DE69634909D1 - Mit lumineszierenden Lanthanidchelaten markierte, biospezifisch bindende Reaktanden und ihre Verwendung - Google Patents

Mit lumineszierenden Lanthanidchelaten markierte, biospezifisch bindende Reaktanden und ihre Verwendung

Info

Publication number
DE69634909D1
DE69634909D1 DE69634909T DE69634909T DE69634909D1 DE 69634909 D1 DE69634909 D1 DE 69634909D1 DE 69634909 T DE69634909 T DE 69634909T DE 69634909 T DE69634909 T DE 69634909T DE 69634909 D1 DE69634909 D1 DE 69634909D1
Authority
DE
Germany
Prior art keywords
lanthanide chelates
luminescent lanthanide
biospecific binding
binding reactants
labeled biospecific
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69634909T
Other languages
English (en)
Other versions
DE69634909T2 (de
Inventor
Juan Carlos Rodriguez-Ubis
Harri Takalo
Veli-Matti Mukkala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wallac Oy
Original Assignee
Wallac Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallac Oy filed Critical Wallac Oy
Application granted granted Critical
Publication of DE69634909D1 publication Critical patent/DE69634909D1/de
Publication of DE69634909T2 publication Critical patent/DE69634909T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
DE69634909T 1995-10-25 1996-09-09 Mit lumineszierenden Lanthanidchelaten markierte, biospezifisch bindende Reaktanden und ihre Verwendung Expired - Lifetime DE69634909T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/548,174 US5859215A (en) 1995-10-25 1995-10-25 Biospecific binding reactants labelled with luminescent lanthanide chelates and their use
US548174 1995-10-25

Publications (2)

Publication Number Publication Date
DE69634909D1 true DE69634909D1 (de) 2005-08-11
DE69634909T2 DE69634909T2 (de) 2006-05-18

Family

ID=24187726

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69634909T Expired - Lifetime DE69634909T2 (de) 1995-10-25 1996-09-09 Mit lumineszierenden Lanthanidchelaten markierte, biospezifisch bindende Reaktanden und ihre Verwendung

Country Status (3)

Country Link
US (1) US5859215A (de)
EP (1) EP0770610B1 (de)
DE (1) DE69634909T2 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7632651B2 (en) * 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US7745142B2 (en) * 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US20050227294A1 (en) * 1997-09-15 2005-10-13 Molecular Devices Corporation Molecular modification assays involving lipids
US6080839A (en) * 1998-06-25 2000-06-27 Wallac Oy Labeling reactants and their use
US6906173B2 (en) 1998-11-03 2005-06-14 Migenix Corp. Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor
EP1049780A1 (de) * 1998-11-03 2000-11-08 Mitokor Adenine nucleotide translocator (ant) fusionsproteine und deren verwendungen
FI20000333A0 (fi) * 2000-02-16 2000-02-16 Jussi Nurmi Homogeeninen menetelmä polynukleotidin havaitsemiseksi
EP1783221A1 (de) * 2000-05-11 2007-05-09 MIGENIX Corp. Herstellung von Adenin-Nukleotidtranslokator (ANT), ANT-Ligande und Verfahren zu ihrer Identifizierung
GB0022081D0 (en) * 2000-09-08 2000-10-25 Isis Innovation Pyrazolone lanthanide complexes
US7569592B2 (en) * 2001-12-18 2009-08-04 Merck & Co., Inc. Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5
EP1406089A1 (de) * 2002-10-02 2004-04-07 Taiwan Unison Biotechnology Co. Ltd. Eine Methode zur selektiven Färbung wasserlöslicher Proteine unter Verwendung von Reaktivfarbstoffen
SG117423A1 (en) * 2002-10-04 2005-12-29 Taiwan Unison Biotechnology Co Methods for selectively staining water soluble protein using reactive dye and its applications thereof
US7018851B2 (en) * 2003-02-13 2006-03-28 Innotrac Diagnostics Oy Biospecific binding reactants labeled with new luminescent lanthanide chelates and their use
CA2524261C (en) * 2003-05-02 2015-02-17 Access Bio, Inc. Chromatographic assay system
US20110282031A1 (en) * 2003-06-06 2011-11-17 Wilson Constance N A1 adenosine receptor diagnostic probes
FR2857967B1 (fr) 2003-07-25 2015-04-24 Centre Nat Rech Scient Complexes de lanthanide, leur preparation et leurs utilisations
CA2581639C (en) 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
US7482444B2 (en) * 2006-03-13 2009-01-27 Wallac Oy Terminating substrates for DNA polymerases
WO2008020113A1 (en) 2006-08-18 2008-02-21 Abacus Diagnostica Oy Luminescent lanthanide labelling reagents and their use
JP5378988B2 (ja) 2007-04-11 2013-12-25 キッセイ薬品工業株式会社 ５員環へテロ環誘導体及びその医薬用途
US20080269065A1 (en) * 2007-04-30 2008-10-30 Syntrix Biosystems, Inc. Conformationally Constrained Analytical Probes
FI20070508A0 (fi) * 2007-06-27 2007-06-27 Turun Yliopisto Peptidisubstraatti ja sen käyttö
WO2010006605A2 (en) * 2008-07-16 2010-01-21 Radiometer Medical Aps Thrombin substrate and assay for determining the level of bioactive thrombin in a sample
FR2935973A1 (fr) * 2008-09-18 2010-03-19 Centre Nat Rech Scient Complexes de lanthanide et d'un ligand 2,6-bis(n-pyrazolyl) pyridine
FI20090100A0 (fi) 2009-03-16 2009-03-16 Wallac Oy Biotinidaasimääritys
FR2980478B1 (fr) 2011-09-22 2014-01-17 Centre Nat Rech Scient Sondes luminescentes pour le marquage biologique et l'imagerie, et leur procede de preparation.
FR2981349B1 (fr) 2011-10-12 2014-01-10 Centre Nat Rech Scient Sondes luminescentes pour le marquage biologique et l'imagerie, leur procede de preparation
ES2534922B1 (es) * 2013-10-29 2016-02-05 Universidad Autónoma de Madrid Compuestos orgánicos para la sensibilización de la luminiscencia de lantánidos en dispositivos on-off con aplicaciones bioanalíticas
CN105541802A (zh) * 2016-02-05 2016-05-04 聊城大学 一种1,3-二(吡啶-2-基)吡唑的合成方法
KR20190077048A (ko) * 2016-11-14 2019-07-02 지앙수 헨그루이 메디슨 컴퍼니 리미티드 3,4-비피리딜 피라졸 유도체, 그의 제조 방법 및 그의 의학적 적용
FR3092115B1 (fr) 2019-01-30 2021-11-12 Cisbio Bioassays analogues de GTP fluorescents et utilisation
CN115286618A (zh) * 2022-07-25 2022-11-04 常州福洛森医疗科技有限公司 镧系配合物及其制备方法、荧光标记试剂、荧光标记方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162508A (en) * 1987-12-18 1992-11-10 Compagnie Oris Industrie Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers
US5202423A (en) * 1988-07-08 1993-04-13 Wallac Oy Terpyridine derivatives
US5216134A (en) * 1989-10-23 1993-06-01 Wallac Oy Spectrofluorometric method and compounds that are of value for the method
FR2680787B1 (fr) * 1991-08-30 1994-11-04 Cis Bio Int Complexes macrocycliques de terres rares et leur utilisation pour reduire les interferences dans un dosage par fluorescence.
WO1993011433A1 (en) * 1991-12-05 1993-06-10 Wallac Oy Luminescent lanthanide chelates
DE69312951T2 (de) * 1992-10-14 1997-12-11 Nycomed Imaging As Chelatpolymere
US5559214A (en) * 1993-05-28 1996-09-24 Sterling Winthrop Inc. Unsymmetrical complexing agents and targeting immunoreagents useful in thearpeutic and diagnostic compositions and methods
US5457186A (en) * 1993-10-13 1995-10-10 Wallac Oy Luminescent lanthanide chelates with decreased non-radiative energy loss

Also Published As

Publication number Publication date
DE69634909T2 (de) 2006-05-18
US5859215A (en) 1999-01-12
EP0770610A1 (de) 1997-05-02
EP0770610B1 (de) 2005-07-06

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