DE69810283D1 - GnRH ANTAGONISTEN - Google Patents

GnRH ANTAGONISTEN

Info

Publication number
DE69810283D1
DE69810283D1 DE69810283T DE69810283T DE69810283D1 DE 69810283 D1 DE69810283 D1 DE 69810283D1 DE 69810283 T DE69810283 T DE 69810283T DE 69810283 T DE69810283 T DE 69810283T DE 69810283 D1 DE69810283 D1 DE 69810283D1
Authority
DE
Germany
Prior art keywords
4aph
acetyl
4cpa
2nal
xaa3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69810283T
Other languages
English (en)
Other versions
DE69810283T2 (de
Inventor
Guangcheng Jiang
Graeme Semple
Dr Rivier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferring BV
Original Assignee
Ferring BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring BV filed Critical Ferring BV
Application granted granted Critical
Publication of DE69810283D1 publication Critical patent/DE69810283D1/de
Publication of DE69810283T2 publication Critical patent/DE69810283T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69810283T 1997-04-11 1998-04-13 GnRH ANTAGONISTEN Expired - Lifetime DE69810283T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/837,041 US5821230A (en) 1997-04-11 1997-04-11 GnRH antagonist decapeptides
PCT/US1998/007519 WO1998046635A1 (en) 1997-04-11 1998-04-13 GnRH ANTAGONISTS

Publications (2)

Publication Number Publication Date
DE69810283D1 true DE69810283D1 (de) 2003-01-30
DE69810283T2 DE69810283T2 (de) 2003-07-24

Family

ID=25273348

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69810283T Expired - Lifetime DE69810283T2 (de) 1997-04-11 1998-04-13 GnRH ANTAGONISTEN

Country Status (10)

Country Link
US (1) US5821230A (de)
EP (1) EP0973801B1 (de)
JP (1) JP4191259B2 (de)
AT (1) ATE229976T1 (de)
AU (1) AU7117498A (de)
DE (1) DE69810283T2 (de)
DK (1) DK0973801T3 (de)
ES (1) ES2187958T3 (de)
PT (1) PT973801E (de)
WO (1) WO1998046635A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6828415B2 (en) * 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
DE19712718C2 (de) * 1997-03-26 1999-09-23 Asta Medica Ag Immobilisierte und aktivitätsstabilisierte Komplexe von LHRH-Antagonisten und Verfahren zu deren Herstellung
US5977302A (en) * 1997-11-20 1999-11-02 Ortho-Mcneil Pharmaceutical, Inc. Liquid phase process for the preparation of GnRH peptides
US8119159B2 (en) * 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US20070148228A1 (en) * 1999-02-22 2007-06-28 Merrion Research I Limited Solid oral dosage form containing an enhancer
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
JP4524823B2 (ja) * 1999-04-14 2010-08-18 住友化学株式会社 タンパク質のアミノ末端のアミノ酸配列決定方法
US7109171B2 (en) * 2000-02-28 2006-09-19 Praecis Pharmaceuticals Inc. Methods for treating FSH related conditions with GnRH antagonists
GB0117057D0 (en) * 2001-07-12 2001-09-05 Ferring Bv Pharmaceutical composition
CN101437522A (zh) * 2006-04-07 2009-05-20 默里昂研究Ⅲ有限公司 包含增强剂的固体口服剂型
TWI539959B (zh) * 2008-02-11 2016-07-01 菲瑞茵國際中心股份有限公司 治療轉移階段攝護腺癌的方法
BRPI0912384A2 (pt) * 2008-05-07 2015-10-13 Merrion Res Iii Ltd composição, e, método para preparar uma composição
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
LT3225249T (lt) 2008-05-21 2019-01-10 Ferring B.V. Burnoje disperguojamas desmopresinas, skirtas pirminio miego periodo, nepertraukiamo nikturija, pailginimui
US20100215743A1 (en) * 2009-02-25 2010-08-26 Leonard Thomas W Composition and drug delivery of bisphosphonates
EP2424503B1 (de) 2009-05-01 2017-07-05 Ferring BV Zusammensetzung zur Behandlung von Prostatakrebs
TW201043221A (en) * 2009-05-06 2010-12-16 Ferring Int Ct Sa Kit and method for preparation of a Degarelix solution
US20110039787A1 (en) * 2009-07-06 2011-02-17 Ferring International Center S.A. Compositions, kits and methods for treating benign prostate hyperplasia
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
WO2011120033A1 (en) * 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration
HUE031113T2 (en) 2010-10-27 2017-06-28 Ferring Bv Procedure for the preparation of Degarelix and its intermediates
EP2447276A1 (de) 2010-10-27 2012-05-02 Ferring B.V. Verfahren zur Herstellung von Degarelix und seinen Zwischenprodukten
KR20140026354A (ko) 2011-01-07 2014-03-05 메리온 리서치 Ⅲ 리미티드 경구 투여용 철의 제약 조성물
JO3755B1 (ar) 2011-01-26 2021-01-31 Ferring Bv تركيبات تستوستيرون
SG11201407679PA (en) 2012-06-01 2014-12-30 Ferring Bv Manufacture of degarelix
WO2016120378A1 (en) 2015-01-29 2016-08-04 Novo Nordisk A/S Tablets comprising glp-1 agonist and enteric coating

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866160A (en) * 1985-04-09 1989-09-12 The Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US5073624A (en) * 1985-04-09 1991-12-17 Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
US4935491A (en) * 1987-08-24 1990-06-19 Board Of Regents, The University Of Texas System Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
US5110904A (en) * 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs
US5171835A (en) * 1988-10-21 1992-12-15 The Administrators Of The Tulane Educational Fund LHRH antagonists
US5169932A (en) * 1989-10-30 1992-12-08 The Salk Institute For Biological Studies Gnrh analogs
US5296468A (en) * 1989-10-30 1994-03-22 The Salk Institute For Biological Studies GnRH analogs
US5064939A (en) * 1990-02-06 1991-11-12 The Salk Institute For Biological Studies Cyclic gnrh antagonists
IL101074A (en) * 1991-03-14 1997-09-30 Salk Inst For Biological Studi GnRH ANALOGS AND THEIR PREPARATION
US5516887A (en) * 1991-04-25 1996-05-14 Romano Deghenghi Luteinizing hormone releasing hormone antagonist peptides
US5508383A (en) * 1994-03-09 1996-04-16 Tap Holdings Inc. Cyclic peptide LHRH antagonists
US5506207A (en) * 1994-03-18 1996-04-09 The Salk Institute For Biological Studies GNRH antagonists XIII
US5681928A (en) * 1994-12-16 1997-10-28 The Salk Institute For Biological Studies Betides and methods for screening peptides using same
AU4974596A (en) * 1995-12-15 1997-07-14 Salk Institute For Biological Studies, The Betide-substituted gnrh antagonists

Also Published As

Publication number Publication date
JP4191259B2 (ja) 2008-12-03
EP0973801B1 (de) 2002-12-18
AU7117498A (en) 1998-11-11
JP2001523232A (ja) 2001-11-20
WO1998046635A1 (en) 1998-10-22
ATE229976T1 (de) 2003-01-15
DE69810283T2 (de) 2003-07-24
US5821230A (en) 1998-10-13
EP0973801A1 (de) 2000-01-26
ES2187958T3 (es) 2003-06-16
PT973801E (pt) 2003-04-30
DK0973801T3 (da) 2003-04-07

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Legal Events

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8364 No opposition during term of opposition