DE69820460T2 - Injektionsgerät - Google Patents

Injektionsgerät Download PDF

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Publication number
DE69820460T2
DE69820460T2 DE69820460T DE69820460T DE69820460T2 DE 69820460 T2 DE69820460 T2 DE 69820460T2 DE 69820460 T DE69820460 T DE 69820460T DE 69820460 T DE69820460 T DE 69820460T DE 69820460 T2 DE69820460 T2 DE 69820460T2
Authority
DE
Germany
Prior art keywords
injection device
injection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69820460T
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English (en)
Other versions
DE69820460D1 (de
Inventor
F Deily
J Bunch
J Drach
M Bonicatto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioject Inc
Original Assignee
Bioject Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioject Inc filed Critical Bioject Inc
Publication of DE69820460D1 publication Critical patent/DE69820460D1/de
Application granted granted Critical
Publication of DE69820460T2 publication Critical patent/DE69820460T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/30Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A61M2005/208Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053Media being expelled from injector by pressurised fluid or vacuum
DE69820460T 1997-05-19 1998-04-22 Injektionsgerät Expired - Lifetime DE69820460T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/858,249 US5993412A (en) 1997-05-19 1997-05-19 Injection apparatus
PCT/US1998/008161 WO1998052632A1 (en) 1997-05-19 1998-04-22 Injection apparatus

Publications (2)

Publication Number Publication Date
DE69820460D1 DE69820460D1 (de) 2004-01-22
DE69820460T2 true DE69820460T2 (de) 2004-10-07

Family

ID=25327861

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69820460T Expired - Lifetime DE69820460T2 (de) 1997-05-19 1998-04-22 Injektionsgerät

Country Status (7)

Country Link
US (1) US5993412A (de)
EP (1) EP1011763B1 (de)
AU (1) AU7254998A (de)
CA (1) CA2290777C (de)
DE (1) DE69820460T2 (de)
GB (1) GB9927246D0 (de)
WO (1) WO1998052632A1 (de)

Families Citing this family (483)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020147143A1 (en) 1998-03-18 2002-10-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US6156008A (en) * 1998-05-04 2000-12-05 Castellano; Thomas P. Device for avoiding subdermal hematomas from an injection
US6129361A (en) * 1998-07-06 2000-10-10 Ford Global Technologies, Inc. Fluid conduit seal
US6315777B1 (en) * 1998-07-07 2001-11-13 Medtronic, Inc. Method and apparatus for creating a virtual electrode used for the ablation of tissue
US20030235557A1 (en) 1998-09-30 2003-12-25 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US6783509B1 (en) 1998-11-18 2004-08-31 Bioject Inc. Single-use needle-less hypodermic jet injection apparatus and method
WO2000030704A1 (en) * 1998-11-24 2000-06-02 Pickrell Marc R Improved multi-dose non-needle jet injection device
US6406455B1 (en) * 1998-12-18 2002-06-18 Biovalve Technologies, Inc. Injection devices
US7060048B1 (en) * 1999-04-16 2006-06-13 Powerject Research Limited Needleless syringe
US6689095B1 (en) 1999-04-22 2004-02-10 Gilbert Garitano Needleless permanent makeup and tattoo device
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US6319224B1 (en) * 1999-08-20 2001-11-20 Bioject Medical Technologies Inc. Intradermal injection system for injecting DNA-based injectables into humans
US20050027239A1 (en) * 1999-08-20 2005-02-03 Stout Richard R. Intradermal injection system for injecting DNA-based injectables into humans
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US20020193740A1 (en) 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US6843781B2 (en) * 1999-10-14 2005-01-18 Becton, Dickinson And Company Intradermal needle
US6776776B2 (en) * 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US6569123B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Prefillable intradermal injector
EP1296730B2 (de) * 2000-01-07 2014-07-30 Valeritas, Inc. Injektionsvorrichtung
IL151097A0 (en) 2000-02-23 2003-04-10 Smithkline Beecham Biolog Tumour-specific animal proteins
US6689131B2 (en) 2001-03-08 2004-02-10 Tissuelink Medical, Inc. Electrosurgical device having a tissue reduction sensor
ES2643763T3 (es) 2000-03-06 2017-11-24 Salient Surgical Technologies, Inc. Sistema de suministro de fluido y controlador para dispositivos electroquirúrgicos
US8048070B2 (en) 2000-03-06 2011-11-01 Salient Surgical Technologies, Inc. Fluid-assisted medical devices, systems and methods
US6558385B1 (en) 2000-09-22 2003-05-06 Tissuelink Medical, Inc. Fluid-assisted medical device
WO2003024349A1 (en) 2001-09-05 2003-03-27 Tissuelink Medical, Inc. Fluid-assisted medical devices, systems and methods
US7811282B2 (en) 2000-03-06 2010-10-12 Salient Surgical Technologies, Inc. Fluid-assisted electrosurgical devices, electrosurgical unit with pump and methods of use thereof
US6645169B1 (en) * 2000-06-08 2003-11-11 Avant Drug Delivery Systems, Inc. Air-in-tip jet injector
JP2004513615A (ja) 2000-06-28 2004-05-13 コリクサ コーポレイション 肺癌の治療および診断のための組成物および方法
US6440096B1 (en) * 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
PT1889630E (pt) 2000-10-18 2012-02-29 Glaxosmithkline Biolog Sa Vacinas compreendendo o antigénio mage ligado a um fragmento da proteína d
US6652483B2 (en) * 2000-11-07 2003-11-25 Avant Drug Delivery Systems, Inc. Needleless jet injector system with separate drug reservoir
US7931614B2 (en) 2000-11-30 2011-04-26 Valeritas, Inc. Injection systems
GB0100756D0 (en) 2001-01-11 2001-02-21 Powderject Res Ltd Needleless syringe
GB2371754B (en) * 2001-02-02 2005-09-21 Biocompatibles Ltd Balloon catheter inflation
DE60239594D1 (de) 2001-02-23 2011-05-12 Glaxosmithkline Biolog Sa Influenza vakzinzusammensetzungen zur intradermaler verabreichung
US6645170B2 (en) * 2001-03-05 2003-11-11 Bioject Medical Technologies, Inc. Simplified disposable needle-free injection apparatus and method
US6471669B2 (en) 2001-03-05 2002-10-29 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
JP2002263106A (ja) * 2001-03-12 2002-09-17 Olympus Optical Co Ltd 光プローブ装置
JP2004529754A (ja) 2001-03-14 2004-09-30 ペンジェット・コーポレーション 溶液から溶解ガスを除去するためのシステムおよび方法
ZA200200808B (en) * 2001-03-22 2002-08-12 Roche Diagnostics Gmbh Needleless hypodermic injection system, application device and medication cartridge therefor.
GB0109297D0 (en) 2001-04-12 2001-05-30 Glaxosmithkline Biolog Sa Vaccine
US6613010B2 (en) 2001-04-13 2003-09-02 Penjet Corporation Modular gas-pressured needle-less injector
WO2002087663A2 (en) 2001-04-27 2002-11-07 Penjet Corporation Method and apparatus for filling or refilling a needle-less injector
WO2002089747A2 (en) 2001-05-09 2002-11-14 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
TWI228420B (en) 2001-05-30 2005-03-01 Smithkline Beecham Pharma Gmbh Novel vaccine composition
US20100221284A1 (en) 2001-05-30 2010-09-02 Saech-Sisches Serumwerk Dresden Novel vaccine composition
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
CN1253220C (zh) 2001-06-29 2006-04-26 贝克顿迪肯森公司 通过微管在真皮内输入疫苗和基因治疗剂
US7767872B2 (en) * 2001-09-06 2010-08-03 Mpg Biotechnologies, Llc Thimerosal removal device
US8440791B2 (en) * 2001-09-06 2013-05-14 Mgp Biotechnologies, Llc Thimerosal removal device
HUP0402259A3 (en) 2001-09-20 2010-01-28 Glaxo Group Ltd Vaccines
US6824526B2 (en) 2001-10-22 2004-11-30 Penjet Corporation Engine and diffuser for use with a needle-less injector
US6607510B2 (en) 2001-11-09 2003-08-19 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
CA2476755C (en) 2001-12-17 2014-08-26 Corixa Corporation Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
US6551314B1 (en) 2002-04-03 2003-04-22 Thomas J. Fogarty Methods and systems for vein harvesting
US7074220B2 (en) * 2002-04-03 2006-07-11 Thomas J. Fogarty Methods and systems for vein harvesting and fistula creation
US20040049208A1 (en) * 2002-04-03 2004-03-11 Thomas Fogarty, M.D. Methods and systems for vein harvesting and fistula creation
US7156823B2 (en) * 2002-06-04 2007-01-02 Bioject Inc. High workload needle-free injection system
US7238167B2 (en) * 2002-06-04 2007-07-03 Bioject Inc. Needle-free injection system
US6676630B2 (en) 2002-06-04 2004-01-13 Bioject Medical Technologies, Inc. Needle-free injection system
US6883222B2 (en) * 2002-10-16 2005-04-26 Bioject Inc. Drug cartridge assembly and method of manufacture
JP2006504472A (ja) 2002-10-29 2006-02-09 ティシューリンク・メディカル・インコーポレーテッド 流体補助電気外科手術鋏及び方法
US20040143213A1 (en) * 2002-11-12 2004-07-22 Collegium Pharmaceutical, Inc. Inertial drug delivery system
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
RU2389732C2 (ru) 2003-01-06 2010-05-20 Корикса Корпорейшн Некоторые аминоалкилглюкозаминидфосфатные производные и их применение
US6935384B2 (en) * 2003-02-19 2005-08-30 Bioject Inc. Needle-free injection system
US20060184101A1 (en) * 2003-04-21 2006-08-17 Ravi Srinivasan Microjet devices and methods for drug delivery
JP2006524120A (ja) * 2003-04-21 2006-10-26 ストラテージェント ライフ サイエンシズ マイクロジェットで反復的に薬物を搬送する装置および方法
IL155967A0 (en) * 2003-05-18 2003-12-23 Menachem Hartman Automatic injector for mass injections
AU2004272972A1 (en) 2003-05-22 2005-03-24 Fraunhofer Usa, Inc. Recombinant carrier molecule for expression, delivery and purification of target polypeptides
EP1648931B1 (de) 2003-07-21 2011-02-09 Transgene S.A. Multifunktionelle cytokine
WO2005034949A1 (en) * 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
ES2308230T3 (es) 2003-10-21 2008-12-01 Basf Se Metodo para la produccion continua de aldehidos.
US7727232B1 (en) 2004-02-04 2010-06-01 Salient Surgical Technologies, Inc. Fluid-assisted medical devices and methods
US7717874B2 (en) * 2004-05-28 2010-05-18 Bioject, Inc. Needle-free injection system
US20060005844A1 (en) * 2004-07-08 2006-01-12 Coulter George G Rolling tube apparatus and method for treating a wound
EP1793849A2 (de) 2004-09-22 2007-06-13 GlaxoSmithKline Biologicals SA Immunogene zusammensetzung zur verwendung bei der impfung gegen staphylokokken
WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
CA2586525C (en) 2004-11-22 2013-01-15 Intelliject, Llc Devices, systems, and methods for medicament delivery
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
US11590286B2 (en) 2004-11-22 2023-02-28 Kaleo, Inc. Devices, systems and methods for medicament delivery
US7947017B2 (en) 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
US10737028B2 (en) 2004-11-22 2020-08-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
JP4904283B2 (ja) 2004-12-01 2012-03-28 アキュショット インク 無針注射器
DE102004063650B4 (de) 2004-12-31 2022-10-20 Ypsomed Ag Lebensdaueranzeige für eine Vorrichtung zur dosierten Verabreichung eines Produkts
NZ560516A (en) 2005-02-01 2010-12-24 Intelliject Inc A delivery system where a medicant is automatically delivered on activation as well as a recorded instruction
US8361026B2 (en) 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
US9022980B2 (en) 2005-02-01 2015-05-05 Kaleo, Inc. Medical injector simulation device
US8231573B2 (en) 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
JP2008529689A (ja) 2005-02-21 2008-08-07 ノボ・ノルデイスク・エー/エス 注射装置内のモータ速度を一定に保つ方法
PE20061428A1 (es) 2005-03-23 2007-01-16 Glaxosmithkline Biolog Sa Formulacion de vacuna que comprende un adyuvante de emulsion aceite en agua y 3d-mpl
ES2732625T3 (es) 2005-04-04 2019-11-25 Univ Florida Análogos de poliéter de desferritiocina
US7618393B2 (en) 2005-05-03 2009-11-17 Pharmajet, Inc. Needle-less injector and method of fluid delivery
US20070118093A1 (en) * 2005-06-20 2007-05-24 Von Muhlen Marcio G High-speed jet devices for drug delivery
EP1919504B1 (de) * 2005-08-03 2013-10-16 iBio, Inc. Antikörper gegen bacillus anthracis protektiv antigen
US20070055199A1 (en) 2005-08-10 2007-03-08 Gilbert Scott J Drug delivery device for buccal and aural applications and other areas of the body difficult to access
US8202249B2 (en) * 2005-09-20 2012-06-19 Panasonic Corporation Injection device with puncture function, method for controlling injection device with puncture function, chemical solution administration device, and method for controlling chemical solution administration device
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
WO2007070682A2 (en) 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
US7988660B2 (en) * 2005-12-20 2011-08-02 Eli Lilly And Company Needle-free injection device
JO2813B1 (en) 2005-12-22 2014-09-15 جلاكسو سميث كلاين بايولوجيكالز اس.ايه A vaccine with multiple pneumococcal saccharides
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
US20090081157A1 (en) 2006-01-09 2009-03-26 Richard Syd Kornbluth Immunostimulatory Combinations for Vaccine Adjuvants
JP2009526526A (ja) * 2006-02-13 2009-07-23 フラウンホーファー ユーエスエー, インコーポレイテッド インフルエンザ抗原、ワクチン組成物、および関連する方法
US8277816B2 (en) * 2006-02-13 2012-10-02 Fraunhofer Usa, Inc. Bacillus anthracis antigens, vaccine compositions, and related methods
US20080279877A1 (en) * 2006-02-13 2008-11-13 Fraunhofer U.S.A. Inc. HPV antigens, vaccine compositions, and related methods
EP1998684A4 (de) * 2006-03-10 2014-09-17 Massachusetts Inst Technology Konjugate und nanosysteme mit ausgelöstem selbstzusammenbau
US7666912B2 (en) 2006-03-23 2010-02-23 Massachusetts Eye And Ear Infirmary Compositions and methods for reducing body fat
MX337528B (es) 2006-03-30 2016-03-09 Glaxosmithkline Biolog Sa Composición inmunogénica que comprende un sacárido capsular estafilocócico o-acetilado y una proteína estafilocócica.
ES2776100T3 (es) 2006-03-31 2020-07-29 Massachusetts Inst Technology Sistema para el suministro dirigido de agentes terapéuticos
WO2007120638A2 (en) * 2006-04-12 2007-10-25 President And Fellows Of Harvard College Methods and compositions for modulating glycosylation
WO2007133807A2 (en) 2006-05-15 2007-11-22 Massachusetts Institute Of Technology Polymers for functional particles
WO2007143574A1 (en) * 2006-06-02 2007-12-13 President And Fellows Of Harvard College Protein surface remodeling
US9381477B2 (en) 2006-06-23 2016-07-05 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
SI2422810T1 (sl) 2006-07-17 2015-01-30 Glaxosmithkline Biologicals S.A. Influenčno cepivo
US7618396B2 (en) * 2006-08-09 2009-11-17 Avant Medical Corp. Injection system with hidden needles
US9115358B2 (en) 2006-08-11 2015-08-25 President And Fellows Of Harvard College Moenomycin biosynthesis-related compositions and methods of use thereof
KR20090050056A (ko) * 2006-08-14 2009-05-19 메사츄세츠 인스티튜트 어브 테크놀로지 헤마글루티닌 폴리펩티드 및 시약 그리고 방법
US20090269342A1 (en) * 2006-08-14 2009-10-29 Massachusetts Institute Of Technology Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto
US7942845B2 (en) * 2006-09-19 2011-05-17 Bioject, Inc. Needle-free injector and process for providing serial injections
US7547293B2 (en) 2006-10-06 2009-06-16 Bioject, Inc. Triggering mechanism for needle-free injector
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
BRPI0717219B8 (pt) 2006-10-12 2021-05-25 Glaxosmithkline Biologicals Sa composição imunogênica, e, uso de uma composição imunogênica
EP2433648A3 (de) 2006-10-12 2012-04-04 GlaxoSmithKline Biologicals S.A. Impfstoff mit einem Öl-in-wasser-emulsionshilfsstoff
US8870821B2 (en) * 2006-10-13 2014-10-28 Michael D. Laufer Device for tissue injection
US7637889B2 (en) * 2006-11-15 2009-12-29 Glynntech, Inc. Drug delivery device with sliding valve and methodology
CN101848702B (zh) 2006-12-01 2013-07-17 安特里奥公司 两亲实体纳米粒子
WO2008073856A2 (en) * 2006-12-08 2008-06-19 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
US8011250B2 (en) * 2006-12-22 2011-09-06 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Apparatus and method for controlling and monitoring the pressure in pressure line or pipes
CN110003079A (zh) 2006-12-26 2019-07-12 兰休斯医疗成像公司 用于使心脏神经支配成像的配体
EP2125075A2 (de) 2007-01-22 2009-12-02 Intelliject, Inc. Medizinischer injektor mit konformitätsverfolgung und -überwachung
AU2008210434C8 (en) 2007-01-31 2014-03-27 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US9217129B2 (en) 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
WO2008103997A2 (en) 2007-02-23 2008-08-28 Bioject Inc. Needle-free injection devices and drug delivery systems therefor
AU2008229472B2 (en) 2007-03-15 2013-03-14 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
BRPI0809366B8 (pt) 2007-03-28 2021-05-25 Harvard College polipeptídeo substancialmente alfa-helicoidal, método para fabricação do mesmo, aminoácido e composição farmacêutica
JP2010523595A (ja) 2007-04-04 2010-07-15 マサチューセッツ インスティテュート オブ テクノロジー ポリ(アミノ酸)ターゲッティング部分
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
DE102007016811A1 (de) 2007-04-05 2008-10-09 Tecpharma Licensing Ag Vorrichtung zur Verabreichung eines fluiden Wirkstoffes aus einer Mehrkammerampulle
WO2008134643A2 (en) * 2007-04-28 2008-11-06 Fraunhofer Usa, Inc. Trypanosoma antigens, vaccine compositions, and related methods
WO2008137747A1 (en) 2007-05-02 2008-11-13 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
GB0708758D0 (en) 2007-05-04 2007-06-13 Powderject Res Ltd Particle cassettes and process thereof
CN101754770B (zh) * 2007-06-14 2015-05-20 克鲁塞尔瑞士股份公司 皮内流感疫苗
WO2008156676A1 (en) 2007-06-15 2008-12-24 President And Fellows Of Harvard College Methods and compositions for detecting and modulating o-glycosylation
PT2167121E (pt) 2007-06-26 2015-12-02 Glaxosmithkline Biolog Sa Vacina compreendendo conjugados de polissacáridos capsulares de streptococcus pneumoniae
WO2009009759A2 (en) * 2007-07-11 2009-01-15 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
WO2009046314A2 (en) * 2007-10-04 2009-04-09 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
US10736848B2 (en) 2007-10-12 2020-08-11 Massachusetts Institute Of Technology Vaccine nanotechnology
EP2215269B1 (de) * 2007-10-15 2017-12-13 Admedus Vaccines Pty Limited Konstruktsystem und verwendungen dafür
JP5067110B2 (ja) * 2007-10-17 2012-11-07 マックス株式会社 ガス燃焼式打込み工具
US20090137949A1 (en) * 2007-11-26 2009-05-28 Bioject Inc. Needle-free injection device with nozzle auto-disable
US8617099B2 (en) * 2007-11-26 2013-12-31 Bioject Inc. Injection device plunger auto-disable
EP2227174B1 (de) 2007-12-28 2019-05-01 Salient Surgical Technologies, Inc. Flüssigkeitsgestützte elektrochirurgische vorrichtung
CN101951927A (zh) * 2008-01-03 2011-01-19 麻省理工学院 诱饵流感疗法
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
AR072249A1 (es) * 2008-04-09 2010-08-18 Infinity Pharmaceuticals Inc Inhibidores de amida hidrolasa de acido graso. usos. metodos.
AU2009237647A1 (en) 2008-04-16 2009-10-22 Glaxosmithkline Biologicals S.A. Vaccine
AU2009243187C1 (en) * 2008-04-28 2015-12-24 President And Fellows Of Harvard College Supercharged proteins for cell penetration
USD994111S1 (en) 2008-05-12 2023-08-01 Kaleo, Inc. Medicament delivery device cover
US8021344B2 (en) 2008-07-28 2011-09-20 Intelliject, Inc. Medicament delivery device configured to produce an audible output
CA2724641C (en) * 2008-05-20 2020-03-24 Avant Medical Corp. Autoinjector system
US8052645B2 (en) 2008-07-23 2011-11-08 Avant Medical Corp. System and method for an injection using a syringe needle
BRPI0914630A2 (pt) 2008-06-26 2019-09-24 Anterios Inc liberação dérmica
JP5986745B2 (ja) 2008-07-15 2016-09-06 アカデミア シニカAcademia Sinica Ptfe様のアルミニウム・コート・ガラススライド上のグリカンアレイおよび関連する方法
AU2009274571A1 (en) * 2008-07-23 2010-01-28 Massachusetts Institute Of Technology Activation of histone deacetylase 1 (HDAC1) protects against DNA damage and increases neuronal survival
EP2356139A4 (de) 2008-07-23 2013-01-09 Harvard College Ligieren zusammengehefteter polypeptide
DE102008048981A1 (de) * 2008-09-25 2010-04-15 Lts Lohmann Therapie-Systeme Ag Injektor und Zwei-Kammer-System mit sterilen Komponenten
WO2010036945A2 (en) * 2008-09-26 2010-04-01 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
WO2010037046A1 (en) 2008-09-28 2010-04-01 Fraunhofer Usa, Inc. Humanized neuraminidase antibody and methods of use thereof
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
WO2010057197A1 (en) 2008-11-17 2010-05-20 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
EP2376619A4 (de) 2008-12-15 2012-07-04 Greenlight Biosciences Inc Verfahren zur flusssteuerung bei stoffwechselwegen
CN105132387A (zh) * 2008-12-22 2015-12-09 绿光生物科学公司 用于制造化合物的组合物和方法
US9254168B2 (en) 2009-02-02 2016-02-09 Medtronic Advanced Energy Llc Electro-thermotherapy of tissue using penetrating microelectrode array
EP2398416B1 (de) 2009-02-23 2015-10-28 Medtronic Advanced Energy LLC Flüssigkeitsunterstütztes elektrochirurgisches gerät
EP2416660B1 (de) 2009-04-07 2014-07-02 Infinity Pharmaceuticals, Inc. Fettsäureamidhydrolase-hemmer
AU2010234449A1 (en) 2009-04-07 2011-11-03 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
US9221886B2 (en) 2009-04-28 2015-12-29 President And Fellows Of Harvard College Supercharged proteins for cell penetration
US9149465B2 (en) * 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8927551B2 (en) * 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8765735B2 (en) * 2009-05-18 2014-07-01 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
EP2438046A4 (de) 2009-06-01 2013-04-17 Harvard College O-glcnac-transferasehemmer und verwendungen davon
WO2010148111A1 (en) 2009-06-16 2010-12-23 The Regents Of The University Of Michigan Nanoemulsion vaccines
AU2010273220B2 (en) 2009-07-13 2015-10-15 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
CN102497832B (zh) 2009-09-08 2015-09-09 显著外科技术公司 用于电外科装置、电外科器械的盒组件及其使用方法
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP2483307A1 (de) 2009-09-29 2012-08-08 Fraunhofer USA, Inc. Influenza-hämagglutinin-antikörper, zusammensetzungen daraus und zugehörige verfahren
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
CA2784807C (en) 2009-12-29 2021-12-14 Dana-Farber Cancer Institute, Inc. Type ii raf kinase inhibitors
EP2528615B1 (de) 2010-01-27 2020-05-13 Massachusetts Institute of Technology Manipulierte polypeptidmittel für gezielte influenza-neutralisierung in einem breiten spektrum
CN102834401B (zh) 2010-02-03 2016-08-24 无限药品股份有限公司 脂肪酸酰胺水解酶抑制剂
CN102844023B (zh) 2010-03-08 2016-01-20 索隆-基特林癌症研究协会 Cdc7激酶抑制剂以及其用途
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
US9592090B2 (en) 2010-03-11 2017-03-14 Medtronic Advanced Energy Llc Bipolar electrosurgical cutter with position insensitive return electrode contact
US9102697B2 (en) 2010-03-22 2015-08-11 President And Fellows Of Harvard College Trioxacarcins and uses thereof
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
CA2736841C (en) 2010-04-15 2014-02-18 Teneo Innovations Inc. Device and electronic controller for syringe piston control
US9795658B2 (en) 2010-04-20 2017-10-24 Admedus Vaccines Pty Ltd Expression system for modulating an immune response
CA2798330A1 (en) 2010-05-05 2011-11-10 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
WO2011140516A2 (en) 2010-05-07 2011-11-10 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through enzyme relocation
BR122020018186B1 (pt) 2010-05-11 2021-07-27 Lantheus Medical Imaging, Inc Uso de agentes de imagiologia para preparação de uma composição para detecção do transportador de norepinefrina (net) e método para a detecção de net
US20110295249A1 (en) * 2010-05-28 2011-12-01 Salient Surgical Technologies, Inc. Fluid-Assisted Electrosurgical Devices, and Methods of Manufacture Thereof
US8658603B2 (en) 2010-06-16 2014-02-25 The Regents Of The University Of Michigan Compositions and methods for inducing an immune response
ES2664872T3 (es) 2010-06-18 2018-04-23 Taiho Pharmaceutical Co., Ltd Moduladores PRPK-TPRKB y sus usos
US9138289B2 (en) 2010-06-28 2015-09-22 Medtronic Advanced Energy Llc Electrode sheath for electrosurgical device
US8906012B2 (en) 2010-06-30 2014-12-09 Medtronic Advanced Energy Llc Electrosurgical devices with wire electrode
US8920417B2 (en) 2010-06-30 2014-12-30 Medtronic Advanced Energy Llc Electrosurgical devices and methods of use thereof
EP3578205A1 (de) 2010-08-06 2019-12-11 ModernaTX, Inc. Pharmazeutische zusammensetzungen enthaltenbearbeitete nukleinsäuren und ihre medizinische verwendung
US8859723B2 (en) 2010-08-13 2014-10-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8916358B2 (en) 2010-08-31 2014-12-23 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through protease manipulation
EP2640405A4 (de) 2010-09-21 2015-04-15 Massachusetts Inst Technology An den menschen angepasste ha-polypeptide, impfstoffe daraus und influenza-behandlung damit
US8957026B2 (en) 2010-09-22 2015-02-17 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
US20120237975A1 (en) 2010-10-01 2012-09-20 Jason Schrum Engineered nucleic acids and methods of use thereof
AU2011312178B2 (en) 2010-10-04 2016-05-12 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
US9023040B2 (en) 2010-10-26 2015-05-05 Medtronic Advanced Energy Llc Electrosurgical cutting devices
CA2817577A1 (en) 2010-11-10 2012-05-18 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8809349B2 (en) 2011-01-10 2014-08-19 Infinity Pharmaceuticals, Inc. Processes for preparing isoquinolinones and solid forms of isoquinolinones
US9089579B2 (en) 2011-01-19 2015-07-28 Topokine Therapeutics, Inc. Methods and compositions for treating metabolic syndrome
AU2012209274A1 (en) 2011-01-24 2013-09-12 Anterios, Inc. Nanoparticle compositions, formulations thereof, and uses therefor
EP2667945A1 (de) 2011-01-24 2013-12-04 Anterios, Inc. Ölzusammensetzungen
TR201905477T4 (tr) 2011-01-24 2019-05-21 Anterios Inc Nano-parçacık bileşimler.
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9084849B2 (en) 2011-01-26 2015-07-21 Kaleo, Inc. Medicament delivery devices for administration of a medicament within a prefilled syringe
CN103889219A (zh) 2011-03-03 2014-06-25 特萨斯制药有限责任公司 包含C16:1n7-棕榈油酸酯的组合物和方法
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
US9427281B2 (en) 2011-03-11 2016-08-30 Medtronic Advanced Energy Llc Bronchoscope-compatible catheter provided with electrosurgical device
WO2012135615A2 (en) 2011-03-30 2012-10-04 Brown University Enopeptins, uses thereof, and methods of synthesis thereto
EP2691101A2 (de) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Freisetzung und formulierung von manipulierten nukleinsäuren
US20140072622A1 (en) 2011-05-17 2014-03-13 Glaxosmithkline Biologicals S.A. Vaccine against streptococcus pneumoniae
CN103796696B (zh) * 2011-05-25 2016-02-03 赛诺菲-安万特德国有限公司 具有配给接口的药剂递送装置和控制该装置的方法
TWI417120B (zh) * 2011-05-27 2013-12-01 Leader Machine Co Ltd A drug delivery device with built - in quantitative pusher
WO2012177595A1 (en) 2011-06-21 2012-12-27 Oncofactor Corporation Compositions and methods for the therapy and diagnosis of cancer
EP2537546A1 (de) * 2011-06-21 2012-12-26 Sanofi-Aventis Deutschland GmbH Medikamentenabgabevorrichtung mit Dosiersteuerungsmechanismus
CA2840224C (en) 2011-06-22 2019-08-13 The General Hospital Corporation Treatment of proteinopathies
AR088218A1 (es) 2011-07-19 2014-05-21 Infinity Pharmaceuticals Inc Compuestos heterociclicos utiles como inhibidores de pi3k
AU2012284088B2 (en) 2011-07-19 2015-10-08 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
CA2842524C (en) 2011-07-22 2020-07-14 Massachusetts Institute Of Technology Activators of class i histone deacetylases (hdacs) and uses thereof
US9408972B2 (en) * 2011-08-02 2016-08-09 Pharmajet, Inc. Needle-free injection device
EP2751093A1 (de) 2011-08-29 2014-07-09 Infinity Pharmaceuticals, Inc. Heterocyclische verbindungen und ihre verwendung
WO2013036787A2 (en) 2011-09-09 2013-03-14 Greenlight Biosciences, Inc. Cell-free preparation of carbapenems
CA2848147C (en) 2011-09-09 2021-08-24 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
WO2013039861A2 (en) 2011-09-12 2013-03-21 modeRNA Therapeutics Engineered nucleic acids and methods of use thereof
WO2013049332A1 (en) 2011-09-29 2013-04-04 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
US9750565B2 (en) 2011-09-30 2017-09-05 Medtronic Advanced Energy Llc Electrosurgical balloons
CA2850624A1 (en) 2011-10-03 2013-04-11 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
CN108929375A (zh) 2011-10-18 2018-12-04 爱勒让治疗公司 拟肽大环化合物
US8870864B2 (en) 2011-10-28 2014-10-28 Medtronic Advanced Energy Llc Single instrument electrosurgery apparatus and its method of use
WO2013074986A1 (en) 2011-11-17 2013-05-23 Dana-Farber Cancer Institute, Inc. Inhibitors of c-jun-n-terminal kinase (jnk)
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
IN2014CN03873A (de) 2011-12-13 2015-10-16 Pharmajet Inc
KR20140102759A (ko) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
CN113398126A (zh) 2011-12-16 2021-09-17 佛罗里达大学研究基金会 4′-去铁硫素类似物的用途
US8426471B1 (en) 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
US8927500B2 (en) 2012-02-15 2015-01-06 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
US9273084B2 (en) 2012-04-06 2016-03-01 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
WO2013151697A1 (en) 2012-04-06 2013-10-10 President And Fellows Of Harvard College Methods and compounds for identifying glycosyltransferase inhibitors
WO2013152279A1 (en) 2012-04-06 2013-10-10 President And Fellows Of Harvard College Chemoenzymatic methods for synthesizing moenomycin analogs
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
US9597385B2 (en) 2012-04-23 2017-03-21 Allertein Therapeutics, Llc Nanoparticles for treatment of allergy
MX2014013678A (es) 2012-05-10 2015-02-04 Massachusetts Inst Technology Agentes para neutralizacion de influenza.
US9522235B2 (en) 2012-05-22 2016-12-20 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
CA2875683A1 (en) 2012-06-05 2013-12-12 The Australian National University Vaccination with interleukin-4 antagonists
US9226792B2 (en) 2012-06-12 2016-01-05 Medtronic Advanced Energy Llc Debridement device and method
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
JP2015525794A (ja) 2012-08-06 2015-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 乳児においてrsv及び百日咳菌に対する免疫応答を惹起するための方法
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
AU2013306098A1 (en) 2012-08-18 2015-02-12 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
HUE054444T2 (hu) 2012-09-26 2021-09-28 Harvard College Prolinnal lezárt kapcsos peptidek és felhasználásuk
US20150225471A1 (en) 2012-10-01 2015-08-13 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
US11234760B2 (en) 2012-10-05 2022-02-01 Medtronic Advanced Energy Llc Electrosurgical device for cutting and removing tissue
JP6321662B2 (ja) 2012-10-12 2018-05-09 ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. Gsk3阻害剤およびその使用の方法
US10112927B2 (en) 2012-10-18 2018-10-30 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
WO2014063061A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
WO2014063054A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
US9657076B2 (en) 2012-10-23 2017-05-23 Emory University GM-CSF and IL-4 conjugates, compositions, and methods related thereto
US9982034B2 (en) 2012-10-24 2018-05-29 Platelet Targeted Therapeutics, Llc Platelet targeted treatment
JP6526563B2 (ja) 2012-11-01 2019-06-05 エイルロン セラピューティクス,インコーポレイテッド 二置換アミノ酸ならびにその調製および使用の方法
PT2914296T (pt) 2012-11-01 2018-10-30 Infinity Pharmaceuticals Inc Tratamento de cancros utilizando moduladores de isoformas de pi3-quinase
US9567301B2 (en) 2012-11-02 2017-02-14 Dana-Farber Cancer Institute, Inc. Pyrrol-1-yl benzoic acid derivatives useful as myc inhibitors
CA2869676C (en) 2012-11-21 2015-06-23 Topokine Therapeutics, Inc. Uses and compositions comprising a thiazolidinedione and oleic acid for locally increasing subcutaneous fat
JP6408478B2 (ja) 2012-11-26 2018-10-17 プレジデント アンド フェローズ オブ ハーバード カレッジ トリオキサカルシン、トリオキサカルシン−抗体複合体、およびその用途
JP6144355B2 (ja) 2012-11-26 2017-06-07 モデルナティエックス インコーポレイテッドModernaTX,Inc. 化学修飾mRNA
JP6678455B2 (ja) 2012-12-21 2020-04-08 エピザイム,インコーポレイティド Prmt5阻害剤およびその使用
US8940726B2 (en) 2012-12-21 2015-01-27 Epizyme, Inc. PRMT5 inhibitors and uses thereof
US8906900B2 (en) 2012-12-21 2014-12-09 Epizyme, Inc. PRMT5 inhibitors and uses thereof
WO2014100716A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
WO2014106056A2 (en) 2012-12-27 2014-07-03 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
CA2897941A1 (en) 2013-01-17 2014-07-24 Moderna Therapeutics, Inc. Signal-sensor polynucleotides for the alteration of cellular phenotypes
WO2014124228A1 (en) 2013-02-07 2014-08-14 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
JP6518597B2 (ja) 2013-02-07 2019-05-22 マサチューセッツ インスティテュート オブ テクノロジー H5インフルエンザのヒトへの適応
KR20150131244A (ko) 2013-03-13 2015-11-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스테이플드 및 스티치드 폴리펩티드 및 그의 용도
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
NZ629037A (en) 2013-03-15 2017-04-28 Infinity Pharmaceuticals Inc Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
US10492990B2 (en) 2013-03-15 2019-12-03 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
AU2014248090B2 (en) 2013-04-03 2018-08-02 N-Fold Llc Novel nanoparticle compositions
CN111825733A (zh) 2013-04-04 2020-10-27 哈佛大学的校长及成员们 大环内酯及其制备和使用方法
ES2774330T3 (es) 2013-04-09 2020-07-20 Massachusetts Inst Technology Polímero de suministro de fármaco y usos del mismo
WO2014179464A1 (en) 2013-04-30 2014-11-06 Massachusetts Institute Of Technology Human adaptation of h3 influenza
US9315472B2 (en) 2013-05-01 2016-04-19 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
NO2753788T3 (de) 2013-05-10 2018-06-16
DK3003309T3 (da) 2013-05-30 2020-12-14 Infinity Pharmaceuticals Inc Behandling af cancer med PI3-kinase-isoform modulatorer
WO2014197723A2 (en) 2013-06-05 2014-12-11 Massachusetts Institute Of Technology Human adaptation of h7 ha
EP3030239A4 (de) 2013-06-11 2017-03-08 Kala Pharmaceuticals, Inc. Harnstoffderivate und verwendungen davon
CN105492460A (zh) 2013-06-14 2016-04-13 哈佛大学的校长及成员们 稳定化多肽胰岛素受体调控剂
US10086054B2 (en) 2013-06-26 2018-10-02 Academia Sinica RM2 antigens and use thereof
EP3013347B1 (de) 2013-06-27 2019-12-11 Academia Sinica Glykankonjugate und verwendung davon
BR112016001457A2 (pt) 2013-07-25 2017-08-29 Dana Farber Cancer Inst Inc Inibidores de fatores de transcrição e usos dos mesmos
BR112016002494A2 (pt) 2013-08-05 2017-09-05 Greenlight Biosciences Inc Proteí-nas construídas com um sítio de clivagem de protease, ácido nucléico, vetor, célula e processo de engenharia de uma proteína recombinante e de um grande número de variantes de ácidos nucleicos que codificam proteínas recombinantes
CA2919773A1 (en) 2013-08-05 2015-02-12 Glaxosmithkline Biologicals S.A. Combination immunogenic compositions
TWI532511B (zh) * 2013-08-16 2016-05-11 京華堂實業股份有限公司 無針型注射系統及其注射方法
CN105682666B (zh) 2013-09-06 2021-06-01 中央研究院 使用醣脂激活人类iNKT细胞
PE20160685A1 (es) 2013-10-04 2016-07-23 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US9982009B2 (en) 2013-10-15 2018-05-29 Massachusetts Institute Of Technology Methods for treating polycystic kidney disease and polycystic liver disease
WO2015057958A2 (en) 2013-10-16 2015-04-23 Massachusetts Institute Of Technology Enterobactin conjugates and uses thereof
JP6491202B2 (ja) 2013-10-18 2019-03-27 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド サイクリン依存性キナーゼ7(cdk7)の多環阻害剤
ES2676734T3 (es) 2013-10-18 2018-07-24 Syros Pharmaceuticals, Inc. Compuestos heteroatómicos útiles para el tratamiento de enfermedades proliferativas
US20160244452A1 (en) 2013-10-21 2016-08-25 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
JP6426194B2 (ja) 2013-11-01 2018-11-21 カラ ファーマシューティカルズ インコーポレイテッド 治療用化合物の結晶形態及びその使用
JP6306700B2 (ja) 2013-11-01 2018-04-04 ユニバーシティ オブ オスロUniversity of Oslo アルブミン改変体及びその使用
US9993541B2 (en) 2013-11-13 2018-06-12 University Of Oslo Outer membrane vesicles and uses thereof
EP3069138B1 (de) 2013-11-15 2019-01-09 Oslo Universitetssykehus HF Ctl-peptid-epitope und antigen-spezifische t-zellen, verfahren zu deren entdeckung und verwendungen davon
US10314647B2 (en) 2013-12-23 2019-06-11 Medtronic Advanced Energy Llc Electrosurgical cutting instrument
EA201891279A1 (ru) 2013-12-24 2019-01-31 Президент Энд Феллоус Оф Гарвард Колледж Аналоги кортистатина, их синтез и применения
US9982041B2 (en) 2014-01-16 2018-05-29 Academia Sinica Compositions and methods for treatment and detection of cancers
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
JP2017504651A (ja) 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド ジアゼパン誘導体の使用
US10813686B2 (en) 2014-02-26 2020-10-27 Medtronic Advanced Energy Llc Electrosurgical cutting instrument
JP6625071B2 (ja) 2014-03-07 2019-12-25 ザ アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ 慢性疼痛用のナトリウムチャネルを標的とする非麻薬性crmp2ペプチド
SG10201808053XA (en) 2014-03-19 2018-10-30 Infinity Pharmaceuticals Inc Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
TWI687428B (zh) 2014-03-27 2020-03-11 中央研究院 反應性標記化合物及其用途
ES2868305T3 (es) 2014-03-28 2021-10-21 Univ Washington Through Its Center For Commercialization Vacunas contra el cáncer de mama y de ovario
US10017477B2 (en) 2014-04-23 2018-07-10 Dana-Farber Cancer Institute, Inc. Janus kinase inhibitors and uses thereof
US9862688B2 (en) 2014-04-23 2018-01-09 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
WO2015168079A1 (en) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Pyrimidine or pyridine derivatives useful as pi3k inhibitors
WO2015168380A1 (en) 2014-04-30 2015-11-05 Massachusetts Institute Of Technology Siderophore-based immunization against gram-negative bacteria
CN106573032B (zh) 2014-05-21 2022-03-18 哈佛大学的校长及成员们 Ras抑制肽和其用途
AU2015267045B2 (en) 2014-05-27 2021-02-25 Academia Sinica Anti-HER2 glycoantibodies and uses thereof
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
CN106573971A (zh) 2014-05-27 2017-04-19 中央研究院 抗cd20醣抗体及其用途
EP3149161B1 (de) 2014-05-27 2021-07-28 Academia Sinica Fucosidase aus bacteroiden und verfahren damit
TWI732738B (zh) 2014-05-28 2021-07-11 中央研究院 抗TNF-α醣抗體及其用途
EP3154576A1 (de) 2014-06-13 2017-04-19 GlaxoSmithKline Biologicals S.A. Immunogene kombinationen
SI3157916T1 (sl) 2014-06-19 2019-05-31 Ariad Pharmaceuticals, Inc. Heteroarilne spojine za zaviranja kinaze
US10188661B2 (en) 2014-06-27 2019-01-29 Topokine Therapeutics, Inc. Topical dosage regimen
WO2016004202A1 (en) 2014-07-02 2016-01-07 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
EP3169699A4 (de) 2014-07-18 2018-06-20 The University of Washington Krebsimpfstoffzusammensetzungen und verfahren zur verwendung davon
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
US10736966B2 (en) 2014-08-12 2020-08-11 Massachusetts Institute Of Technology Brush-poly (glycoamidoamine)-lipids and uses thereof
US9974599B2 (en) 2014-08-15 2018-05-22 Medtronic Ps Medical, Inc. Multipurpose electrosurgical device
WO2016040369A2 (en) 2014-09-08 2016-03-17 Academia Sinica HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS
SG10201902594QA (en) 2014-09-24 2019-04-29 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
US10905739B2 (en) 2014-09-24 2021-02-02 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
EP3204039B1 (de) 2014-10-10 2022-06-08 The Regents Of The University Of Michigan Nanoemulsionszusammensetzungen zur prävention, unterdrückung oder eliminierung von allergischen und entzündlichen erkrankungen
TN2017000157A1 (en) 2014-10-21 2018-10-19 Ariad Pharma Inc Crystalline forms of 5-chloro-n4-[-2-(dimethylphosphoryl) phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl] pyrimidine-2,4-diamine
US20180015101A1 (en) 2014-10-28 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Compositions and methods for antigen-specific tolerance
AR102547A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y su uso
AR102548A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y uso
EP3461904A1 (de) 2014-11-10 2019-04-03 ModernaTX, Inc. Alternative nukleinsäuremoleküle mit reduziertem uracilgehalt und verwendungen davon
US10253045B2 (en) 2014-11-26 2019-04-09 Kala Pharmaceuticals, Inc. Crystalline forms of a therapeutic compound and uses thereof
EP3230272B1 (de) 2014-12-10 2020-08-19 Kala Pharmaceuticals, Inc. 1-amino-triazol(1,5-a)pyridin-substituiertes harnstoffderivat und verwendungen davon
AU2015369707B2 (en) 2014-12-23 2020-07-23 Sloan-Kettering Institute For Cancer Research Polymorph of granaticin B
WO2016105528A2 (en) 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
EP3248005B1 (de) 2015-01-24 2020-12-09 Academia Sinica Neuartige glycankonjugate und verfahren zur verwendung davon
US10188456B2 (en) 2015-02-18 2019-01-29 Medtronic Xomed, Inc. Electrode assembly for RF energy enabled tissue debridement device
US10376302B2 (en) 2015-02-18 2019-08-13 Medtronic Xomed, Inc. Rotating electrical connector for RF energy enabled tissue debridement device
WO2016134156A1 (en) 2015-02-18 2016-08-25 Medtronic Xomed, Inc. Rf energy enabled tissue debridement device
EP4226937A3 (de) 2015-03-05 2023-09-27 Northwestern University Nichtneuroinvasive viren und verwendungen davon
MX2017011834A (es) 2015-03-20 2018-04-11 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
WO2016154010A1 (en) 2015-03-20 2016-09-29 Makidon Paul Immunogenic compositions for use in vaccination against bordetella
AU2016235054B2 (en) 2015-03-24 2020-07-16 Kaleo, Inc. Devices and methods for delivering a lyophilized medicament
CA2978518C (en) 2015-03-27 2023-11-21 Nathanael S. Gray Inhibitors of cyclin-dependent kinases
MX2017012665A (es) 2015-03-30 2018-04-24 Greenlight Biosciences Inc Produccion de acido ribonucleico libre de celulas.
US10570104B2 (en) 2015-04-27 2020-02-25 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
EP3307728A4 (de) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. Kombinationstherapie von transkriptionshemmern und kinasehemmern
US10201618B2 (en) 2015-06-19 2019-02-12 Massachusetts Institute Of Technology Alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
JP6830067B2 (ja) 2015-06-30 2021-02-17 カレオ,インコーポレイテッド プレフィルドシリンジ内の医薬を投与する自動注射器
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US11389227B2 (en) 2015-08-20 2022-07-19 Medtronic Advanced Energy Llc Electrosurgical device with multivariate control
US11051875B2 (en) 2015-08-24 2021-07-06 Medtronic Advanced Energy Llc Multipurpose electrosurgical device
EP4019515A1 (de) 2015-09-09 2022-06-29 Dana-Farber Cancer Institute, Inc. Hemmer von cyclinabhängigen kinasen
EP3347372A4 (de) 2015-09-10 2019-09-04 Aileron Therapeutics, Inc. Peptidomimetische makrocyclen als modulatoren von mcl-1
KR20180051576A (ko) 2015-09-11 2018-05-16 다나-파버 캔서 인스티튜트 인크. 아세트아미드 티에노트리아졸로디아제핀 및 그의 용도
RU2750164C2 (ru) 2015-09-11 2021-06-22 Дана-Фарбер Кэнсер Инститьют, Инк. Цианотиенотриазолодиазепины и пути их применения
US20180256750A1 (en) 2015-09-17 2018-09-13 Moderna Therapeutics, Inc. Polynucleotides containing a stabilizing tail region
AU2016324310B2 (en) 2015-09-17 2021-04-08 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
WO2017059389A1 (en) 2015-10-01 2017-04-06 Kythera Biopharmaceuticals, Inc. Compositions comprising a statin for use in methods of adipolysis
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
WO2017091673A2 (en) 2015-11-25 2017-06-01 Dana-Farber Cancer Institute, Inc. Bivalent bromodomain inhibtors and uses thereof
US10596248B2 (en) 2015-12-09 2020-03-24 Jingang Medicine (Australia) Pty Ltd Immunomodulating composition for treatment
US10716612B2 (en) 2015-12-18 2020-07-21 Medtronic Advanced Energy Llc Electrosurgical device with multiple monopolar electrode assembly
PL3394030T3 (pl) 2015-12-22 2022-04-11 Modernatx, Inc. Związki i kompozycje do wewnątrzkomórkowego dostarczania środków
TW201808978A (zh) 2016-03-08 2018-03-16 中央研究院 N-聚醣及其陣列之模組化合成方法
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
EP4293104A3 (de) 2016-04-06 2024-04-24 Greenlight Biosciences, Inc. Zellfreie herstellung von ribonukleinsäure
US11173207B2 (en) 2016-05-19 2021-11-16 The Regents Of The University Of Michigan Adjuvant compositions
SG10201913650WA (en) 2016-06-03 2020-03-30 Sanofi Pasteur Inc Modification of engineered influenza hemagglutinin polypeptides
US10105449B2 (en) 2016-06-07 2018-10-23 Massachusetts Institute Of Technology Drug delivery polymers and uses thereof
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AU2017286606A1 (en) 2016-06-14 2018-12-13 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
WO2018018082A1 (en) 2016-07-26 2018-02-01 The Australian National University Immunostimulatory compositions and uses therefor
CN109862908B (zh) 2016-08-05 2023-05-02 圣诺菲·帕斯图尔公司 多价肺炎球菌多糖-蛋白质缀合物组合物
MX2019001341A (es) 2016-08-05 2019-07-04 Sanofi Pasteur Inc Composicion de conjugado de polisacarido neumococico multivalente-proteina.
JP7213549B2 (ja) 2016-08-22 2023-01-27 シーエイチオー ファーマ インコーポレイテッド 抗体、結合性断片、および使用の方法
WO2018089540A1 (en) 2016-11-08 2018-05-17 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
WO2018096396A1 (en) 2016-11-22 2018-05-31 University Of Oslo Albumin variants and uses thereof
WO2018106738A1 (en) 2016-12-05 2018-06-14 Massachusetts Institute Of Technology Brush-arm star polymers, conjugates and particles, and uses thereof
AU2017379094B2 (en) 2016-12-23 2023-08-24 Kaleo, Inc. Medicament delivery device and methods for delivering drugs to infants and children
US10332623B2 (en) 2017-01-17 2019-06-25 Kaleo, Inc. Medicament delivery devices with wireless connectivity and event detection
CA3055653A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Lipid nanoparticle formulation
HUE060693T2 (hu) 2017-03-15 2023-04-28 Modernatx Inc Vegyület és készítmények terápiás szerek intracelluláris bejuttatására
US11555031B2 (en) 2017-03-20 2023-01-17 The Broad Institute, Inc. Compounds and methods for regulating insulin secretion
JP7157075B2 (ja) 2017-04-05 2022-10-19 ザ ブロード インスティテュート,インコーポレーテッド グリコーゲンシンターゼキナーゼ3(gsk3)インヒビターとしての三環式化合物およびそれらの使用
US20210198200A1 (en) 2017-06-14 2021-07-01 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
US11612647B2 (en) 2017-06-23 2023-03-28 University Of Maryland, Baltimore Immunogenic compositions
BR112019027300B1 (pt) * 2017-06-29 2023-05-02 Regeneron Pharmaceuticals, Inc Método para preparar um produto farmacêutico e produto farmacêutico
WO2019013789A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc ANTIMICROBIAL COMPOUNDS
WO2019013790A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc ANTIMICROBIAL COMPOUNDS AND USES THEREOF
JP7275111B2 (ja) 2017-08-31 2023-05-17 モデルナティエックス インコーポレイテッド 脂質ナノ粒子の生成方法
US20220118076A1 (en) 2017-09-07 2022-04-21 University Of Oslo Vaccine molecules
EP3678699A1 (de) 2017-09-07 2020-07-15 University Of Oslo Impfstoffmoleküle
AU2018347405B2 (en) 2017-10-11 2022-02-03 Greenlight Biosciences, Inc. Methods and compositions for nucleoside triphosphate and ribonucleic acid production
US11730802B2 (en) 2017-11-03 2023-08-22 Takeda Vaccines, Inc. Zika vaccines and immunogenic compositions, and methods of using the same
US11786477B2 (en) 2017-12-01 2023-10-17 North Carolina State University Fibrin particles and methods of making the same
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
US11929160B2 (en) 2018-07-16 2024-03-12 Kaleo, Inc. Medicament delivery devices with wireless connectivity and compliance detection
CA3113436A1 (en) 2018-09-19 2020-03-26 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
WO2020061457A1 (en) 2018-09-20 2020-03-26 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
CN113924292A (zh) 2019-01-16 2022-01-11 库扎环球有限责任公司 抗微生物化合物和方法
CN113825748A (zh) 2019-01-16 2021-12-21 库扎环球有限责任公司 抗微生物化合物和方法
CA3128215A1 (en) 2019-01-31 2020-08-06 Modernatx, Inc. Methods of preparing lipid nanoparticles
WO2020168466A1 (en) 2019-02-19 2020-08-27 Stemirna Therapeutics Co., Ltd. Modified nucleoside and synthetic methods thereof
WO2021021729A1 (en) 2019-07-31 2021-02-04 Sanofi Pasteur Inc. Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same
EP4003296A1 (de) 2019-07-31 2022-06-01 ModernaTX, Inc. Zusammensetzungen und verfahren zur abgabe von rna-interferenzmitteln an immunzellen
CA3145580A1 (en) 2019-08-09 2021-02-18 Kaleo, Inc. Devices and methods for delivery of substances within a prefilled syringe
AU2020384885A1 (en) 2019-11-13 2022-06-09 Curza Global, Llc Antimicrobial compounds and methods
EP4077994A4 (de) 2019-12-19 2024-01-03 Saint Gobain Performance Plastics Corp Ventilteller, anordnung sowie verfahren zur montage und verwendung davon
CA3169669A1 (en) 2020-01-31 2021-08-05 Modernatx, Inc. Methods of preparing lipid nanoparticles
WO2021173965A1 (en) 2020-02-28 2021-09-02 Massachusetts Institute Of Technology Identification of variable influenza residues and uses thereof
WO2021195089A1 (en) 2020-03-23 2021-09-30 Sorrento Therapeutics, Inc. Fc-coronavirus antigen fusion proteins, and nucleic acids, vectors, compositions and methods of use thereof
WO2021231729A1 (en) 2020-05-13 2021-11-18 Sanofi Adjuvanted stabilized stem hemagglutinin nanoparticles and methods of using the same to induce broadly neutralizing antibodies against influenza
WO2022092294A1 (ja) 2020-10-30 2022-05-05 学校法人慶應義塾 サルコペニア関連疾患等の新規治療および予防
JPWO2022092295A1 (de) 2020-10-30 2022-05-05
AR124267A1 (es) 2020-12-09 2023-03-01 Genentech Inc Métodos de alto rendimiento para preparar nanopartículas lipídicas y sus usos
EP4305088A1 (de) 2021-03-09 2024-01-17 Massachusetts Institute of Technology Verzweigte poly(aminoester) zur verabreichung von nukleinsäuren
TW202313065A (zh) 2021-05-28 2023-04-01 美商季卡尼醫療公司 用於治療遺傳疾病之化合物
WO2023018817A1 (en) 2021-08-11 2023-02-16 Sanofi Pasteur Inc. Truncated influenza neuraminidase and methods of using the same
WO2023039108A1 (en) 2021-09-08 2023-03-16 Affinivax, Inc. Coronavirus vaccine
CA3233926A1 (en) 2021-10-08 2023-04-13 Sanofi Pasteur Inc. Multivalent influenza vaccines
WO2023081798A1 (en) 2021-11-05 2023-05-11 Sanofi Pasteur Inc. Multivalent influenza vaccines comprising recombinant hemagglutinin and neuraminidase and methods of using the same
WO2023079113A1 (en) 2021-11-05 2023-05-11 Sanofi Hybrid multivalent influenza vaccines comprising hemagglutinin and neuraminidase and methods of using the same
WO2023114889A1 (en) 2021-12-16 2023-06-22 Modernatx, Inc. Processes for preparing lipid nanoparticles
WO2023129963A1 (en) 2021-12-30 2023-07-06 Curza Global, Llc Antimicrobial compounds and methods
WO2023144206A1 (en) 2022-01-27 2023-08-03 Sanofi Pasteur Modified vero cells and methods of using the same for virus production
WO2023177579A1 (en) 2022-03-14 2023-09-21 Sanofi Pasteur Inc. Machine-learning techniques in protein design for vaccine generation
WO2023193002A1 (en) 2022-04-01 2023-10-05 Modernatx, Inc. Cross mixers for lipid nanoparticle production, and methods of operating the same
WO2023235380A1 (en) 2022-06-01 2023-12-07 Zikani Therapeutics, Inc. Macrolides for treating genetic diseases
WO2023250513A1 (en) 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation
WO2024026487A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising phospholipid derivatives and related uses
WO2024026475A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses
WO2024026482A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising surface lipid derivatives and related uses
WO2024049994A1 (en) 2022-09-01 2024-03-07 Zikani Therapeutics, Inc. Treatment of familial adenomatous polyopsis using a 13-membered macrolide

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2704543A (en) * 1955-03-22 Hypo jet injector
US1742497A (en) * 1925-01-15 1930-01-07 Fairleigh S Dickinson Hypodermic syringe
US2025219A (en) * 1927-03-25 1935-12-24 Arthur E Smith Hypodermic syringe
US2101140A (en) * 1935-03-23 1937-12-07 Raymond W Hege Automatic injecting syringe device
US2380534A (en) * 1941-04-26 1945-07-31 Marshall L Lockhart Hypodermic injector
US2322245A (en) * 1943-05-20 1943-06-22 Marshall L Lockhart Ypodermic injector and method of use thereof
US2547009A (en) * 1944-10-17 1951-04-03 William D Huston Telemetering system
US2605763A (en) * 1948-01-31 1952-08-05 Becton Dickinson Co Injection device
US2680439A (en) * 1948-09-08 1954-06-08 Arnold K Sutermeister High-pressure injection device
US2688968A (en) * 1949-05-14 1954-09-14 Scherer Corp R P Hypo jet ampoule
US2737946A (en) * 1949-09-01 1956-03-13 Jr George N Hein Hypodermic injection apparatus
US2653602A (en) * 1950-06-17 1953-09-29 Becton Dickinson Co Injection device
US2754818A (en) * 1950-06-24 1956-07-17 Scherer Corp R P Hypo jet injector
US2764977A (en) * 1951-05-24 1956-10-02 Becton Dickinson Co Hypodermic injection mechanism
US2821193A (en) * 1952-07-22 1958-01-28 Geoffrey W Walker Multiple injection inoculator instrument
US2714887A (en) * 1954-04-26 1955-08-09 Scherer Corp R P Intradermal injector
US2816543A (en) * 1954-07-12 1957-12-17 Scherer Corp R P Hypodermic injector
US2821981A (en) * 1954-07-21 1958-02-04 Geoffrey W Walker Multi-shot inoculant injector instrument with adjustable ejection pressure control
US2902995A (en) * 1954-10-11 1959-09-08 Abbott Lab Hypodermic syringe and needle hub structure
US3110309A (en) * 1960-08-15 1963-11-12 Brunswick Corp Plastic cartridge needle assembly
NL268186A (de) * 1960-08-15
US3167071A (en) * 1961-07-17 1965-01-26 Scherer Corp R P Apparatus for administering intradermal injections
US3179107A (en) * 1962-11-21 1965-04-20 Becton Dickinson Co Hypodermic unit with an improved mounting for a replaceable needle assembly
BE643768A (de) * 1963-02-18
US3292621A (en) * 1963-07-19 1966-12-20 Oscar H Banker Jet type protable inoculator
US3292622A (en) * 1964-09-21 1966-12-20 Oscar H Banker Power operated inoculator
US3424154A (en) * 1965-11-08 1969-01-28 Charles W Kinsley Injection system
US3515130A (en) * 1966-09-21 1970-06-02 Yuryo Kikakuhin Kenkyusho Kk Jet-injection hypodermic device
US3490451A (en) * 1967-11-13 1970-01-20 Scherer Corp R P Hypodermic jet injector nozzle
US3561443A (en) * 1968-09-06 1971-02-09 Oscar H Banker Inoculator gun with delayed action
US3557784A (en) * 1968-12-24 1971-01-26 Walter A Shields Syringe
US3688765A (en) * 1969-10-03 1972-09-05 Jack S Gasaway Hypodermic injection device
US3695266A (en) * 1970-06-18 1972-10-03 Maurice G Lussier Needleless sequential dosing syringe
US3714943A (en) * 1970-12-01 1973-02-06 H Yanof Medicament injectors
US3855380A (en) * 1971-06-09 1974-12-17 Wheeling Stamping Co Method for manufacturing unitary, seamless, collapsible thermoplastic tubes
US3853125A (en) * 1971-10-05 1974-12-10 W Clark Disposable needleless injector
US3802430A (en) * 1972-06-30 1974-04-09 L Arnold Disposable pyrotechnically powered injector
US3945383A (en) * 1974-08-08 1976-03-23 Smithkline Corporation Unit dose ampul for jet injector
US3945379A (en) * 1974-08-08 1976-03-23 Smithkline Corporation Injection device
JPS51130094A (en) * 1975-05-08 1976-11-12 Asahi Chemical Ind Twoostage pressure injector
US4124024A (en) * 1977-03-03 1978-11-07 Schwebel Paul R Disposable hypodermic injection ampule
US4284459A (en) * 1978-07-03 1981-08-18 The Kendall Company Method for making a molded catheter
BR7806153A (pt) * 1978-09-19 1980-04-01 Halen Elliot Brasil Ind Com Eq Injetor hipodermico a pressao para vacinacao intermitente
US4252159A (en) * 1979-04-02 1981-02-24 Maki Eugene B Dosage device
US4329988A (en) * 1980-12-23 1982-05-18 Survival Technology, Inc. Plural injection assembly
US4421508A (en) * 1981-02-24 1983-12-20 Cohen Edgar C Vacuum-compression injector
US4403989A (en) * 1981-09-14 1983-09-13 Syntex (U.S.A.) Inc. Injection device
US4516967A (en) * 1981-12-21 1985-05-14 Kopfer Rudolph J Wet-dry compartmental syringe
CA1178503A (en) * 1982-05-27 1984-11-27 Health-Mor Personal Care Corporation Needleless hypodermic injector
US4475905A (en) * 1982-09-30 1984-10-09 Himmelstrup Anders B Injection device
DE3372172D1 (en) * 1982-10-27 1987-07-30 Duphar Int Res Hypodermic syringe having a telescopic assembly between cartridge and medicament holder
US4507113A (en) * 1982-11-22 1985-03-26 Derata Corporation Hypodermic jet injector
HU186718B (en) * 1983-06-29 1985-09-30 Radelkis Electrokemiai Automatic needleless syringe operable by cardox cylinder suitable for personal giving injection e.g. insulin
US4581014A (en) * 1984-04-03 1986-04-08 Ivac Corporation Fluid infusion system
BR8404286A (pt) * 1984-08-28 1986-04-08 Sergio Landau Seringa hipodermica a pressao
US4759756A (en) * 1984-09-14 1988-07-26 Baxter Travenol Laboratories, Inc. Reconstitution device
US4596556A (en) * 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4680027A (en) * 1985-12-12 1987-07-14 Injet Medical Products, Inc. Needleless hypodermic injection device
EP0250022A3 (de) * 1986-06-17 1988-06-22 SICIM SpA Tragbarer hypodermatischer Injektor
US4717384A (en) * 1987-01-15 1988-01-05 Pneu Dart Inc. Pneumatic hypodermic syringe pole
US4722728A (en) * 1987-01-23 1988-02-02 Patents Unlimited, Ltd. Needleless hypodermic injector
US4886495A (en) * 1987-07-08 1989-12-12 Duoject Medical Systems Inc. Vial-based prefilled syringe system for one or two component medicaments
EP0294272B1 (de) * 1987-05-26 1992-03-18 Claude Accaries Nadelloser Injektor, insbesondere für die zahnmedizinische Anwendung
US5080648A (en) * 1987-06-08 1992-01-14 Antonio Nicholas F D Hypodermic fluid dispenser
US5569190A (en) * 1987-06-08 1996-10-29 D'antonio; Nicholas F. Hypodermic fluid dispenser
US4790824A (en) * 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4940460A (en) * 1987-06-19 1990-07-10 Bioject, Inc. Patient-fillable and non-invasive hypodermic injection device assembly
US4941880A (en) * 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
AU628029B2 (en) * 1987-11-16 1992-09-10 Sy-Quest International Limited Improved apparatus for hypodermic injection of liquids
US5073165A (en) * 1988-02-05 1991-12-17 Marpam International, Inc. Hypodermic jet injector and cartridge therefor
US4874367A (en) * 1988-02-05 1989-10-17 Marpam International, Inc. Hypodermic jet injector and cartridge therefor
FR2627698A1 (fr) * 1988-02-26 1989-09-01 Vci Corp Cartouche d'injection de medicament a utiliser dans un injecteur a vide-compression
US4913699A (en) * 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
BR8801952A (pt) * 1988-04-22 1989-11-14 Sergio Landau Capsula descartavel,nao re-utilizavel,contendo dose individual de vacina a ser injetada hipodermicamente,sem agulha,com aparelho injetor a pressao
US5024656A (en) * 1988-08-30 1991-06-18 Injet Medical Products, Inc. Gas-pressure-regulated needleless injection system
US4944726A (en) * 1988-11-03 1990-07-31 Applied Vascular Devices Device for power injection of fluids
FR2648352A1 (fr) * 1989-06-16 1990-12-21 Merieux Inst Perfectionnement aux appareils d'injection sans aiguille a doses contenues dans des cartouches et cartouches a utiliser dans un tel appareil
US4944736A (en) * 1989-07-05 1990-07-31 Holtz Leonard J Adaptor cap for centering, sealing, and holding a syringe to a bottle
CA1325149C (en) * 1989-08-31 1993-12-14 Gavin Mcgregor Variable intensity remote controlled needleless injector
US4997430A (en) * 1989-09-06 1991-03-05 Npbi Nederlands Produktielaboratorium Voor Bloedtransfusieapparatuur En Infusievloeistoffen B.V. Method of and apparatus for administering medicament to a patient
US5312335A (en) * 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) * 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5078690A (en) * 1990-01-11 1992-01-07 Accumed Systems, Incorporated High pressure syringe
US5062830A (en) * 1990-04-04 1991-11-05 Derata Corporation Dry disposable nozzle assembly for medical jet injector
GB9118204D0 (en) * 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
US5312577A (en) * 1992-05-08 1994-05-17 Bioject Inc. Method for manufacturing an ampule
US5383851A (en) * 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5472022A (en) * 1993-11-02 1995-12-05 Genentech, Inc. Injection pen solution transfer apparatus and method
US5505697A (en) * 1994-01-14 1996-04-09 Mckinnon, Jr.; Charles N. Electrically powered jet injector
US5466220A (en) * 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device

Also Published As

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CA2290777C (en) 2006-07-11
CA2290777A1 (en) 1998-11-26
EP1011763B1 (de) 2003-12-10
DE69820460D1 (de) 2004-01-22
EP1011763A1 (de) 2000-06-28
EP1011763A4 (de) 2001-03-21
US5993412A (en) 1999-11-30
AU7254998A (en) 1998-12-11
GB9927246D0 (en) 2000-01-12
WO1998052632A1 (en) 1998-11-26

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