DE69637011D1 - Herstellung enzymatisch aktiver, rekombinanter carboxypeptidase b - Google Patents

Herstellung enzymatisch aktiver, rekombinanter carboxypeptidase b

Info

Publication number
DE69637011D1
DE69637011D1 DE69637011T DE69637011T DE69637011D1 DE 69637011 D1 DE69637011 D1 DE 69637011D1 DE 69637011 T DE69637011 T DE 69637011T DE 69637011 T DE69637011 T DE 69637011T DE 69637011 D1 DE69637011 D1 DE 69637011D1
Authority
DE
Germany
Prior art keywords
procpb
enzymatically active
preparation
active cpb
recombinant carboxypeptidase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69637011T
Other languages
English (en)
Other versions
DE69637011T2 (de
Inventor
Jacob Hartman
Netta Fulga
Simona Mendelovitch
Marian Gorecki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferring International Center SA
Original Assignee
Ferring International Center SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring International Center SA filed Critical Ferring International Center SA
Publication of DE69637011D1 publication Critical patent/DE69637011D1/de
Application granted granted Critical
Publication of DE69637011T2 publication Critical patent/DE69637011T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
DE69637011T 1995-01-25 1996-01-25 Herstellung enzymatisch aktiver, rekombinanter carboxypeptidase b Expired - Lifetime DE69637011T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37823395A 1995-01-25 1995-01-25
US378233 1995-01-25
PCT/US1996/000995 WO1996023064A1 (en) 1995-01-25 1996-01-25 Production of enzymatically active recombinant carboxypeptidase b

Publications (2)

Publication Number Publication Date
DE69637011D1 true DE69637011D1 (de) 2007-05-16
DE69637011T2 DE69637011T2 (de) 2007-12-13

Family

ID=23492292

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69637011T Expired - Lifetime DE69637011T2 (de) 1995-01-25 1996-01-25 Herstellung enzymatisch aktiver, rekombinanter carboxypeptidase b

Country Status (22)

Country Link
US (1) US5948668A (de)
EP (1) EP0871718B1 (de)
JP (1) JP4250716B2 (de)
KR (1) KR100566136B1 (de)
CN (1) CN1144874C (de)
AT (1) ATE358717T1 (de)
AU (1) AU698889B2 (de)
BR (1) BR9606795A (de)
CA (1) CA2210242C (de)
CZ (1) CZ292541B6 (de)
DE (1) DE69637011T2 (de)
DK (1) DK0871718T3 (de)
ES (1) ES2284167T3 (de)
HK (1) HK1014986A1 (de)
HU (1) HU225673B1 (de)
IL (1) IL116696A (de)
MX (1) MX9705279A (de)
NZ (1) NZ302874A (de)
PL (1) PL183228B1 (de)
PT (1) PT871718E (de)
WO (1) WO1996023064A1 (de)
ZA (1) ZA96515B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9610050A (pt) 1995-08-16 1999-10-13 Zeneca Ltd Conjugado,sitemas de dois componentes combinados destinados a uso em um hospedeiro, compostos ou um sal destes famaceuticamente aceitavel,enzima,sequencia de polinucleotìdeos e de02 nucleotìdeos,vetor, célula hospedeira,processos de producão de uma enzima e de um conjugado e de tratamento de célulasneoplásticas em um hospedeiro,composicão farmaceutica e plasmìdeo
DK2158923T3 (da) 1998-08-06 2013-03-25 Mountain View Pharmaceuticals Peg-uratoxidase-konjugater og anvendelse deraf
US20040117863A1 (en) * 1998-09-18 2004-06-17 Edge Michael D. Transgenically produced fusion proteins
DE19915938A1 (de) 1999-04-09 2000-10-19 Aventis Pharma Gmbh Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
CN1414970A (zh) * 1999-09-17 2003-04-30 Gtc生物治疗学公司 以转基因方式生产的融合蛋白
EP1632575B1 (de) * 1999-09-29 2009-01-28 Lexicon Pharmaceuticals, Inc. Humane Carboxypeptidasen und diese kodierende Polynukleotide
DE60023928T2 (de) * 1999-09-29 2006-07-27 Lexicon Genetics Inc., The Woodlands Humane carboxypeptidasen und diese kodierende polynukleotide
AU2001229253A1 (en) * 2000-01-12 2001-07-24 Eli Lilly And Company Carboxypeptidase b free of animal products and contaminating enyzme activity
EP1538203B1 (de) * 2003-12-05 2010-01-20 Roche Diagnostics GmbH Rekombinante Carboxypeptidase B und ihre Aufreinigung
JP4411192B2 (ja) * 2003-12-05 2010-02-10 エフ．ホフマン−ラ ロシュ アーゲー 組換えで発現されるカルボキシペプチダーゼｂおよびその精製
PL1794294T3 (pl) * 2004-09-27 2011-12-30 Sanofi Aventis Deutschland Rekombinowana karboksypeptydaza b
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
US8188224B2 (en) 2005-04-11 2012-05-29 Savient Pharmaceuticals, Inc. Variant forms of urate oxidase and use thereof
CZ2007700A3 (cs) 2005-04-11 2008-02-27 Savient Pharmaceuticals, Inc. Variantní forma urátoxidázy a její použití
US20080159976A1 (en) * 2005-04-11 2008-07-03 Jacob Hartman Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
JP2008545665A (ja) * 2005-05-23 2008-12-18 ユニベルシテ ドゥ ジュネーブ 高体温による処置のための注入可能な超常磁性ナノ粒子および高体温インプラントを形成するための使用
KR101288027B1 (ko) 2006-04-12 2013-07-22 새비언트 파마수티컬즈 인크. 양이온 계면활성제를 이용한 단백질 정제 방법
CN101058805B (zh) * 2007-03-21 2011-09-07 北京贯虹科技有限公司 突变羧肽酶原b及突变羧肽酶b的生产方法
US8993714B2 (en) * 2007-10-26 2015-03-31 Imiplex Llc Streptavidin macromolecular adaptor and complexes thereof
US9102526B2 (en) 2008-08-12 2015-08-11 Imiplex Llc Node polypeptides for nanostructure assembly
WO2010132363A1 (en) 2009-05-11 2010-11-18 Imiplex Llc Method of protein nanostructure fabrication
CN102803954A (zh) 2009-06-25 2012-11-28 萨文特制药公司 通过监测peg化尿酸酶治疗期间的血清尿酸预测输液反应风险和抗体介导的响应丧失的方法和试剂盒
CN101967467B (zh) * 2009-07-28 2012-11-14 上海雅心生物技术有限公司 一种高稳定性的重组羧肽酶b的生产及应用
US11918624B2 (en) * 2020-06-10 2024-03-05 Kelsius Laboratories LLC Therapeutic composition for use in the treatment of COVID-19 and other cytokine storm associated disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3625829A (en) * 1967-12-04 1971-12-07 Bayer Ag Purification of carboxypeptidase b
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
HU190129B (en) * 1983-07-11 1986-08-28 Reanal Finomvegyszergyar,Hu Process for the isolation of carboxypeptidase b enzyme from mammal pancreas
US5206161A (en) * 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
FR2692907B1 (fr) * 1992-06-25 1995-06-30 Rhone Poulenc Rorer Sa Levures kluyveromyces modifiees, preparation et utilisation.
JP3472587B2 (ja) * 1992-08-28 2003-12-02 アベンティス ファーマ株式会社 骨関連カルボキシペプチダーゼ様タンパク質およびその製造法
CA2175834A1 (en) * 1993-11-16 1995-05-26 Jeffrey Tobin Fayerman Dna sequences encoding porcine pancreatic carboxypeptidase b

Also Published As

Publication number Publication date
CA2210242C (en) 2010-04-27
ES2284167T3 (es) 2007-11-01
HUP9800091A3 (en) 2004-03-29
ZA96515B (en) 1996-08-15
EP0871718A4 (de) 2000-06-07
KR19980701652A (ko) 1998-06-25
CZ292541B6 (cs) 2003-10-15
HUP9800091A2 (hu) 1998-05-28
HU225673B1 (en) 2007-06-28
PT871718E (pt) 2007-06-26
NZ302874A (en) 1998-11-25
KR100566136B1 (ko) 2006-11-10
AU698889B2 (en) 1998-11-12
US5948668A (en) 1999-09-07
DK0871718T3 (da) 2007-07-02
EP0871718A1 (de) 1998-10-21
HK1014986A1 (en) 1999-10-08
CN1144874C (zh) 2004-04-07
EP0871718B1 (de) 2007-04-04
ATE358717T1 (de) 2007-04-15
AU4903496A (en) 1996-08-14
DE69637011T2 (de) 2007-12-13
CA2210242A1 (en) 1996-08-01
CN1177377A (zh) 1998-03-25
CZ225897A3 (cs) 1998-10-14
IL116696A0 (en) 1996-05-14
WO1996023064A1 (en) 1996-08-01
MX9705279A (es) 1998-06-30
JPH11503002A (ja) 1999-03-23
IL116696A (en) 1999-08-17
JP4250716B2 (ja) 2009-04-08
PL321499A1 (en) 1997-12-08
BR9606795A (pt) 1997-12-30
PL183228B1 (pl) 2002-06-28

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