DE69730534D1 - Zusatzstoff für transkutane immunisierung - Google Patents
Zusatzstoff für transkutane immunisierungInfo
- Publication number
- DE69730534D1 DE69730534D1 DE69730534T DE69730534T DE69730534D1 DE 69730534 D1 DE69730534 D1 DE 69730534D1 DE 69730534 T DE69730534 T DE 69730534T DE 69730534 T DE69730534 T DE 69730534T DE 69730534 D1 DE69730534 D1 DE 69730534D1
- Authority
- DE
- Germany
- Prior art keywords
- additive
- transcutaneous immunization
- transcutaneous
- immunization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000654 additive Substances 0.000 title 1
- 230000000996 additive effect Effects 0.000 title 1
- 230000003053 immunization Effects 0.000 title 1
- 238000002649 immunization Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US749164 | 1985-06-27 | ||
US08/749,164 US5910306A (en) | 1996-11-14 | 1996-11-14 | Transdermal delivery system for antigen |
US08/896,085 US5980898A (en) | 1996-11-14 | 1997-07-17 | Adjuvant for transcutaneous immunization |
US896085 | 1997-07-17 | ||
PCT/US1997/021324 WO1998020734A1 (en) | 1996-11-14 | 1997-11-14 | Adjuvant for transcutaneous immunization |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69730534D1 true DE69730534D1 (de) | 2004-10-07 |
DE69730534T2 DE69730534T2 (de) | 2005-09-15 |
Family
ID=27669393
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69737218T Expired - Lifetime DE69737218T2 (de) | 1996-11-14 | 1997-11-14 | Adjuvant für transkutane Immunisation |
DE69730534T Expired - Lifetime DE69730534T2 (de) | 1996-11-14 | 1997-11-14 | Zusatzstoff für transkutane immunisierung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69737218T Expired - Lifetime DE69737218T2 (de) | 1996-11-14 | 1997-11-14 | Adjuvant für transkutane Immunisation |
Country Status (14)
Country | Link |
---|---|
US (3) | US5980898A (de) |
EP (4) | EP1384403B1 (de) |
JP (1) | JP4584361B2 (de) |
KR (1) | KR100517028B1 (de) |
CN (1) | CN1279976C (de) |
AP (1) | AP9901540A0 (de) |
AT (2) | ATE349890T1 (de) |
AU (1) | AU744537B2 (de) |
BR (1) | BR9712952A (de) |
CA (1) | CA2272417C (de) |
DE (2) | DE69737218T2 (de) |
IL (1) | IL129919A (de) |
NZ (1) | NZ335749A (de) |
WO (1) | WO1998020734A1 (de) |
Families Citing this family (280)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020032316A1 (en) * | 1995-03-31 | 2002-03-14 | Cantab Pharmaceuticals Research Limited | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
US6375955B1 (en) * | 1995-09-22 | 2002-04-23 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of leishmaniasis |
US6607731B1 (en) | 1995-09-22 | 2003-08-19 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of leishmaniasis |
US6613337B1 (en) | 1997-02-12 | 2003-09-02 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of leishmaniasis |
US6500437B1 (en) | 1995-09-22 | 2002-12-31 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of leishmaniasis |
US6638517B2 (en) | 1995-09-22 | 2003-10-28 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of leishmaniasis |
US6365165B1 (en) | 1995-09-22 | 2002-04-02 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of Leishmaniasis |
EP0909323B1 (de) | 1996-01-04 | 2007-02-28 | Novartis Vaccines and Diagnostics, Inc. | Bakterioferritin aus helicobacter pylori |
US6797276B1 (en) * | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
CA2276450C (en) * | 1997-01-02 | 2013-02-19 | Thomas Jefferson University | A method of modulating an immune response in an infected mammal by transmucosal administration of modulating agent |
US6818222B1 (en) * | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
EP1486215A3 (de) * | 1997-03-21 | 2006-04-12 | Chiron Corporation | Detoxifizierte Mutanten bakterieller ADP-ribosylierender Toxine als parenterale Adjuvantien |
FR2766193B1 (fr) * | 1997-07-18 | 2001-09-14 | Inst Curie | Polypeptide chimerique comprenant le fragment b de la toxine shiga et des peptides d'interet therapeutique |
US20030125278A1 (en) * | 1997-08-13 | 2003-07-03 | Tang De-Chu C. | Immunization of animals by topical applications of a salmonella-based vector |
US5993852A (en) * | 1997-08-29 | 1999-11-30 | Pharmaderm Laboratories Ltd. | Biphasic lipid vesicle composition for transdermal administration of an immunogen |
DE69841807D1 (de) | 1997-11-06 | 2010-09-16 | Novartis Vaccines & Diagnostic | Neisseriale antigene |
US6914131B1 (en) | 1998-10-09 | 2005-07-05 | Chiron S.R.L. | Neisserial antigens |
GB9800487D0 (en) * | 1998-01-09 | 1998-03-04 | Oratol Limited | Therapies |
DK1047784T4 (en) | 1998-01-14 | 2015-06-15 | Novartis Vaccines & Diagnostic | NEISSERA meningitidis ANTIGENS |
EP1356821B1 (de) * | 1998-02-25 | 2007-06-20 | THE GOVERNMENT OF THE UNITED STATES, as represented by THE SECRETARY OF THE ARMY | Verwendung von Hautpenetrationsförderern und für die Zerstörung der oberen Hautschichten geeigneten Mitteln zur Erhöhung der transkutanen Immunantwort |
WO1999043350A1 (en) * | 1998-02-25 | 1999-09-02 | Iomai Corporation | Use of skin penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response induced by adp-ribosylating exotoxin |
EP1849477A1 (de) * | 1998-02-25 | 2007-10-31 | THE GOVERNMENT OF THE UNITED STATES, as represented by THE SECRETARY OF THE ARMY | Verwendung von Mitteln zur Verbesserung der Hautpenetration und schrankenbrechenden Mitteln zur Verbesserung der transkutanen Immunantwort |
JP4820000B2 (ja) * | 1998-05-15 | 2011-11-24 | アラン エム グリーン | 免疫処置のためのベロ毒素bサブユニット |
CA2335487A1 (en) * | 1998-06-19 | 1999-12-23 | Merieux Oravax | Lt and ct in parenteral immunization methods against helicobacter infection |
US6210672B1 (en) | 1998-10-20 | 2001-04-03 | Torrey Pines Institute For Molecular Studies | Topical immunostimulation to induce Langerhans cell migration |
US7229621B2 (en) * | 1998-10-20 | 2007-06-12 | Torrey Pines Institute For Molecular Studies | Method to enhance the immunogenicity of an antigen |
BR9916515A (pt) * | 1998-12-22 | 2001-11-06 | Thompson Boyce Plant Res | Polinucleotìdeo, vetor de expressão, células de e. coli e de agrobacterium tumefaciens transformadas com o vetor de expressão, célula de planta transgênica, semente de planta transgênica, célula eucariótica transgênica, composição imunogênica, método de evocar uma resposta imune em um animal ou ser humano, planta transgênica, e, adjuvante |
IL144380A0 (en) * | 1999-01-22 | 2002-05-23 | Powderject Res Ltd | Method of enhancing needleless transdermal powdered drug delivery |
SI1031346T1 (en) * | 1999-01-27 | 2002-08-31 | Idea Ag | Noninvasive vaccination through the skin |
JP4932086B2 (ja) * | 1999-04-08 | 2012-05-16 | インターセル ユーエスエイ、インコーポレイテッド | 経皮的免疫のための乾燥製剤 |
US6558670B1 (en) | 1999-04-19 | 2003-05-06 | Smithkline Beechman Biologicals S.A. | Vaccine adjuvants |
ES2228497T3 (es) | 1999-04-19 | 2005-04-16 | Glaxosmithkline Biologicals S.A. | Composicion adyuvante que comprende saponina y un oligonucleotido inmunoestimulante. |
ES2477194T3 (es) | 1999-04-30 | 2014-07-16 | Novartis Vaccines And Diagnostics S.R.L. | Ant�genos neisseriales conservados |
US20040009936A1 (en) | 1999-05-03 | 2004-01-15 | Tang De-Chu C. | Vaccine and drug delivery by topical application of vectors and vector extracts |
CZ20013916A3 (cs) | 1999-05-13 | 2002-06-12 | American Cyanamid Company | Adjuvantní kombinované prostředky |
GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
AU5315000A (en) * | 1999-06-03 | 2000-12-28 | Gregory M. Glenn | Indicators for monitoring the technique of transcutaneous immunization |
US20020151515A1 (en) * | 1999-06-18 | 2002-10-17 | Roberts Bruce L. | Preparation and use of superior vaccines |
GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
US6835184B1 (en) | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
GB9923060D0 (en) * | 1999-09-29 | 1999-12-01 | Chiron Spa | Vaccine |
GB9924351D0 (en) | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
CN1796404A (zh) | 1999-10-29 | 2006-07-05 | 启龙有限公司 | 奈瑟球菌的抗原性肽 |
US7041296B1 (en) * | 1999-11-12 | 2006-05-09 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of treating inflammatory bowel disease using cholera toxin B subunit |
GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
MXPA02006962A (es) | 2000-01-17 | 2002-12-13 | Chiron Spa | Vacuna de vesicula de membrana exterior que comprende proteinas de membrana exterior de neisseria meningitidis serogrupo b. |
ATE503837T1 (de) | 2000-02-28 | 2011-04-15 | Novartis Vaccines & Diagnostic | Hybride expression neisserscher proteine |
US20010036463A1 (en) * | 2000-03-09 | 2001-11-01 | Compans Richard W. | Transcutaneous immunization for large particulate antigens |
US6595947B1 (en) | 2000-05-22 | 2003-07-22 | Becton, Dickinson And Company | Topical delivery of vaccines |
GB0013810D0 (en) | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
GB0017999D0 (en) | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
PT2266603E (pt) | 2000-10-18 | 2012-11-02 | Glaxosmithkline Biolog Sa | Vacinas tumorais |
AU2002214127B2 (en) | 2000-10-27 | 2007-06-07 | J. Craig Venter Institute, Inc. | Nucleic acids and proteins from streptococcus groups A and B |
EP1333858B8 (de) * | 2000-11-07 | 2006-06-14 | Immunovaccine Technologies Inc. | Impfstoffe mit erhöhter immunantwort und verfahren zur deren herstellung |
JP2004523483A (ja) | 2000-11-10 | 2004-08-05 | ワイス・ホールデイングス・コーポレーシヨン | アジュバントの組合せ製剤 |
KR20040045391A (ko) * | 2000-11-27 | 2004-06-01 | 파우더젝트 백신, 인코포레이티드 | 핵산 어쥬번트 |
US20030162733A1 (en) * | 2000-11-27 | 2003-08-28 | Haynes Joel R. | Nucleic acid adjuvants |
WO2002064162A2 (en) * | 2001-02-13 | 2002-08-22 | Government Of The United States, As Represented By The Secretary Of The Army | Vaccine for transcutaneous immunization |
EP1372706B1 (de) | 2001-03-09 | 2010-12-01 | ID Biomedical Corporation of Quebec | Proteosom-liposaccharid-vakzine-adjuvans |
CN1516595A (zh) * | 2001-03-19 | 2004-07-28 | Iomai公司 | 用于经皮免疫的贴剂 |
AU2002252378B2 (en) * | 2001-03-19 | 2007-10-18 | Intercell Usa, Inc. | Transcutaneous immunostimulation |
US20040109869A1 (en) * | 2001-03-19 | 2004-06-10 | Iomai Corporation | Transcutaneous immunostimulation |
GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
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GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
EP1425423B1 (de) | 2001-08-13 | 2010-06-23 | University of Rochester | Transkutane immunisierung gegen papillomavirus mit virusähnlichen papillomaviruspartikeln |
JP2005508915A (ja) | 2001-10-04 | 2005-04-07 | ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー | インターロイキン21受容体活性を調節する方法および組成物 |
GB0124317D0 (en) | 2001-10-10 | 2001-11-28 | Celltech R&D Ltd | Biological products |
US20040120964A1 (en) * | 2001-10-29 | 2004-06-24 | Mikszta John A. | Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses |
ATE420676T1 (de) * | 2001-10-29 | 2009-01-15 | Becton Dickinson Co | Vorrichtung für die abgabe einer substanz |
EP2335724A1 (de) | 2001-12-12 | 2011-06-22 | Novartis Vaccines and Diagnostics S.r.l. | Immunisierung gegen Chlamydia trachomatis |
US20040137004A1 (en) * | 2002-03-19 | 2004-07-15 | Glenn Gregory M | Patch for transcutaneous immunization |
MY139721A (en) * | 2002-04-19 | 2009-10-30 | Cpex Pharmaceuticals Inc | Pharmaceutical composition |
GB0210121D0 (en) | 2002-05-02 | 2002-06-12 | Celltech R&D Ltd | Biological products |
PL224150B1 (pl) | 2002-05-02 | 2016-11-30 | Wyeth Corp | Kompozycja zawierająca koniugat leku obejmujący pochodne kalicheamycyny i przeciwciało, oraz kompozycja farmaceutyczna ją zawierająca |
US7601817B2 (en) | 2002-05-28 | 2009-10-13 | Ucb Pharma S.A. | Antibody peg positional isomers, compositions comprising same, and use thereof |
GB0218921D0 (en) * | 2002-08-14 | 2002-09-25 | Glaxosmithkline Biolog Sa | Novel vaccine |
AU2003288660A1 (en) | 2002-11-15 | 2004-06-15 | Chiron Srl | Unexpected surface proteins in neisseria meningitidis |
EP1447080A1 (de) * | 2003-02-13 | 2004-08-18 | Bestewil Holding B.V. | Methode zur Herstellung von Virosomen-artigen Partikeln |
GB0303337D0 (en) | 2003-02-13 | 2003-03-19 | Celltech R&D Ltd | Biological products |
EP2241330A1 (de) | 2003-02-14 | 2010-10-20 | The Curators Of The University Of Missouri | Empfängnisverhütende Verfahren und Zusammensetzungen betreffend proteasomale Störung |
GB2398783A (en) | 2003-02-26 | 2004-09-01 | Antonio Lanzavecchia | A method for producing immortalised human B memory lymphocytes |
GB0307989D0 (en) * | 2003-04-07 | 2003-05-14 | Mcewen Lab Ltd | Therapeutic composition |
GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
EA009607B1 (ru) | 2003-05-21 | 2008-02-28 | Арес Трейдинг С.А. | Tnf-подобный секретируемый белок |
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IL159273A0 (en) * | 2003-12-09 | 2004-06-01 | Transpharma Medical Ltd | Transdermal delivery system for sustained release of polypeptides |
ES2297688T3 (es) * | 2004-03-12 | 2008-05-01 | Intercell Ag | Procedimiento para solubizar mezclas de peptidos. |
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TW200613554A (en) | 2004-06-17 | 2006-05-01 | Wyeth Corp | Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV |
CA2572870A1 (en) * | 2004-07-06 | 2006-01-12 | Transpharma Medical Ltd. | Delivery system for transdermal immunization |
CA2580103C (en) | 2004-09-22 | 2021-11-16 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
EP1676602A1 (de) | 2005-01-04 | 2006-07-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Kontinuierlicheverabreichung von Epitope aus dem atherosklerotischem Belag zur Behandlung von Atheriosklerose |
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- 1997-11-14 AU AU52652/98A patent/AU744537B2/en not_active Ceased
- 1997-11-14 EP EP03017154A patent/EP1384403B1/de not_active Revoked
- 1997-11-14 AT AT03017154T patent/ATE349890T1/de active
- 1997-11-14 NZ NZ335749A patent/NZ335749A/xx not_active IP Right Cessation
- 1997-11-14 EP EP97947608A patent/EP1014787B1/de not_active Expired - Lifetime
- 1997-11-14 IL IL129919A patent/IL129919A/en not_active IP Right Cessation
- 1997-11-14 EP EP05002995A patent/EP1557177A1/de not_active Withdrawn
- 1997-11-14 EP EP10183575A patent/EP2272526A3/de not_active Withdrawn
- 1997-11-14 JP JP52294298A patent/JP4584361B2/ja not_active Expired - Fee Related
- 1997-11-14 DE DE69737218T patent/DE69737218T2/de not_active Expired - Lifetime
- 1997-11-14 DE DE69730534T patent/DE69730534T2/de not_active Expired - Lifetime
- 1997-11-14 AT AT97947608T patent/ATE274805T1/de not_active IP Right Cessation
- 1997-11-14 CN CNB97180947XA patent/CN1279976C/zh not_active Expired - Fee Related
- 1997-11-14 KR KR10-1999-7004299A patent/KR100517028B1/ko not_active IP Right Cessation
- 1997-11-14 CA CA002272417A patent/CA2272417C/en not_active Expired - Fee Related
- 1997-11-14 AP APAP/P/1999/001540A patent/AP9901540A0/en unknown
- 1997-11-14 BR BR9712952-6A patent/BR9712952A/pt active Search and Examination
- 1997-11-14 WO PCT/US1997/021324 patent/WO1998020734A1/en active IP Right Grant
-
1999
- 1999-03-12 US US09/266,803 patent/US7037499B1/en not_active Expired - Fee Related
-
2006
- 2006-01-19 US US11/334,349 patent/US20060269593A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2001511115A (ja) | 2001-08-07 |
ATE274805T1 (de) | 2004-09-15 |
CA2272417C (en) | 2003-07-29 |
KR20000053306A (ko) | 2000-08-25 |
DE69737218T2 (de) | 2007-11-08 |
EP1014787B1 (de) | 2004-09-01 |
EP2272526A2 (de) | 2011-01-12 |
EP1384403A1 (de) | 2004-01-28 |
CN1241906A (zh) | 2000-01-19 |
DE69737218D1 (de) | 2007-02-15 |
ATE349890T1 (de) | 2007-01-15 |
AU744537B2 (en) | 2002-02-28 |
NZ335749A (en) | 2001-01-26 |
EP1014787A1 (de) | 2000-07-05 |
CA2272417A1 (en) | 1998-05-22 |
EP1557177A1 (de) | 2005-07-27 |
IL129919A0 (en) | 2000-02-29 |
CN1279976C (zh) | 2006-10-18 |
EP1014787A4 (de) | 2002-08-07 |
KR100517028B1 (ko) | 2005-09-26 |
US20060269593A1 (en) | 2006-11-30 |
WO1998020734A1 (en) | 1998-05-22 |
JP4584361B2 (ja) | 2010-11-17 |
AP9901540A0 (en) | 1999-06-30 |
US7037499B1 (en) | 2006-05-02 |
EP1384403B1 (de) | 2007-01-03 |
BR9712952A (pt) | 1999-12-07 |
DE69730534T2 (de) | 2005-09-15 |
IL129919A (en) | 2008-04-13 |
US5980898A (en) | 1999-11-09 |
EP2272526A3 (de) | 2012-02-08 |
AU5265298A (en) | 1998-06-03 |
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