DE69724545D1 - Neues arzneimittel mit anästhetischer wirkung - Google Patents

Neues arzneimittel mit anästhetischer wirkung

Info

Publication number
DE69724545D1
DE69724545D1 DE69724545T DE69724545T DE69724545D1 DE 69724545 D1 DE69724545 D1 DE 69724545D1 DE 69724545 T DE69724545 T DE 69724545T DE 69724545 T DE69724545 T DE 69724545T DE 69724545 D1 DE69724545 D1 DE 69724545D1
Authority
DE
Germany
Prior art keywords
medicinal product
anesthetic effect
new medicinal
new
anesthetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69724545T
Other languages
English (en)
Other versions
DE69724545T2 (de
Inventor
Arne Brodin
Raymond Fynes
Lars Heijl
Adela Nyqvist-Mayer
Marie Scherlund
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maillefer Instruments Trading SARL
Original Assignee
Dentsply Anesthetics SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dentsply Anesthetics SARL filed Critical Dentsply Anesthetics SARL
Application granted granted Critical
Publication of DE69724545D1 publication Critical patent/DE69724545D1/de
Publication of DE69724545T2 publication Critical patent/DE69724545T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
DE69724545T 1996-04-12 1997-04-01 Neues arzneimittel mit anästhetischer wirkung Expired - Lifetime DE69724545T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9601421 1996-04-12
SE9601421A SE9601421D0 (sv) 1996-04-12 1996-04-12 New composition
PCT/SE1997/000566 WO1997038675A1 (en) 1996-04-12 1997-04-01 New pharmaceutical composition with anaesthetic effect

Publications (2)

Publication Number Publication Date
DE69724545D1 true DE69724545D1 (de) 2003-10-09
DE69724545T2 DE69724545T2 (de) 2004-06-03

Family

ID=20402194

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69724545T Expired - Lifetime DE69724545T2 (de) 1996-04-12 1997-04-01 Neues arzneimittel mit anästhetischer wirkung

Country Status (30)

Country Link
US (1) US6031007A (de)
EP (1) EP0833612B1 (de)
JP (2) JPH11501678A (de)
KR (1) KR100508601B1 (de)
CN (1) CN1149072C (de)
AR (1) AR006484A1 (de)
AT (1) ATE248584T1 (de)
AU (1) AU716540B2 (de)
BR (1) BR9702147A (de)
CA (1) CA2222676C (de)
CZ (1) CZ371197A3 (de)
DE (1) DE69724545T2 (de)
DK (1) DK0833612T3 (de)
EE (1) EE9700363A (de)
ES (1) ES2203799T3 (de)
HK (1) HK1010144A1 (de)
HU (1) HUP9903544A3 (de)
ID (1) ID16420A (de)
IL (1) IL122447A (de)
IS (1) IS4618A (de)
NO (1) NO318239B1 (de)
NZ (1) NZ329246A (de)
PL (1) PL324170A1 (de)
RU (1) RU2185153C2 (de)
SE (1) SE9601421D0 (de)
SK (1) SK169897A3 (de)
TR (1) TR199701584T1 (de)
TW (1) TW473386B (de)
WO (1) WO1997038675A1 (de)
ZA (1) ZA973022B (de)

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FR2764800B1 (fr) * 1997-06-23 1999-09-10 Sanofi Sa Composition pharmaceutique solide contenant des derives de benzofuranne
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
AU759641B2 (en) * 1998-08-19 2003-04-17 Skyepharma Canada Inc. Injectable aqueous dispersions of propofol
US6528086B2 (en) * 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations
US20020013331A1 (en) * 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
KR100416646B1 (ko) * 2000-08-14 2004-02-05 구주제약주식회사 리도카인을 함유한 조루치료용 마이크로에멀젼 하이드로겔 제형의 약학 조성물
GB0120701D0 (en) 2001-08-24 2001-10-17 Maelor Pharmaceuticals Ltd Pharmaceutical formulations
US20040087520A1 (en) * 2002-10-25 2004-05-06 Chowdhury Dipak K. Compositions and methods for delivery of therapeutic agents
TW200410717A (en) * 2002-12-31 2004-07-01 Ind Tech Res Inst Delivery system for control release of temperature sensitive bioactive material
US8802116B2 (en) 2003-02-27 2014-08-12 Novasel Australia Pty. Ltd. Poloxamer emulsion preparations
AU2003900887A0 (en) * 2003-02-27 2003-03-13 Novasel Australia Pty Ltd Poloxamer emulsion preparations
BR0301968A (pt) * 2003-05-22 2005-06-28 Cristalia Prod Quimicos Farm Misturas eutéticas ternárias e quaternárias constituìdas por substâncias anestésicas locais, seu emprego no preparo de composições farmacêuticas e seu uso em anestesia e analgesia tópica
JP4669960B2 (ja) * 2003-06-03 2011-04-13 株式会社 メドレックス 局所麻酔薬を含有する口中用または咽頭部用製剤
US7943179B2 (en) * 2003-09-23 2011-05-17 Massachusetts Institute Of Technology pH triggerable polymeric particles
US20050123596A1 (en) * 2003-09-23 2005-06-09 Kohane Daniel S. pH-triggered microparticles
US20070232695A1 (en) * 2004-01-28 2007-10-04 Collegium Pharmaceutical, Inc. Gelled Periodontal Anesthetic Preparation
US8741333B2 (en) 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for treating dermatitis or psoriasis
US8741332B2 (en) 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for dermally treating neuropathic pain
US8907153B2 (en) 2004-06-07 2014-12-09 Nuvo Research Inc. Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same
US7718674B2 (en) * 2004-09-27 2010-05-18 Bridge Pharma, Inc. Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine
WO2006037047A2 (en) * 2004-09-27 2006-04-06 Bridge Pharma, Inc. The r-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents
CA2655809C (en) * 2006-07-21 2013-10-01 Bridge Pharma, Inc. Dermal anesthetic compounds
US20080021068A1 (en) * 2006-07-24 2008-01-24 Akorn, Inc. Aqueous gel formulation and method for inducing topical anesthesia
US20090123527A1 (en) * 2006-07-24 2009-05-14 Akorn, Inc. Method of inducing topical anesthesia and transdermal patch
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US9012477B2 (en) 2009-01-06 2015-04-21 Nuvo Research Inc. Method of treating neuropathic pain
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
SG175327A1 (en) * 2009-04-22 2011-11-28 Agency Science Tech & Res Emulsions for transdermal delivery
WO2011074015A2 (en) 2009-12-17 2011-06-23 Themis Medicare Limited Novel composition of pharmaceutical product to treat sexual dysfunction
AU2011205730C1 (en) 2010-01-14 2014-10-09 Nuvo Research Inc. Solid-forming local anesthetic formulations for pain control
MY163215A (en) 2010-04-01 2017-08-30 Pharmanest Ab Thermogelling anaesthetic compositions
CN102869344A (zh) 2010-04-01 2013-01-09 帕玛内斯特公司 局部麻醉剂的生物黏附性组合物
WO2011121034A2 (en) 2010-04-01 2011-10-06 Pharmanest Ab Water-free pharmaceutical compositions suitable for local anaesthetics
CN102844022A (zh) * 2010-04-21 2012-12-26 帝国制药美国公司 局部麻醉剂乳液组合物及其制造和使用方法
GB201222455D0 (en) * 2012-12-13 2013-01-30 Perioc Ltd Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
US20140275170A1 (en) * 2013-03-14 2014-09-18 Jsn I, Llc Taste masking of anesthetics and analgesics
EP3344230B1 (de) 2015-09-02 2022-04-06 T.C. Istanbul Medipol Universitesi Formulierungen von benzocainbeladenen mikroemulsionsbasierten hydrogelen für therapeutische zwecke und deren herstellungsverfahren
WO2020182535A1 (en) 2019-03-08 2020-09-17 Bayer Oy Uterine sound tube with anaesthetic applicator
CN113244167B (zh) * 2021-05-20 2022-11-29 河北科技大学 一种盐酸利多卡因凝胶及其制备方法

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US4188373A (en) * 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4478822A (en) * 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US5288498A (en) * 1985-05-01 1994-02-22 University Of Utah Research Foundation Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments
US5288497A (en) * 1985-05-01 1994-02-22 The University Of Utah Compositions of oral dissolvable medicaments
JPS62223112A (ja) * 1986-03-25 1987-10-01 Rooto Seiyaku Kk 歯周病治療剤
US4780320A (en) * 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
US5114719A (en) * 1987-04-29 1992-05-19 Sabel Bernhard A Extended drug delivery of small, water-soluble molecules
US5411738A (en) * 1989-03-17 1995-05-02 Hind Health Care, Inc. Method for treating nerve injury pain associated with shingles (herpes-zoster and post-herpetic neuralgia) by topical application of lidocaine
US5292516A (en) * 1990-05-01 1994-03-08 Mediventures, Inc. Body cavity drug delivery with thermoreversible gels containing polyoxyalkylene copolymers
CA2040460C (en) * 1990-05-01 1997-06-10 Tacey X. Viegas Drug delivery with thermoreversible gels
FR2704429B3 (fr) * 1993-04-30 1995-07-13 Algovital Sarl Formulation associant une réaction alcaline et des composants d'huiles essentielles pour réaliser une anesthésie locale, par voie externe, transcutanée, sans injection.
US5635540A (en) * 1994-12-09 1997-06-03 The University Of Virginia Patent Foundation Stabilized topical pharmaceutical preparations
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof

Also Published As

Publication number Publication date
CN1149072C (zh) 2004-05-12
TR199701584T1 (xx) 1999-03-22
IL122447A0 (en) 1998-06-15
HK1010144A1 (en) 1999-06-17
ATE248584T1 (de) 2003-09-15
JP2004149544A (ja) 2004-05-27
EP0833612A1 (de) 1998-04-08
WO1997038675A1 (en) 1997-10-23
ID16420A (id) 1997-09-25
EE9700363A (et) 1998-06-15
EP0833612B1 (de) 2003-09-03
AU2416897A (en) 1997-11-07
DK0833612T3 (da) 2003-12-01
JPH11501678A (ja) 1999-02-09
NZ329246A (en) 2000-06-23
IS4618A (is) 1997-11-21
IL122447A (en) 2001-04-30
ES2203799T3 (es) 2004-04-16
SK169897A3 (en) 1998-07-08
CA2222676A1 (en) 1997-10-23
HUP9903544A3 (en) 2000-07-28
NO318239B1 (no) 2005-02-21
AR006484A1 (es) 1999-08-25
US6031007A (en) 2000-02-29
KR19990022833A (ko) 1999-03-25
MX9709941A (es) 1998-03-29
NO975831L (no) 1997-12-11
CZ371197A3 (cs) 1998-06-17
CN1188407A (zh) 1998-07-22
PL324170A1 (en) 1998-05-11
RU2185153C2 (ru) 2002-07-20
ZA973022B (en) 1997-10-13
CA2222676C (en) 2008-01-22
AU716540B2 (en) 2000-02-24
DE69724545T2 (de) 2004-06-03
SE9601421D0 (sv) 1996-04-12
KR100508601B1 (ko) 2006-03-23
TW473386B (en) 2002-01-21
HUP9903544A2 (hu) 2000-06-28
NO975831D0 (no) 1997-12-11
BR9702147A (pt) 1999-07-20

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: MAILLEFER INSTRUMENTS TRADING S.A.R.L., BALLAIGUES