DE69810459D1 - Reagenzien zur impfung, die eine cd8 t-zell-immunantwort erzeugen - Google Patents
Reagenzien zur impfung, die eine cd8 t-zell-immunantwort erzeugenInfo
- Publication number
- DE69810459D1 DE69810459D1 DE69810459T DE69810459T DE69810459D1 DE 69810459 D1 DE69810459 D1 DE 69810459D1 DE 69810459 T DE69810459 T DE 69810459T DE 69810459 T DE69810459 T DE 69810459T DE 69810459 D1 DE69810459 D1 DE 69810459D1
- Authority
- DE
- Germany
- Prior art keywords
- generate
- immune response
- cell immune
- vaccination
- reagents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002255 vaccination Methods 0.000 title abstract 3
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 2
- 230000028993 immune response Effects 0.000 title abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 230000037452 priming Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003362 replicative effect Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
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- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
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- A61P31/14—Antivirals for RNA viruses
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
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- A61K2039/5258—Virus-like particles
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- A—HUMAN NECESSITIES
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- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/24011—Poxviridae
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- C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
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- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9711957.2A GB9711957D0 (en) | 1997-06-09 | 1997-06-09 | Methods and reagents for vaccination |
GB9711957 | 1997-06-09 | ||
PCT/GB1998/001681 WO1998056919A2 (en) | 1997-06-09 | 1998-06-09 | Methods and reagents for vaccination which generate a cd8 t cell immune response |
Publications (3)
Publication Number | Publication Date |
---|---|
DE69810459D1 true DE69810459D1 (de) | 2003-02-06 |
DE69810459T2 DE69810459T2 (de) | 2003-10-23 |
DE69810459T3 DE69810459T3 (de) | 2010-12-16 |
Family
ID=10813841
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69810459T Expired - Lifetime DE69810459T3 (de) | 1997-06-09 | 1998-06-09 | Reagenzien zur impfung, die eine cd8 t-zell-immunantwort erzeugen |
DE69839359T Expired - Lifetime DE69839359T2 (de) | 1997-06-09 | 1998-06-09 | Verfahren und Reagenzien zur Erzeugung einer CD8+T-Zellen Immunantwort gegen Hepatitis B oder C |
DE69839405T Expired - Lifetime DE69839405T2 (de) | 1997-06-09 | 1998-06-09 | Verfahren und Reagenzien zur Erzeugung einer CD8+ T-Zellen Immunantwort |
DE69839357T Expired - Lifetime DE69839357T2 (de) | 1997-06-09 | 1998-06-09 | Verfahren und Reagenzien zur Erzeugung einer CD8+ T-Zellen Immunantwort gegen Melanoma |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69839359T Expired - Lifetime DE69839359T2 (de) | 1997-06-09 | 1998-06-09 | Verfahren und Reagenzien zur Erzeugung einer CD8+T-Zellen Immunantwort gegen Hepatitis B oder C |
DE69839405T Expired - Lifetime DE69839405T2 (de) | 1997-06-09 | 1998-06-09 | Verfahren und Reagenzien zur Erzeugung einer CD8+ T-Zellen Immunantwort |
DE69839357T Expired - Lifetime DE69839357T2 (de) | 1997-06-09 | 1998-06-09 | Verfahren und Reagenzien zur Erzeugung einer CD8+ T-Zellen Immunantwort gegen Melanoma |
Country Status (12)
Country | Link |
---|---|
US (10) | US6663871B1 (de) |
EP (5) | EP1335023B1 (de) |
JP (2) | JP4282095B2 (de) |
CN (1) | CN100379865C (de) |
AT (4) | ATE391783T1 (de) |
AU (1) | AU737780B2 (de) |
CA (1) | CA2293692C (de) |
DE (4) | DE69810459T3 (de) |
DK (2) | DK1335023T3 (de) |
ES (1) | ES2189185T5 (de) |
GB (1) | GB9711957D0 (de) |
WO (1) | WO1998056919A2 (de) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9711957D0 (en) * | 1997-06-09 | 1997-08-06 | Isis Innovation | Methods and reagents for vaccination |
US20030138454A1 (en) * | 1997-06-09 | 2003-07-24 | Oxxon Pharmaccines, Ltd. | Vaccination method |
GB0023203D0 (en) * | 2000-09-21 | 2000-11-01 | Isis Innovation | Vaccination method |
EP1078092B1 (de) * | 1998-05-13 | 2011-08-03 | Epimmune Inc. | Expressionsvektoren zur stimulierung einer immunantwort und verfahren zu deren verwendung |
SI1117421T1 (en) * | 1998-10-05 | 2004-12-31 | Pharamexa A/S | Methods for therapeutic vaccination |
EP1117421B2 (de) | 1998-10-05 | 2014-03-19 | Bavarian Nordic Inc. | Verfahren zur therapeutischen impfung |
US7148035B1 (en) | 1998-11-18 | 2006-12-12 | Oxford Biomedica (Uk) Limited | Polypeptide |
WO2000044410A2 (en) * | 1999-01-28 | 2000-08-03 | Stichting Biomedical Primate Research Centre | Composition and method for obtaining specific immunisation against one or more antigens using different recombinant vectors |
CA2372709C (en) | 1999-05-28 | 2011-10-25 | Stefan Wintersperger | Vector for integration of heterologous sequences into poxviral genomes |
WO2001002607A1 (en) | 1999-07-06 | 2001-01-11 | Merck & Co., Inc. | Adenovirus carrying gag gene hiv vaccine |
EP1808180A3 (de) | 1999-10-22 | 2010-12-22 | Sanofi Pasteur Limited | Modifiziertes GP 100 und Verwendung dafür |
DE60043856D1 (de) * | 1999-12-23 | 2010-04-01 | Medical Res Council | Verbesserungen in oder in bezug auf immunantworten gegen hiv |
ES2288885T3 (es) * | 1999-12-28 | 2008-02-01 | Pharmexa Inc. | Minigenes optimizados y peptidos codificados por los mismos. |
US8623379B2 (en) | 2000-03-02 | 2014-01-07 | Emory University | Compositions and methods for generating an immune response |
US20020106798A1 (en) | 2000-03-02 | 2002-08-08 | Robinson Harriet L. | DNA expression vectors and methods of use |
WO2002072754A2 (en) | 2001-03-08 | 2002-09-19 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mva expressing modified hiv envelope, gag, and pol genes |
JP2003531865A (ja) * | 2000-04-28 | 2003-10-28 | アメリカ合衆国 | Dnaおよびワクシニアウイルスベクターワクチンの組み合わせを用いた免疫原性の改善 |
US6733993B2 (en) | 2000-09-15 | 2004-05-11 | Merck & Co., Inc. | Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-gag, pol, nef and modifications |
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US7628980B2 (en) | 2000-11-23 | 2009-12-08 | Bavarian Nordic A/S | Modified vaccinia virus ankara for the vaccination of neonates |
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