DE69813291D1 - Herstellung stellen-spezifischer polyethylenglycol-grf konjugate - Google Patents

Herstellung stellen-spezifischer polyethylenglycol-grf konjugate

Info

Publication number
DE69813291D1
DE69813291D1 DE69813291T DE69813291T DE69813291D1 DE 69813291 D1 DE69813291 D1 DE 69813291D1 DE 69813291 T DE69813291 T DE 69813291T DE 69813291 T DE69813291 T DE 69813291T DE 69813291 D1 DE69813291 D1 DE 69813291D1
Authority
DE
Germany
Prior art keywords
grf
conjugates
polyethylene glycol
manufacturing site
specific polyethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69813291T
Other languages
English (en)
Other versions
DE69813291T2 (de
Inventor
Maria Veronese
Paolo Caliceti
Oddone Schiavon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SA
Original Assignee
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems ARS Holding NV filed Critical Applied Research Systems ARS Holding NV
Publication of DE69813291D1 publication Critical patent/DE69813291D1/de
Application granted granted Critical
Publication of DE69813291T2 publication Critical patent/DE69813291T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
DE69813291T 1997-12-03 1998-12-01 Herstellung stellen-spezifischer polyethylenglycol-grf konjugate Expired - Lifetime DE69813291T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97121264A EP0922446A1 (de) 1997-12-03 1997-12-03 Lösungsphase Verfahrung zur ortspezifischer Herstellung von GRF-PEG Konjugaten
PCT/EP1998/007748 WO1999027897A1 (en) 1997-12-03 1998-12-01 Site-specific preparation of polyethylene glycol-grf conjugates

Publications (2)

Publication Number Publication Date
DE69813291D1 true DE69813291D1 (de) 2003-05-15
DE69813291T2 DE69813291T2 (de) 2003-11-13

Family

ID=8227732

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69813291T Expired - Lifetime DE69813291T2 (de) 1997-12-03 1998-12-01 Herstellung stellen-spezifischer polyethylenglycol-grf konjugate

Country Status (30)

Country Link
US (3) US6528485B1 (de)
EP (2) EP0922446A1 (de)
JP (2) JP2001524505A (de)
KR (1) KR100561768B1 (de)
CN (1) CN1149967C (de)
AR (1) AR017780A1 (de)
AT (1) ATE236607T1 (de)
AU (1) AU755285B2 (de)
BG (1) BG64815B1 (de)
BR (1) BR9815159A (de)
CA (1) CA2312004C (de)
DE (1) DE69813291T2 (de)
DK (1) DK1037587T3 (de)
EA (1) EA004269B1 (de)
EE (1) EE200000319A (de)
ES (1) ES2194376T3 (de)
HK (1) HK1034203A1 (de)
HU (1) HUP0100507A3 (de)
IL (2) IL136551A0 (de)
NO (1) NO327238B1 (de)
NZ (1) NZ504570A (de)
PL (1) PL192082B1 (de)
PT (1) PT1037587E (de)
SI (1) SI1037587T1 (de)
SK (1) SK8242000A3 (de)
TR (1) TR200001615T2 (de)
TW (1) TWI254641B (de)
UA (1) UA73716C2 (de)
WO (1) WO1999027897A1 (de)
ZA (1) ZA9811068B (de)

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US6407218B1 (en) * 1997-11-10 2002-06-18 Cytimmune Sciences, Inc. Method and compositions for enhancing immune response and for the production of in vitro mabs
CA2422707A1 (en) 2000-10-05 2002-04-11 Ares Trading S.A. Regioselective liquid phase pegylation
EP1234583A1 (de) 2001-02-23 2002-08-28 F. Hoffmann-La Roche Ag PEG-Konjugate des HGF-NK4
US20030171285A1 (en) * 2001-11-20 2003-09-11 Finn Rory F. Chemically-modified human growth hormone conjugates
EP1465933B1 (de) 2002-01-16 2007-08-29 Biocompatibles UK Limited Polymerkonjugate
US7998705B2 (en) * 2002-08-06 2011-08-16 FUJIFILM Diosynth Biotechnologies U.S.A., Inc Increased dynamic binding capacity in ion exchange chromatography by addition of polyethylene glycol
BR0314619A (pt) * 2002-09-18 2005-08-02 Univ Montreal Ct Hospitalier Chum Análogos de ghrh
GB0301014D0 (en) * 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
JP4339797B2 (ja) * 2003-01-18 2009-10-07 ペスフェア カンパニー リミテッド 非標的部位のアミンが保護されたペプチド、その製造方法、及びこれを利用したｐｅｇが特異的に接合されたペプチドの製造方法
EP1644408A1 (de) * 2003-07-15 2006-04-12 Barros Research Institute Eimeria tenella-antigen zur immuntherapie von kokzidiose
WO2005010163A2 (en) * 2003-07-15 2005-02-03 Barros Research Institute Compositions and methods for immunotherapy of human immunotherapy of human immunodeficiency virus (hiv)
CA2548179A1 (en) * 2003-12-02 2005-07-21 Cytimmune Sciences, Inc. Methods and compositions for the production of monoclonal antibodies
EP1715971A4 (de) * 2004-01-28 2010-10-13 Cytimmune Sciences Inc Funktionalisierte kolloidale metallzusammensetzungen und verfahren
CN100355784C (zh) * 2004-02-12 2007-12-19 江苏恒瑞医药股份有限公司 聚乙二醇修饰α－干扰素1b的制备方法
US20050261475A1 (en) * 2004-02-13 2005-11-24 Harvard Medical School Solid-phase capture-release-tag methods for phosphoproteomic analyses
US6986264B1 (en) * 2004-07-15 2006-01-17 Carrier Corporation Economized dehumidification system
ES2633916T3 (es) 2004-11-12 2017-09-26 Bayer Healthcare Llc Modificación de FVIII dirigida al sitio
JP2009503191A (ja) * 2005-07-26 2009-01-29 ローディア インコーポレイティド ペンダントポリ（アルキレンオキシ）置換基を備えたポリマー及びパーソナルケア用途におけるそれらの使用
US20070238656A1 (en) * 2006-04-10 2007-10-11 Eastman Kodak Company Functionalized poly(ethylene glycol)
US20080096819A1 (en) 2006-05-02 2008-04-24 Allozyne, Inc. Amino acid substituted molecules
EP2395099A3 (de) 2006-05-02 2012-05-16 Allozyne, Inc. Aminosäuresubstituierte Moleküle
CA2659990C (en) * 2006-08-04 2016-03-22 Prolong Pharmaceuticals, Inc. Polyethylene glycol erythropoietin conjugates
US20080083154A1 (en) * 2006-10-05 2008-04-10 Timothy M Gregory Bait retention fish hook
CA2707840A1 (en) 2007-08-20 2009-02-26 Allozyne, Inc. Amino acid substituted molecules
KR20100123674A (ko) * 2007-09-21 2010-11-24 싸이티뮨 사이언스, 인크. 나노치료제 콜로이드성 금속 조성물 및 방법
US20110014118A1 (en) * 2007-09-21 2011-01-20 Lawrence Tamarkin Nanotherapeutic colloidal metal compositions and methods
CA2706700A1 (en) * 2007-11-08 2009-05-14 Cytimmune Sciences, Inc. Compositions and methods for generating antibodies
ES2723098T3 (es) * 2008-11-04 2019-08-21 Janssen Pharmaceutica Nv Agonistas del péptido CRHR2 y usos de los mismos
MX2011009803A (es) * 2009-03-20 2011-09-30 Hanmi Holdings Co Ltd Metodo para preparar un polipeptido conjugado fisiologicamente activo en un sitio especifico.
US20100267636A1 (en) * 2009-04-20 2010-10-21 Theratechnologies Inc. Use of cytochrome p450-metabolized drugs and grf molecules in combination therapy
US20100267635A1 (en) * 2009-04-20 2010-10-21 Theratechonolgies Inc. Use of protease inhibitors and grf molecules in combination therapy
CA2766634A1 (en) 2009-06-22 2011-01-13 Burnham Institute For Medical Research Methods and compositions using peptides and proteins with c-terminal elements
BR112012010661A2 (pt) * 2009-11-04 2016-11-22 Janssen Pharmaceutica Nv método para tratar insuficiência cardíaca com peptídeos semelhantes à estressecopina
WO2012118778A1 (en) 2011-02-28 2012-09-07 Sanford-Burnham Medical Research Institute Truncated car peptides and methods and compositions using truncated car peptides
MX2013012259A (es) 2011-04-21 2013-11-22 Theratechnologies Inc Analogos del factor de liberacion de la hormona de crecimiento (grf) y usos de estos.
AU2012262488A1 (en) 2011-05-31 2014-01-16 Airware, Inc. Re-calibration of AB NDIR gas sensors
US10179801B2 (en) 2011-08-26 2019-01-15 Sanford-Burnham Medical Research Institute Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides
WO2013190520A2 (en) 2012-06-22 2013-12-27 The General Hospital Corporation Gh-releasing agents in the treatment of vascular stenosis and associated conditions
US10064940B2 (en) 2013-12-11 2018-09-04 Siva Therapeutics Inc. Multifunctional radiation delivery apparatus and method
CA2986927C (en) 2015-05-28 2023-12-19 Institut National De La Recherche Scientifique Inhibitors of prototypic galectin dimerization and uses thereof
US9988428B2 (en) * 2016-04-19 2018-06-05 Griffon Pharmaceuticals Inc. Pegylated bioactive peptides and uses thereof
CN110317826B (zh) * 2019-05-22 2020-11-10 中国农业大学 调控PvGRF9含量或活性的物质在调控植物茎生长发育中的应用
WO2021133407A1 (en) 2019-12-27 2021-07-01 Compagnie Generale Des Etablissements Michelin Rubber mix with high specific surface area and high structure acetylene carbon black
CN117440966A (zh) 2021-01-28 2024-01-23 塔勒姆治疗有限责任公司 抗SARS-CoV-2刺突糖蛋白抗体及其治疗用途

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US4563352A (en) * 1982-10-04 1986-01-07 The Salk Institute For Biological Studies Human pancreatic GRF
DK0400472T3 (da) * 1989-05-27 1996-05-13 Sumitomo Pharma Fremgangsmåde til fremstilling af polyethylenglycolderivater og modificeret protein
AU656144B2 (en) * 1990-06-29 1995-01-27 F. Hoffmann-La Roche Ag Histidine substituted growth hormone releasing factor analogs
JP3051145B2 (ja) * 1990-08-28 2000-06-12 住友製薬株式会社 新規なポリエチレングリコール誘導体修飾ペプチド
JPH05507939A (ja) * 1991-04-09 1993-11-11 エフ・ホフマン―ラ　ロシユ　アーゲー 成長ホルモン放出因子の類似体
EP0518295A3 (en) * 1991-06-14 1993-09-01 Millipore Corporation Allyl side chain protection in peptide synthesis
FR2687681B1 (fr) * 1992-02-20 1995-10-13 Transgene Sa Conjugues polyethyleneglycol-hirudine, leur procede de preparation et leur emploi pour le traitement des thromboses.
US5932462A (en) * 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
WO1997017367A1 (en) * 1995-11-03 1997-05-15 Theratechnologies Inc. Method of grf peptides synthesis

Also Published As

Publication number Publication date
TR200001615T2 (tr) 2000-12-21
TWI254641B (en) 2006-05-11
HUP0100507A2 (hu) 2001-08-28
WO1999027897A1 (en) 1999-06-10
EA004269B1 (ru) 2004-02-26
AU1563399A (en) 1999-06-16
NO327238B1 (no) 2009-05-18
EP1037587A1 (de) 2000-09-27
CN1149967C (zh) 2004-05-19
PL192082B1 (pl) 2006-08-31
BG104484A (en) 2000-12-29
EP0922446A1 (de) 1999-06-16
HK1034203A1 (en) 2001-10-19
NO20002664D0 (no) 2000-05-24
ZA9811068B (en) 1999-06-28
BG64815B1 (bg) 2006-05-31
NZ504570A (en) 2003-10-31
AU755285B2 (en) 2002-12-05
US20040029794A1 (en) 2004-02-12
US6869932B2 (en) 2005-03-22
EE200000319A (et) 2001-08-15
EA200000601A1 (ru) 2000-12-25
US7317002B2 (en) 2008-01-08
UA73716C2 (en) 2005-09-15
CN1280483A (zh) 2001-01-17
IL136551A0 (en) 2001-06-14
DK1037587T3 (da) 2003-07-28
PL341139A1 (en) 2001-03-26
SI1037587T1 (en) 2003-08-31
JP2010024245A (ja) 2010-02-04
CA2312004C (en) 2009-05-19
HUP0100507A3 (en) 2001-11-28
IL136551A (en) 2008-12-29
ATE236607T1 (de) 2003-04-15
BR9815159A (pt) 2000-10-10
US6528485B1 (en) 2003-03-04
NO20002664L (no) 2000-07-13
ES2194376T3 (es) 2003-11-16
JP5431874B2 (ja) 2014-03-05
JP2001524505A (ja) 2001-12-04
PT1037587E (pt) 2003-08-29
KR100561768B1 (ko) 2006-03-16
AR017780A1 (es) 2001-10-24
DE69813291T2 (de) 2003-11-13
EP1037587B1 (de) 2003-04-09
KR20010032494A (ko) 2001-04-25
SK8242000A3 (en) 2001-01-18
WO1999027897A9 (en) 1999-09-30
CA2312004A1 (en) 1999-06-10
US20050159353A1 (en) 2005-07-21

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Legal Events

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8327 Change in the person/name/address of the patent owner

Owner name: LABORATOIRES SERONO S.A., COINSINS, VAUD, CH