DE69715639D1 - Nicht wässrige polar-aprotische peptidzubereitung - Google Patents
Nicht wässrige polar-aprotische peptidzubereitungInfo
- Publication number
- DE69715639D1 DE69715639D1 DE69715639T DE69715639T DE69715639D1 DE 69715639 D1 DE69715639 D1 DE 69715639D1 DE 69715639 T DE69715639 T DE 69715639T DE 69715639 T DE69715639 T DE 69715639T DE 69715639 D1 DE69715639 D1 DE 69715639D1
- Authority
- DE
- Germany
- Prior art keywords
- polar aprotic
- peptide preparation
- aqueous polar
- aprotic peptide
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Genetics & Genomics (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2269996P | 1996-07-03 | 1996-07-03 | |
PCT/US1997/011450 WO1998000158A1 (en) | 1996-07-03 | 1997-07-01 | Non-aqueous polar aprotic peptide formulations |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69715639D1 true DE69715639D1 (de) | 2002-10-24 |
DE69715639T2 DE69715639T2 (de) | 2003-02-06 |
Family
ID=21810971
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69715639T Expired - Lifetime DE69715639T2 (de) | 1996-07-03 | 1997-07-01 | Nicht wässrige polar-aprotische peptidzubereitung |
DE69728582T Expired - Lifetime DE69728582T2 (de) | 1996-07-03 | 1997-07-01 | Stabile, nichtwäßrige Formulierung einer Peptidverbindung |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69728582T Expired - Lifetime DE69728582T2 (de) | 1996-07-03 | 1997-07-01 | Stabile, nichtwäßrige Formulierung einer Peptidverbindung |
Country Status (29)
Country | Link |
---|---|
US (3) | US5932547A (de) |
EP (2) | EP0921808B1 (de) |
JP (2) | JP2000515131A (de) |
CN (4) | CN1636589A (de) |
AR (1) | AR007714A1 (de) |
AT (2) | ATE263570T1 (de) |
AU (1) | AU739169B2 (de) |
BR (1) | BR9710132A (de) |
CA (1) | CA2259557A1 (de) |
CO (1) | CO4870762A1 (de) |
CY (1) | CY2486B1 (de) |
CZ (2) | CZ300378B6 (de) |
DE (2) | DE69715639T2 (de) |
DK (2) | DK1208846T3 (de) |
ES (2) | ES2181010T3 (de) |
HU (1) | HUP9904270A3 (de) |
ID (2) | ID28822A (de) |
IL (3) | IL127771A0 (de) |
MY (1) | MY128850A (de) |
NO (2) | NO322514B1 (de) |
NZ (1) | NZ333294A (de) |
PL (1) | PL189015B1 (de) |
PT (2) | PT1208846E (de) |
RO (1) | RO119863B1 (de) |
RU (1) | RU2203084C2 (de) |
SK (1) | SK283926B6 (de) |
TW (1) | TW584562B (de) |
WO (1) | WO1998000158A1 (de) |
ZA (1) | ZA975941B (de) |
Families Citing this family (81)
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---|---|---|---|---|
US5932547A (en) * | 1996-07-03 | 1999-08-03 | Alza Corporation | Non-aqueous polar aprotic peptide formulations |
MY125870A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system flow modulator apparatus and method |
US7258869B1 (en) * | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
US7919109B2 (en) | 1999-02-08 | 2011-04-05 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
US8119159B2 (en) * | 1999-02-22 | 2012-02-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
US20070148228A1 (en) * | 1999-02-22 | 2007-06-28 | Merrion Research I Limited | Solid oral dosage form containing an enhancer |
US7658938B2 (en) * | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
AU2001259111B2 (en) | 2000-04-19 | 2005-12-08 | Durect Corporation | Sustained release formulations comprising growth hormone |
US8470359B2 (en) | 2000-11-13 | 2013-06-25 | Qlt Usa, Inc. | Sustained release polymer |
US7824700B2 (en) * | 2001-02-23 | 2010-11-02 | Genentech, Inc. | Erodible polymers for injection |
ES2554106T3 (es) * | 2001-06-21 | 2015-12-16 | Genentech, Inc. | Formulación de liberación sostenida |
ES2425738T3 (es) | 2001-12-21 | 2013-10-17 | Human Genome Sciences, Inc. | Proteínas de fusión de la albúmina |
JP2006514914A (ja) * | 2002-02-14 | 2006-05-18 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | 有機溶媒中および乾燥状態のペプチドの安定化における製剤の戦略 |
DE60315474T2 (de) * | 2002-06-17 | 2008-04-24 | Alza Corp., Mountain View | Osmotische abgabesysteme mit osmotischen antrieb und verfahren zur herstellung sowohl des osmotischen antriebs als auch des osmotischen abgabesystems |
KR20050088196A (ko) * | 2002-12-19 | 2005-09-02 | 알자 코포레이션 | 안정한 비수성 단일 상 겔 및 이식가능한 장치로부터전달하기 위한 이의 제형 |
US7731947B2 (en) * | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
EP3597262B1 (de) | 2002-12-20 | 2023-12-27 | Xeris Pharmaceuticals, Inc. | Formulierung für intrakutane injektion |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
CL2004000696A1 (es) * | 2003-03-31 | 2005-05-20 | Alza Corp | Bomba osmotica, esta formada por una cubierta cilindrica con una camara que recibe al agente osmotico, un extremo abierto que recibe un tapon semipermeable y un orificio de ventilacion en la pared lateral ubicado proximo al extremo abierto, para disi |
JP2006521898A (ja) * | 2003-03-31 | 2006-09-28 | アルザ・コーポレーション | 浸透送り出しシステム及び浸透送り出しシステムの始動時間を短縮する方法 |
US20040247671A1 (en) * | 2003-04-25 | 2004-12-09 | Prescott James H. | Solid drug formulation and device for storage and controlled delivery thereof |
EP1631308B1 (de) * | 2003-05-30 | 2013-07-31 | Amylin Pharmaceuticals, LLC | Neue verfahren und zusammensetzungen für die verbesserte transmukosale abgabe von peptiden und proteinen |
BRPI0416094A (pt) * | 2003-10-31 | 2007-01-02 | Alza Corp | bomba osmótica com plugue de membrana de inicialização rápida, de auto-retenção |
US20050101943A1 (en) * | 2003-11-06 | 2005-05-12 | Alza Corporation | Modular imbibition rate reducer for use with implantable osmotic pump |
FI116942B (fi) * | 2004-05-10 | 2006-04-13 | Biohit Oyj | Proteiini- ja peptidistabilointi |
US20050266087A1 (en) * | 2004-05-25 | 2005-12-01 | Gunjan Junnarkar | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
US20060039949A1 (en) * | 2004-08-20 | 2006-02-23 | Nycz Jeffrey H | Acetabular cup with controlled release of an osteoinductive formulation |
US20060045902A1 (en) * | 2004-09-01 | 2006-03-02 | Serbousek Jon C | Polymeric wrap for in vivo delivery of osteoinductive formulations |
US20060057184A1 (en) * | 2004-09-16 | 2006-03-16 | Nycz Jeffrey H | Process to treat avascular necrosis (AVN) with osteoinductive materials |
US8137664B2 (en) * | 2005-02-02 | 2012-03-20 | Sdgi Holdings, Inc. | Method and kit for repairing a defect in bone |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
JP2008528698A (ja) * | 2005-02-03 | 2008-07-31 | インターシア セラピューティクス,インコーポレイティド | 埋め込み可能なインターフェロン含有デバイス |
US7959938B2 (en) * | 2005-03-15 | 2011-06-14 | Intarcia Therapeutics, Inc. | Polyoxaester suspending vehicles for use with implantable delivery systems |
AU2006235183B2 (en) * | 2005-04-08 | 2011-02-10 | Amylin Pharmaceuticals, Llc | Pharmaceutical formulations comprising incretin peptide and aprotic polar solvent |
US20070015689A1 (en) * | 2005-06-23 | 2007-01-18 | Alza Corporation | Complexation of metal ions with polypeptides |
CN101511170B (zh) * | 2005-12-22 | 2014-03-26 | 奥克伍德药业有限公司 | 可升华持续释放传递系统和其制造方法 |
AU2007235251B2 (en) * | 2006-04-07 | 2013-02-07 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
MX2008014870A (es) | 2006-05-30 | 2009-02-12 | Intarcia Therapeutics Inc | Modulador de flujo para sistema de suministro osmotico con canal interno de dos piezas. |
EP2040731A4 (de) * | 2006-06-09 | 2010-05-19 | Merrion Res Iii Ltd | Feste orale dosierform mit einem verstärkungsmittel |
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US8968786B2 (en) | 2007-06-22 | 2015-03-03 | Board Of Regents, The University Of Texas System | Formation of stable submicron peptide or protein particles by thin film freezing |
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EP2161030A1 (de) * | 2008-09-09 | 2010-03-10 | Rijksuniversiteit te Groningen | Oxytozinformulierungen und ihre Verwendungen |
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EP2376522A4 (de) | 2008-11-16 | 2013-12-25 | Univ Texas | Niederviskose hochkonzentrierte suspensionen |
AR075613A1 (es) * | 2009-02-25 | 2011-04-20 | Merrion Res Iii Ltd | Composicion y suministro de drogas de bifosfonato. metodo de tratamiento |
JP2013501071A (ja) | 2009-08-06 | 2013-01-10 | アイロンウッド ファーマシューティカルズ, インコーポレイテッド | リナクロチドを含む処方物 |
SI2462246T1 (en) | 2009-09-28 | 2018-01-31 | Intarcia Therapeutics, Inc. | Fast-setting and / or cessation of substantially unchanged delivery of the product |
US20110182985A1 (en) * | 2010-01-28 | 2011-07-28 | Coughlan David C | Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof |
PL2536742T3 (pl) | 2010-02-17 | 2017-11-30 | Ironwood Pharmaceuticals, Inc. | Leczenie zaburzeń żołądkowo-jelitowych |
US9089484B2 (en) * | 2010-03-26 | 2015-07-28 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor Xa inhibitors for oral administration |
US20120046225A1 (en) | 2010-07-19 | 2012-02-23 | The Regents Of The University Of Colorado, A Body Corporate | Stable glucagon formulations for the treatment of hypoglycemia |
JP5921545B2 (ja) | 2010-08-11 | 2016-05-24 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | リナクロチドの安定な製剤 |
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US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
DK2683364T3 (en) | 2011-03-10 | 2017-02-27 | Xeris Pharmaceuticals Inc | Stable formulations for parenteral injection of peptide drugs. |
PL2776055T3 (pl) | 2011-08-17 | 2017-06-30 | Ironwood Pharmaceuticals, Inc. | Sposoby leczenia zaburzeń żołądkowo-jelitowych |
EA027744B1 (ru) * | 2011-10-31 | 2017-08-31 | Ксерис Фармасьютикалс, Инк. | Лекарственные формы для лечения сахарного диабета |
WO2013154779A1 (en) * | 2012-04-10 | 2013-10-17 | The Regents Of The University Of California | Nanocrystal-polymer nanocomposite electrochromic device |
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KR102650751B1 (ko) | 2015-06-03 | 2024-03-22 | 인타르시아 세라퓨틱스 인코포레이티드 | 임플란트 배치 및 제거 시스템들 |
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US11590205B2 (en) | 2015-09-25 | 2023-02-28 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents |
SG10201913699QA (en) | 2016-05-16 | 2020-03-30 | Intarcia Therapeutics Inc | Glucagon-receptor selective polypeptides and methods of use thereof |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
AU2018206539A1 (en) | 2017-01-03 | 2019-07-18 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug |
EP3630061B1 (de) | 2017-06-02 | 2024-04-03 | Xeris Pharmaceuticals, Inc. | Niederschlagsbeständige kleinmolekulare zubereitung |
EP4360651A2 (de) | 2017-08-24 | 2024-05-01 | Novo Nordisk A/S | Glp-1-zusammensetzungen und verwendungen davon |
EP4106724A1 (de) | 2020-02-18 | 2022-12-28 | Novo Nordisk A/S | Glp-1-zusammensetzungen und verwendungen davon |
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IL22493A (en) * | 1963-12-09 | 1968-10-24 | Crown Zellerbach Corp | Membrane penetrant composition containing a dialkyl sulfoxide |
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-
1997
- 1997-06-13 US US08/874,233 patent/US5932547A/en not_active Expired - Lifetime
- 1997-07-01 ES ES97932416T patent/ES2181010T3/es not_active Expired - Lifetime
- 1997-07-01 RU RU99102245/14A patent/RU2203084C2/ru not_active IP Right Cessation
- 1997-07-01 CZ CZ20070287A patent/CZ300378B6/cs not_active IP Right Cessation
- 1997-07-01 AT AT02075347T patent/ATE263570T1/de active
- 1997-07-01 AU AU35879/97A patent/AU739169B2/en not_active Ceased
- 1997-07-01 CN CNA2004100926181A patent/CN1636589A/zh active Pending
- 1997-07-01 DK DK02075347T patent/DK1208846T3/da active
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