DE69637011D1 - Herstellung enzymatisch aktiver, rekombinanter carboxypeptidase b - Google Patents

Herstellung enzymatisch aktiver, rekombinanter carboxypeptidase b

Info

Publication number
DE69637011D1
DE69637011D1 DE69637011T DE69637011T DE69637011D1 DE 69637011 D1 DE69637011 D1 DE 69637011D1 DE 69637011 T DE69637011 T DE 69637011T DE 69637011 T DE69637011 T DE 69637011T DE 69637011 D1 DE69637011 D1 DE 69637011D1
Authority
DE
Germany
Prior art keywords
procpb
enzymatically active
preparation
active cpb
recombinant carboxypeptidase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69637011T
Other languages
English (en)
Other versions
DE69637011T2 (de
Inventor
Jacob Hartman
Netta Fulga
Simona Mendelovitch
Marian Gorecki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferring International Center SA
Original Assignee
Ferring International Center SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring International Center SA filed Critical Ferring International Center SA
Application granted granted Critical
Publication of DE69637011D1 publication Critical patent/DE69637011D1/de
Publication of DE69637011T2 publication Critical patent/DE69637011T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
DE69637011T 1995-01-25 1996-01-25 Herstellung enzymatisch aktiver, rekombinanter carboxypeptidase b Expired - Lifetime DE69637011T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37823395A 1995-01-25 1995-01-25
US378233 1995-01-25
PCT/US1996/000995 WO1996023064A1 (en) 1995-01-25 1996-01-25 Production of enzymatically active recombinant carboxypeptidase b

Publications (2)

Publication Number Publication Date
DE69637011D1 true DE69637011D1 (de) 2007-05-16
DE69637011T2 DE69637011T2 (de) 2007-12-13

Family

ID=23492292

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69637011T Expired - Lifetime DE69637011T2 (de) 1995-01-25 1996-01-25 Herstellung enzymatisch aktiver, rekombinanter carboxypeptidase b

Country Status (22)

Country Link
US (1) US5948668A (de)
EP (1) EP0871718B1 (de)
JP (1) JP4250716B2 (de)
KR (1) KR100566136B1 (de)
CN (1) CN1144874C (de)
AT (1) ATE358717T1 (de)
AU (1) AU698889B2 (de)
BR (1) BR9606795A (de)
CA (1) CA2210242C (de)
CZ (1) CZ292541B6 (de)
DE (1) DE69637011T2 (de)
DK (1) DK0871718T3 (de)
ES (1) ES2284167T3 (de)
HK (1) HK1014986A1 (de)
HU (1) HU225673B1 (de)
IL (1) IL116696A (de)
MX (1) MX9705279A (de)
NZ (1) NZ302874A (de)
PL (1) PL183228B1 (de)
PT (1) PT871718E (de)
WO (1) WO1996023064A1 (de)
ZA (1) ZA96515B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ315713A (en) 1995-08-16 1999-08-30 Zeneca Ltd A conjugate comprising an antibody as targeting moiety linked to a carboxypeptidase b (cpb)
PT1588716E (pt) 1998-08-06 2011-05-25 Mountain View Pharmaceuticals Conjugados de peg-urato oxidase e sua utiliza??o
US20040117863A1 (en) * 1998-09-18 2004-06-17 Edge Michael D. Transgenically produced fusion proteins
DE19915938A1 (de) * 1999-04-09 2000-10-19 Aventis Pharma Gmbh Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
EP1220864A4 (de) * 1999-09-17 2003-05-21 Genzyme Transgenics Corp Transgen hergestellte fusionsproteine
JP2003512027A (ja) 1999-09-29 2003-04-02 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトカルボキシペプチダーゼおよびそれをコードするポリヌクレオチド
EP1632575B1 (de) * 1999-09-29 2009-01-28 Lexicon Pharmaceuticals, Inc. Humane Carboxypeptidasen und diese kodierende Polynukleotide
WO2001051624A2 (en) * 2000-01-12 2001-07-19 Eli Lilly And Company Carboxypeptidase b free of animal products and contaminating enyzme activity
EP1538203B1 (de) * 2003-12-05 2010-01-20 Roche Diagnostics GmbH Rekombinante Carboxypeptidase B und ihre Aufreinigung
ATE455849T1 (de) * 2003-12-05 2010-02-15 Hoffmann La Roche Rekombinante carboxypeptidase b und ihre aufreinigung
DK1794294T3 (da) * 2004-09-27 2011-10-31 Sanofi Aventis Deutschland Rekombinant carboxypeptidase B
JP2008535500A (ja) 2005-04-11 2008-09-04 サビエント ファーマセウティカルズ インク． 変異型尿酸オキシダーゼおよびその利用
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
US7811800B2 (en) 2005-04-11 2010-10-12 Savient Pharmaceuticals, Inc. Variant form of urate oxidase and use thereof
US20080159976A1 (en) * 2005-04-11 2008-07-03 Jacob Hartman Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
US20090081122A1 (en) * 2005-05-23 2009-03-26 Universite De Geneve Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant
CN101622270B (zh) 2006-04-12 2014-01-01 萨文特医药公司 用阳离子表面活性剂纯化蛋白质的方法
CN101058805B (zh) * 2007-03-21 2011-09-07 北京贯虹科技有限公司 突变羧肽酶原b及突变羧肽酶b的生产方法
US8993714B2 (en) * 2007-10-26 2015-03-31 Imiplex Llc Streptavidin macromolecular adaptor and complexes thereof
US9102526B2 (en) 2008-08-12 2015-08-11 Imiplex Llc Node polypeptides for nanostructure assembly
WO2010132363A1 (en) 2009-05-11 2010-11-18 Imiplex Llc Method of protein nanostructure fabrication
SG176897A1 (en) 2009-06-25 2012-01-30 Savient Pharmaceuticals Inc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
CN101967467B (zh) * 2009-07-28 2012-11-14 上海雅心生物技术有限公司 一种高稳定性的重组羧肽酶b的生产及应用
US11918624B2 (en) * 2020-06-10 2024-03-05 Kelsius Laboratories LLC Therapeutic composition for use in the treatment of COVID-19 and other cytokine storm associated disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK124483B (da) * 1967-12-04 1972-10-23 Bayer Ag Fremgangsmåde til rensning af carboxypeptidase B.
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
HU190129B (en) * 1983-07-11 1986-08-28 Reanal Finomvegyszergyar,Hu Process for the isolation of carboxypeptidase b enzyme from mammal pancreas
US5206161A (en) * 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
FR2692907B1 (fr) * 1992-06-25 1995-06-30 Rhone Poulenc Rorer Sa Levures kluyveromyces modifiees, preparation et utilisation.
JP3472587B2 (ja) * 1992-08-28 2003-12-02 アベンティス ファーマ株式会社 骨関連カルボキシペプチダーゼ様タンパク質およびその製造法
WO1995014096A1 (en) * 1993-11-16 1995-05-26 Eli Lilly And Company Dna sequences encoding porcine pancreatic carboxypeptidase b

Also Published As

Publication number Publication date
HK1014986A1 (en) 1999-10-08
KR100566136B1 (ko) 2006-11-10
DE69637011T2 (de) 2007-12-13
ZA96515B (en) 1996-08-15
ES2284167T3 (es) 2007-11-01
US5948668A (en) 1999-09-07
IL116696A0 (en) 1996-05-14
CA2210242A1 (en) 1996-08-01
CA2210242C (en) 2010-04-27
BR9606795A (pt) 1997-12-30
DK0871718T3 (da) 2007-07-02
CZ292541B6 (cs) 2003-10-15
HUP9800091A3 (en) 2004-03-29
EP0871718A1 (de) 1998-10-21
ATE358717T1 (de) 2007-04-15
WO1996023064A1 (en) 1996-08-01
HUP9800091A2 (hu) 1998-05-28
PT871718E (pt) 2007-06-26
KR19980701652A (ko) 1998-06-25
PL321499A1 (en) 1997-12-08
MX9705279A (es) 1998-06-30
CN1177377A (zh) 1998-03-25
CZ225897A3 (cs) 1998-10-14
NZ302874A (en) 1998-11-25
EP0871718A4 (de) 2000-06-07
JPH11503002A (ja) 1999-03-23
EP0871718B1 (de) 2007-04-04
HU225673B1 (en) 2007-06-28
JP4250716B2 (ja) 2009-04-08
AU698889B2 (en) 1998-11-12
PL183228B1 (pl) 2002-06-28
AU4903496A (en) 1996-08-14
IL116696A (en) 1999-08-17
CN1144874C (zh) 2004-04-07

Similar Documents

Publication Publication Date Title
DE69637011D1 (de) Herstellung enzymatisch aktiver, rekombinanter carboxypeptidase b
DE122007000014I1 (de) Herstellung von menschlichem Papillomavirus Hüllprotein und virus-ähnlichen Teilchen
FI102962B1 (fi) Menetelmä ksylitolin valmistamiseksi
ATE326476T1 (de) Verfahren zur herstellung von phosphorothioat- oligomeren
ATE252157T1 (de) Nucleinsäuremoleküle aus pflanzen codierend enzyme, die an der stärkesynthese beteiligt sind
FI963093A (fi) Bakteriosiini
ATE196458T1 (de) Verfahren zur herstellung von xylitol
DE3789309T2 (de) Enzymatische membran, verfahren zur herstellung und trennung von peptiden.
DE69722195D1 (de) Verfahren zur herstellung von methylmercatopropanal
HUP0001837A2 (hu) Új DNS és eljárás az új DNS által kódolt protein előállítására
EP0733711A3 (de) Methode zur Klonierung und Herstellung einer SacI Restriktionsendonuklease
HUT47976A (en) Process for producing recombinant expression dna vectors encoding isopenicillin-n-synthetase enzyme of aspergillus nidulans, as well as dna molecules
FI962609A0 (fi) Menetelmä ksylitolin valmistamiseksi
ATE202798T1 (de) D-aminosäure-oxidase kodierendes dns-fragment
EP0959131A3 (de) Verfahren zur Klonierung und Vorbereitung der AgeI Restriktions-Endonuklease in E. coli
DE59611293D1 (de) Protein mit dnase-aktivität
SE9503379D0 (sv) A modified GAD, a method for producing a modified GAD, a method for supplying a modified GAD, a peptide and the use of an ordinary and/or a modified GAD
WO1998023762A3 (en) Methods of producing a recombinant protein
WO1997016457A3 (de) Protein mit anti-tumorwirkung
EP0780398A3 (de) Verfahren zur Reinigung von Tamm-Horsfall-Glykoprotein und Uromodulin, die gereinigten Produkte und ein Verfahren für die Unterscheidung beider Stoffe
HUP9903854A2 (hu) Eljárás rekombináns humán interleukin-8 tisztítására
WO1998044103A3 (de) Protein zur inhibierung von apoptose
MX9701267A (es) Receptor de glutamato.
HUP9701119A2 (hu) Eljárás homokirális alkoholok előállítására
TH26735B (th) กระบวนการสำหรับการลดคอนเทนต์ผลพลอยได้ของคาร์เบนเดซิม

Legal Events

Date Code Title Description
8364 No opposition during term of opposition