DE69736293D1 - Verfahren und zusammensetzung zur auffindung von cervix-krebs - Google Patents
Verfahren und zusammensetzung zur auffindung von cervix-krebsInfo
- Publication number
- DE69736293D1 DE69736293D1 DE69736293T DE69736293T DE69736293D1 DE 69736293 D1 DE69736293 D1 DE 69736293D1 DE 69736293 T DE69736293 T DE 69736293T DE 69736293 T DE69736293 T DE 69736293T DE 69736293 D1 DE69736293 D1 DE 69736293D1
- Authority
- DE
- Germany
- Prior art keywords
- cervical cancer
- provides
- individual
- preparation
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 title abstract 8
- 201000010881 cervical cancer Diseases 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 206010008342 Cervix carcinoma Diseases 0.000 abstract 7
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 238000001514 detection method Methods 0.000 abstract 2
- 206010027476 Metastases Diseases 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57411—Specifically defined cancers of cervix
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/705,660 US5858683A (en) | 1996-08-30 | 1996-08-30 | Methods and compositions for the detection of cervical cancer |
PCT/US1997/014526 WO1998009170A2 (en) | 1996-08-30 | 1997-08-19 | Methods and compositions for the detection of cervical cancer |
US705660 | 2000-11-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69736293D1 true DE69736293D1 (de) | 2006-08-17 |
DE69736293T2 DE69736293T2 (de) | 2007-06-14 |
Family
ID=24834422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69736293T Expired - Lifetime DE69736293T2 (de) | 1996-08-30 | 1997-08-19 | Verfahren und zusammensetzung zur auffindung von cervix-krebs |
Country Status (9)
Country | Link |
---|---|
US (4) | US5858683A (de) |
EP (1) | EP0923740B1 (de) |
JP (1) | JP4116082B2 (de) |
AT (1) | ATE332505T1 (de) |
AU (1) | AU4073297A (de) |
CA (1) | CA2263888C (de) |
DE (1) | DE69736293T2 (de) |
ES (1) | ES2268735T3 (de) |
WO (1) | WO1998009170A2 (de) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1025444B1 (de) * | 1997-10-21 | 2005-03-02 | Cancer Research Technology Limited | Nachweis von zellwachstumabnormalität |
US6303323B1 (en) | 1997-10-21 | 2001-10-16 | Cancer Research Campaign Technology Limited | Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies |
GB9805477D0 (en) * | 1998-03-13 | 1998-05-13 | Oxford Glycosciences Limited | Methods and compositions for diagnosis of rheumatoid arthritis |
DE19829473C2 (de) * | 1998-07-01 | 2000-08-10 | Magnus Von Knebel Doeberitz Ch | Verfahren zur frühen Diagnose von Carcinomen |
US7306926B2 (en) * | 1998-07-01 | 2007-12-11 | Mtm Laboratories Ag | Method for detecting carcinomas in a solubilized cervical body sample |
DE19855819C2 (de) * | 1998-12-03 | 2001-02-15 | Roche Diagnostics Gmbh | Stabilisierung von Cytokeratin enthaltenden Kalibratoren |
US6294349B1 (en) | 1999-03-01 | 2001-09-25 | University Of Mississippi Medical Ctr. | Method of diagnosing and monitoring malignant breast carcinomas |
US6379970B1 (en) * | 1999-04-30 | 2002-04-30 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Analysis of differential protein expression |
IL146374A0 (en) | 1999-05-17 | 2002-07-25 | Pro Duct Health Inc | Identifying material from a breast duct |
CA2376831A1 (en) * | 1999-06-29 | 2001-01-04 | Intercet, Ltd. | Human cancer virtual simulation system |
WO2001042467A2 (en) * | 1999-12-08 | 2001-06-14 | Millennium Pharmaceuticals, Inc. | Genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer |
AU2074101A (en) * | 1999-12-08 | 2001-06-18 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer |
WO2002021428A1 (en) * | 2000-09-01 | 2002-03-14 | Large Scale Proteomics Corporation | Reference database |
US6980674B2 (en) * | 2000-09-01 | 2005-12-27 | Large Scale Proteomics Corp. | Reference database |
US6539102B1 (en) * | 2000-09-01 | 2003-03-25 | Large Scale Proteomics | Reference database |
EP1202211A3 (de) * | 2000-10-26 | 2004-12-22 | Riken | Computerprogramm zur Analyse von genomischer DNS |
KR100426453B1 (ko) * | 2000-11-28 | 2004-04-13 | 김진우 | 인간 자궁경부암 2 원암 유전자 및 이에 의해 코딩되는단백질, 이를 포함하는 발현벡터 및 이 벡터로 형질전환된세포 |
KR100426454B1 (ko) * | 2000-11-28 | 2004-04-13 | 김진우 | 인간 원암 유전자 및 이에 의해 코드되는 단백질 |
US20030009293A1 (en) * | 2001-01-09 | 2003-01-09 | Anderson Norman G. | Reference database |
AUPR595601A0 (en) | 2001-06-27 | 2001-07-19 | International Diabetes Institute | Hypoglycaemic peptides and methods of use thereof |
KR100472746B1 (ko) * | 2001-08-13 | 2005-03-07 | 김진우 | 원암 유전자 kg-20 및 이에 의해 코드되는 단백질 |
US20030138425A1 (en) * | 2001-09-21 | 2003-07-24 | Mather Jennie Powell | Antibodies that bind to cancer-associated antigen cytokeratin 8 and methods of use thereof |
US7906102B2 (en) | 2001-10-03 | 2011-03-15 | Vanderbilt University | Ligands to radiation-induced molecules |
US7306925B2 (en) | 2001-11-09 | 2007-12-11 | Vanderbilt University | Phage antibodies to radiation-inducible neoantigens |
EP1333278B1 (de) | 2002-02-01 | 2004-03-10 | MTM molecular tools in medicine | Verfahren zur Prognose gastrointestinaler Tumoren |
KR100472747B1 (ko) * | 2002-03-12 | 2005-03-09 | 김진우 | 인간 원암 유전자 및 이에 의해 코드되는 단백질 |
EP1369694A1 (de) * | 2002-04-09 | 2003-12-10 | MTM Laboratories AG | Verfahren zur Unterscheidung zwischen Metaplasien und neoplastischen oder präneoplastischen Läsionen |
DE60229920D1 (de) * | 2002-05-21 | 2009-01-02 | Mtm Lab Ag | Marker für Lungentumore |
KR20030094905A (ko) * | 2002-06-10 | 2003-12-18 | 김진우 | 생쥐 발암유전자, 이에 의해 코드되는 단백질 및 이를포함하는 발현벡터 |
AU2002345407A1 (en) * | 2002-06-29 | 2004-01-19 | Jin-Woo Kim | Human cervical cancer 5 protooncogene and protein encoded therein |
AU2002345414A1 (en) * | 2002-07-04 | 2004-01-23 | Jin Woo Kim | Human protooncogene 6 and protein encoded therein |
ATE261126T1 (de) * | 2002-08-01 | 2004-03-15 | Mtm Lab Ag | Verfahren für lösung-basierte diagnose |
EP1422526A1 (de) | 2002-10-28 | 2004-05-26 | MTM Laboratories AG | Verfahren zur verbesserten Diagnose von Dysplasien |
US20040137551A1 (en) * | 2003-01-13 | 2004-07-15 | Markovic Nenad S. | Cervical acid phosphatase - papanicolaou (CAP-PAP) test kit, method and accesories, processes for producing and using the same |
US7291699B2 (en) * | 2003-03-18 | 2007-11-06 | The Regents Of The University Of Colorado | Product and methods for diagnosis and therapy for cardiac and skeletal muscle disorders |
US7361460B2 (en) * | 2003-04-11 | 2008-04-22 | Digene Corporation | Approach to molecular diagnosis of human papillomavirus-related diseases |
ATE289685T1 (de) * | 2003-08-25 | 2005-03-15 | Mtm Lab Ag | Verfahren zum nachweis von karzinomen in solubilisierten zervikalen körperproben |
JPWO2005043166A1 (ja) * | 2003-10-30 | 2007-11-29 | シスメックス株式会社 | 子宮腺癌の診断薬及び腺癌細胞の検出方法 |
WO2005054548A2 (en) | 2003-11-28 | 2005-06-16 | Invitrogen Corporation | Methods, compositions, and kits for protein crystallization |
KR100882249B1 (ko) * | 2004-03-24 | 2009-02-06 | 트리패스 이미징, 인코포레이티드 | 자궁경부 질환의 검사 방법 및 조성물 |
EP1586903A1 (de) * | 2004-03-30 | 2005-10-19 | Sysmex Corporation | Methode zum Screenen nach Zervixkarzinomen |
US7183057B2 (en) * | 2004-03-31 | 2007-02-27 | Dermtech International | Tape stripping methods for analysis of skin disease and pathological skin state |
US7316904B1 (en) | 2004-06-30 | 2008-01-08 | Chromodynamics, Inc. | Automated pap screening using optical detection of HPV with or without multispectral imaging |
EP1835929B8 (de) | 2005-01-06 | 2016-07-27 | Novo Nordisk A/S | Behandlungen und verfahren mit anti-kir-kombination |
KR100689275B1 (ko) | 2005-03-30 | 2007-03-08 | 김현기 | 인간 원암유전자 trg 및 이에 의해 코드되는 단백질 |
US7595380B2 (en) * | 2005-04-27 | 2009-09-29 | Tripath Imaging, Inc. | Monoclonal antibodies and methods for their use in the detection of cervical disease |
US20070015166A1 (en) * | 2005-07-14 | 2007-01-18 | Nilsen Thor W | Lateral flow methods and devices for detection of nucleic acid binding proteins |
US7632498B2 (en) * | 2005-12-19 | 2009-12-15 | Tripath Imaging, Inc. | MCM6 and MCM7 monoclonal antibodies and methods for their use in the detection of cervical disease |
WO2009015294A1 (en) | 2007-07-24 | 2009-01-29 | Wisconsin Alumni Research Foundation | Biomarkers for human papillomavirus-associated cancers |
JP2011520451A (ja) | 2008-05-14 | 2011-07-21 | ダームテック インターナショナル | 核酸解析による黒色腫および日光黒子の診断法 |
US10011884B2 (en) | 2010-11-12 | 2018-07-03 | Incelldx, Inc. | Methods and systems for predicting whether a subject has a cervical intraepithelial neoplasia (CIN) lesion from a suspension sample of cervical cells |
WO2013019730A1 (en) | 2011-07-29 | 2013-02-07 | The Washington University | Antibodies to tip-1 and grp78 |
CN105899673B (zh) * | 2013-08-08 | 2019-09-13 | 纽约州州立大学研究基金会 | 作为子宫颈癌和存活期的生物标记物的角蛋白 |
WO2016014939A1 (en) | 2014-07-24 | 2016-01-28 | Washington University | Compositions targeting radiation-induced molecules and methods of use thereof |
KR20180132807A (ko) * | 2016-04-07 | 2018-12-12 | 케이스 웨스턴 리저브 유니버시티 | 신경퇴행성 질환의 치료용 tdp-43 미토콘드리아 국소화 억제제 |
US11352436B2 (en) | 2017-02-10 | 2022-06-07 | Washington University | Antibodies to TIP1 and methods of use thereof |
WO2020198229A1 (en) | 2019-03-26 | 2020-10-01 | Dermtech, Inc. | Novel gene classifiers and uses thereof in skin cancers |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56145222A (en) * | 1980-04-28 | 1981-11-11 | Toshiyuki Hamaoka | Improved antibody and its preparation |
US4474893A (en) * | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
DE3588043T2 (de) * | 1984-01-06 | 1996-03-21 | Univ California | Cytokeratin-tumormarkierer und test zu deren nachweis. |
JPS6284100A (ja) * | 1985-10-08 | 1987-04-17 | Dainabotsuto Kk | 扁平上皮癌関連抗原に対する抗体及びその免疫学的利用法 |
US4882268A (en) * | 1985-12-24 | 1989-11-21 | Massachusetts Institute Of Technology | Method for determining tissue of origin and degree of malignancy of tumor cells |
US5273877A (en) * | 1985-12-24 | 1993-12-28 | Massachusetts Institute Of Technology | Non-histological cell type determination |
US5091513A (en) * | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5098890A (en) * | 1988-11-07 | 1992-03-24 | Temple University-Of The Commonwealth System Of Higher Education | Antisence oligonucleotides to c-myb proto-oncogene and uses thereof |
CA1340245C (en) * | 1989-04-21 | 1998-12-15 | John Samuel | Monoclonal antibody for differentiation of squamous cell carcinoma antigens and method of use for same |
DK51092D0 (da) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
JP3190042B2 (ja) * | 1991-10-31 | 2001-07-16 | マトリテク インコーポレイテッド | 核マトリックス蛋白液アッセー |
US5688511A (en) * | 1991-11-05 | 1997-11-18 | Board Of Regents, The University Of Texas System | Cellular protein TDP-43 and regulation of HIV-1 gene expression |
US5350835A (en) * | 1991-11-05 | 1994-09-27 | Board Of Regents, University Of Texas | Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids |
WO1994000573A1 (en) * | 1992-06-22 | 1994-01-06 | Matritech, Inc. | Novel malignant cell type markers of the interior nuclear matrix |
AU5694694A (en) * | 1992-12-02 | 1994-06-22 | Denis F. Hochstrasser | A method for detecting growing cells using translationally controlled tumor protein p21 |
US5547928A (en) * | 1993-12-17 | 1996-08-20 | Matritech, Inc. | Methods and compositions for the detection of colon cancers |
US5519003A (en) * | 1994-02-01 | 1996-05-21 | Board Of Trustees Of The Leland Stanford Junior University | WD-40-derived peptides and uses thereof |
-
1996
- 1996-08-30 US US08/705,660 patent/US5858683A/en not_active Expired - Lifetime
-
1997
- 1997-08-19 AT AT97938400T patent/ATE332505T1/de not_active IP Right Cessation
- 1997-08-19 WO PCT/US1997/014526 patent/WO1998009170A2/en active IP Right Grant
- 1997-08-19 EP EP97938400A patent/EP0923740B1/de not_active Expired - Lifetime
- 1997-08-19 ES ES97938400T patent/ES2268735T3/es not_active Expired - Lifetime
- 1997-08-19 DE DE69736293T patent/DE69736293T2/de not_active Expired - Lifetime
- 1997-08-19 CA CA002263888A patent/CA2263888C/en not_active Expired - Fee Related
- 1997-08-19 JP JP51170698A patent/JP4116082B2/ja not_active Expired - Fee Related
- 1997-08-19 AU AU40732/97A patent/AU4073297A/en not_active Abandoned
- 1997-12-11 US US08/989,045 patent/US6027905A/en not_active Expired - Lifetime
-
1999
- 1999-05-17 US US09/315,355 patent/US6803189B2/en not_active Expired - Fee Related
-
2004
- 2004-05-18 US US10/848,572 patent/US20050164313A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6027905A (en) | 2000-02-22 |
WO1998009170A3 (en) | 1998-04-23 |
CA2263888C (en) | 2004-10-26 |
ATE332505T1 (de) | 2006-07-15 |
WO1998009170A2 (en) | 1998-03-05 |
AU4073297A (en) | 1998-03-19 |
US20030157482A1 (en) | 2003-08-21 |
JP2001500609A (ja) | 2001-01-16 |
EP0923740A2 (de) | 1999-06-23 |
EP0923740B1 (de) | 2006-07-05 |
US20050164313A1 (en) | 2005-07-28 |
CA2263888A1 (en) | 1998-03-05 |
US6803189B2 (en) | 2004-10-12 |
ES2268735T3 (es) | 2007-03-16 |
US5858683A (en) | 1999-01-12 |
DE69736293T2 (de) | 2007-06-14 |
JP4116082B2 (ja) | 2008-07-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: MATRITECH, INC. (N.D.GES.D. STAATES DELAWARE),, US |