DE69814917D1 - Transdermale therapeutische vorrichtung mit capsaicin und seinen analogen - Google Patents

Transdermale therapeutische vorrichtung mit capsaicin und seinen analogen

Info

Publication number
DE69814917D1
DE69814917D1 DE69814917T DE69814917T DE69814917D1 DE 69814917 D1 DE69814917 D1 DE 69814917D1 DE 69814917 T DE69814917 T DE 69814917T DE 69814917 T DE69814917 T DE 69814917T DE 69814917 D1 DE69814917 D1 DE 69814917D1
Authority
DE
Germany
Prior art keywords
capsaicin
analogs
therapeutic device
transdermal therapeutic
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69814917T
Other languages
English (en)
Other versions
DE69814917T2 (de
Inventor
R Robbins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of DE69814917D1 publication Critical patent/DE69814917D1/de
Application granted granted Critical
Publication of DE69814917T2 publication Critical patent/DE69814917T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245Amino benzoic acid types, e.g. procaine, novocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
DE69814917T 1997-12-15 1998-12-08 Transdermale therapeutische vorrichtung mit capsaicin und seinen analogen Expired - Lifetime DE69814917T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US990633 1997-12-15
US08/990,633 US6239180B1 (en) 1995-11-08 1997-12-15 Transdermal therapeutic device and method with capsaicin and capsaicin analogs
PCT/US1998/025794 WO1999030560A1 (en) 1997-12-15 1998-12-08 Transdermal therapeutic device and method with capsaicin and capsaicin analogs

Publications (2)

Publication Number Publication Date
DE69814917D1 true DE69814917D1 (de) 2003-06-26
DE69814917T2 DE69814917T2 (de) 2004-02-12

Family

ID=25536360

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69836352T Expired - Lifetime DE69836352T2 (de) 1997-12-15 1998-12-08 Transdermales therapeutisches Pflaster mit Capsaicin und seinen Analogen
DE69814917T Expired - Lifetime DE69814917T2 (de) 1997-12-15 1998-12-08 Transdermale therapeutische vorrichtung mit capsaicin und seinen analogen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69836352T Expired - Lifetime DE69836352T2 (de) 1997-12-15 1998-12-08 Transdermales therapeutisches Pflaster mit Capsaicin und seinen Analogen

Country Status (11)

Country Link
US (2) US6239180B1 (de)
EP (2) EP1039802B1 (de)
AT (2) ATE344023T1 (de)
CA (1) CA2314326C (de)
CY (1) CY1107582T1 (de)
DE (2) DE69836352T2 (de)
DK (2) DK1039802T3 (de)
ES (2) ES2272827T3 (de)
HK (1) HK1030853A1 (de)
PT (1) PT1039802E (de)
WO (1) WO1999030560A1 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6239180B1 (en) * 1995-11-08 2001-05-29 The Regents Of The University Of California Transdermal therapeutic device and method with capsaicin and capsaicin analogs
US6383511B1 (en) * 1999-10-25 2002-05-07 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
GB2355934B (en) * 1999-11-05 2003-11-05 Lohmann Gmbh & Co Kg Wound dressing
AUPQ622600A0 (en) * 2000-03-15 2000-04-06 Unisearch Limited Treatment and/or prevention of ocular pain
DE10056009A1 (de) * 2000-11-11 2002-05-16 Beiersdorf Ag Hautfreundliches Wirkstoffpflaster zur transdermalen Verabreichung hyperämisierender Wirkstoffe
US8110217B2 (en) * 2001-08-13 2012-02-07 University Of Pittsburgh Sphingomyelin liposomes for the treatment of hyperactive bladder disorders
AU2002323151A1 (en) * 2001-08-13 2003-03-03 University Of Pittsburgh Application of lipid vehicles and use for drug delivery
EP1450824A4 (de) * 2001-11-02 2005-09-28 Elan Corp Plc Pharmazeutische zusammensetzung
DK1539124T3 (en) 2002-09-05 2018-10-08 Vanderbilt Royalty Sub L P : COMPOSITIONS AND KITS FOR REMOVAL OF BODY SURFACES
WO2004026262A2 (en) * 2002-09-23 2004-04-01 Verion, Inc. Abuse-resistant pharmaceutical compositions
US7687080B2 (en) * 2002-11-25 2010-03-30 Taraxos Inc. Treatment of neuropathy
EP1605956B1 (de) 2002-12-18 2015-11-11 Centrexion Therapeutics Corporation Verabreichung von capsaicinoiden zur behandlung von arthrose
US20050058734A1 (en) * 2002-12-18 2005-03-17 Algorx Administration of capsaicinoids
US7235270B2 (en) 2003-03-10 2007-06-26 Mayeux Jerry V Pain balm
JP2006522815A (ja) * 2003-04-08 2006-10-05 アルゴルクス ファーマスーティカルズ,インク 合成カプサイシンの製造および精製
EP2907503A1 (de) 2003-04-10 2015-08-19 Neurogesx, Inc. Verfahren und Zusammensetzungen zur Verabreichung von TRPV1-Agonisten
EP1613297B1 (de) * 2003-04-14 2007-06-06 LTS Lohmann Therapie-Systeme AG Therapeutisches pflaster mit capsaicin-haltiger polysiloxan-matrix
DE102004009904A1 (de) * 2004-02-26 2005-09-22 Grünenthal GmbH Kit aus einem gegebenenfalls wirkstoffhaltigen Pflaster und einem Hautirritationen verhindernden Mittel
WO2005117981A1 (en) * 2004-06-02 2005-12-15 Sri International Formulations comprising a capsaicinoid a local anesthetic and/or an antipruritic agent for the treatment of pain
US7704522B2 (en) * 2004-09-08 2010-04-27 Clyde Morgan Topical medicament
JP2008521815A (ja) * 2004-11-24 2008-06-26 アルゴルクス ファーマスーティカルズ,インク カプシノイドゲル製剤及びその使用
JP2006206471A (ja) * 2005-01-26 2006-08-10 Nitto Denko Corp テープ製剤
WO2006089012A2 (en) * 2005-02-14 2006-08-24 Neurogesx, Inc. Device for delivery of trpv1 agonists
WO2006099541A2 (en) * 2005-03-15 2006-09-21 Richard Daniel Carliss Therapeutic wound care product
EP1865933B1 (de) * 2005-03-30 2015-11-04 Vanderbilt Royalty Sub L.P. Capsaicin-pflaster mit geringer konzentration und verfahren zur behandlung von neuropathischem schmerz
ES2353399T3 (es) * 2005-04-01 2011-03-01 Neurogesx, Inc. Aceites de capsaicinoides y métodos para obtenerlos y usarlos.
US7282224B1 (en) 2006-06-09 2007-10-16 Guthy-Renker Corporation Pain relief composition
US7943666B2 (en) * 2006-07-24 2011-05-17 Trinity Laboratories, Inc. Esters of capsaicin for treating pain
US7645767B2 (en) * 2006-08-31 2010-01-12 Trinity Laboratories, Inc. Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy
US20080107747A1 (en) * 2006-10-23 2008-05-08 Roederer Joy E Pain relief composition
EP2276420B1 (de) 2008-04-04 2021-10-06 Journey1, Inc. Vorrichtung zur behandlung eines auges mit einem epithel mit einem defekt
US8987328B2 (en) * 2008-10-30 2015-03-24 Trinity Laboratories, Inc. Esters of capsaicinoids as dietary supplements
US20130066283A1 (en) 2009-10-23 2013-03-14 Nexisvision, Inc. Corneal Denervation for Treatment of Ocular Pain
EP2490620A4 (de) 2009-10-23 2017-03-22 Forsight Labs, Llc Biegsamer therapeutischer schild für sicht und schmerzen
US8591025B1 (en) 2012-09-11 2013-11-26 Nexisvision, Inc. Eye covering and refractive correction methods for LASIK and other applications
KR20130107321A (ko) 2010-10-25 2013-10-01 넥시스비젼, 인코포레이티드 시력용 눈 보호막을 인식하기 위한 방법 및 장치
JP2014514613A (ja) 2011-04-28 2014-06-19 ネクシスビジョン, インコーポレイテッド 涙流、快適性、および/または適用性が改善された、眼被覆物および屈折矯正法および装置
JP6228540B2 (ja) 2011-09-09 2017-11-08 ヴィズリ・ヘルス・サイエンスィズ・エルエルシー Trpv1選択的アゴニストを含む疼痛軽減組成物、ならびにその製造および使用
CN104335104B (zh) 2012-04-20 2017-06-09 内希斯视觉股份有限公司 用于屈光矫正的接触透镜
US9465233B2 (en) 2012-04-20 2016-10-11 Nexisvision, Inc. Bimodular contact lenses
EP2852569B1 (de) 2012-05-23 2020-10-14 Cellixbio Private Limited Zusammensetzungen und verfahren zur behandlung von multipler sklerose
CN104603100A (zh) 2012-05-23 2015-05-06 塞利克斯比奥私人有限公司 用于治疗炎症性肠病的组合物和方法
CA2916885A1 (en) 2013-06-26 2014-12-31 Nexisvision, Inc. Contact lenses for refractive correction
US9341864B2 (en) 2013-11-15 2016-05-17 Nexisvision, Inc. Contact lenses having a reinforcing scaffold
WO2015116559A1 (en) 2014-01-29 2015-08-06 Nexisvision, Inc. Multifocal bimodulus contact lenses
BR112016023815A2 (pt) 2014-04-15 2017-08-15 Vizuri Health Sciences Llc composições tópicas para o alívio da dor, produção e uso
WO2016046835A1 (en) 2014-09-26 2016-03-31 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy and neurological disorders
SG11201702554QA (en) 2014-09-29 2017-04-27 Cellix Bio Private Ltd Compositions and methods for the treatment of multiple sclerosis
WO2016067297A1 (en) 2014-10-27 2016-05-06 Cellix Bio Private Limited Salts of valproic acid with piperazine, ethylenediamine, lysine and/or eicosapentaenoic ecid (epa) amine derivatives for the treatment of epilepsy
WO2016098119A1 (en) 2014-10-27 2016-06-23 Cellix Bio Private Limited Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis
JP2017537088A (ja) 2014-12-01 2017-12-14 セリックス バイオ プライヴェート リミテッドCellix Bio Private Limited 多発性硬化症の治療のための組成物及び方法
SG11201706369PA (en) 2015-02-09 2017-09-28 Cellix Bio Private Ltd Compositions and methods for the treatment of mucositis
US10898537B2 (en) 2015-07-31 2021-01-26 Delivra Inc. Transdermal formulations for delivery of capsaicinoids
CN109640965A (zh) 2016-08-11 2019-04-16 塞尔利克斯生物私人有限公司 用于治疗肠易激综合征的组合物和方法
IL265791B (en) 2016-10-04 2022-07-01 Cellix Bio Private Ltd Compositions and methods for treating dry mouth
EP3554494A4 (de) 2016-12-19 2021-02-17 Cellixbio Private Limited Zusammensetzungen und verfahren zur behandlung von entzündungen
EP3658187A1 (de) 2017-07-27 2020-06-03 Allergan, Inc. Prostacyclinrezeptor-agonisten zur reduktion von körperfett
WO2019097318A1 (en) 2017-11-17 2019-05-23 Cellix Bio Private Limited Compositions and methods for the treatment of eye disorders
MX2020004667A (es) 2017-11-17 2022-05-16 Cellix Bio Private Ltd Compuestos, composiciones y metodos para el tratamiento de trastornos oculares y enfermedades cutaneas.
AU2021238637A1 (en) 2020-03-17 2022-11-10 Grünenthal GmbH Repeated topical application of capsaicin patch for treating initial non-responders
BR112022020000A2 (pt) 2020-04-03 2022-11-22 Gruenenthal Gmbh Regime para aplicação tópica repetida de emplastro de capsaicina
RU2755206C1 (ru) 2020-05-20 2021-09-14 Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) Средство пролонгированного анальгетического действия и лекарственный препарат на его основе
US11234947B2 (en) * 2020-06-30 2022-02-01 Imperial College Innovations Limited Treatment of peripheral neuropathy induced by cancer chemotherapy

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486450B1 (en) 1980-07-14 1998-07-28 Joel E Bernstein Method of treating psoriatic skin and composition
US4313958A (en) 1980-10-24 1982-02-02 The Procter & Gamble Company Method of producing analgesia
US4424205A (en) 1982-03-18 1984-01-03 The Procter & Gamble Company Hydroxyphenylacetamides having analgesic and anti-irritant activity
US4536404A (en) 1983-06-16 1985-08-20 Dermatological Enterprises, Ltd. Method and composition for treating post-herpetic neuralgia
US4544668A (en) 1983-07-14 1985-10-01 The Procter & Gamble Company Compounds and compositions useful for producing analgesia
US4544669A (en) 1983-07-14 1985-10-01 The Procter & Gamble Company Compounds and compositions useful for producing analgesia
US4532139A (en) 1983-07-14 1985-07-30 The Procter & Gamble Company Compounds and compositions useful for producing analgesia
US4592912A (en) 1983-10-31 1986-06-03 Harriet Nickolaus Ache and pain relieving and preventing composition
US4681897A (en) 1984-01-16 1987-07-21 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
US4898887A (en) * 1984-12-20 1990-02-06 The Procter & Gamble Company Compounds and compositions having anti-inflammatory and analgesic activity
US4971800A (en) 1988-07-08 1990-11-20 The Regents Of The University Of California Method and compositions for enhancing the cutaneous penetration of pharmacologically active agents
US4939149A (en) 1988-10-24 1990-07-03 The United States Of America As Represented By The Department Of Health And Human Services Resiniferatoxin and analogues thereof to cause sensory afferent C-fiber and thermoregulatory desensitization
US4997853A (en) 1988-12-02 1991-03-05 Galenpharma, Inc. Method and compositions utilizing capsaicin as an external analgesic
CA1338779C (en) 1989-03-17 1996-12-10 Harry Hind Method for treating pain associated with herpes-zoster and post-herpetic neuralgia by topical application of local anesthetics
US5411738A (en) 1989-03-17 1995-05-02 Hind Health Care, Inc. Method for treating nerve injury pain associated with shingles (herpes-zoster and post-herpetic neuralgia) by topical application of lidocaine
AU5744490A (en) 1989-05-15 1990-12-18 Afferon Corporation Composition and method for neural desensitization
US5063060A (en) 1989-12-19 1991-11-05 Cisco Limited Partnership Compositions and method for treating painful, inflammatory or allergic disorders
JP2748199B2 (ja) * 1991-08-27 1998-05-06 泰一郎 岩倉 気管支喘息発作の予防と治療貼付剤
US5260313A (en) 1992-03-12 1993-11-09 National Pain Institute, Inc. Diagnosis and treatment of various neuralgias
US5431914A (en) 1992-04-17 1995-07-11 Adekunle; Michael Method of treating an internal condition by external application of capsaicin without the need for systemic absorption
JP3414423B2 (ja) * 1992-11-27 2003-06-09 積水化学工業株式会社 眠気防止用外用剤及び貼付剤
US5665360A (en) 1993-05-14 1997-09-09 Mann; Richard H. Method of treating peripheral neuropathies of the feet and legs
US5910512A (en) 1994-04-18 1999-06-08 Healthline Laboratories, Inc. Topical analgesic using water soluble capsaicin
DE4414502A1 (de) * 1994-04-26 1995-11-02 Edda Scholten Salbe zur äußerlichen Anwendung bei Schmerzen
US5665378A (en) 1994-09-30 1997-09-09 Davis; Roosevelt Transdermal therapeutic formulation
US5762963A (en) 1995-06-07 1998-06-09 Emory University Method and compositions for controlling oral and pharyngeal pain using capsaicinoids
US5788982A (en) 1995-06-16 1998-08-04 Nadoolman; Wolffe Method and composition for treating oral pain using capsaicin
US6239180B1 (en) * 1995-11-08 2001-05-29 The Regents Of The University Of California Transdermal therapeutic device and method with capsaicin and capsaicin analogs
US5856361A (en) 1996-04-23 1999-01-05 Medical Merchandising, Inc. Pain reliever and method of use
US5854291A (en) 1996-04-23 1998-12-29 Medical Merchandising, Inc. Pain reliever and method of use
US5869533A (en) 1996-04-23 1999-02-09 Holt; Stephen D. Non-irritating capsaicin formulations and applicators therefor
PT998288E (pt) 1997-03-13 2002-11-29 James N Campbell Composicoes contendo capsaicina ou analogos de capsaicina e um anestesico local
AU2466799A (en) 1998-01-22 1999-08-09 Regents Of The University Of California, The Nucleic acid sequences encoding capsaicin receptors
AU3308099A (en) 1998-02-24 1999-09-15 Wake Forest University Method for the treatment of pain, including chronic and female specific pain

Also Published As

Publication number Publication date
ATE240723T1 (de) 2003-06-15
US20010002406A1 (en) 2001-05-31
US6239180B1 (en) 2001-05-29
DK1316308T3 (da) 2007-03-05
EP1039802A1 (de) 2000-10-04
DE69836352D1 (de) 2006-12-14
ES2272827T3 (es) 2007-05-01
CA2314326A1 (en) 1999-06-24
EP1316308A1 (de) 2003-06-04
DE69836352T2 (de) 2007-05-24
ES2196640T3 (es) 2003-12-16
EP1039802A4 (de) 2002-01-23
DE69814917T2 (de) 2004-02-12
CY1107582T1 (el) 2013-03-13
CA2314326C (en) 2008-11-18
WO1999030560A1 (en) 1999-06-24
DK1039802T3 (da) 2003-09-22
ATE344023T1 (de) 2006-11-15
EP1039802B1 (de) 2003-05-21
PT1039802E (pt) 2003-10-31
EP1316308B1 (de) 2006-11-02
HK1030853A1 (en) 2001-05-25

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