DE69732868D1 - Mittel gegen Juckreiz - Google Patents

Mittel gegen Juckreiz

Info

Publication number
DE69732868D1
DE69732868D1 DE69732868T DE69732868T DE69732868D1 DE 69732868 D1 DE69732868 D1 DE 69732868D1 DE 69732868 T DE69732868 T DE 69732868T DE 69732868 T DE69732868 T DE 69732868T DE 69732868 D1 DE69732868 D1 DE 69732868D1
Authority
DE
Germany
Prior art keywords
itching
remedy
morphinian
antipruritic
opiate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69732868T
Other languages
English (en)
Other versions
DE69732868T2 (de
Inventor
Hiroshi Nagase
Jun Utsumi
Takashi Endoh
Toshiaki Tanaka
Kuniaki Kawamura
Junzo Kamei
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18041771&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69732868(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of DE69732868D1 publication Critical patent/DE69732868D1/de
Publication of DE69732868T2 publication Critical patent/DE69732868T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
DE69732868T 1996-11-25 1997-11-21 Mittel gegen Juckreiz Expired - Lifetime DE69732868T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP31347696 1996-11-25
JP31347696 1996-11-25

Publications (2)

Publication Number Publication Date
DE69732868D1 true DE69732868D1 (de) 2005-04-28
DE69732868T2 DE69732868T2 (de) 2006-04-13

Family

ID=18041771

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69737592T Expired - Lifetime DE69737592T2 (de) 1996-11-25 1997-11-21 Mittel gegen juckreiz
DE69728585T Expired - Lifetime DE69728585T2 (de) 1996-11-25 1997-11-21 Mittel gegen Juckreiz
DE69732868T Expired - Lifetime DE69732868T2 (de) 1996-11-25 1997-11-21 Mittel gegen Juckreiz

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69737592T Expired - Lifetime DE69737592T2 (de) 1996-11-25 1997-11-21 Mittel gegen juckreiz
DE69728585T Expired - Lifetime DE69728585T2 (de) 1996-11-25 1997-11-21 Mittel gegen Juckreiz

Country Status (15)

Country Link
US (2) US6174891B1 (de)
EP (5) EP1327444B1 (de)
KR (1) KR100557801B1 (de)
CN (3) CN1535687A (de)
AT (3) ATE291429T1 (de)
AU (1) AU738743B2 (de)
CA (1) CA2244256C (de)
DE (3) DE69737592T2 (de)
DK (1) DK0897726T3 (de)
ES (3) ES2236630T3 (de)
NO (1) NO316309B1 (de)
NZ (1) NZ331001A (de)
PT (1) PT897726E (de)
TW (1) TW542838B (de)
WO (1) WO1998023290A1 (de)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
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US5763445A (en) * 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
DE69637416T2 (de) * 1996-12-24 2009-01-22 George F. Long Beach Elkhoury Topische anwendung von opioiden, wie morphin, zur linderung von juckreiz und hautkrankheiten sowie hautreizungen
JP2003526594A (ja) * 1997-07-14 2003-09-09 アドラー コーポレーション カッパ・アゴニスト抗掻痒薬学的製剤およびそれにより掻痒を治療する方法
JP3211027B2 (ja) * 1998-11-13 2001-09-25 丸石製薬株式会社 カプサイシン含有外用剤
WO2001014382A1 (fr) * 1999-08-23 2001-03-01 Toray Industries, Inc. Analgesiques contenant des derives sel d'ammonium quaternaire comme principe actif
CA2383146C (en) * 1999-08-24 2010-11-16 Hiroshi Nagase Therapeutic agent for neuropathic pain and neuropathic pain animal model
WO2001074819A1 (fr) * 2000-04-03 2001-10-11 Toray Industries, Inc. Agents analgesiques contenant des derives de n-oxyde de morphinane en tant que principe actif
JP2002249442A (ja) * 2001-02-21 2002-09-06 Fumakilla Ltd アレルギー減感作治療薬
AU2002241326B2 (en) * 2001-03-30 2007-09-06 Toray Industries, Inc Remedies for psychoneurosis
US6617308B2 (en) 2001-04-30 2003-09-09 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1865 daltons
US7294688B2 (en) 2001-04-30 2007-11-13 Nanogen Inc. Biopolymer marker indicative of disease state having a molecular weight of 1348 daltons
CN1283317C (zh) * 2001-05-08 2006-11-08 东丽株式会社 类鸦片κ受体激动性化合物在制备治疗败血症的药物中的应用
US6844438B2 (en) * 2001-08-15 2005-01-18 Mclean Hospital Corporation N-substituted derivatives of morphinan and uses thereof
US20030125347A1 (en) * 2001-11-02 2003-07-03 Elan Corporation Plc Pharmaceutical composition
US7112598B2 (en) 2002-03-29 2006-09-26 Santen Pharmaceutical Co., Ltd. κ opioid receptor agonist comprising 2-phenylbenzothiazoline derivative
WO2004026262A2 (en) * 2002-09-23 2004-04-01 Verion, Inc. Abuse-resistant pharmaceutical compositions
EP1803724A1 (de) * 2002-09-25 2007-07-04 Euro-Celtique S.A. N-substituierte Hydromorphone und ihre Anwendung
CN100586434C (zh) 2004-03-30 2010-02-03 东丽株式会社 止痒剂
US7704522B2 (en) * 2004-09-08 2010-04-27 Clyde Morgan Topical medicament
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US20060069086A1 (en) * 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US20060159748A1 (en) * 2004-12-23 2006-07-20 Rajesh Jain Oral immediate release formulation of a poorly water-soluble active substance
US7453122B2 (en) * 2005-02-08 2008-11-18 Taiwan Semiconductor Manufacturing Co., Ltd. SOI MOSFET device with reduced polysilicon loading on active area
AU2006221314B2 (en) * 2005-03-10 2012-09-06 Toray Industries, Inc. Antipruritic agent for pruritus caused by multiple sclerosis
ES2568475T3 (es) 2005-04-06 2016-04-29 Toray Industries, Inc. Cristales de derivado de morfinano y procedimiento para producir los mismos
JP5119925B2 (ja) * 2005-11-09 2013-01-16 東レ株式会社 機能性腸障害の治療または予防剤
JP5163127B2 (ja) * 2005-12-21 2013-03-13 東レ株式会社 鎮咳剤
EP2099764B1 (de) * 2006-09-20 2011-07-27 Mallinckrodt Inc. Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon
WO2008109156A2 (en) * 2007-03-06 2008-09-12 Mallinckrodt Inc. Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
CA2685126C (en) 2007-04-24 2015-04-14 Toray Industries, Inc. Therapeutic or prophylactic agent for dyskinesia
EP2151241B1 (de) * 2007-04-26 2012-03-21 Toray Industries, Inc. Stabile feste zubereitung mit 4,5-epoxymorphinanderivat
EP2168580B1 (de) 2007-06-22 2015-12-02 Toray Industries, Inc. Heilmittel oder prophylaktikum für schizophrenie
ES2748274T3 (es) 2007-10-05 2020-03-16 Toray Industries Remedio para aliviar los problemas de la piel que comprende un derivado de morfinano o una sal de adición de ácido farmacológicamente aceptable del mismo como el principio activo
WO2009138734A2 (en) * 2008-05-14 2009-11-19 Serentis Limited Use of opioid compounds in peripheral pain, wound healing and scar formation
US8148528B2 (en) * 2008-05-27 2012-04-03 Mallinckrodt Llc Processes and compounds for the preparation of normorphinans
US9458109B2 (en) * 2008-09-03 2016-10-04 Mallinckrodt Llc Substituted berbines and processes for their synthesis
JP2012518651A (ja) * 2009-02-23 2012-08-16 マリンクロッド インコーポレイテッド （＋）−モルフィナニウムｎ−オキシドおよびそれらの生成方法
EP2398807A1 (de) * 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-6-hydroxymorphinan- oder (+)-6-aminomorphinanderivate
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
CN102325776A (zh) * 2009-02-23 2012-01-18 马林克罗特公司 (+)-吗啡喃*季盐及其制备方法
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
BR112012018765B1 (pt) 2010-01-29 2019-09-03 Toray Industries uso de um derivado de morfinano como agente profilático ou terapêutico em doenças do trato biliar
CN103327977B (zh) 2011-01-31 2016-05-04 东丽株式会社 恶液质的治疗或预防剂
RU2014112493A (ru) 2011-09-08 2015-10-20 МАЛЛИНКРОДТ Эл-Эл-Си Получения алкалоидов без выделения промежуточных продуктов
JP6064252B2 (ja) * 2012-01-19 2017-01-25 三笠製薬株式会社 そう痒症改善経皮吸収貼付剤
US8987289B2 (en) 2012-12-14 2015-03-24 Trevi Therapeutics, Inc. Methods for treating pruritus
NZ708371A (en) * 2012-12-14 2020-05-29 Trevi Therapeutics Inc Methods for treating pruritus
US8637538B1 (en) 2012-12-14 2014-01-28 Trevi Therapeutics, Inc. Methods for treatment of pruritis
US20140179727A1 (en) 2012-12-14 2014-06-26 Trevi Therapeutics, Inc. Methods for treating pruritus
WO2016052617A1 (ja) * 2014-09-30 2016-04-07 国立大学法人筑波大学 ナルフラフィン含有局所適用製剤
TW201707703A (zh) * 2015-06-04 2017-03-01 Tokai Capsule Co Ltd 軟膠囊劑
CN106866688B (zh) * 2015-12-10 2019-05-03 山东诚创医药技术开发有限公司 一种纳呋拉啡的精制方法
WO2017165409A1 (en) * 2016-03-21 2017-09-28 Trevi Therapeutics, Inc. Treatment of uremic pruritus
CN108883185B (zh) * 2016-12-06 2021-10-08 江苏恒瑞医药股份有限公司 一种κ阿片受体激动剂在制备治疗法尼醇X受体激动剂引起的瘙痒的药物中的用途
CA3091752A1 (en) 2018-03-08 2019-09-12 Victoria Link Ltd Treatment of demyelinating diseases
SG11202100580UA (en) 2018-07-23 2021-02-25 Trevi Therapeutics Inc Treatment of chronic cough, breathlessness and dyspnea
CA3135344A1 (en) * 2019-03-29 2020-10-08 Nippon Chemiphar Co., Ltd. Use of t-type calcium channel blocker for treating pruritus
CN115768430A (zh) 2020-06-30 2023-03-07 东丽株式会社 伴随代谢异常的疾病或综合征中的肌力下降症状的改善剂或预防剂
WO2022265993A1 (en) 2021-06-14 2022-12-22 Scorpion Therapeutics, Inc. Urea derivatives which can be used to treat cancer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196376B (en) * 1985-05-23 1988-11-28 Sandoz Ag Process for preparing morphinane derivatives and pharmaceutical compositions containing such compounds
US5021413B1 (en) * 1988-08-24 1994-12-13 Sankyo Co Analgesic thiomorpholins, their preparation, and pharmaceutical compositions containing them
US5116842A (en) * 1989-05-18 1992-05-26 Glaxo Group Limited Chemical compounds
US6323212B1 (en) * 1992-01-23 2001-11-27 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications
JPH06122677A (ja) * 1992-08-28 1994-05-06 Sankyo Co Ltd 光学活性なカルボン酸アミド誘導体
DE69413933T2 (de) * 1993-06-30 1999-04-08 Toray Industries Antitussiva
CA2174619A1 (en) * 1993-10-20 1995-04-27 Kenneth Donald Vaughan Ibuprofen and flurbiprofen as anti-pruritic agents
IT1273751B (it) * 1994-02-11 1997-07-10 Smithkline Beecham Farma Derivati azaciclici
US5760023A (en) 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
JP2003526594A (ja) * 1997-07-14 2003-09-09 アドラー コーポレーション カッパ・アゴニスト抗掻痒薬学的製剤およびそれにより掻痒を治療する方法

Also Published As

Publication number Publication date
EP1310251A1 (de) 2003-05-14
EP0897726B1 (de) 2007-04-11
EP1310255B1 (de) 2004-04-07
DK0897726T3 (da) 2007-08-13
AU738743B2 (en) 2001-09-27
JP3531170B2 (ja) 2004-05-24
NO316309B1 (no) 2004-01-12
CA2244256A1 (en) 1998-06-04
KR100557801B1 (ko) 2006-04-21
DE69737592D1 (de) 2007-05-24
DE69728585T2 (de) 2004-08-05
CA2244256C (en) 2006-07-11
ATE291429T1 (de) 2005-04-15
US6316461B1 (en) 2001-11-13
CN1214634A (zh) 1999-04-21
TW542838B (en) 2003-07-21
KR19990081978A (ko) 1999-11-15
ES2285733T3 (es) 2007-11-16
EP0897726A4 (de) 2003-05-28
CN1180844C (zh) 2004-12-22
EP1327444A1 (de) 2003-07-16
DE69737592T2 (de) 2008-01-03
DE69732868T2 (de) 2006-04-13
CN1291717C (zh) 2006-12-27
CN1535687A (zh) 2004-10-13
CN1530111A (zh) 2004-09-22
PT897726E (pt) 2007-07-09
EP1310255A1 (de) 2003-05-14
DE69728585D1 (de) 2004-05-13
NZ331001A (en) 2000-05-26
US6174891B1 (en) 2001-01-16
ATE263563T1 (de) 2004-04-15
AU4968397A (en) 1998-06-22
ATE359076T1 (de) 2007-05-15
EP1312361A1 (de) 2003-05-21
ES2215158T3 (es) 2004-10-01
WO1998023290A1 (fr) 1998-06-04
NO983431D0 (no) 1998-07-24
EP0897726A1 (de) 1999-02-24
NO983431L (no) 1998-09-24
ES2236630T3 (es) 2005-07-16
EP1327444B1 (de) 2005-03-23

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