
US5094782A (en) * 1990-12-24 1992-03-10 National Science Council Of Republic Of China Synthesis of capsacin derivatives and their use as an analgesic drug and vessel dilation drug
FI91535C (fi) * 1992-07-28 1994-07-11 Hurme Consulting Oy Menetelmä tiesuolan denaturoimiseksi ja denaturoitu tiesuola
US5397385A (en) * 1994-03-28 1995-03-14 Watts; James L. Anti-fouling coating composition containing capsaicin

Also Published As

Publication number Publication date
DE69824191T2 (de) 2005-05-04
US5891919A (en) 1999-04-06
ATE267802T1 (de) 2004-06-15
EP1015418A1 (de) 2000-07-05
AU8603598A (en) 1999-04-12
WO1999015495A1 (en) 1999-04-01
EP1015418B1 (de) 2004-05-26

Similar Documents

Publication Publication Date Title
ATE267802T1 (de) Denatonium capsaicinat und verfahren zu ihrer herstellung
DE69901045D1 (de) Verfahren zur Herstellung von Kohlenwasserstoffen aus Synthesegas
WO2003035830A3 (en) Efficient synthesis of protein-oligonucleotide conjugates
DE69906884D1 (de) Verfahren zur Herstellung von Kohlenwasserstoffen aus Synthesegas
WO1998041513A3 (de) Substituierte aminosalicylsäureamide mit fungizider wirkung und zwischenprodukte zu ihrer herstellung
BR9503619A (pt) Processo para a síntese de trans-1,4-polibutadieno
CA2325919A1 (en) Processes for the preparation of threo-1,2-epoxy-3-amino-4-phenylbutane derivatives
WO2002030870A3 (de) Substituierte c-cyclohexylmethylamin-derivate
WO2003029195A1 (fr) Intermediaires pour l'elaboration d'un derive de l'epothilone, et leur procede de production
AU2003291987A1 (en) Method for regenerating a hydrogenation catalyst
EP1544187A4 (de) 1,7,8-trifluornaphthalin-2-naphthol und verfahren zur herstellung von fl ssigkristallinen verbindungen unter dessen verwendung
WO2004092122A3 (en) Preparation and purification of synthetic capsaicin
ATE137222T1 (de) Verfahren für die herstellung von dialkyl-2,3- pyridinedicarboxylaten und deren derivaten aus einem alpha-beta-ungesättigten oxim und einem aminobutenedioat
EA200000661A1 (ru) Новый способ получения кетимина
DE60316359D1 (de) Verfahren zur herstellung von 3,5-bis(trifluormethyl)benzylalkohol
DE59605545D1 (de) Alkoholhaltige instant-getränkemischung, ihre herstellung und verwendung
WO2003006656A3 (en) Process for the preparation of 2,4-dideoxyhexoses and 2,4,6-trideoxyhexoses
MX9800124A (es) Proceso para la manufatura de metilaminas.
DE50110561D1 (de) Non-metallocene, verfahren zur herstellung von diesen und deren verwendung zur polymerisation von olefinen
IL114488A0 (en) Amino acid-derived diaminopropanols
IL147660A0 (en) Geometrical isomer of acrylonitrile compound, mixture thereof, and process for producing these
DK1140785T3 (da) Fremgangsmåde til fremstilling af polyhalogenerede paratrifluormethylaniliner
WO2004043400A3 (en) Peptide deformylase activated prodrugs
DE59903779D1 (de) Verfahren zur herstellung von trion-bis(oximether) derivaten sowie damit erhältliche trion-mono- und trion-bis(oximether) derivate
ATE301625T1 (de) Verfahren zur herstellung von 2,6- dimethylnaphthalin

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee