DE69715639T2 - Nicht wässrige polar-aprotische peptidzubereitung - Google Patents
Nicht wässrige polar-aprotische peptidzubereitungInfo
- Publication number
- DE69715639T2 DE69715639T2 DE69715639T DE69715639T DE69715639T2 DE 69715639 T2 DE69715639 T2 DE 69715639T2 DE 69715639 T DE69715639 T DE 69715639T DE 69715639 T DE69715639 T DE 69715639T DE 69715639 T2 DE69715639 T2 DE 69715639T2
- Authority
- DE
- Germany
- Prior art keywords
- polar aprotic
- peptide preparation
- aqueous polar
- aprotic peptide
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2269996P | 1996-07-03 | 1996-07-03 | |
PCT/US1997/011450 WO1998000158A1 (en) | 1996-07-03 | 1997-07-01 | Non-aqueous polar aprotic peptide formulations |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69715639D1 DE69715639D1 (de) | 2002-10-24 |
DE69715639T2 true DE69715639T2 (de) | 2003-02-06 |
Family
ID=21810971
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69715639T Expired - Lifetime DE69715639T2 (de) | 1996-07-03 | 1997-07-01 | Nicht wässrige polar-aprotische peptidzubereitung |
DE69728582T Expired - Lifetime DE69728582T2 (de) | 1996-07-03 | 1997-07-01 | Stabile, nichtwäßrige Formulierung einer Peptidverbindung |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69728582T Expired - Lifetime DE69728582T2 (de) | 1996-07-03 | 1997-07-01 | Stabile, nichtwäßrige Formulierung einer Peptidverbindung |
Country Status (29)
Country | Link |
---|---|
US (3) | US5932547A (de) |
EP (2) | EP1208846B1 (de) |
JP (2) | JP2000515131A (de) |
CN (4) | CN1636589A (de) |
AR (1) | AR007714A1 (de) |
AT (2) | ATE263570T1 (de) |
AU (1) | AU739169B2 (de) |
BR (1) | BR9710132A (de) |
CA (1) | CA2259557A1 (de) |
CO (1) | CO4870762A1 (de) |
CY (1) | CY2486B1 (de) |
CZ (2) | CZ300378B6 (de) |
DE (2) | DE69715639T2 (de) |
DK (2) | DK1208846T3 (de) |
ES (2) | ES2181010T3 (de) |
HU (1) | HUP9904270A3 (de) |
ID (2) | ID19718A (de) |
IL (3) | IL127771A0 (de) |
MY (1) | MY128850A (de) |
NO (2) | NO322514B1 (de) |
NZ (1) | NZ333294A (de) |
PL (1) | PL189015B1 (de) |
PT (2) | PT1208846E (de) |
RO (1) | RO119863B1 (de) |
RU (1) | RU2203084C2 (de) |
SK (1) | SK283926B6 (de) |
TW (1) | TW584562B (de) |
WO (1) | WO1998000158A1 (de) |
ZA (1) | ZA975941B (de) |
Families Citing this family (81)
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US5932547A (en) * | 1996-07-03 | 1999-08-03 | Alza Corporation | Non-aqueous polar aprotic peptide formulations |
MY125870A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system flow modulator apparatus and method |
US7919109B2 (en) | 1999-02-08 | 2011-04-05 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
US7258869B1 (en) * | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
US20070148228A1 (en) * | 1999-02-22 | 2007-06-28 | Merrion Research I Limited | Solid oral dosage form containing an enhancer |
US8119159B2 (en) * | 1999-02-22 | 2012-02-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
EP1274459B1 (de) | 2000-04-19 | 2005-11-16 | Genentech, Inc. | Formulierungen mit verzögerter freisetzung enthaltend wachstumshormon |
US8470359B2 (en) | 2000-11-13 | 2013-06-25 | Qlt Usa, Inc. | Sustained release polymer |
CA2439120C (en) * | 2001-02-23 | 2011-07-05 | Genentech, Inc. | Erodible polymers for injection |
US7318931B2 (en) * | 2001-06-21 | 2008-01-15 | Genentech, Inc. | Sustained release formulation |
EP2277888A3 (de) | 2001-12-21 | 2011-04-27 | Human Genome Sciences, Inc. | Fusionsprotein von Albumin und Erythropoietin |
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CN1668279A (zh) * | 2002-06-17 | 2005-09-14 | 阿尔萨公司 | 具有包含分散在液体载体中的渗透物质的早期零级推动力动力系统的渗透递送体系 |
BR0317421A (pt) * | 2002-12-19 | 2005-11-08 | Alza Corp | Géis de fase única não-aquosa estável e formulações destes para liberação a partir de um dispositivo implantável |
US7731947B2 (en) * | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
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US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
AU2004227986A1 (en) * | 2003-03-31 | 2004-10-21 | Alza Corporation | Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems |
JP2006521897A (ja) * | 2003-03-31 | 2006-09-28 | アルザ・コーポレーション | 内部圧力を放散する手段を備える浸透ポンプ |
JP4734236B2 (ja) * | 2003-04-25 | 2011-07-27 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 固形型の薬物の貯蔵及び制御された放出のための装置及びその製造方法 |
EP1631308B1 (de) * | 2003-05-30 | 2013-07-31 | Amylin Pharmaceuticals, LLC | Neue verfahren und zusammensetzungen für die verbesserte transmukosale abgabe von peptiden und proteinen |
CA2537811A1 (en) * | 2003-10-31 | 2005-05-19 | Alza Corporation | Osmotic pump with self-retaining, fast-start membrane plug |
CA2545027A1 (en) * | 2003-11-06 | 2005-05-26 | Alza Corporation | Modular imbibition rate reducer for use with implantable osmotic pump |
FI116942B (fi) * | 2004-05-10 | 2006-04-13 | Biohit Oyj | Proteiini- ja peptidistabilointi |
US20050266087A1 (en) * | 2004-05-25 | 2005-12-01 | Gunjan Junnarkar | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
US20060039949A1 (en) * | 2004-08-20 | 2006-02-23 | Nycz Jeffrey H | Acetabular cup with controlled release of an osteoinductive formulation |
US20060045902A1 (en) * | 2004-09-01 | 2006-03-02 | Serbousek Jon C | Polymeric wrap for in vivo delivery of osteoinductive formulations |
US20060057184A1 (en) * | 2004-09-16 | 2006-03-16 | Nycz Jeffrey H | Process to treat avascular necrosis (AVN) with osteoinductive materials |
US8137664B2 (en) * | 2005-02-02 | 2012-03-20 | Sdgi Holdings, Inc. | Method and kit for repairing a defect in bone |
WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
EP2361630A1 (de) * | 2005-02-03 | 2011-08-31 | Intarcia Therapeutics, Inc | Implantierbares Arzneimittelfreigabesystem Partikel und eine osmotische Pumpe enthaltend |
US7959938B2 (en) | 2005-03-15 | 2011-06-14 | Intarcia Therapeutics, Inc. | Polyoxaester suspending vehicles for use with implantable delivery systems |
WO2006110551A2 (en) * | 2005-04-08 | 2006-10-19 | Amylin Pharmaceuticals, Inc. | Pharmaceutical formulations comprising incretin peptide and aprotic polar solvent |
US20070015689A1 (en) * | 2005-06-23 | 2007-01-18 | Alza Corporation | Complexation of metal ions with polypeptides |
JP5276448B2 (ja) * | 2005-12-22 | 2013-08-28 | オークウッド ラボラトリーズ,エル.エル.シー. | 昇華可能な持続放出デリバリーシステム及びその製造方法 |
CN101437522A (zh) * | 2006-04-07 | 2009-05-20 | 默里昂研究Ⅲ有限公司 | 包含增强剂的固体口服剂型 |
CN101453982B (zh) * | 2006-05-30 | 2011-05-04 | 精达制药公司 | 两件式内部通道渗透递送系统流动调节器 |
WO2007146234A2 (en) * | 2006-06-09 | 2007-12-21 | Merrion Research Ii Limited | Solid oral dosage form containing an enhancer |
ES2422864T3 (es) * | 2006-08-09 | 2013-09-16 | Intarcia Therapeutics, Inc | Sistemas de liberación osmótica y unidades de pistón |
RU2440097C2 (ru) | 2007-04-23 | 2012-01-20 | Интарсия Терапьютикс, Инк. | Способ лечения диабета ii типа и ожирения, осмотическое устройство для доставки и способ его изготовления |
HUE043228T2 (hu) | 2007-06-22 | 2019-08-28 | Univ Texas | Stabil szubmikron peptid vagy protein részecskék képzése vékonyfilm fagyasztással |
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EP2240155B1 (de) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Vorrichtungen, formulierungen und verfahren zur freisetzung mehrerer wirkstoffe |
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JP5713897B2 (ja) * | 2008-07-16 | 2015-05-07 | エボニック コーポレイションEvonik Corporation | 生理活性ペプチドを含有する微粒子を調製するためのプロセス |
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EP2161030A1 (de) * | 2008-09-09 | 2010-03-10 | Rijksuniversiteit te Groningen | Oxytozinformulierungen und ihre Verwendungen |
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EP2376522A4 (de) | 2008-11-16 | 2013-12-25 | Univ Texas | Niederviskose hochkonzentrierte suspensionen |
US20100215743A1 (en) * | 2009-02-25 | 2010-08-26 | Leonard Thomas W | Composition and drug delivery of bisphosphonates |
JP2013501071A (ja) | 2009-08-06 | 2013-01-10 | アイロンウッド ファーマシューティカルズ, インコーポレイテッド | リナクロチドを含む処方物 |
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US20110182985A1 (en) * | 2010-01-28 | 2011-07-28 | Coughlan David C | Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof |
TR201711271T4 (tr) | 2010-02-17 | 2019-02-21 | Ironwood Pharmaceuticals Inc | Gastrointestinal Bozukluklar İçin Tedaviler |
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PL2603232T3 (pl) | 2010-08-11 | 2020-05-18 | Ironwood Pharmaceuticals, Inc. | Stabilne formulacje linaklotydu |
KR20140026354A (ko) | 2011-01-07 | 2014-03-05 | 메리온 리서치 Ⅲ 리미티드 | 경구 투여용 철의 제약 조성물 |
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CN105853348B (zh) * | 2011-03-10 | 2019-08-30 | Xeris药物公司 | 肠胃外注射用稳定溶液 |
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WO2013154779A1 (en) * | 2012-04-10 | 2013-10-17 | The Regents Of The University Of California | Nanocrystal-polymer nanocomposite electrochromic device |
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US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
WO2016120378A1 (en) | 2015-01-29 | 2016-08-04 | Novo Nordisk A/S | Tablets comprising glp-1 agonist and enteric coating |
EP3302354B1 (de) | 2015-06-03 | 2023-10-04 | i2o Therapeutics, Inc. | Systeme zum einsetzen eines implantats |
US9649364B2 (en) | 2015-09-25 | 2017-05-16 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic formulations in aprotic polar solvents |
US11590205B2 (en) | 2015-09-25 | 2023-02-28 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents |
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USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
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KR20190104039A (ko) | 2017-01-03 | 2019-09-05 | 인타르시아 세라퓨틱스 인코포레이티드 | Glp-1 수용체 효능제의 연속적인 투여 및 약물의 동시-투여를 포함하는 방법 |
KR20240036128A (ko) | 2017-06-02 | 2024-03-19 | 엑스에리스 파머수티클스, 인크. | 침전 방지 저분자 약물 제제 |
PE20211202A1 (es) | 2017-08-24 | 2021-07-05 | Novo Nordisk As | Composiciones de glp-1 y sus usos |
EP4106724A1 (de) | 2020-02-18 | 2022-12-28 | Novo Nordisk A/S | Glp-1-zusammensetzungen und verwendungen davon |
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-
1997
- 1997-06-13 US US08/874,233 patent/US5932547A/en not_active Expired - Lifetime
- 1997-07-01 NZ NZ333294A patent/NZ333294A/xx not_active IP Right Cessation
- 1997-07-01 WO PCT/US1997/011450 patent/WO1998000158A1/en active Application Filing
- 1997-07-01 AU AU35879/97A patent/AU739169B2/en not_active Ceased
- 1997-07-01 CN CNA2004100926181A patent/CN1636589A/zh active Pending
- 1997-07-01 DK DK02075347T patent/DK1208846T3/da active
- 1997-07-01 ES ES97932416T patent/ES2181010T3/es not_active Expired - Lifetime
- 1997-07-01 JP JP10504401A patent/JP2000515131A/ja not_active Withdrawn
- 1997-07-01 RU RU99102245/14A patent/RU2203084C2/ru not_active IP Right Cessation
- 1997-07-01 RO RO98-01771A patent/RO119863B1/ro unknown
- 1997-07-01 CZ CZ20070287A patent/CZ300378B6/cs not_active IP Right Cessation
- 1997-07-01 DK DK97932416T patent/DK0921808T3/da active
- 1997-07-01 IL IL12777197A patent/IL127771A0/xx not_active IP Right Cessation
- 1997-07-01 HU HU9904270A patent/HUP9904270A3/hu unknown
- 1997-07-01 DE DE69715639T patent/DE69715639T2/de not_active Expired - Lifetime
- 1997-07-01 CN CNA2006101493995A patent/CN101116742A/zh active Pending
- 1997-07-01 CN CN2011104119069A patent/CN102512658A/zh active Pending
- 1997-07-01 EP EP02075347A patent/EP1208846B1/de not_active Expired - Lifetime
- 1997-07-01 CA CA002259557A patent/CA2259557A1/en not_active Abandoned
- 1997-07-01 PT PT02075347T patent/PT1208846E/pt unknown
- 1997-07-01 AT AT02075347T patent/ATE263570T1/de active
- 1997-07-01 BR BR9710132A patent/BR9710132A/pt not_active Application Discontinuation
- 1997-07-01 SK SK1797-98A patent/SK283926B6/sk not_active IP Right Cessation
- 1997-07-01 DE DE69728582T patent/DE69728582T2/de not_active Expired - Lifetime
- 1997-07-01 CN CNA200810087659XA patent/CN101239179A/zh active Pending
- 1997-07-01 EP EP97932416A patent/EP0921808B1/de not_active Expired - Lifetime
- 1997-07-01 AT AT97932416T patent/ATE224199T1/de active
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- 1997-07-01 PT PT97932416T patent/PT921808E/pt unknown
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- 1997-07-02 AR ARP970102965A patent/AR007714A1/es active IP Right Grant
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1998
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1999
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2000
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2004
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2005
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2006
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