DE69633679D1 - Substituierte aryl-oder heteroarylamide mit retinoid-ähnlicher biologischer aktivität - Google Patents

Substituierte aryl-oder heteroarylamide mit retinoid-ähnlicher biologischer aktivität

Info

Publication number
DE69633679D1
DE69633679D1 DE69633679T DE69633679T DE69633679D1 DE 69633679 D1 DE69633679 D1 DE 69633679D1 DE 69633679 T DE69633679 T DE 69633679T DE 69633679 T DE69633679 T DE 69633679T DE 69633679 D1 DE69633679 D1 DE 69633679D1
Authority
DE
Germany
Prior art keywords
retinoid
biological activity
heteroarylamid
substituted aryl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69633679T
Other languages
English (en)
Other versions
DE69633679T2 (de
Inventor
Min Teng
Tien T Duong
Roshantha A Chandraratna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of DE69633679D1 publication Critical patent/DE69633679D1/de
Application granted granted Critical
Publication of DE69633679T2 publication Critical patent/DE69633679T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/66—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems and singly-bound oxygen atoms, bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
DE69633679T 1995-11-22 1996-11-19 Substituierte aryl-oder heteroarylamide mit retinoid-ähnlicher biologischer aktivität Expired - Fee Related DE69633679T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US561999 1995-11-22
US08/561,999 US5663357A (en) 1995-11-22 1995-11-22 Substituted heteroarylamides having retinoid-like biological activity
PCT/US1996/018529 WO1997019062A1 (en) 1995-11-22 1996-11-19 Substituted aryl or heteroarylamides having retinoid-like biological activity

Publications (2)

Publication Number Publication Date
DE69633679D1 true DE69633679D1 (de) 2004-11-25
DE69633679T2 DE69633679T2 (de) 2006-02-09

Family

ID=24244378

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69633679T Expired - Fee Related DE69633679T2 (de) 1995-11-22 1996-11-19 Substituierte aryl-oder heteroarylamide mit retinoid-ähnlicher biologischer aktivität

Country Status (16)

Country Link
US (6) US5663357A (de)
EP (1) EP0862555B1 (de)
JP (1) JP4125785B2 (de)
KR (1) KR100483442B1 (de)
CN (1) CN1207727A (de)
AT (1) ATE280160T1 (de)
AU (1) AU715624B2 (de)
BR (1) BR9611615A (de)
CA (1) CA2238310A1 (de)
DE (1) DE69633679T2 (de)
HU (1) HUP9901993A3 (de)
IL (3) IL124593A (de)
MX (2) MX206851B (de)
NZ (1) NZ323574A (de)
PL (1) PL326925A1 (de)
WO (1) WO1997019062A1 (de)

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US20030219832A1 (en) * 1996-03-11 2003-11-27 Klein Elliott S. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
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EP0862555A1 (de) 1998-09-09
KR100483442B1 (ko) 2006-04-21
US6320047B1 (en) 2001-11-20
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US5917048A (en) 1999-06-29
MX230771B (es) 2005-09-21
HUP9901993A2 (hu) 1999-10-28
IL124593A0 (en) 1998-12-06
PL326925A1 (en) 1998-11-09
WO1997019062A1 (en) 1997-05-29
CN1207727A (zh) 1999-02-10
BR9611615A (pt) 1999-05-25
EP0862555B1 (de) 2004-10-20
IL124593A (en) 2002-09-12
US5663357A (en) 1997-09-02
ATE280160T1 (de) 2004-11-15
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US6437129B1 (en) 2002-08-20
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US6245786B1 (en) 2001-06-12
JP4125785B2 (ja) 2008-07-30
US20020091262A1 (en) 2002-07-11
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CA2238310A1 (en) 1997-05-29
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