DE69711882T2 - Carbolinderivate - Google Patents
CarbolinderivateInfo
- Publication number
- DE69711882T2 DE69711882T2 DE69711882T DE69711882T DE69711882T2 DE 69711882 T2 DE69711882 T2 DE 69711882T2 DE 69711882 T DE69711882 T DE 69711882T DE 69711882 T DE69711882 T DE 69711882T DE 69711882 T2 DE69711882 T2 DE 69711882T2
- Authority
- DE
- Germany
- Prior art keywords
- carboline derivatives
- carboline
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9609777.9A GB9609777D0 (en) | 1996-05-10 | 1996-05-10 | Chemical compounds |
GBGB9609820.7A GB9609820D0 (en) | 1996-05-10 | 1996-05-10 | Chemical compounds |
PCT/EP1997/002277 WO1997043287A1 (en) | 1996-05-10 | 1997-05-05 | Carboline derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69711882D1 DE69711882D1 (en) | 2002-05-16 |
DE69711882T2 true DE69711882T2 (de) | 2002-10-31 |
Family
ID=26309303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69711882T Expired - Fee Related DE69711882T2 (de) | 1996-05-10 | 1997-05-05 | Carbolinderivate |
Country Status (26)
Country | Link |
---|---|
US (2) | US6117881A (de) |
EP (1) | EP0912567B1 (de) |
JP (1) | JP3418405B2 (de) |
KR (1) | KR20000010918A (de) |
CN (1) | CN1067071C (de) |
AP (1) | AP9801365A0 (de) |
AT (1) | ATE215950T1 (de) |
AU (1) | AU711885B2 (de) |
BG (1) | BG102879A (de) |
BR (1) | BR9709230A (de) |
CA (1) | CA2253948C (de) |
CZ (1) | CZ358598A3 (de) |
DE (1) | DE69711882T2 (de) |
EA (1) | EA199800907A1 (de) |
EE (1) | EE9800390A (de) |
ES (1) | ES2175404T3 (de) |
HU (1) | HUP9901478A3 (de) |
IL (1) | IL126951A0 (de) |
IS (1) | IS4864A (de) |
NO (1) | NO985222L (de) |
OA (1) | OA10920A (de) |
PL (1) | PL329875A1 (de) |
SK (1) | SK154498A3 (de) |
TR (1) | TR199802282T2 (de) |
WO (1) | WO1997043287A1 (de) |
YU (1) | YU49898A (de) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69711882T2 (de) * | 1996-05-10 | 2002-10-31 | Icos Corp | Carbolinderivate |
US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
DE19837069C1 (de) | 1998-08-17 | 2000-01-05 | Bayer Ag | Substituierte Zimtsäuren und Zimtsäureester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von substituierten Indanoncarbonsäureestern |
EP1114048A1 (de) * | 1998-09-16 | 2001-07-11 | Agnès Bombrun | Carbolin-derivate als cgmp phosphodiesterase-inhibitoren |
DE19903087A1 (de) * | 1999-01-27 | 2000-08-10 | Forssmann Wolf Georg | Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern |
ES2213004T3 (es) | 1999-03-24 | 2004-08-16 | Harbor Branch Oceanographic Institution, Inc. | Usos antiinflamatorios de manzaminas. |
US6451807B1 (en) | 1999-04-30 | 2002-09-17 | Lilly Icos, Llc. | Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor |
IL135817A0 (en) | 1999-04-30 | 2001-05-20 | Lilly Icos Llc | Phosphodiesterase enzyme inhibitors and their use in pharmaceutical articles |
CA2407031A1 (en) | 2000-04-19 | 2001-10-25 | Lilly Icos Llc | Use of cyclic gmp-specific phosphodiesterase inhibitors for treatment of parkinson's disease |
UA74826C2 (en) | 2000-05-17 | 2006-02-15 | Ortho Mcneil Pharm Inc | ?-carboline derivatives as phosphodiesterase inhibitors |
ATE333457T1 (de) | 2000-06-23 | 2006-08-15 | Lilly Icos Llc | Zyklische gmp-spezifische phosphodiesteraseinhibitoren |
US6821978B2 (en) | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
EP1360185B1 (de) * | 2001-02-12 | 2005-08-24 | Lilly Icos LLC | Carbolinderivate |
WO2002064591A2 (en) * | 2001-02-12 | 2002-08-22 | Lilly Icos Llc | Carboline derivatives |
ES2278956T3 (es) * | 2001-04-25 | 2007-08-16 | Lilly Icos Llc | Derivados de carbolina como inhibidores de fosfodiesterasa 5 (pde5) para el tratamiento de enfermedades cardiovasculares y de la disfuncion erectil. |
MXPA03011081A (es) * | 2001-06-05 | 2004-07-08 | Lilly Icos Llc | Derivados de carbolina como inhibidores de pde5. |
ES2269679T3 (es) * | 2001-06-21 | 2007-04-01 | Lilly Icos Llc | Derivados de carbolina como inhibidores de pdev. |
EP1442042A1 (de) | 2001-11-09 | 2004-08-04 | Schering Corporation | Polyzyklisches guaninderivat phosphodiesterase-v-inhibitoren |
JP4554931B2 (ja) * | 2001-12-20 | 2010-09-29 | メルク セローノ ソシエテ アノニム | プロスタグランジン調節物質としてのピロリジン誘導体 |
US7595311B2 (en) | 2002-05-24 | 2009-09-29 | Exelixis, Inc. | Azepinoindole derivatives as pharmaceutical agents |
TWI329111B (en) | 2002-05-24 | 2010-08-21 | X Ceptor Therapeutics Inc | Azepinoindole and pyridoindole derivatives as pharmaceutical agents |
PL1644021T3 (pl) * | 2003-06-13 | 2013-01-31 | Ironwood Pharmaceuticals Inc | Sposoby i kompozycje do leczenia zaburzeń żołądkowo-jelitowych |
ES2427166T3 (es) * | 2003-06-23 | 2013-10-29 | Ono Pharmaceutical Co., Ltd. | Compuesto heterocíclico tricíclico novedoso |
US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
EA201200555A1 (ru) | 2004-03-15 | 2013-01-30 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Производные карболина, полезные в ингибировании ангиогенеза |
CN1972916B (zh) * | 2004-05-26 | 2013-03-27 | 卫材R&D管理有限公司 | 肉桂酰胺类化合物 |
NZ551144A (en) | 2004-05-26 | 2009-12-24 | Eisai R&D Man Co Ltd | Cinnamide compound |
DE602005019602D1 (de) | 2004-10-26 | 2010-04-08 | Eisai R&D Man Co Ltd | Amorphe form einer zimtsäureamidverbindung |
PT1829874E (pt) | 2004-12-22 | 2014-04-10 | Ono Pharmaceutical Co | Composto tricíclico e sua utilização |
US8506934B2 (en) | 2005-04-29 | 2013-08-13 | Robert I. Henkin | Methods for detection of biological substances |
CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
EP1942879A1 (de) | 2005-10-31 | 2008-07-16 | Braincells, Inc. | Gaba-rezeptor-vermittelte modulation von neurogenese |
NZ568694A (en) | 2005-11-09 | 2011-09-30 | Zalicus Inc | Method, compositions, and kits for the treatment of medical conditions |
WO2007058304A1 (ja) * | 2005-11-18 | 2007-05-24 | Eisai R & D Management Co., Ltd. | シンナミド化合物の塩またはそれらの溶媒和物 |
CN101309916A (zh) * | 2005-11-18 | 2008-11-19 | 卫材R&D管理有限公司 | 制备肉桂酰胺衍生物的方法 |
TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
BRPI0618814A2 (pt) | 2005-11-24 | 2014-04-29 | Eisai R&D Man Co Ltd | Composto ou um sal farmacologicamente aceitável do mesmo, e, agente farmacêutico |
US20070117839A1 (en) * | 2005-11-24 | 2007-05-24 | Eisai R&D Management Co., Ltd. | Two cyclic cinnamide compound |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | アンジオテンシン調節による神経新生 |
JP2009536667A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | 5ht受容体介在性の神経新生 |
AR062095A1 (es) | 2006-07-28 | 2008-10-15 | Eisai R&D Man Co Ltd | Profarmaco de compuesto cinamida |
AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
US8293489B2 (en) | 2007-01-31 | 2012-10-23 | Henkin Robert I | Methods for detection of biological substances |
TW200848054A (en) * | 2007-02-28 | 2008-12-16 | Eisai R&D Man Co Ltd | Two cyclic oxomorpholine derivatives |
WO2008140111A1 (ja) * | 2007-05-16 | 2008-11-20 | Eisai R & D Management Co., Ltd. | シンナミド誘導体のワンポット製造方法 |
US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
JP5433418B2 (ja) | 2007-08-31 | 2014-03-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 多環式化合物 |
CN101925607A (zh) * | 2008-01-28 | 2010-12-22 | 卫材R&D管理有限公司 | 结晶性的肉桂酰胺化合物或其盐 |
US8580801B2 (en) | 2008-07-23 | 2013-11-12 | Robert I. Henkin | Phosphodiesterase inhibitor treatment |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
EP2903619B1 (de) | 2012-10-05 | 2019-06-05 | Robert I. Henkin | Phosphodiesterasehemmer zur behandlung von geschmacks- und geruchsstörungen |
US10598672B2 (en) | 2014-02-18 | 2020-03-24 | Cyrano Therapeutics, Inc. | Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell |
CA2999503A1 (en) | 2015-09-23 | 2017-03-30 | Minerva Biotechnologies Corporation | Method of screening for agents for differentiating stem cells |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3644384A (en) * | 1969-06-09 | 1972-02-22 | Sterling Drug Inc | Certain 2-(alpha-haloacetyl) - 1 2 3 4-tetrahydro - 9h - pyrido(3 4-b)indole-3-carboxylates and derivatives |
US3717638A (en) * | 1971-03-11 | 1973-02-20 | Sterling Drug Inc | 1,2,3,4,6,7,12,12A-OCTAHYDRO-2-PHENYLPYRAZINO[2',1':6,1]PYRIDO[3,4-b]INDOLES AND INTERMEDIATES THEREFOR |
US3917599A (en) * | 1973-03-30 | 1975-11-04 | Council Scient Ind Res | 2-Substituted-1,2,3,4,6,7,12,12A-octahydropyrazino(2{40 ,1{40 :6,1)pyrido(3,4-B)indoles |
GB1454171A (en) * | 1973-10-19 | 1976-10-27 | Council Scient Ind Res | Tetracyclic compounds |
US4188390A (en) * | 1977-11-05 | 1980-02-12 | Pfizer Inc. | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines |
GR79603B (de) * | 1982-07-24 | 1984-10-31 | Pfizer | |
IT1217190B (it) * | 1988-04-22 | 1990-03-14 | Recordati Chem Pharm | Composti utili per il trattamento e diagnosi di disfunzioni frettili |
FI892362A (fi) * | 1988-06-01 | 1989-12-02 | Eisai Co Ltd | Buten- eller propensyraderivat. |
EP0357122A3 (de) * | 1988-08-29 | 1991-10-23 | Duphar International Research B.V | Verwendung von Beta-Carbolinen und deren bio-isosterischen Benzofuran- und Benzothiophenanalogen zur Herstellung eines Arzneimittels mit cytostatischer Wirkung |
DE3830096A1 (de) * | 1988-09-03 | 1990-03-15 | Hoechst Ag | Piperazindione mit psychotroper wirkung |
FR2649613B1 (fr) * | 1989-07-11 | 1991-09-27 | Virag Ronald | Medicament vaso-actif |
JPH0344324A (ja) * | 1989-07-13 | 1991-02-26 | Kazuoki Tsuchiya | 性機能賦活剤 |
EP0459666B1 (de) * | 1990-05-31 | 1994-11-09 | Pfizer Inc. | Arzneimittel gegen Impotenz |
US5270323A (en) * | 1990-05-31 | 1993-12-14 | Pfizer Inc. | Method of treating impotence |
GB9013750D0 (en) * | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
GB9114760D0 (en) * | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
GB9218322D0 (en) * | 1992-08-28 | 1992-10-14 | Pfizer Ltd | Therapeutic agents |
GB9311920D0 (en) * | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
GB9401090D0 (en) * | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
DE69711882T2 (de) * | 1996-05-10 | 2002-10-31 | Icos Corp | Carbolinderivate |
US5874437A (en) * | 1996-11-01 | 1999-02-23 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
US6043252A (en) * | 1997-05-05 | 2000-03-28 | Icos Corporation | Carboline derivatives |
-
1997
- 1997-05-05 DE DE69711882T patent/DE69711882T2/de not_active Expired - Fee Related
- 1997-05-05 EA EA199800907A patent/EA199800907A1/ru unknown
- 1997-05-05 IL IL12695197A patent/IL126951A0/xx unknown
- 1997-05-05 CA CA002253948A patent/CA2253948C/en not_active Expired - Fee Related
- 1997-05-05 YU YU49898A patent/YU49898A/sh unknown
- 1997-05-05 AT AT97922960T patent/ATE215950T1/de not_active IP Right Cessation
- 1997-05-05 CN CN97194508A patent/CN1067071C/zh not_active Expired - Fee Related
- 1997-05-05 ES ES97922960T patent/ES2175404T3/es not_active Expired - Lifetime
- 1997-05-05 KR KR1019980709066A patent/KR20000010918A/ko not_active Application Discontinuation
- 1997-05-05 WO PCT/EP1997/002277 patent/WO1997043287A1/en not_active Application Discontinuation
- 1997-05-05 SK SK1544-98A patent/SK154498A3/sk unknown
- 1997-05-05 AU AU28910/97A patent/AU711885B2/en not_active Ceased
- 1997-05-05 US US09/155,811 patent/US6117881A/en not_active Expired - Fee Related
- 1997-05-05 TR TR1998/02282T patent/TR199802282T2/xx unknown
- 1997-05-05 PL PL97329875A patent/PL329875A1/xx unknown
- 1997-05-05 EP EP97922960A patent/EP0912567B1/de not_active Expired - Lifetime
- 1997-05-05 CZ CZ983585A patent/CZ358598A3/cs unknown
- 1997-05-05 EE EE9800390A patent/EE9800390A/xx unknown
- 1997-05-05 AP APAP/P/1998/001365A patent/AP9801365A0/en unknown
- 1997-05-05 JP JP54045697A patent/JP3418405B2/ja not_active Expired - Fee Related
- 1997-05-05 BR BR9709230A patent/BR9709230A/pt not_active IP Right Cessation
- 1997-05-05 HU HU9901478A patent/HUP9901478A3/hu unknown
-
1998
- 1998-10-13 IS IS4864A patent/IS4864A/is unknown
- 1998-10-29 BG BG102879A patent/BG102879A/xx unknown
- 1998-11-09 OA OA9800218A patent/OA10920A/en unknown
- 1998-11-09 NO NO985222A patent/NO985222L/no not_active Application Discontinuation
-
2000
- 2000-06-12 US US09/592,514 patent/US6306870B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR20000010918A (ko) | 2000-02-25 |
AU2891097A (en) | 1997-12-05 |
EE9800390A (et) | 1999-06-15 |
CN1067071C (zh) | 2001-06-13 |
TR199802282T2 (xx) | 1999-03-22 |
EA199800907A1 (ru) | 1999-04-29 |
AU711885B2 (en) | 1999-10-21 |
PL329875A1 (en) | 1999-04-12 |
YU49898A (sh) | 2000-03-21 |
EP0912567B1 (de) | 2002-04-10 |
JP3418405B2 (ja) | 2003-06-23 |
IL126951A0 (en) | 1999-09-22 |
ATE215950T1 (de) | 2002-04-15 |
CZ358598A3 (cs) | 1999-03-17 |
HUP9901478A3 (en) | 1999-11-29 |
BR9709230A (pt) | 1999-08-10 |
CN1218471A (zh) | 1999-06-02 |
EP0912567A1 (de) | 1999-05-06 |
US6117881A (en) | 2000-09-12 |
OA10920A (en) | 2003-02-21 |
SK154498A3 (en) | 2000-01-18 |
CA2253948C (en) | 2005-07-26 |
DE69711882D1 (en) | 2002-05-16 |
US6306870B1 (en) | 2001-10-23 |
WO1997043287A1 (en) | 1997-11-20 |
NO985222D0 (no) | 1998-11-09 |
HUP9901478A2 (hu) | 1999-08-30 |
ES2175404T3 (es) | 2002-11-16 |
BG102879A (en) | 1999-09-30 |
NO985222L (no) | 1999-01-11 |
AP9801365A0 (en) | 1998-12-31 |
IS4864A (is) | 1998-10-13 |
JP2000513717A (ja) | 2000-10-17 |
CA2253948A1 (en) | 1997-11-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |