DE69739165D1 - Matrix mit verzögerter freisetzung für hochdosierte unlösliche arzneistoffe - Google Patents
Matrix mit verzögerter freisetzung für hochdosierte unlösliche arzneistoffeInfo
- Publication number
- DE69739165D1 DE69739165D1 DE69739165T DE69739165T DE69739165D1 DE 69739165 D1 DE69739165 D1 DE 69739165D1 DE 69739165 T DE69739165 T DE 69739165T DE 69739165 T DE69739165 T DE 69739165T DE 69739165 D1 DE69739165 D1 DE 69739165D1
- Authority
- DE
- Germany
- Prior art keywords
- medicaments
- insulated
- matrix
- delayed release
- highly dosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2133596P | 1996-07-08 | 1996-07-08 | |
PCT/US1997/013331 WO1998001117A1 (en) | 1996-07-08 | 1997-07-08 | Sustained release matrix for high-dose insoluble drugs |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69739165D1 true DE69739165D1 (de) | 2009-01-29 |
Family
ID=21803631
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69739165T Expired - Lifetime DE69739165D1 (de) | 1996-07-08 | 1997-07-08 | Matrix mit verzögerter freisetzung für hochdosierte unlösliche arzneistoffe |
Country Status (12)
Country | Link |
---|---|
US (4) | US6093420A (de) |
EP (1) | EP0859603B1 (de) |
JP (1) | JP3148256B2 (de) |
KR (1) | KR100321489B1 (de) |
AT (1) | ATE417604T1 (de) |
AU (1) | AU695734B2 (de) |
CA (1) | CA2231195C (de) |
DE (1) | DE69739165D1 (de) |
ES (1) | ES2322405T3 (de) |
IL (1) | IL123505A (de) |
MX (1) | MX9801835A (de) |
WO (1) | WO1998001117A1 (de) |
Families Citing this family (80)
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MX9801835A (es) * | 1996-07-08 | 1998-08-30 | Mendell Co Inc Edward | Matriz de liberacion sostenida para medicamentos insolubles de dosis altas. |
US6284269B1 (en) * | 1997-08-27 | 2001-09-04 | Hexal Ag | Pharmaceutical compositions of meloxicam with improved solubility and bioavailability |
US6056977A (en) | 1997-10-15 | 2000-05-02 | Edward Mendell Co., Inc. | Once-a-day controlled release sulfonylurea formulation |
ES2203103T3 (es) * | 1998-04-07 | 2004-04-01 | Alcon Manufacturing Ltd. | Composiciones oftalmicas gelificantes que contienen goma xantana. |
US8293277B2 (en) * | 1998-10-01 | 2012-10-23 | Alkermes Pharma Ireland Limited | Controlled-release nanoparticulate compositions |
US8236352B2 (en) * | 1998-10-01 | 2012-08-07 | Alkermes Pharma Ireland Limited | Glipizide compositions |
US20040013613A1 (en) * | 2001-05-18 | 2004-01-22 | Jain Rajeev A | Rapidly disintegrating solid oral dosage form |
JP2002525311A (ja) * | 1998-10-01 | 2002-08-13 | エラン ファーマ インターナショナル,リミティド | 徐放性ナノ粒子組成物 |
US6419960B1 (en) | 1998-12-17 | 2002-07-16 | Euro-Celtique S.A. | Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations |
US7083808B2 (en) * | 1998-12-17 | 2006-08-01 | Euro-Celtique S.A. | Controlled/modified release oral methylphenidate formulations |
US6673367B1 (en) | 1998-12-17 | 2004-01-06 | Euro-Celtique, S.A. | Controlled/modified release oral methylphenidate formulations |
HUP0104472A3 (en) * | 1999-09-30 | 2002-12-28 | Penwest Pharmaceuticals Co Pat | Sustained release matrix systems for highly soluble drugs |
US20050037073A1 (en) * | 2000-01-13 | 2005-02-17 | Alpharx Inc. | Solid self-emulsifying dosage form for improved delivery of poorly soluble hydrophobic compounds and the process for preparation thereof |
US7198795B2 (en) * | 2000-09-21 | 2007-04-03 | Elan Pharma International Ltd. | In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions |
ES2436523T3 (es) * | 2001-03-13 | 2014-01-02 | Endo Pharmaceuticals Inc. | Formas de dosificación terapéutica |
US9820982B2 (en) * | 2001-07-06 | 2017-11-21 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
US20030129234A1 (en) * | 2001-07-06 | 2003-07-10 | Penwest Pharmaceuticals Company | Methods of making sustained release formulations of oxymorphone |
US8329216B2 (en) * | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
US6705028B2 (en) * | 2001-09-12 | 2004-03-16 | Honda Giken Kogyo Kabushiki Kaisha | Self-propelled snowplow vehicle |
US20030091635A1 (en) * | 2001-09-26 | 2003-05-15 | Baichwal Anand R. | Opioid formulations having reduced potential for abuse |
PE20030527A1 (es) | 2001-10-24 | 2003-07-26 | Gruenenthal Chemie | Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen |
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US20030104052A1 (en) * | 2001-10-25 | 2003-06-05 | Bret Berner | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
US20030091630A1 (en) * | 2001-10-25 | 2003-05-15 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data |
US20030152622A1 (en) * | 2001-10-25 | 2003-08-14 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral diuretic |
US20040101566A1 (en) * | 2002-02-04 | 2004-05-27 | Elan Pharma International Limited | Novel benzoyl peroxide compositions |
ATE464880T1 (de) | 2002-02-04 | 2010-05-15 | Elan Pharma Int Ltd | Arzneistoffnanopartikel mit lysozym- oberflächenstabilisator |
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CA2494281A1 (en) * | 2002-08-02 | 2004-02-12 | Penwest Pharmaceuticals Company | Sustained release formulations of metformin |
CA2520775A1 (en) * | 2003-03-31 | 2004-10-21 | Alza Corporation | Non-aqueous single phase vehicles and formulations utilizing such vehicles |
US20050042289A1 (en) * | 2003-04-29 | 2005-02-24 | Yamanouchi Pharma Technologies, Inc. | Tablets and methods for modified release of hydrophylic and other active agents |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
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US20070212414A1 (en) * | 2006-03-08 | 2007-09-13 | Penwest Pharmaceuticals Co. | Ethanol-resistant sustained release formulations |
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US7749537B2 (en) * | 2006-12-04 | 2010-07-06 | Scolr Pharma, Inc. | Method of forming a tablet |
US9023381B2 (en) * | 2007-01-26 | 2015-05-05 | Michelle Chow | Enhanced medicinal delivery system processes and products thereby especially useful for children |
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JP2012515765A (ja) * | 2009-01-22 | 2012-07-12 | アボット ヘルスケア プライベート リミテッド | 時間治療用医薬組成物 |
ES2560210T3 (es) | 2009-07-22 | 2016-02-17 | Grünenthal GmbH | Forma de dosificación resistente a la manipulación para opiádes sensibles a la oxidación |
JP5667183B2 (ja) | 2009-07-22 | 2015-02-12 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 加熱溶融押出成型した制御放出性投与剤型 |
KR20130137627A (ko) | 2010-09-02 | 2013-12-17 | 그뤼넨탈 게엠베하 | 음이온성 중합체를 포함하는 내변조성 투여형 |
RU2604676C2 (ru) | 2010-09-02 | 2016-12-10 | Грюненталь Гмбх | Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль |
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AR087359A1 (es) | 2011-07-29 | 2014-03-19 | Gruenenthal Gmbh | Tableta a prueba de alteracion que proporciona liberacion inmediata del farmaco |
MX356421B (es) | 2012-02-28 | 2018-05-29 | Gruenenthal Gmbh | Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico. |
EP2827839B1 (de) | 2012-03-20 | 2019-02-27 | Particle Dynamics International, LLC | Dosierungsform auf basis eines gelierungsmittels |
ES2692944T3 (es) | 2012-04-18 | 2018-12-05 | Grünenthal GmbH | Forma de dosificación farmacéutica resistente a la manipulación y resistente a la descarga rápida de la dosis |
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-
1997
- 1997-07-08 MX MX9801835A patent/MX9801835A/es unknown
- 1997-07-08 CA CA002231195A patent/CA2231195C/en not_active Expired - Fee Related
- 1997-07-08 JP JP50540898A patent/JP3148256B2/ja not_active Expired - Fee Related
- 1997-07-08 AU AU38183/97A patent/AU695734B2/en not_active Ceased
- 1997-07-08 ES ES97935184T patent/ES2322405T3/es not_active Expired - Lifetime
- 1997-07-08 KR KR1019980701734A patent/KR100321489B1/ko not_active IP Right Cessation
- 1997-07-08 DE DE69739165T patent/DE69739165D1/de not_active Expired - Lifetime
- 1997-07-08 AT AT97935184T patent/ATE417604T1/de not_active IP Right Cessation
- 1997-07-08 WO PCT/US1997/013331 patent/WO1998001117A1/en active IP Right Grant
- 1997-07-08 US US08/889,424 patent/US6093420A/en not_active Expired - Lifetime
- 1997-07-08 IL IL12350597A patent/IL123505A/en not_active IP Right Cessation
- 1997-07-08 EP EP97935184A patent/EP0859603B1/de not_active Expired - Lifetime
-
1999
- 1999-10-19 US US09/420,247 patent/US6245355B1/en not_active Expired - Lifetime
-
2001
- 2001-04-25 US US09/842,289 patent/US6689386B2/en not_active Expired - Fee Related
-
2003
- 2003-12-09 US US10/731,859 patent/US20040121012A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1998001117A1 (en) | 1998-01-15 |
JP3148256B2 (ja) | 2001-03-19 |
AU3818397A (en) | 1998-02-02 |
MX9801835A (es) | 1998-08-30 |
US20010021392A1 (en) | 2001-09-13 |
AU695734B2 (en) | 1998-08-20 |
US6093420A (en) | 2000-07-25 |
JPH10511407A (ja) | 1998-11-04 |
EP0859603B1 (de) | 2008-12-17 |
CA2231195C (en) | 2003-01-21 |
KR19990044486A (ko) | 1999-06-25 |
CA2231195A1 (en) | 1998-01-15 |
EP0859603A4 (de) | 2006-05-24 |
ATE417604T1 (de) | 2009-01-15 |
IL123505A0 (en) | 1998-10-30 |
IL123505A (en) | 2004-12-15 |
KR100321489B1 (ko) | 2002-10-09 |
ES2322405T3 (es) | 2009-06-19 |
US20040121012A1 (en) | 2004-06-24 |
US6245355B1 (en) | 2001-06-12 |
EP0859603A1 (de) | 1998-08-26 |
US6689386B2 (en) | 2004-02-10 |
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