DE69811237T2 - Extrusionsmechanismus für aerosole - Google Patents

Extrusionsmechanismus für aerosole

Info

Publication number
DE69811237T2
DE69811237T2 DE69811237T DE69811237T DE69811237T2 DE 69811237 T2 DE69811237 T2 DE 69811237T2 DE 69811237 T DE69811237 T DE 69811237T DE 69811237 T DE69811237 T DE 69811237T DE 69811237 T2 DE69811237 T2 DE 69811237T2
Authority
DE
Germany
Prior art keywords
aerosols
extrusion mechanism
extrusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69811237T
Other languages
English (en)
Other versions
DE69811237D1 (en
Inventor
Stephen J Ruskewicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aradigm Corp
Original Assignee
Aradigm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aradigm Corp filed Critical Aradigm Corp
Publication of DE69811237D1 publication Critical patent/DE69811237D1/de
Application granted granted Critical
Publication of DE69811237T2 publication Critical patent/DE69811237T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0053—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
    • A61M15/0055—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being coiled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/008—Electronic counters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0081—Locking means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0083—Timers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6054—Magnetic identification systems
DE69811237T 1997-08-20 1998-08-17 Extrusionsmechanismus für aerosole Expired - Lifetime DE69811237T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/914,962 US5855564A (en) 1997-08-20 1997-08-20 Aerosol extrusion mechanism
PCT/US1998/016981 WO1999008737A1 (en) 1997-08-20 1998-08-17 Aerosol extrusion mechanism

Publications (2)

Publication Number Publication Date
DE69811237D1 DE69811237D1 (en) 2003-03-13
DE69811237T2 true DE69811237T2 (de) 2003-09-11

Family

ID=25435009

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69811237T Expired - Lifetime DE69811237T2 (de) 1997-08-20 1998-08-17 Extrusionsmechanismus für aerosole

Country Status (8)

Country Link
US (2) US5855564A (de)
EP (1) EP1003582B1 (de)
JP (1) JP2001514940A (de)
AU (1) AU737296B2 (de)
CA (1) CA2301122A1 (de)
DE (1) DE69811237T2 (de)
ES (1) ES2191958T3 (de)
WO (1) WO1999008737A1 (de)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6237590B1 (en) * 1997-09-18 2001-05-29 Delsys Pharmaceutical Corporation Dry powder delivery system apparatus
US6598603B1 (en) * 1997-12-31 2003-07-29 Astra Aktiebolag Method for treating respiratory diseases
US6158431A (en) * 1998-02-13 2000-12-12 Tsi Incorporated Portable systems and methods for delivery of therapeutic material to the pulmonary system
US6354516B1 (en) 1999-11-02 2002-03-12 Aradigm Corporation Pore structures for reduced pressure aerosolization
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
CA2382442C (en) 1999-09-15 2009-07-07 Aradigm Corporation Pore structures for reduced pressure aerosolization
US20010035184A1 (en) * 1999-12-17 2001-11-01 Carlos Schuler Systems and methods for treating packaged powders
JP2003519169A (ja) * 1999-12-30 2003-06-17 インターミューン インコーポレイテッド γ−ＩＦＮ液滴エアロゾルおよび方法
DE60139110D1 (de) 2000-01-10 2009-08-13 Maxygen Holdings Ltd G-csf konjugate
DE10011120A1 (de) * 2000-03-09 2001-09-13 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
TWI224512B (en) 2000-06-23 2004-12-01 Norton Healthcare Ltd Reservoir pressure system for medicament inhaler
GB0026647D0 (en) * 2000-10-31 2000-12-13 Glaxo Group Ltd Medicament dispenser
DE60232434D1 (de) 2001-02-27 2009-07-09 Maxygen Aps Neue interferon-beta-ähnliche moleküle
US20030051728A1 (en) * 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US7458374B2 (en) * 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7458373B2 (en) * 2002-01-15 2008-12-02 Philip Morris Usa Inc. Aerosol generator for drug formulation
JP4681231B2 (ja) 2002-03-20 2011-05-11 マンカインド コーポレイション 吸入装置
US6889690B2 (en) * 2002-05-10 2005-05-10 Oriel Therapeutics, Inc. Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
US7677411B2 (en) * 2002-05-10 2010-03-16 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders
US7118010B2 (en) 2002-05-10 2006-10-10 Oriel Therapeutics, Inc. Apparatus, systems and related methods for dispensing and /or evaluating dry powders
US6985798B2 (en) 2002-05-10 2006-01-10 Oriel Therapeutics, Inc. Dry powder dose filling systems and related methods
EP1535349B1 (de) * 2002-06-27 2014-06-25 Oriel Therapeutics, Inc. Geräte, systeme und relevante verfahren für die aufbereitung, ausgabe und/oder beurteilung von nichtpharmazeutischen trockenpulvern
US20040055595A1 (en) * 2002-09-19 2004-03-25 Noymer Peter D. Aerosol drug delivery system employing formulation pre-heating
US20040105818A1 (en) * 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
GB2400565B (en) * 2003-04-17 2005-03-02 Bespak Plc Nasal drug delivery
ES2370395T3 (es) 2003-05-21 2011-12-15 Alexza Pharmaceuticals, Inc. Utilización de una capa de combustible sólido, procedimiento para fabricarla y unidad de calefacción correspondiente.
US7451761B2 (en) * 2003-10-27 2008-11-18 Oriel Therapeutics, Inc. Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
US7377277B2 (en) * 2003-10-27 2008-05-27 Oriel Therapeutics, Inc. Blister packages with frames and associated methods of fabricating dry powder drug containment systems
US7607435B2 (en) * 2004-01-21 2009-10-27 Battelle Memorial Institute Gas or liquid flow sensor
US7540286B2 (en) * 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
CA2576961A1 (en) * 2004-08-12 2006-03-02 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
US20100006092A1 (en) * 2004-08-12 2010-01-14 Alexza Pharmaceuticals, Inc. Aerosol Drug Delivery Device Incorporating Percussively Activated Heat Packages
BRPI0514263B8 (pt) 2004-08-20 2021-05-25 Mannkind Corp método para a síntese de bis-3,6-[4-aminobutil]-2,5-dicetopiperazina n-protegida
KR101306384B1 (ko) 2004-08-23 2013-09-09 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는디케토디옥산염
GB0418738D0 (en) * 2004-08-23 2004-09-22 3M Innovative Properties Co Medicinal aerosol formulation receptacle and production thereof
JP5020824B2 (ja) 2004-11-16 2012-09-05 ロバート・エル・バリー 肺治療の装置及び方法
GB0428169D0 (en) * 2004-12-23 2005-01-26 3M Innovative Properties Co Pressurized inhalation devices
FR2881119B1 (fr) * 2005-01-25 2010-07-30 Valois Sas Dispositif de distribution de produit fluide.
WO2006091914A2 (en) * 2005-02-25 2006-08-31 Battelle Memorial Institute Spray indication
GB0507100D0 (en) * 2005-04-08 2005-05-11 Team Holdings Uk Ltd Improvements in or relating to inhalers
UA95446C2 (ru) 2005-05-04 2011-08-10 Іллюміджен Байосайєнсіз, Інк. Мутаци в генах oas1
CA2900093C (en) 2005-05-18 2018-11-13 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8524735B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
EP1928423B1 (de) 2005-09-14 2015-12-09 Mannkind Corporation Verfahren zur arzneimittelformulierung basierend auf der affinitätssteigerung von aktiven wirkstoffen für kristalline mikropartikel-flächen
WO2007098500A2 (en) 2006-02-22 2007-08-30 Mannkind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
WO2007118881A1 (en) * 2006-04-19 2007-10-25 N.V. Organon Drug delivery device
US7946453B2 (en) * 2006-11-09 2011-05-24 Ethicon Endo-Surgery, Inc. Surgical band fluid media dispenser
US7993323B2 (en) 2006-11-13 2011-08-09 Uptake Medical Corp. High pressure and high temperature vapor catheters and systems
US7726223B2 (en) * 2006-11-14 2010-06-01 Cb Products, Inc. Apparatus and methods for accessing packaged medicaments
WO2008112661A2 (en) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
US8322335B2 (en) 2007-10-22 2012-12-04 Uptake Medical Corp. Determining patient-specific vapor treatment and delivery parameters
AU2008334099B2 (en) 2007-11-30 2014-07-24 Abbvie Biotechnology Ltd. Protein formulations and methods of making same
CA2982550C (en) 2008-06-13 2020-08-25 Mannkind Corporation A dry powder inhaler and system for drug delivery
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CN102065942B (zh) 2008-06-20 2013-12-11 曼金德公司 用于对吸入工作进行实时描绘的交互式设备和方法
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
LT2344129T (lt) 2008-10-07 2018-05-10 Horizon Orphan Llc Aerozolinės fluorchinolono kompozicijos, skirtos farmakokinetikų pagerinimui
SI2346509T1 (sl) 2008-10-07 2020-08-31 Horizon Orphan Llc Inhalacija levofloksacina za zmanjšanje vnetja pljuč
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
PL2405963T3 (pl) 2009-03-11 2014-04-30 Mannkind Corp Urządzenie, układ i sposób pomiaru oporu inhalatora
JP5908397B2 (ja) 2009-06-09 2016-04-26 デフィルス、インコーポレイテッドＤｅｆｙｒｕｓ， Ｉｎｃ． 病原体感染を予防又は治療するためのインターフェロン投与
ES2943333T3 (es) 2009-06-12 2023-06-12 Mannkind Corp Micropartículas de dicetopiperazina con superficies específicas definidas
DK2473170T3 (da) 2009-09-04 2019-08-12 Horizon Orphan Llc Anvendelse af aerosoliseret levofloxacin til behandling af cystisk fibrose
EP2496295A1 (de) 2009-11-03 2012-09-12 MannKind Corporation Vorrichtung und verfahren zur simulation von einatmungsanstrengungen
US10857311B2 (en) 2010-01-12 2020-12-08 Omega Life Science Ltd. Method and apparatus for producing fine concentrated aerosol
AU2011271097B2 (en) 2010-06-21 2014-11-27 Mannkind Corporation Dry powder drug delivery system and methods
US8598131B2 (en) * 2010-07-12 2013-12-03 Xellia Pharmaceuticals Aps Method for treatment of lung infections by administration of aminoglycosides by aerolisation
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
EP2654864B1 (de) 2010-12-22 2020-10-28 Syqe Medical Ltd. System zur wirkstofffreisetzung
EP4059499A1 (de) 2011-01-31 2022-09-21 Avalyn Pharma Inc. Aerosolförmige pirfenidon- und pyridonanalogverbindungen und verwendungen davon
CN103826988B (zh) 2011-04-01 2016-03-09 曼金德公司 用于药物药盒的泡罩包装
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
UA111630C2 (uk) 2011-10-06 2016-05-25 Сіс Рісорсез Лтд. Система для паління
JP6018640B2 (ja) 2011-10-24 2016-11-02 マンカインド コーポレイション 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム
US9603907B2 (en) 2012-02-01 2017-03-28 Protalix Ltd. Dry powder formulations of dNase I
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
EP2877164B1 (de) 2012-07-24 2023-07-05 Avalyn Pharma Inc. Aerosolpirfenidon und pyridonanalogverbindungen
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
US10034988B2 (en) 2012-11-28 2018-07-31 Fontem Holdings I B.V. Methods and devices for compound delivery
KR102391750B1 (ko) 2013-03-15 2022-04-28 맨카인드 코포레이션 미세결정성 디케토피페라진 조성물 및 방법
CN105451716A (zh) 2013-07-18 2016-03-30 曼金德公司 热稳定性干粉药物组合物和方法
EP3027026A4 (de) 2013-07-31 2017-05-03 Windward Pharma, Inc. Aerosoltyrosinkinasehemmer-verbindungen und verwendungen davon
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
WO2015042412A1 (en) 2013-09-20 2015-03-26 E-Nicotine Technology. Inc. Devices and methods for modifying delivery devices
US9782211B2 (en) 2013-10-01 2017-10-10 Uptake Medical Technology Inc. Preferential volume reduction of diseased segments of a heterogeneous lobe
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
CN112451811A (zh) * 2014-10-13 2021-03-09 欧米伽生命科学公司 雾化器及其用途
FR3028765B1 (fr) * 2014-11-21 2016-12-23 Aptar France Sas Dispositif de distribution de produit fluide declenche par l'inhalation.
US10485604B2 (en) 2014-12-02 2019-11-26 Uptake Medical Technology Inc. Vapor treatment of lung nodules and tumors
MX2017008567A (es) 2015-01-04 2018-04-26 Protalix Ltd Dnasa modificada y usos de la misma.
US10531906B2 (en) 2015-02-02 2020-01-14 Uptake Medical Technology Inc. Medical vapor generator
ES2745552T3 (es) 2015-07-20 2020-03-02 Pearl Therapeutics Inc Sistemas de administración de aerosol
ES2874087T3 (es) 2016-01-06 2021-11-04 Syqe Medical Ltd Tratamiento terapéutico con dosis bajas
US10894142B2 (en) * 2016-03-24 2021-01-19 Trudell Medical International Respiratory care system with electronic indicator
CN106038290B (zh) * 2016-07-01 2019-04-30 成都杰仕德科技有限公司 用于西林瓶配药的输液袋挤压机构及配药方法
EP3984579A1 (de) 2016-07-08 2022-04-20 Trudell Medical International Intelligente schwingende vorrichtung für positiven ausatmungsdruck
US11129673B2 (en) 2017-05-05 2021-09-28 Uptake Medical Technology Inc. Extra-airway vapor ablation for treating airway constriction in patients with asthma and COPD
US11938056B2 (en) 2017-06-10 2024-03-26 Eyenovia, Inc. Methods and devices for handling a fluid and delivering the fluid to the eye
US11344364B2 (en) 2017-09-07 2022-05-31 Uptake Medical Technology Inc. Screening method for a target nerve to ablate for the treatment of inflammatory lung disease
US11350988B2 (en) 2017-09-11 2022-06-07 Uptake Medical Technology Inc. Bronchoscopic multimodality lung tumor treatment
USD845467S1 (en) 2017-09-17 2019-04-09 Uptake Medical Technology Inc. Hand-piece for medical ablation catheter
US11419658B2 (en) 2017-11-06 2022-08-23 Uptake Medical Technology Inc. Method for treating emphysema with condensable thermal vapor
WO2019110099A1 (en) 2017-12-06 2019-06-13 Qrumpharma Inc. Inhalable clofazimine formulation
US11490946B2 (en) 2017-12-13 2022-11-08 Uptake Medical Technology Inc. Vapor ablation handpiece
CA3103946A1 (en) * 2018-06-26 2020-01-02 Omega Life Science Ltd. Aerosol generation devices
EP3840737A1 (de) 2018-08-23 2021-06-30 MannKind Corporation Clofazimin-zusammensetzungen, diese enthaltende kombinationen, verfahren zu ihrer herstellung, ihre verwendungen und verfahren damit
WO2020123336A1 (en) 2018-12-13 2020-06-18 Qrumpharma Inc. Compositions of bedaquiline, combinations comprising them, processes for their preparation, uses and methods of treatment comprising them
US11653927B2 (en) 2019-02-18 2023-05-23 Uptake Medical Technology Inc. Vapor ablation treatment of obstructive lung disease
WO2020245574A1 (en) 2019-06-04 2020-12-10 Thirty Respiratory Limited Methods and compositions for generating nitric oxide and uses thereof to deliver nitric oxide via the respiratory tract
CN114206325A (zh) 2019-06-04 2022-03-18 三十控股有限公司 用于生成一氧化氮的方法和组合物及其用途
EP4138795A1 (de) 2020-04-23 2023-03-01 Thirty Respiratory Limited Stickoxid oder stickoxid freisetzende zusammensetzungen zur verwendung bei der behandlung von sars-cov und sars-cov-2
WO2021214439A1 (en) 2020-04-23 2021-10-28 Thirty Respiratory Limited Methods and compositions for treating and combatting tuberculosis
KR20230054611A (ko) 2020-06-01 2023-04-25 애드벤트 테라퓨틱스 인크. 불용성 활성 성분을 포함하는 약제학적 조성물
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
WO2023028364A1 (en) 2021-08-27 2023-03-02 Sepelo Therapeutics, Llc Targeted compositions and uses therof

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2632444A (en) * 1951-06-14 1953-03-24 Kas John Leo Pellet injector
US3259077A (en) * 1964-10-26 1966-07-05 Dow Chemical Co Multi-syringe-type pump
US3669104A (en) * 1970-06-15 1972-06-13 Pfizer Implant gun
US4400170A (en) * 1981-09-29 1983-08-23 Syntex (U.S.A.) Inc. Implanting device and implant magazine
US4687465A (en) * 1986-04-25 1987-08-18 Ideal Instruments, Inc. Automatic clip or pellet carrier fed pellet implanter apparatus
US4857056A (en) * 1988-07-06 1989-08-15 Sherwood Medical Company Auto-flush syringe pump
US4947874A (en) * 1988-09-08 1990-08-14 R. J. Reynolds Tobacco Company Smoking articles utilizing electrical energy
ES2051371T3 (es) * 1988-10-04 1994-06-16 Univ Johns Hopkins Inhalador de aerosoles.
US5037396A (en) * 1989-03-02 1991-08-06 Becton, Dickinson And Company Thermoelectric chiller and automatic syringe
US5060671A (en) * 1989-12-01 1991-10-29 Philip Morris Incorporated Flavor generating article
GB9016789D0 (en) * 1990-07-31 1990-09-12 Lilly Industries Ltd Medicament administering devices
FR2673142A1 (fr) * 1991-02-21 1992-08-28 Ribal Annick Dispositif de soudure autonome, portatif pour poches plastiques.
US5394866A (en) * 1991-03-05 1995-03-07 Aradigm Corporation Automatic aerosol medication delivery system and methods
US5450336A (en) * 1991-03-05 1995-09-12 Aradigm Corporation Method for correcting the drift offset of a transducer
US5404871A (en) * 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
US5469843A (en) * 1991-11-12 1995-11-28 Minnesota Mining And Manufacturing Company Inhalation device
GB9209779D0 (en) * 1992-05-06 1992-06-17 Caswell Simon J Intermittent external pulse pump
US5558085A (en) * 1993-01-29 1996-09-24 Aradigm Corporation Intrapulmonary delivery of peptide drugs
US5743250A (en) * 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
US5497763A (en) * 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
US5792057A (en) * 1993-05-21 1998-08-11 Aradigm Corporation Ventilation imaging using a fine particle aerosol generator
GB9314614D0 (en) * 1993-07-14 1993-08-25 Minnesota Mining & Mfg Dry powder inhalers
US5509404A (en) * 1994-07-11 1996-04-23 Aradigm Corporation Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values
US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
JP3320261B2 (ja) * 1995-06-01 2002-09-03 株式会社ユニシアジェックス 吸入式投薬器
IT1276916B1 (it) * 1995-10-12 1997-11-03 Istoria Farmaceutici S P A Dispositivo per il trattamento di pazienti asmatici, atto a misurare il picco di flusso espiratorio e ad erogare farmaci per il
US5694920A (en) * 1996-01-25 1997-12-09 Abrams; Andrew L. Inhalation device
US5829436A (en) * 1996-02-05 1998-11-03 Aradigm Corporation Ventilation imaging using a fine particle aerosol generator
US5829435A (en) * 1997-02-24 1998-11-03 Aradigm Corporation Prefilter for prevention of clogging of a nozzle in the generation of an aerosol and prevention of administration of undesirable particles

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US5971951A (en) 1999-10-26
DE69811237D1 (en) 2003-03-13
US5855564A (en) 1999-01-05
WO1999008737A1 (en) 1999-02-25
ES2191958T3 (es) 2003-09-16
CA2301122A1 (en) 1999-02-25
EP1003582A1 (de) 2000-05-31
AU737296B2 (en) 2001-08-16
JP2001514940A (ja) 2001-09-18
AU8909098A (en) 1999-03-08
EP1003582B1 (de) 2003-02-05
EP1003582A4 (de) 2001-03-14

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