DE69810283T2 - GnRH ANTAGONISTEN - Google Patents

GnRH ANTAGONISTEN

Info

Publication number
DE69810283T2
DE69810283T2 DE69810283T DE69810283T DE69810283T2 DE 69810283 T2 DE69810283 T2 DE 69810283T2 DE 69810283 T DE69810283 T DE 69810283T DE 69810283 T DE69810283 T DE 69810283T DE 69810283 T2 DE69810283 T2 DE 69810283T2
Authority
DE
Germany
Prior art keywords
4aph
acetyl
4cpa
2nal
xaa3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69810283T
Other languages
English (en)
Other versions
DE69810283D1 (de
Inventor
Guangcheng Jiang
Graeme Semple
Dr Rivier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferring BV
Original Assignee
Ferring BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring BV filed Critical Ferring BV
Application granted granted Critical
Publication of DE69810283D1 publication Critical patent/DE69810283D1/de
Publication of DE69810283T2 publication Critical patent/DE69810283T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE69810283T 1997-04-11 1998-04-13 GnRH ANTAGONISTEN Expired - Lifetime DE69810283T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/837,041 US5821230A (en) 1997-04-11 1997-04-11 GnRH antagonist decapeptides
PCT/US1998/007519 WO1998046635A1 (en) 1997-04-11 1998-04-13 GnRH ANTAGONISTS

Publications (2)

Publication Number Publication Date
DE69810283D1 DE69810283D1 (de) 2003-01-30
DE69810283T2 true DE69810283T2 (de) 2003-07-24

Family

ID=25273348

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69810283T Expired - Lifetime DE69810283T2 (de) 1997-04-11 1998-04-13 GnRH ANTAGONISTEN

Country Status (10)

Country Link
US (1) US5821230A (de)
EP (1) EP0973801B1 (de)
JP (1) JP4191259B2 (de)
AT (1) ATE229976T1 (de)
AU (1) AU7117498A (de)
DE (1) DE69810283T2 (de)
DK (1) DK0973801T3 (de)
ES (1) ES2187958T3 (de)
PT (1) PT973801E (de)
WO (1) WO1998046635A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6828415B2 (en) * 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
DE19712718C2 (de) * 1997-03-26 1999-09-23 Asta Medica Ag Immobilisierte und aktivitätsstabilisierte Komplexe von LHRH-Antagonisten und Verfahren zu deren Herstellung
US5977302A (en) * 1997-11-20 1999-11-02 Ortho-Mcneil Pharmaceutical, Inc. Liquid phase process for the preparation of GnRH peptides
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
US8119159B2 (en) * 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US20070148228A1 (en) * 1999-02-22 2007-06-28 Merrion Research I Limited Solid oral dosage form containing an enhancer
JP4524823B2 (ja) * 1999-04-14 2010-08-18 住友化学株式会社 タンパク質のアミノ末端のアミノ酸配列決定方法
US7109171B2 (en) * 2000-02-28 2006-09-19 Praecis Pharmaceuticals Inc. Methods for treating FSH related conditions with GnRH antagonists
GB0117057D0 (en) * 2001-07-12 2001-09-05 Ferring Bv Pharmaceutical composition
AU2007235251B2 (en) * 2006-04-07 2013-02-07 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
TWI539959B (zh) 2008-02-11 2016-07-01 菲瑞茵國際中心股份有限公司 治療轉移階段攝護腺癌的方法
AU2009244799B2 (en) * 2008-05-07 2014-11-20 Merrion Research Iii Limited Compositions of GnRH related compounds and processes of preparation
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
PT2712622T (pt) 2008-05-21 2016-10-13 Ferring Bv Desmopressina orodispersível para aumentar o período inicial de sono tranquilo
AR075613A1 (es) * 2009-02-25 2011-04-20 Merrion Res Iii Ltd Composicion y suministro de drogas de bifosfonato. metodo de tratamiento
CN102421414A (zh) 2009-05-01 2012-04-18 辉凌公司 用于治疗前列腺癌的组合物
TW201043221A (en) * 2009-05-06 2010-12-16 Ferring Int Ct Sa Kit and method for preparation of a Degarelix solution
US20110039787A1 (en) * 2009-07-06 2011-02-17 Ferring International Center S.A. Compositions, kits and methods for treating benign prostate hyperplasia
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
US9089484B2 (en) * 2010-03-26 2015-07-28 Merrion Research Iii Limited Pharmaceutical compositions of selective factor Xa inhibitors for oral administration
EP2447276A1 (de) 2010-10-27 2012-05-02 Ferring B.V. Verfahren zur Herstellung von Degarelix und seinen Zwischenprodukten
RS55457B1 (sr) 2010-10-27 2017-04-28 Ferring Bv Postupak za proizvodnju degareliksa i njegovih intermedijara
AU2012204213A1 (en) 2011-01-07 2013-06-13 Merrion Research Iii Limited Pharmaceutical compositions of iron for oral administration
JO3755B1 (ar) 2011-01-26 2021-01-31 Ferring Bv تركيبات تستوستيرون
NZ727679A (en) 2012-06-01 2018-05-25 Ferring Bv Manufacture of degarelix
WO2016120378A1 (en) 2015-01-29 2016-08-04 Novo Nordisk A/S Tablets comprising glp-1 agonist and enteric coating

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073624A (en) * 1985-04-09 1991-12-17 Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US4866160A (en) * 1985-04-09 1989-09-12 The Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
US4935491A (en) * 1987-08-24 1990-06-19 Board Of Regents, The University Of Texas System Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
US5110904A (en) * 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs
US5171835A (en) * 1988-10-21 1992-12-15 The Administrators Of The Tulane Educational Fund LHRH antagonists
US5296468A (en) * 1989-10-30 1994-03-22 The Salk Institute For Biological Studies GnRH analogs
US5169932A (en) * 1989-10-30 1992-12-08 The Salk Institute For Biological Studies Gnrh analogs
US5064939A (en) * 1990-02-06 1991-11-12 The Salk Institute For Biological Studies Cyclic gnrh antagonists
IL101074A (en) * 1991-03-14 1997-09-30 Salk Inst For Biological Studi GnRH ANALOGS AND THEIR PREPARATION
DK0593491T3 (da) * 1991-04-25 1997-03-17 Romano Deghenghi Luteiniseringshormonfrigørende hormonantagonistpeptider
US5508383A (en) * 1994-03-09 1996-04-16 Tap Holdings Inc. Cyclic peptide LHRH antagonists
US5506207A (en) * 1994-03-18 1996-04-09 The Salk Institute For Biological Studies GNRH antagonists XIII
US5681928A (en) * 1994-12-16 1997-10-28 The Salk Institute For Biological Studies Betides and methods for screening peptides using same
WO1997022622A1 (en) * 1995-12-15 1997-06-26 The Salk Institute For Biological Studies Betide-substituted gnrh antagonists

Also Published As

Publication number Publication date
WO1998046635A1 (en) 1998-10-22
JP2001523232A (ja) 2001-11-20
ES2187958T3 (es) 2003-06-16
JP4191259B2 (ja) 2008-12-03
US5821230A (en) 1998-10-13
PT973801E (pt) 2003-04-30
EP0973801A1 (de) 2000-01-26
ATE229976T1 (de) 2003-01-15
EP0973801B1 (de) 2002-12-18
AU7117498A (en) 1998-11-11
DE69810283D1 (de) 2003-01-30
DK0973801T3 (da) 2003-04-07

Similar Documents

Publication Publication Date Title
DK0973801T3 (da) GnRH-antagonister
US5003011A (en) Therapeutic decapeptides
CY1107051T1 (el) Αντι-διηθητικα και αντι-αγγειογενετικα θραυσματα ουροκινασης και η χρηση τους
NO982731L (no) Antagonister av gonadotropinfrigivende hormon
EE9800173A (et) Gonadotropiini riliisinghormooni antagonistid
MXPA02006029A (es) Lipopeptidos novedosos como agentes antibacterianos.
MXPA02006030A (es) Lipopeptidos como agentes antibacterianos.
MY139203A (en) Pharmaceutical composition
KR970701730A (ko) GnRH 길항물질(GNRH ANTAGONISTS)
CA2286190A1 (en) Gnrh antagonists being modified in positions 5 and 6
SE9604341D0 (sv) Hepta-peptide oxytocin analogue
KR920004418A (ko) 브래디키닌 길항제
ATE202708T1 (de) Peptidantagonisten des bradykinin
US5413990A (en) N-terminus modified analogs of LHRH
CA2097192A1 (en) Bombesin antagonists
US5502035A (en) N-terminus modified analogs of LHRH
CY1107990T1 (el) Τριπεπτιδια και παραγωγα τριπεπτιδιων για τη θepαπεια νευροεκφυλιστικων ασθενειων
HU218288B (en) Bombesin-antagonistic polypeptide derivatives and pharmaceutical compositions containing them
DK1309613T3 (da) Farmaceutisk præparat omfattende et analgetisk peptid
KR20000076211A (ko) 택산과 조합된 돌라스태틴-15 유도체
RU2010130763A (ru) Способы и фармакологические композиции для заживления ран
US5516759A (en) LHRH antagonists having lactam groups at the N-terminus
KR920002628A (ko) 펩티드
WO1995004541A1 (en) N-terminus modified analogs of lhrh
IE51068B1 (en) Lrf antagonists

Legal Events

Date Code Title Description
8364 No opposition during term of opposition