DE69814885D1 - Verfahren zur herstellung von arzneiformen mit kontrollierter wirkstoffabgabe auf polymerbasis - Google Patents

Verfahren zur herstellung von arzneiformen mit kontrollierter wirkstoffabgabe auf polymerbasis

Info

Publication number
DE69814885D1
DE69814885D1 DE69814885T DE69814885T DE69814885D1 DE 69814885 D1 DE69814885 D1 DE 69814885D1 DE 69814885 T DE69814885 T DE 69814885T DE 69814885 T DE69814885 T DE 69814885T DE 69814885 D1 DE69814885 D1 DE 69814885D1
Authority
DE
Germany
Prior art keywords
polymer
active agent
solvent
production
active substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69814885T
Other languages
English (en)
Other versions
DE69814885T2 (de
Inventor
A Tracy
D Herberger
A Burke
F Herbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Inc
Alkermes Controlled Therapeutics Inc
Original Assignee
Alkermes Inc
Alkermes Controlled Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc, Alkermes Controlled Therapeutics Inc filed Critical Alkermes Inc
Application granted granted Critical
Publication of DE69814885D1 publication Critical patent/DE69814885D1/de
Publication of DE69814885T2 publication Critical patent/DE69814885T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
DE69814885T 1997-09-24 1998-09-21 Verfahren zur herstellung von arzneiformen mit kontrollierter wirkstoffabgabe auf polymerbasis Expired - Fee Related DE69814885T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/935,452 US5989463A (en) 1997-09-24 1997-09-24 Methods for fabricating polymer-based controlled release devices
US935452 1997-09-24
PCT/US1998/019603 WO1999015154A1 (en) 1997-09-24 1998-09-21 Methods for fabricating polymer-based controlled release preparations

Publications (2)

Publication Number Publication Date
DE69814885D1 true DE69814885D1 (de) 2003-06-26
DE69814885T2 DE69814885T2 (de) 2004-05-19

Family

ID=25467166

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69814885T Expired - Fee Related DE69814885T2 (de) 1997-09-24 1998-09-21 Verfahren zur herstellung von arzneiformen mit kontrollierter wirkstoffabgabe auf polymerbasis

Country Status (11)

Country Link
US (2) US5989463A (de)
EP (1) EP1017367B1 (de)
JP (1) JP2001517615A (de)
AT (1) ATE240718T1 (de)
AU (1) AU746337B2 (de)
CA (1) CA2304662C (de)
DE (1) DE69814885T2 (de)
DK (1) DK1017367T3 (de)
ES (1) ES2200375T3 (de)
PT (1) PT1017367E (de)
WO (1) WO1999015154A1 (de)

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