DE69728585D1 - Mittel gegen Juckreiz - Google Patents

Mittel gegen Juckreiz

Info

Publication number
DE69728585D1
DE69728585D1 DE69728585T DE69728585T DE69728585D1 DE 69728585 D1 DE69728585 D1 DE 69728585D1 DE 69728585 T DE69728585 T DE 69728585T DE 69728585 T DE69728585 T DE 69728585T DE 69728585 D1 DE69728585 D1 DE 69728585D1
Authority
DE
Germany
Prior art keywords
antipruritic agent
antipruritic
morphinian
opiate
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69728585T
Other languages
English (en)
Other versions
DE69728585T2 (de
Inventor
Hiroshi Nagase
Jun Utsumi
Takashi Endoh
Toshiaki Tanaka
Kuniaki Kawamura
Junzo Kamei
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18041771&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69728585(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of DE69728585D1 publication Critical patent/DE69728585D1/de
Publication of DE69728585T2 publication Critical patent/DE69728585T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
DE69728585T 1996-11-25 1997-11-21 Mittel gegen Juckreiz Expired - Lifetime DE69728585T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP31347696 1996-11-25
JP31347696 1996-11-25

Publications (2)

Publication Number Publication Date
DE69728585D1 true DE69728585D1 (de) 2004-05-13
DE69728585T2 DE69728585T2 (de) 2004-08-05

Family

ID=18041771

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69728585T Expired - Lifetime DE69728585T2 (de) 1996-11-25 1997-11-21 Mittel gegen Juckreiz
DE69737592T Expired - Lifetime DE69737592T2 (de) 1996-11-25 1997-11-21 Mittel gegen juckreiz
DE69732868T Expired - Lifetime DE69732868T2 (de) 1996-11-25 1997-11-21 Mittel gegen Juckreiz

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69737592T Expired - Lifetime DE69737592T2 (de) 1996-11-25 1997-11-21 Mittel gegen juckreiz
DE69732868T Expired - Lifetime DE69732868T2 (de) 1996-11-25 1997-11-21 Mittel gegen Juckreiz

Country Status (15)

Country Link
US (2) US6174891B1 (de)
EP (5) EP1327444B1 (de)
KR (1) KR100557801B1 (de)
CN (3) CN1180844C (de)
AT (3) ATE359076T1 (de)
AU (1) AU738743B2 (de)
CA (1) CA2244256C (de)
DE (3) DE69728585T2 (de)
DK (1) DK0897726T3 (de)
ES (3) ES2215158T3 (de)
NO (1) NO316309B1 (de)
NZ (1) NZ331001A (de)
PT (1) PT897726E (de)
TW (1) TW542838B (de)
WO (1) WO1998023290A1 (de)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
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US5763445A (en) * 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
DE69637416T2 (de) * 1996-12-24 2009-01-22 George F. Long Beach Elkhoury Topische anwendung von opioiden, wie morphin, zur linderung von juckreiz und hautkrankheiten sowie hautreizungen
NZ500438A (en) * 1997-07-14 2001-11-30 Adolor Corp Compositions containing a compound having kappa opioid agonist activity for treatment of pruritis (itchiness)
JP3211027B2 (ja) * 1998-11-13 2001-09-25 丸石製薬株式会社 カプサイシン含有外用剤
WO2001014382A1 (fr) * 1999-08-23 2001-03-01 Toray Industries, Inc. Analgesiques contenant des derives sel d'ammonium quaternaire comme principe actif
CA2383146C (en) 1999-08-24 2010-11-16 Hiroshi Nagase Therapeutic agent for neuropathic pain and neuropathic pain animal model
WO2001074819A1 (fr) * 2000-04-03 2001-10-11 Toray Industries, Inc. Agents analgesiques contenant des derives de n-oxyde de morphinane en tant que principe actif
JP2002249442A (ja) * 2001-02-21 2002-09-06 Fumakilla Ltd アレルギー減感作治療薬
AU2002241326B2 (en) 2001-03-30 2007-09-06 Toray Industries, Inc Remedies for psychoneurosis
US7294688B2 (en) 2001-04-30 2007-11-13 Nanogen Inc. Biopolymer marker indicative of disease state having a molecular weight of 1348 daltons
US6617308B2 (en) 2001-04-30 2003-09-09 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1865 daltons
CA2451133C (en) * 2001-05-08 2012-09-18 Toray Industries, Inc. Therapeutic agent for sepsis
US6844438B2 (en) 2001-08-15 2005-01-18 Mclean Hospital Corporation N-substituted derivatives of morphinan and uses thereof
CA2464528A1 (en) * 2001-11-02 2003-05-15 Elan Corporation, Plc Pharmaceutical composition
NZ535987A (en) 2002-03-29 2006-08-31 Santen Pharmaceutical Co Ltd k-opioid receptor agonist comprising 2-henylbenzothiazoline derivative
JP5189242B2 (ja) * 2002-09-23 2013-04-24 アルケルメス ファーマ アイルランド リミテッド 乱用抵抗性の医薬組成物
JP4806190B2 (ja) * 2002-09-25 2011-11-02 ユーロ−セルティーク エス．エイ． Ｎ−置換ヒドロモルホン及びそれらの使用
WO2005094826A1 (ja) 2004-03-30 2005-10-13 Toray Industries, Inc. 止痒剤
US7704522B2 (en) * 2004-09-08 2010-04-27 Clyde Morgan Topical medicament
CA2580694A1 (en) * 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US20060159748A1 (en) * 2004-12-23 2006-07-20 Rajesh Jain Oral immediate release formulation of a poorly water-soluble active substance
US7453122B2 (en) * 2005-02-08 2008-11-18 Taiwan Semiconductor Manufacturing Co., Ltd. SOI MOSFET device with reduced polysilicon loading on active area
CN101137658B (zh) * 2005-03-10 2011-06-08 东丽株式会社 用于与多发性硬化症伴随的搔痒的止痒剂
NZ563133A (en) * 2005-04-06 2010-07-30 Toray Industries Crystals of morphinan derivative and process for producing the same
JP5119925B2 (ja) * 2005-11-09 2013-01-16 東レ株式会社 機能性腸障害の治療または予防剤
CN101340911B (zh) * 2005-12-21 2013-01-02 东丽株式会社 镇咳剂
EP2099764B1 (de) * 2006-09-20 2011-07-27 Mallinckrodt Inc. Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon
US9040726B2 (en) 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
AU2008223328B2 (en) * 2007-03-06 2012-10-11 SpecGx LLC Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
MX2009011449A (es) 2007-04-24 2010-01-25 Toray Industries Agente terapeutico o profilactico para disquinesia.
CN101686976B (zh) 2007-04-26 2013-04-24 东丽株式会社 含有4,5-环氧基吗啡喃衍生物的稳定的固体制剂
CA2691220C (en) 2007-06-22 2015-05-05 Toray Industries, Inc. Remedy or preventive for integration dysfunction syndrome
CN101848714B (zh) * 2007-10-05 2014-08-20 东丽株式会社 以吗啡喃衍生物或其药理学上允许的酸加成盐为有效成分的皮肤性状改善治疗药
WO2009138734A2 (en) * 2008-05-14 2009-11-19 Serentis Limited Use of opioid compounds in peripheral pain, wound healing and scar formation
NZ589496A (en) * 2008-05-27 2013-02-22 Mallinckrodt Llc Processes and compounds for the preparation of normorphinans
US9458109B2 (en) 2008-09-03 2016-10-04 Mallinckrodt Llc Substituted berbines and processes for their synthesis
WO2010096791A1 (en) * 2009-02-23 2010-08-26 Mallinckrodt Inc. (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
JP5784507B2 (ja) * 2009-02-23 2015-09-24 マリンクロッド エルエルシー （＋）−モルフィナニウム第四級塩およびその生成方法
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
CN102325777B (zh) * 2009-02-23 2015-08-12 马林克罗特公司 (+)-吗啡喃*n-氧化物及其制备方法
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
MY173491A (en) 2010-01-29 2020-01-29 Toray Industries Therapeutic or prophylactic agent for biliary tract diseases
WO2012105475A1 (ja) 2011-01-31 2012-08-09 東レ株式会社 悪液質の治療又は予防剤
RU2014112493A (ru) 2011-09-08 2015-10-20 МАЛЛИНКРОДТ Эл-Эл-Си Получения алкалоидов без выделения промежуточных продуктов
JP6064252B2 (ja) * 2012-01-19 2017-01-25 三笠製薬株式会社 そう痒症改善経皮吸収貼付剤
MX2015007518A (es) * 2012-12-14 2016-03-01 Trevi Therapeutics Inc Metodos para tratar el prurito.
US8637538B1 (en) 2012-12-14 2014-01-28 Trevi Therapeutics, Inc. Methods for treatment of pruritis
US20140179727A1 (en) 2012-12-14 2014-06-26 Trevi Therapeutics, Inc. Methods for treating pruritus
US8987289B2 (en) 2012-12-14 2015-03-24 Trevi Therapeutics, Inc. Methods for treating pruritus
JPWO2016052617A1 (ja) * 2014-09-30 2017-09-21 国立大学法人 筑波大学 ナルフラフィン含有局所適用製剤
TW201707703A (zh) * 2015-06-04 2017-03-01 Tokai Capsule Co Ltd 軟膠囊劑
CN106866688B (zh) * 2015-12-10 2019-05-03 山东诚创医药技术开发有限公司 一种纳呋拉啡的精制方法
CN109310656A (zh) * 2016-03-21 2019-02-05 特雷维治疗股份有限公司 尿毒症性瘙痒症的治疗
CN108883185B (zh) * 2016-12-06 2021-10-08 江苏恒瑞医药股份有限公司 一种κ阿片受体激动剂在制备治疗法尼醇X受体激动剂引起的瘙痒的药物中的用途
WO2019171333A1 (en) 2018-03-08 2019-09-12 Victoria Link Ltd Treatment of demyelinating diseases
WO2020023486A1 (en) 2018-07-23 2020-01-30 Trevi Therapeutics, Inc. Treatment of chronic cough, breathlessness and dyspnea
CA3135344A1 (en) * 2019-03-29 2020-10-08 Nippon Chemiphar Co., Ltd. Use of t-type calcium channel blocker for treating pruritus
TW202216145A (zh) 2020-06-30 2022-05-01 日商東麗股份有限公司 伴隨代謝異常之疾病或症候群中的肌力低下症狀之改善劑或預防劑
EP4334298A1 (de) 2021-06-14 2024-03-13 Scorpion Therapeutics, Inc. Harnstoffderivate zur behandlung von krebs

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196376B (en) * 1985-05-23 1988-11-28 Sandoz Ag Process for preparing morphinane derivatives and pharmaceutical compositions containing such compounds
US5021413B1 (en) * 1988-08-24 1994-12-13 Sankyo Co Analgesic thiomorpholins, their preparation, and pharmaceutical compositions containing them
CA2017020A1 (en) * 1989-05-18 1990-11-18 Alan Naylor Chemical compounds
ATE172201T1 (de) * 1992-01-23 1998-10-15 Toray Industries Morphinan-derivate und medizinische verwendung
JPH06122677A (ja) * 1992-08-28 1994-05-06 Sankyo Co Ltd 光学活性なカルボン酸アミド誘導体
WO1995001178A1 (fr) * 1993-06-30 1995-01-12 Toray Industries, Inc. Antitussif
CZ112496A3 (en) * 1993-10-20 1997-04-16 Boots Co Plc Application of ibuprofen and flurbiprofen as agents relieving itching and pharmaceutical preparations for such application
IT1273751B (it) 1994-02-11 1997-07-10 Smithkline Beecham Farma Derivati azaciclici
NZ500438A (en) * 1997-07-14 2001-11-30 Adolor Corp Compositions containing a compound having kappa opioid agonist activity for treatment of pruritis (itchiness)
US5760023A (en) 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith

Also Published As

Publication number Publication date
CN1291717C (zh) 2006-12-27
DE69728585T2 (de) 2004-08-05
TW542838B (en) 2003-07-21
EP1312361A1 (de) 2003-05-21
PT897726E (pt) 2007-07-09
EP0897726A1 (de) 1999-02-24
EP1327444A1 (de) 2003-07-16
DE69737592T2 (de) 2008-01-03
KR100557801B1 (ko) 2006-04-21
NO983431L (no) 1998-09-24
ATE263563T1 (de) 2004-04-15
CN1180844C (zh) 2004-12-22
WO1998023290A1 (fr) 1998-06-04
DE69732868D1 (de) 2005-04-28
ES2215158T3 (es) 2004-10-01
DK0897726T3 (da) 2007-08-13
EP1310255A1 (de) 2003-05-14
CA2244256A1 (en) 1998-06-04
NO316309B1 (no) 2004-01-12
ES2285733T3 (es) 2007-11-16
CA2244256C (en) 2006-07-11
EP0897726A4 (de) 2003-05-28
US6174891B1 (en) 2001-01-16
EP1327444B1 (de) 2005-03-23
NZ331001A (en) 2000-05-26
JP3531170B2 (ja) 2004-05-24
NO983431D0 (no) 1998-07-24
AU4968397A (en) 1998-06-22
CN1214634A (zh) 1999-04-21
US6316461B1 (en) 2001-11-13
EP1310251A1 (de) 2003-05-14
KR19990081978A (ko) 1999-11-15
ATE291429T1 (de) 2005-04-15
ES2236630T3 (es) 2005-07-16
AU738743B2 (en) 2001-09-27
CN1530111A (zh) 2004-09-22
DE69737592D1 (de) 2007-05-24
CN1535687A (zh) 2004-10-13
ATE359076T1 (de) 2007-05-15
EP0897726B1 (de) 2007-04-11
EP1310255B1 (de) 2004-04-07
DE69732868T2 (de) 2006-04-13

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