DE69719220D1 - Neue nucleotidanaloga - Google Patents

Neue nucleotidanaloga

Info

Publication number
DE69719220D1
DE69719220D1 DE69719220T DE69719220T DE69719220D1 DE 69719220 D1 DE69719220 D1 DE 69719220D1 DE 69719220 T DE69719220 T DE 69719220T DE 69719220 T DE69719220 T DE 69719220T DE 69719220 D1 DE69719220 D1 DE 69719220D1
Authority
DE
Germany
Prior art keywords
analog
nucleotid
new
hydrolyzable
oligo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69719220T
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English (en)
Other versions
DE69719220T2 (de
Inventor
Takeshi Imanishi
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Individual
Original Assignee
Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of DE69719220D1 publication Critical patent/DE69719220D1/de
Application granted granted Critical
Publication of DE69719220T2 publication Critical patent/DE69719220T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
DE69719220T 1996-11-18 1997-11-18 Neue nucleotidanaloga Expired - Fee Related DE69719220T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP30658596 1996-11-18
JP30658596 1996-11-18
PCT/JP1997/004187 WO1998022489A1 (fr) 1996-11-18 1997-11-18 Nouveaux analogues de nucleotides

Publications (2)

Publication Number Publication Date
DE69719220D1 true DE69719220D1 (de) 2003-03-27
DE69719220T2 DE69719220T2 (de) 2004-01-22

Family

ID=17958844

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69719220T Expired - Fee Related DE69719220T2 (de) 1996-11-18 1997-11-18 Neue nucleotidanaloga

Country Status (7)

Country Link
US (1) US6043060A (de)
EP (1) EP0963997B1 (de)
AT (1) ATE232880T1 (de)
AU (1) AU4966997A (de)
DE (1) DE69719220T2 (de)
ES (1) ES2192672T3 (de)
WO (1) WO1998022489A1 (de)

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WO1998022489A1 (fr) 1998-05-28
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ATE232880T1 (de) 2003-03-15
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