DE69717263T2 - Zubereitung mit verzögerter freisetzung und deren herstellung - Google Patents

Zubereitung mit verzögerter freisetzung und deren herstellung

Info

Publication number
DE69717263T2
DE69717263T2 DE69717263T DE69717263T DE69717263T2 DE 69717263 T2 DE69717263 T2 DE 69717263T2 DE 69717263 T DE69717263 T DE 69717263T DE 69717263 T DE69717263 T DE 69717263T DE 69717263 T2 DE69717263 T2 DE 69717263T2
Authority
DE
Germany
Prior art keywords
production
preparation
delayed release
sustained
dispersing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69717263T
Other languages
English (en)
Other versions
DE69717263D1 (de
Inventor
Shigeyuki Takada
Tomofumi Kurokawa
Susumu Iwasa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE69717263D1 publication Critical patent/DE69717263D1/de
Publication of DE69717263T2 publication Critical patent/DE69717263T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
DE69717263T 1996-03-28 1997-03-27 Zubereitung mit verzögerter freisetzung und deren herstellung Expired - Lifetime DE69717263T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7301696 1996-03-28
PCT/JP1997/001041 WO1997035563A2 (en) 1996-03-28 1997-03-27 Sustained-release preparation and its production

Publications (2)

Publication Number Publication Date
DE69717263D1 DE69717263D1 (de) 2003-01-02
DE69717263T2 true DE69717263T2 (de) 2003-07-24

Family

ID=13506129

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69717263T Expired - Lifetime DE69717263T2 (de) 1996-03-28 1997-03-27 Zubereitung mit verzögerter freisetzung und deren herstellung

Country Status (8)

Country Link
US (2) US6190702B1 (de)
EP (1) EP0889722B1 (de)
AT (1) ATE227980T1 (de)
AU (1) AU2043297A (de)
CA (1) CA2241322C (de)
DE (1) DE69717263T2 (de)
DK (1) DK0889722T3 (de)
WO (1) WO1997035563A2 (de)

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US6287587B2 (en) 1997-07-15 2001-09-11 Takeda Chemical Industries, Ltd. Process for producing sustained-release preparation by in-water drying
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KR100595340B1 (ko) * 1998-01-21 2006-07-03 다케다 야쿠힌 고교 가부시키가이샤 서방형 제제의 동결 건조법
WO1999048519A1 (en) 1998-03-20 1999-09-30 Takeda Chemical Industries, Ltd. Sustained-release preparation of physiologically active polypeptide and production thereof
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
WO2001051032A2 (en) * 2000-01-14 2001-07-19 Brown University Research Foundation Micronized freeze-dried particles
US7029700B2 (en) 2000-01-14 2006-04-18 Brown University Research Foundation Micronized freeze-dried particles
ATE328605T1 (de) 2000-03-24 2006-06-15 Genentech Inc Verwendung von insulin zur behandlung von knorpelkrankheiten
US20080233165A1 (en) * 2000-08-07 2008-09-25 Biolok International, Inc. Time release calcium sulfate and growth factor matrix for bone augmentation
US7488761B2 (en) * 2000-08-07 2009-02-10 Orthogen Llc Polymer containing calcium sulfate particles for bone augmentation
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
EP1356809A4 (de) * 2000-12-28 2008-05-14 Takeda Pharmaceutical Retardzubereitungen
JP2002265383A (ja) * 2001-03-14 2002-09-18 Mitsubishi Pharma Corp インターフェロンα注射用液状製剤
WO2002078673A1 (fr) * 2001-03-29 2002-10-10 Takeda Chemical Industries, Ltd. Procede de production d'un medicament sous forme de granules fins
US20040126900A1 (en) * 2001-04-13 2004-07-01 Barry Stephen E High affinity peptide- containing nanoparticles
US6887897B2 (en) 2001-07-31 2005-05-03 Mission Pharmacal Company Calcium glutarate supplement and phosphorus binder
EP1466596B8 (de) * 2001-12-26 2017-01-11 Takeda Pharmaceutical Company Limited Mikrosphäre und verfahren zu deren herstellung
WO2004035537A2 (en) 2002-10-16 2004-04-29 Euro-Celtique S.A. Antibodies that bind cell-associated ca 125/o772p and methods of use thereof
AU2003286472A1 (en) * 2002-10-17 2004-05-04 Alkermes Controlled Therapeutics, Inc. Ii Microencapsulation and sustained release of biologically active polypeptides
US20070219131A1 (en) * 2004-04-15 2007-09-20 Ben-Sasson Shmuel A Compositions capable of facilitating penetration across a biological barrier
US8617613B2 (en) 2004-04-15 2013-12-31 Alkermes Pharma Ireland Limited Polymer-based sustained release device
US7456254B2 (en) * 2004-04-15 2008-11-25 Alkermes, Inc. Polymer-based sustained release device
US20060110423A1 (en) * 2004-04-15 2006-05-25 Wright Steven G Polymer-based sustained release device
US8075910B2 (en) * 2004-05-20 2011-12-13 Pbm Pharmaceuticals, Inc. Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
DE102005017777A1 (de) * 2005-04-13 2006-10-19 Pharmasol Gmbh Verfahren zur schonenden Herstellung von hochfeinen Partikelsuspensionen
EP1868574B1 (de) * 2005-04-13 2010-01-06 Abbott GmbH & Co. KG Verfahren zur schonenden herstellung hochfeiner partikelsuspensionen und hochfeiner partikel sowie deren verwendung
CN102274557B (zh) 2006-08-09 2014-12-03 精达制药公司 渗透性递送系统和活塞组件
CA2680365A1 (en) * 2007-03-22 2008-10-02 Alkermes, Inc. Coacervation process
DK2157967T3 (da) 2007-04-23 2013-04-08 Intarcia Therapeutics Inc Suspensionsformuleringer af insulinotropiske peptider og anvendelser deraf
WO2008157540A1 (en) * 2007-06-20 2008-12-24 Alkermes, Inc. Quench liquids and washing systems for production of microparticles
EP2044934A1 (de) 2007-10-01 2009-04-08 Institut National De La Sante Et De La Recherche Medicale (Inserm) Dispersion von Poloxamer-Proteinpartikeln, Herstellungsmethoden und Verwendung davon
US8343140B2 (en) 2008-02-13 2013-01-01 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
MX352189B (es) * 2008-09-04 2017-11-10 Amylin Pharmaceuticals Llc Formulaciones de liberación sostenida usando portadores no acuosos.
PT2343982T (pt) 2008-09-17 2017-07-04 Chiasma Inc Composições farmacêuticas e métodos de administração associados
LT2462246T (lt) 2009-09-28 2017-11-27 Intarcia Therapeutics, Inc Esminio stacionaraus vaisto tiekimo greitas įgyvendinimas ir (arba) nutraukimas
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10238709B2 (en) 2015-02-03 2019-03-26 Chiasma, Inc. Method of treating diseases
CN113598842A (zh) 2015-06-03 2021-11-05 因塔西亚制药公司 植入物放置和移除系统
EP3458084B1 (de) 2016-05-16 2020-04-01 Intarcia Therapeutics, Inc Für den glucagonrezeptor selektive polypeptide und verfahren zu deren verwendung
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
EP3565580B1 (de) 2017-01-03 2024-03-06 i2o Therapeutics, Inc. Kontinuierlicher verabreichung von exenatid und co-verabreichung von acetaminophen, ethinylestradiol oder levonorgestrel
WO2018156935A1 (en) 2017-02-24 2018-08-30 The Regents Of The University Of California Particle-drop structures and methods for making and using the same
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods

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US4774091A (en) 1983-10-14 1988-09-27 Sumitomo Pharmaceuticals Company, Ltd. Long-term sustained-release preparation
US5385738A (en) 1983-10-14 1995-01-31 Sumitomo Pharmaceuticals Company, Ltd. Sustained-release injection
US4963367A (en) * 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
US4962091A (en) 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
JP3116311B2 (ja) 1990-06-13 2000-12-11 エーザイ株式会社 マイクロスフィアの製法
ZA918168B (en) 1990-10-16 1993-04-14 Takeda Chemical Industries Ltd Prolonged release preparation and polymers thereof.
US5288502A (en) 1991-10-16 1994-02-22 The University Of Texas System Preparation and uses of multi-phase microspheres
ES2151541T3 (es) 1992-12-02 2001-01-01 Alkermes Inc Microesferas que contienen hormona del crecimiento de liberacion prolongada.
RU2143889C1 (ru) 1993-02-23 2000-01-10 Генентек, Инк. Способ стабилизации полипептида, способы получения композиций полипептида и композиции
NZ260909A (en) * 1993-07-05 1995-04-27 Takeda Chemical Industries Ltd Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution
ATE175110T1 (de) * 1993-10-22 1999-01-15 Genentech Inc Verfahren zur herstellung von mikrospharen mit einer wirbelschichtstufe
US6117455A (en) * 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
TW448055B (en) * 1995-09-04 2001-08-01 Takeda Chemical Industries Ltd Method of production of sustained-release preparation
EP0765660A3 (de) * 1995-09-28 1998-09-23 Takeda Chemical Industries, Ltd. Mikrokapseln enthaltend 2-Piperazinon-1-essigsäure Verbindungen

Also Published As

Publication number Publication date
DE69717263D1 (de) 2003-01-02
DK0889722T3 (da) 2003-02-10
EP0889722B1 (de) 2002-11-20
US6190702B1 (en) 2001-02-20
ATE227980T1 (de) 2002-12-15
WO1997035563A2 (en) 1997-10-02
AU2043297A (en) 1997-10-17
WO1997035563A3 (en) 1997-11-20
US20010006678A1 (en) 2001-07-05
EP0889722A2 (de) 1999-01-13
CA2241322C (en) 2009-01-13
CA2241322A1 (en) 1997-10-02

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP