DE69718619T2 - Synthese von azyklischen nukleosiden - Google Patents

Synthese von azyklischen nukleosiden

Info

Publication number
DE69718619T2
DE69718619T2 DE69718619T DE69718619T DE69718619T2 DE 69718619 T2 DE69718619 T2 DE 69718619T2 DE 69718619 T DE69718619 T DE 69718619T DE 69718619 T DE69718619 T DE 69718619T DE 69718619 T2 DE69718619 T2 DE 69718619T2
Authority
DE
Germany
Prior art keywords
synthesis
acyclic nucleosides
nucleosides
acyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69718619T
Other languages
English (en)
Other versions
DE69718619D1 (de
Inventor
Per Engelhardt
Marita Hoegberg
Xiao-Xiong Zhou
Bjoern Lindborg
Gunnar Johansson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medivir AB
Original Assignee
Medivir AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9600613A external-priority patent/SE9600613D0/xx
Priority claimed from SE9600614A external-priority patent/SE9600614D0/xx
Application filed by Medivir AB filed Critical Medivir AB
Publication of DE69718619D1 publication Critical patent/DE69718619D1/de
Application granted granted Critical
Publication of DE69718619T2 publication Critical patent/DE69718619T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69718619T 1996-02-16 1997-02-14 Synthese von azyklischen nukleosiden Expired - Lifetime DE69718619T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9600613A SE9600613D0 (sv) 1996-02-16 1996-02-16 Acyclic nucleoside derivatives
SE9600614A SE9600614D0 (sv) 1996-02-16 1996-02-16 Antiviral compounds
PCT/SE1997/000242 WO1997030052A1 (en) 1996-02-16 1997-02-14 Synthesis of acyclic nucleosides

Publications (2)

Publication Number Publication Date
DE69718619D1 DE69718619D1 (de) 2003-02-27
DE69718619T2 true DE69718619T2 (de) 2003-08-21

Family

ID=26662518

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69718619T Expired - Lifetime DE69718619T2 (de) 1996-02-16 1997-02-14 Synthese von azyklischen nukleosiden
DE69718626T Expired - Lifetime DE69718626T2 (de) 1996-02-16 1997-02-14 Azyklische nukleosidderivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69718626T Expired - Lifetime DE69718626T2 (de) 1996-02-16 1997-02-14 Azyklische nukleosidderivate

Country Status (26)

Country Link
US (5) US5869493A (de)
EP (2) EP0880521B1 (de)
JP (2) JP4171069B2 (de)
KR (1) KR100464692B1 (de)
CN (1) CN1067073C (de)
AR (1) AR005827A1 (de)
AT (2) ATE231508T1 (de)
AU (1) AU715062B2 (de)
BG (1) BG64179B1 (de)
CA (1) CA2243826C (de)
CZ (1) CZ292169B6 (de)
DE (2) DE69718619T2 (de)
DK (1) DK0888348T3 (de)
EA (2) EA001404B1 (de)
ES (2) ES2189942T3 (de)
HK (1) HK1015773A1 (de)
HU (1) HU229865B1 (de)
IL (1) IL124760A (de)
MY (1) MY123083A (de)
NO (1) NO322930B1 (de)
NZ (1) NZ330472A (de)
PL (1) PL184892B1 (de)
SK (1) SK284613B6 (de)
TR (1) TR199801318T2 (de)
TW (1) TW533213B (de)
WO (2) WO1997030051A1 (de)

Families Citing this family (18)

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Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
CA2271135A1 (en) * 1996-11-12 1998-05-22 Medivir Ab Nucleosides
US6184376B1 (en) * 1997-02-10 2001-02-06 Mediver Ab Synthesis of acyclic nucleoside derivatives
DE69809205T2 (de) * 1997-02-10 2003-05-28 Medivir Ab Huddinge Verfahren zur herstellung von azyklischen nukleosiden
KR100529272B1 (ko) * 1997-08-15 2005-11-17 메디비르 아베 레트로바이러스 역전사효소 및 ｂ형 간염바이러스(ｈｂｖ)의 ｄｎａ 중합효소의 억제제를 포함한항바이러스제와 같은 뉴클레오시드 유사체
WO1999032490A1 (en) * 1997-12-19 1999-07-01 Bristol-Myers Squibb Company Prodrugs of lobucavir and methods of use
WO2004099208A1 (en) * 2003-04-30 2004-11-18 Teva Pharmaceutical Industries Ltd. Process for the preparation of famciclovir
EP1835916B1 (de) 2004-12-30 2009-04-01 Medivir Ab Verbindungen zur behandlung von hiv
US20080233053A1 (en) * 2005-02-07 2008-09-25 Pharmalight Inc. Method and Device for Ophthalmic Administration of Active Pharmaceutical Ingredients
CN101033238B (zh) * 2006-03-06 2011-02-16 中国科学院上海药物研究所 嘌呤类化合物双氨基酸酯的制备方法和用途
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
CN101835374B (zh) 2007-07-09 2014-08-27 东弗吉尼亚医学院 具有抗病毒和抗微生物性质的取代的核苷衍生物
WO2009042081A1 (en) * 2007-09-21 2009-04-02 Epiphany Biosciences, Inc. Valomaciclovir polymorphs
WO2011022712A1 (en) * 2009-08-21 2011-02-24 Epiphany Biosciences, Inc. Method of treating infectious mononucleosis with acylic nucleoside derivatives
LT2691530T (lt) 2011-06-10 2018-08-10 Oregon Health & Science University Cmv glikoproteinai ir rekombinantiniai vektoriai
KR101763127B1 (ko) 2015-06-23 2017-08-01 (주)농협아그로 끈끈이 엠보싱 트랩 테이프

Family Cites Families (43)

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US3116282A (en) 1960-04-27 1963-12-31 Upjohn Co Pyrimidine nucleosides and process
FR2040177A1 (en) 1969-01-31 1971-01-22 Robugen Gmbh 2-deoxyribosyl-uracil derivs
US3817982A (en) 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
US4247544A (en) 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
US4267171A (en) 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
JPS57146798A (en) 1981-03-06 1982-09-10 Yamasa Shoyu Co Ltd Hexosyl nucleoside derivative
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4724232A (en) 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
EP0286825A3 (de) 1987-03-18 1989-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verwendung von 3'-fluro-3'-deoxythymidine zur Herstellung von medicamenten zur Behandlung von Viruskrankheiten
SE8701605D0 (sv) 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds
AP55A (en) * 1987-08-15 1989-09-26 The Wellcome Foundation Ltd Therapeutic Acyclic Nucleosides
JP2894610B2 (ja) * 1987-10-28 1999-05-24 プロ−ニューロン，インコーポレーテッド アシル化ウリジンおよびシチジンならびにその使用
SE8704298D0 (sv) 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy
US5284837A (en) 1988-05-06 1994-02-08 Medivir Ab Derivatives of purine, process for their preparation and a pharmaceutical preparation
SE8801729D0 (sv) 1988-05-06 1988-05-06 Astra Ab Purine derivatives for use in therapy
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
SE8802173D0 (sv) 1988-06-10 1988-06-10 Astra Ab Pyrimidine derivatives
US5043339A (en) * 1988-12-19 1991-08-27 Burroughs Wellcome Co. Antiviral compounds
FI95384C (fi) 1989-04-06 1996-01-25 Squibb Bristol Myers Co Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita
IE980216A1 (en) * 1989-04-17 2000-02-23 Scotia Holdings Plc Anti-virals
US5674869A (en) * 1990-07-07 1997-10-07 Beecham Group Plc Pharmaceutical treatment
SE9003151D0 (sv) 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
GB2260319B (en) * 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
US5874578A (en) 1992-07-13 1999-02-23 Bristol-Myers Squibb Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
GB9307043D0 (en) * 1993-04-05 1993-05-26 Norsk Hydro As Chemical compounds
DE4311801A1 (de) * 1993-04-09 1994-10-13 Hoechst Ag Neue Carbonsäureester von 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purin, deren Herstellung sowie deren Verwendung
GB9320316D0 (en) * 1993-10-01 1993-11-17 Smithkline Beecham Plc Pharmaceuticals
TW282470B (de) * 1993-11-18 1996-08-01 Ajinomoto Kk
US5521161A (en) 1993-12-20 1996-05-28 Compagnie De Developpment Aguettant S.A. Method of treating HIV in humans by administration of ddI and hydroxycarbamide
WO1995022330A1 (en) * 1994-02-17 1995-08-24 Commonwealth Scientific And Industrial Research Organisation Antiviral agents
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
JP3906488B2 (ja) 1995-02-21 2007-04-18 味の素株式会社 プリン誘導体の製造方法
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
AU1592897A (en) * 1996-01-26 1997-08-20 F. Hoffmann-La Roche Ag Process for preparing purine derivatives
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
CN1064683C (zh) * 1996-01-26 2001-04-18 弗·哈夫曼-拉罗切有限公司 制备嘌呤衍生物的方法
US6703394B2 (en) * 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
EP0827960A1 (de) 1996-09-10 1998-03-11 Ajinomoto Co., Inc. Verfahren zur Herstellung von Purinderivaten

Also Published As

Publication number Publication date
US8124609B2 (en) 2012-02-28
MY123083A (en) 2006-05-31
JP2000504721A (ja) 2000-04-18
ES2189942T3 (es) 2003-07-16
ATE231508T1 (de) 2003-02-15
US5869493A (en) 1999-02-09
CA2243826A1 (en) 1997-08-21
DE69718619D1 (de) 2003-02-27
AU1818397A (en) 1997-09-02
JP2000504720A (ja) 2000-04-18
HK1015773A1 (en) 1999-10-22
US6255312B1 (en) 2001-07-03
WO1997030051A1 (en) 1997-08-21
SK98598A3 (en) 1998-12-02
ATE231507T1 (de) 2003-02-15
US20090076041A1 (en) 2009-03-19
TR199801318T2 (xx) 1998-10-21
NZ330472A (en) 2000-02-28
TW533213B (en) 2003-05-21
CZ232298A3 (cs) 1998-10-14
NO983216L (no) 1998-10-13
IL124760A0 (en) 1999-01-26
PL328335A1 (en) 1999-01-18
US6576763B1 (en) 2003-06-10
CA2243826C (en) 2005-12-27
SK284613B6 (sk) 2005-07-01
EA002809B1 (ru) 2002-10-31
EP0888348B1 (de) 2003-01-22
KR100464692B1 (ko) 2005-06-21
BG64179B1 (bg) 2004-03-31
DE69718626T2 (de) 2003-09-11
CN1210537A (zh) 1999-03-10
AR005827A1 (es) 1999-07-14
HU229865B1 (en) 2014-10-28
KR19990082571A (ko) 1999-11-25
PL184892B1 (pl) 2003-01-31
ES2189941T3 (es) 2003-07-16
IL124760A (en) 2003-09-17
US20120123119A1 (en) 2012-05-17
HUP9900680A3 (en) 2001-02-28
EP0880521B1 (de) 2003-01-22
CZ292169B6 (cs) 2003-08-13
EP0880521A1 (de) 1998-12-02
HUP9900680A2 (hu) 1999-06-28
EA001404B1 (ru) 2001-02-26
AU1818297A (en) 1997-09-02
CN1067073C (zh) 2001-06-13
DK0888348T3 (da) 2003-04-14
NO983216D0 (no) 1998-07-13
EA200000787A1 (ru) 2001-04-23
EA199800729A1 (ru) 1999-02-25
AU713916B2 (en) 1999-12-16
NO322930B1 (no) 2006-12-18
BG102647A (en) 1999-04-30
DE69718626D1 (de) 2003-02-27
JP4171069B2 (ja) 2008-10-22
WO1997030052A1 (en) 1997-08-21
EP0888348A1 (de) 1999-01-07
AU715062B2 (en) 2000-01-13

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