DE69636635D1 - Kontrastmittel für diagnostische bildgebung mit verlängerter verweilzeit im blut - Google Patents

Kontrastmittel für diagnostische bildgebung mit verlängerter verweilzeit im blut

Info

Publication number
DE69636635D1
DE69636635D1 DE69636635T DE69636635T DE69636635D1 DE 69636635 D1 DE69636635 D1 DE 69636635D1 DE 69636635 T DE69636635 T DE 69636635T DE 69636635 T DE69636635 T DE 69636635T DE 69636635 D1 DE69636635 D1 DE 69636635D1
Authority
DE
Germany
Prior art keywords
blood
diagnostic imaging
dwelling time
contrasting agent
extended
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69636635T
Other languages
English (en)
Other versions
DE122006000061I1 (de
DE69636635T2 (de
Inventor
J Mcmurry
Hironao Sajiki
M Scott
B Lauffer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epix Pharmaceuticals Inc
Original Assignee
Epix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epix Pharmaceuticals Inc filed Critical Epix Pharmaceuticals Inc
Publication of DE69636635D1 publication Critical patent/DE69636635D1/de
Application granted granted Critical
Publication of DE69636635T2 publication Critical patent/DE69636635T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/50—Clinical applications
    • A61B6/507—Clinical applications involving determination of haemodynamic parameters, e.g. perfusion CT
DE69636635T 1995-02-01 1996-01-16 Kontrastmittel für diagnostische bildgebung mit verlängerter verweilzeit im blut Expired - Lifetime DE69636635T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38231795A 1995-02-01 1995-02-01
US382317 1995-02-01
PCT/US1996/000164 WO1996023526A2 (en) 1995-02-01 1996-01-16 Diagnostic imaging contrast agents with extended blood retention

Publications (2)

Publication Number Publication Date
DE69636635D1 true DE69636635D1 (de) 2006-11-30
DE69636635T2 DE69636635T2 (de) 2007-10-31

Family

ID=23508434

Family Applications (3)

Application Number Title Priority Date Filing Date
DE1996636635 Pending DE122006000061I1 (de) 1995-02-01 1996-01-16 Kontrastmittel f}r Diagnostische Bildgebung mit Verl{ngerter Verweilzeit im Blut
DE69636635T Expired - Lifetime DE69636635T2 (de) 1995-02-01 1996-01-16 Kontrastmittel für diagnostische bildgebung mit verlängerter verweilzeit im blut
DE200612000061 Active DE122006000061I2 (de) 1995-02-01 2006-11-10 Kontrastmittel fur diagnostische bildgebung mit verlangerter verweilzeit im blut.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE1996636635 Pending DE122006000061I1 (de) 1995-02-01 1996-01-16 Kontrastmittel f}r Diagnostische Bildgebung mit Verl{ngerter Verweilzeit im Blut

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE200612000061 Active DE122006000061I2 (de) 1995-02-01 2006-11-10 Kontrastmittel fur diagnostische bildgebung mit verlangerter verweilzeit im blut.

Country Status (25)

Country Link
US (8) US6676929B2 (de)
EP (2) EP1716871A3 (de)
JP (4) JP4064458B2 (de)
KR (1) KR100403755B1 (de)
CN (3) CN101011586A (de)
AR (1) AR006510A1 (de)
AT (1) ATE342738T1 (de)
AU (1) AU689700B2 (de)
BR (1) BR9607136A (de)
CA (1) CA2211100C (de)
DE (3) DE122006000061I1 (de)
DK (1) DK0806968T3 (de)
ES (1) ES2274523T3 (de)
FI (1) FI973183A (de)
HK (2) HK1002551A1 (de)
IL (1) IL116847A (de)
IS (1) IS2505B (de)
MY (1) MY128089A (de)
NL (1) NL300253I2 (de)
NO (2) NO326114B1 (de)
NZ (1) NZ301181A (de)
PT (1) PT806968E (de)
TW (1) TW319763B (de)
WO (1) WO1996023526A2 (de)
ZA (1) ZA96417B (de)

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