DE69813560D1 - Kristallmodifikation von 1-(2,6-difluorbenzyl)-1h-1,2,3-triazol-4-carbonsäureamid und seine verwendung als antiepileptikum - Google Patents

Kristallmodifikation von 1-(2,6-difluorbenzyl)-1h-1,2,3-triazol-4-carbonsäureamid und seine verwendung als antiepileptikum

Info

Publication number
DE69813560D1
DE69813560D1 DE69813560T DE69813560T DE69813560D1 DE 69813560 D1 DE69813560 D1 DE 69813560D1 DE 69813560 T DE69813560 T DE 69813560T DE 69813560 T DE69813560 T DE 69813560T DE 69813560 D1 DE69813560 D1 DE 69813560D1
Authority
DE
Germany
Prior art keywords
pileptic
difluorbenzyl
triazol
acid amide
carbonic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69813560T
Other languages
English (en)
Other versions
DE69813560T2 (de
Inventor
Robert Portmann
Christoph Hofmeier
Andreas Burkhard
Walter Scherrer
Martin Szelagiewicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69813560(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of DE69813560D1 publication Critical patent/DE69813560D1/de
Publication of DE69813560T2 publication Critical patent/DE69813560T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
DE69813560T 1997-06-10 1998-06-08 Kristallmodifikation von 1-(2,6-difluorbenzyl)-1h-1,2,3-triazol-4-carbonsäureamid und seine verwendung als antiepileptikum Expired - Lifetime DE69813560T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10
CH140497 1997-06-10
PCT/EP1998/003428 WO1998056773A1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic

Publications (2)

Publication Number Publication Date
DE69813560D1 true DE69813560D1 (de) 2003-05-22
DE69813560T2 DE69813560T2 (de) 2004-02-05

Family

ID=4209650

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69811500T Expired - Lifetime DE69811500T2 (de) 1997-06-10 1998-06-08 Kristallmodifikation von 1-(2,6-difluorbenzyl)-1h-1,2,3-triazol-4-carbonsäureamid und seine verwendung als antiepileptikum
DE69813560T Expired - Lifetime DE69813560T2 (de) 1997-06-10 1998-06-08 Kristallmodifikation von 1-(2,6-difluorbenzyl)-1h-1,2,3-triazol-4-carbonsäureamid und seine verwendung als antiepileptikum
DE122007000051C Active DE122007000051I2 (de) 1997-06-10 1998-06-08 Kristallmodifikation von 1-(2,6-difluorbenzyl) -1h-1,2,3-triazol-4-carbonsäureamid und seine verwendung als antiepileptikum

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69811500T Expired - Lifetime DE69811500T2 (de) 1997-06-10 1998-06-08 Kristallmodifikation von 1-(2,6-difluorbenzyl)-1h-1,2,3-triazol-4-carbonsäureamid und seine verwendung als antiepileptikum

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE122007000051C Active DE122007000051I2 (de) 1997-06-10 1998-06-08 Kristallmodifikation von 1-(2,6-difluorbenzyl) -1h-1,2,3-triazol-4-carbonsäureamid und seine verwendung als antiepileptikum

Country Status (37)

Country Link
US (6) US6740669B1 (de)
EP (2) EP0994864B1 (de)
JP (2) JP3672574B2 (de)
KR (2) KR100425656B1 (de)
CN (3) CN1298708C (de)
AR (4) AR012945A1 (de)
AT (2) ATE232852T1 (de)
AU (2) AU725528B2 (de)
BR (2) BR9804946A (de)
CA (3) CA2256013C (de)
CO (2) CO4940452A1 (de)
CY (1) CY2007014I2 (de)
CZ (2) CZ292260B6 (de)
DE (3) DE69811500T2 (de)
DK (2) DK0994864T3 (de)
ES (2) ES2192779T3 (de)
FR (1) FR07C0037I2 (de)
HK (3) HK1028242A1 (de)
HU (2) HU225153B1 (de)
ID (2) ID27660A (de)
IL (2) IL125733A (de)
LU (1) LU91345I2 (de)
MY (2) MY125854A (de)
NL (1) NL300284I2 (de)
NO (2) NO329315B1 (de)
NZ (2) NZ331370A (de)
PE (2) PE80999A1 (de)
PL (2) PL192114B1 (de)
PT (1) PT994864E (de)
RU (2) RU2198167C2 (de)
SI (2) SI0994864T1 (de)
SK (2) SK283685B6 (de)
TR (2) TR199801630T1 (de)
TW (2) TW526195B (de)
UY (1) UY25844A1 (de)
WO (2) WO1998056773A1 (de)
ZA (2) ZA984967B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW526195B (en) 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use
JP2005529933A (ja) * 2002-05-31 2005-10-06 シェーリング　コーポレイション キサンチンホスホジエステラーゼｖインヒビター多形体
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
AU2009305255B2 (en) 2008-10-13 2014-02-06 Cipla Limited Process for the preparation of rufinamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) * 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
EP2473051B1 (de) * 2009-09-04 2016-02-10 Tactical Therapeutics, Inc. Neue zusammensetzungen und verfahren zur herstellung von 5-amino- oder substituierten amino-1,2,3-triazolen und triazolorotatformulierungen
WO2011135105A1 (en) 2010-04-30 2011-11-03 Laboratorios Lesvi, S.L. Improved process for preparing rufinamide intermediate
EP2465853A1 (de) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph von Rufinamid und Verfahren zu seiner Herstellung
ITMI20110718A1 (it) 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
WO2014013511A2 (en) * 2012-07-20 2014-01-23 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992378A (en) 1973-12-26 1976-11-16 Eli Lilly And Company Fluoralkyl quinoxadinediones
US4156734A (en) 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
FI834666A (fi) 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
PH22568A (en) * 1985-04-18 1988-10-17 Ciba Geigy Ag Fluorinated benzyl triazoles and pharmaceutical compositions containing the same
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
JPH04506967A (ja) 1989-07-27 1992-12-03 ジー．ディー．サール　アンド　カンパニー 高血圧症治療用腎選択性生成物
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
AU656154B2 (en) 1990-11-06 1995-01-27 Astellas Pharma Inc. Fused pyrazine derivative
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
GB9419318D0 (en) 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
US6096779A (en) 1995-02-22 2000-08-01 Hoechst Pharmaceuticals & Chemicals K.K. Amorphous piretanide, piretanide polymorphs, process for their preparation and their use
NZ333505A (en) * 1996-07-11 2000-06-23 Novartis Ag Preparing 1-substituted 4-cyano-1,2,3-triazoles using 4-cyano-1-(2,6-difuorobenzyl)-1H-1,2,3-triazole
TW526195B (en) 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use

Also Published As

Publication number Publication date
CA2256015C (en) 2008-06-03
EP0994864B1 (de) 2003-04-16
AU725528B2 (en) 2000-10-12
IL125732A (en) 2002-12-01
DE69811500D1 (de) 2003-03-27
CA2256013C (en) 2007-10-16
WO1998056772A1 (en) 1998-12-17
AR012945A1 (es) 2000-11-22
NO983667L (no) 1998-12-17
HK1028031A1 (en) 2001-02-02
CZ253398A3 (cs) 1999-04-14
HUP0000798A2 (hu) 2000-10-30
HUP0002113A2 (hu) 2001-02-28
DE122007000051I1 (de) 2007-11-08
FR07C0037I1 (de) 2007-08-17
CN1132820C (zh) 2003-12-31
KR19990087835A (ko) 1999-12-27
US20060116520A1 (en) 2006-06-01
CN1259127A (zh) 2000-07-05
SI0994863T1 (en) 2003-08-31
CA2256013A1 (en) 1998-12-17
TW403740B (en) 2000-09-01
CN1159300C (zh) 2004-07-28
ID27660A (id) 2001-04-19
ATE237599T1 (de) 2003-05-15
CN1298708C (zh) 2007-02-07
FR07C0037I2 (de) 2008-05-16
CO4940452A1 (es) 2000-07-24
TW526195B (en) 2003-04-01
BR9804946A (pt) 1999-08-24
TR199801630T1 (xx) 1999-06-21
AU725517B2 (en) 2000-10-12
SK283685B6 (sk) 2003-12-02
JP2000516258A (ja) 2000-12-05
US20100310655A1 (en) 2010-12-09
CN1217716A (zh) 1999-05-26
HU226107B1 (en) 2008-04-28
SI0994864T1 (en) 2003-10-31
CZ292481B6 (cs) 2003-09-17
DK0994864T3 (da) 2003-07-21
UY25844A1 (es) 2001-08-27
BR9804947A (pt) 1999-08-24
US20030125568A1 (en) 2003-07-03
IL125733A0 (en) 1999-04-11
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
JP2000516259A (ja) 2000-12-05
US6740669B1 (en) 2004-05-25
IL125733A (en) 2002-12-01
EP0994863A1 (de) 2000-04-26
ES2197485T3 (es) 2004-01-01
NO329314B1 (no) 2010-09-27
LU91345I9 (de) 2018-12-31
NO983666D0 (no) 1998-08-11
NO983666L (no) 1998-12-17
HK1028242A1 (en) 2001-02-09
RU2198167C2 (ru) 2003-02-10
HK1028241A1 (en) 2001-02-09
US7750028B2 (en) 2010-07-06
CN1572789A (zh) 2005-02-02
CZ292260B6 (cs) 2003-08-13
HUP0000798A3 (en) 2000-10-30
HUP0002113A3 (en) 2002-09-30
KR100409168B1 (ko) 2004-01-31
PT994864E (pt) 2003-07-31
JP3672575B2 (ja) 2005-07-20
MY125854A (en) 2006-08-30
PL330798A1 (en) 1999-06-07
DE69813560T2 (de) 2004-02-05
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
IL125732A0 (en) 1999-04-11
EP0994863B1 (de) 2003-02-19
RU2194041C2 (ru) 2002-12-10
CO4940448A1 (es) 2000-07-24
KR100425656B1 (ko) 2004-05-17
AR061004A2 (es) 2008-07-30
ID21014A (id) 1999-04-08
NZ331371A (en) 2000-08-25
AR012946A1 (es) 2000-11-22
US20040167186A1 (en) 2004-08-26
DE69811500T2 (de) 2004-04-01
CA2256015A1 (en) 1998-12-17
PL330764A1 (en) 1999-05-24
DK0994863T3 (da) 2003-05-26
US6455556B2 (en) 2002-09-24
LU91345I2 (fr) 2007-09-04
PE79799A1 (es) 1999-09-03
JP3672574B2 (ja) 2005-07-20
AU8437198A (en) 1998-12-30
CY2007014I1 (el) 2009-11-04
CZ253498A3 (cs) 1999-04-14
AR061005A2 (es) 2008-07-30
ZA984967B (en) 1999-01-11
CA2614926A1 (en) 1998-12-17
DE122007000051I2 (de) 2009-02-19
PL191943B1 (pl) 2006-07-31
ES2192779T3 (es) 2003-10-16
SK109398A3 (en) 1998-12-02
US20010037029A1 (en) 2001-11-01
ZA984966B (en) 1999-01-11
NO329315B1 (no) 2010-09-27
NZ331370A (en) 2000-08-25
NL300284I2 (nl) 2007-11-01
CA2614926C (en) 2010-02-09
CY2007014I2 (el) 2009-11-04
US8076362B2 (en) 2011-12-13
TR199801631T1 (xx) 1999-06-21
PE80999A1 (es) 1999-09-06
ATE232852T1 (de) 2003-03-15
PL192114B1 (pl) 2006-08-31
EP0994864A1 (de) 2000-04-26
HU225153B1 (en) 2006-07-28
AU8437298A (en) 1998-12-30
SK109498A3 (en) 1998-12-02
KR19990087836A (ko) 1999-12-27
MY120156A (en) 2005-09-30

Similar Documents

Publication Publication Date Title
ATE202347T1 (de) Aminothiophencarbonsäureamide und ihre verwendung als phosphodiesterase inhibitoren
ATE248150T1 (de) Lactam-enthaltende hydroxamsäure-derivate, deren herstellung und deren verwendung als inhibitoren von matrix-metalloproteasen
DE69615025D1 (de) Benzamid-derivate und deren verwendung als vasopressin-antagonisten
ATE331719T1 (de) Verwendung von kristallformen von 2- methylthienobenzodiazepinen
DE59712887D1 (de) Substituierte phenylketoenole und ihre verwendung als schädlingsbekämpfungsmittel
DE69813560D1 (de) Kristallmodifikation von 1-(2,6-difluorbenzyl)-1h-1,2,3-triazol-4-carbonsäureamid und seine verwendung als antiepileptikum
DE59608154D1 (de) Verwendung von polyasparaginsäureamiden als lederhilfsmittel
ATE232207T1 (de) N-triazolyl-2-indolcarbonsäureamide und ihre verwendung als cck-a agonisten
DE69628195D1 (de) Verwendung von xyloglucanendotransglycosylase
ATE181071T1 (de) Piperidinessigsäurederivate und ihre verwendung als fibrinogenantagonistmittel
DE69531048D1 (de) Verwendung von steroidsulphatase-hemmern
ATE229034T1 (de) 3-mercaptoacetylamino-1,5-substituierte-2-oxo- azepan derivate und deren verwendung als inhibitoren von matrix-metalloproteinasen
DE69616944D1 (de) Verwendung von des-aspartat-angiotensin i als wirkstoff gegen herzhypertrophie
DE69708629D1 (de) Alkyloxyamin-substituierte fluorenonderivate und ihre verwendung als proteinkinase-c-inhibitoren
DE59508900D1 (de) Verwendung von Dibrom-thiophen-carbonsäure-Derivaten als Mikrobizide
DE59407240D1 (de) Substituierte azadioxacycloalkene und ihre verwendung als fungizide
DE59813467D1 (de) Verwendung von aerogelen als adsorptionsmittel
DE59605796D1 (de) Oximether- und acrylsäurederivate und ihre verwendung als fungizide
DE69418001D1 (de) Hydrazin-Derivate und ihre Verwendung als Insektizide
DE59510203D1 (de) Aminosäure-Derivate und ihre Verwendung als Schädlingsbekämpfungsmittel
DE69505124D1 (de) Verwendung von dibutylmalat als insektenlockstoff
DE69616760T2 (de) Verwendung von 4-tert-butyl-1-cyclohexanol als antioxidant
DE69718850T2 (de) Heterocyclische N-Acetonylbenzamide und ihre Verwendung als Fungizide
DE69621617D1 (de) Verwendung von substituierten und nichtsubstituierten n-(pyrrol-1-yl)pyridinaminen als antikonvulsiva
DE59607367D1 (de) Hydrazonoessigsäureamide und ihre verwendung als schädlingsbekämpfungsmittel

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN