DE69618231T2 - TETRAHYDROIMIDAZOPYRIDOINDOLDIONE ALS cGMP SPEZIFISCHE PDE HEMMER - Google Patents
TETRAHYDROIMIDAZOPYRIDOINDOLDIONE ALS cGMP SPEZIFISCHE PDE HEMMERInfo
- Publication number
- DE69618231T2 DE69618231T2 DE69618231T DE69618231T DE69618231T2 DE 69618231 T2 DE69618231 T2 DE 69618231T2 DE 69618231 T DE69618231 T DE 69618231T DE 69618231 T DE69618231 T DE 69618231T DE 69618231 T2 DE69618231 T2 DE 69618231T2
- Authority
- DE
- Germany
- Prior art keywords
- tetrahydroimidazopyridoindoldione
- pde inhibitors
- specific pde
- cgmp specific
- cgmp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9514473.9A GB9514473D0 (en) | 1995-07-14 | 1995-07-14 | Chemical compounds |
PCT/EP1996/003023 WO1996032003A2 (en) | 1995-07-14 | 1996-07-11 | Tetrahydroimidazopyridoindolediones and their use as medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69618231D1 DE69618231D1 (de) | 2002-01-31 |
DE69618231T2 true DE69618231T2 (de) | 2002-08-22 |
Family
ID=10777704
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69618231T Expired - Fee Related DE69618231T2 (de) | 1995-07-14 | 1996-07-11 | TETRAHYDROIMIDAZOPYRIDOINDOLDIONE ALS cGMP SPEZIFISCHE PDE HEMMER |
Country Status (13)
Country | Link |
---|---|
US (3) | US6001847A (de) |
EP (1) | EP0859778B1 (de) |
JP (1) | JP4012246B2 (de) |
CN (1) | CN1095841C (de) |
AT (1) | ATE211139T1 (de) |
AU (1) | AU702548B2 (de) |
BR (1) | BR9609503A (de) |
CA (1) | CA2226759A1 (de) |
DE (1) | DE69618231T2 (de) |
ES (1) | ES2170252T3 (de) |
GB (1) | GB9514473D0 (de) |
MX (1) | MX9800415A (de) |
WO (1) | WO1996032003A2 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0998274B1 (de) | 1997-06-23 | 2006-01-18 | Cellegy Pharmaceuticals, Inc | Microdosistherapie von gefässbedingten erscheinungen durch no-donoren |
US6403597B1 (en) | 1997-10-28 | 2002-06-11 | Vivus, Inc. | Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation |
US6548490B1 (en) | 1997-10-28 | 2003-04-15 | Vivus, Inc. | Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
JP2002524564A (ja) * | 1998-09-16 | 2002-08-06 | アイコス コーポレイション | cGMPホスホジエステラーゼ阻害剤としてのカルボリン誘導体 |
US6451807B1 (en) | 1999-04-30 | 2002-09-17 | Lilly Icos, Llc. | Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor |
ES2187234A1 (es) * | 1999-04-30 | 2003-05-16 | Lilly Icos Llc | Forma de dosificacion oral para tratar la disfuncion sexual. |
US20010036959A1 (en) * | 2000-04-03 | 2001-11-01 | Gabel Rolf Dieter | Carvedilol-hydrophilic solutions |
ATE343388T1 (de) | 2000-04-19 | 2006-11-15 | Lilly Icos Llc | Pde-v hemmer zur behandlung von morbus parkinson |
AU2001263278A1 (en) | 2000-06-23 | 2002-01-08 | Lilly Icos Llc | Cyclic gmp-specific phosphodiesterase inhibitors |
DE60112960T2 (de) | 2000-10-02 | 2006-02-09 | Lilly Icos Llc, Wilmington | Kondensierte pyridoindolderivate |
US6858620B2 (en) | 2000-10-03 | 2005-02-22 | Lilly Icos, Llc | Condensed pyridoindole derivatives |
CA2437754C (en) * | 2001-02-15 | 2010-05-18 | Tanabe Seiyaku Co., Ltd. | Tablets quickly disintegrated in oral cavity |
DE10118306A1 (de) | 2001-04-12 | 2002-10-17 | Bayer Ag | Imidazotriazinonhaltige Zusammensetzungen zur nasalen Applikation |
DE60216745T2 (de) | 2001-04-25 | 2007-05-16 | Lilly Icos Llc, Wilmington | Chemische Verbindungen |
US6992192B2 (en) | 2001-06-05 | 2006-01-31 | Lilly Icos Llc. | Carboline derivatives as PDE5 inhibitors |
WO2003053923A2 (en) * | 2001-12-20 | 2003-07-03 | Applied Research Systems Ars Holding N.V. | Pyrrolidine derivatives as prostaglandin modulators |
MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
US7276529B2 (en) * | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
US7208516B2 (en) * | 2002-03-20 | 2007-04-24 | Celgene Corporation | Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
US7893101B2 (en) * | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
ES2211295B1 (es) * | 2002-07-19 | 2005-12-01 | Consejo Sup. De Investig. Cientificas | Tetrahidro-beta-carbolinas fenolicas como antioxidantes. |
WO2004011463A1 (en) * | 2002-07-31 | 2004-02-05 | Lilly Icos, Llc. | Modified pictet-spengler reaction and products prepared therefrom |
US20050048573A1 (en) * | 2003-02-03 | 2005-03-03 | Plexxikon, Inc. | PDE5A crystal structure and uses |
SI1606261T1 (sl) | 2003-03-10 | 2010-03-31 | Nycomed Gmbh | Novi postopek za pripravo roflumilasta |
ES2391974T3 (es) | 2003-06-13 | 2012-12-03 | Ironwood Pharmaceuticals, Inc. | Procedimientos y composiciones para el tratamiento de trastornos gastrointestinales |
DE10348022A1 (de) * | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
CN102408425A (zh) | 2004-03-15 | 2012-04-11 | Ptc医疗公司 | 用于抑制血管生成的咔啉衍生物及其应用 |
US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
CN1960725A (zh) | 2004-03-15 | 2007-05-09 | Ptc医疗公司 | 用于抑制血管发生的四环咔啉衍生物 |
JP2008509971A (ja) | 2004-08-18 | 2008-04-03 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Eg5キネシンのインヒビターとして使用するためのベンゾチエノピリジン |
US8663694B2 (en) * | 2005-03-16 | 2014-03-04 | Takeda Gmbh | Taste masked dosage form containing roflumilast |
US20070155791A1 (en) * | 2005-12-29 | 2007-07-05 | Zeldis Jerome B | Methods for treating cutaneous lupus using aminoisoindoline compounds |
KR101415354B1 (ko) | 2006-02-22 | 2014-07-04 | 4에스체 악티엔게젤샤프트 | Eg5 키네신 조절제로서의 인돌로피리딘 |
WO2007113243A2 (en) * | 2006-03-31 | 2007-10-11 | Investigación Y Clínica Andrológicas S.L. | Use of pde 5 inhibitors for the treatment of overactive bladder |
FR2912405A1 (fr) * | 2007-02-08 | 2008-08-15 | Fourtillan Snc | Derives des imidazo[1',5':1,6]pyrido[3,4-b]indoles et leur utilisation en therapeutique |
CA2697246A1 (en) * | 2007-08-22 | 2009-02-26 | 4Sc Ag | Indolopyridines as inhibitors of the kinesin spindle protein (eg5) |
EP2098524A1 (de) * | 2008-03-05 | 2009-09-09 | 4Sc Ag | Verfahren zur Herstellung enantiomerenreiner Indolopyrinidine |
CN102036663A (zh) * | 2008-03-24 | 2011-04-27 | 细胞基因公司 | 用环丙基-n-{2-[(1s)-1-(3-乙氧基-4-甲氧基苯基)-2-(甲磺酰基)乙基]-3-氧代异吲哚啉-4基}甲酰胺治疗银屑病或者银屑病关节炎 |
CN105764903B (zh) | 2013-11-22 | 2018-09-18 | 法玛克亚公司 | 四环自分泌运动因子抑制剂 |
MY182095A (en) | 2013-11-22 | 2021-01-18 | Sabre Therapeutics Llc | Autotaxin inhibitor compounds |
EP3082428A4 (de) | 2013-12-09 | 2017-08-02 | Respira Therapeutics, Inc. | Pde5-inhibitorpulverformulierungen und zugehörige verfahren |
MX2016014384A (es) | 2014-06-23 | 2017-01-20 | Celgene Corp | Apremilast para el tratamiento de una enfermedad del higado o una anormalidad en la funcion del higado. |
WO2016191427A1 (en) | 2015-05-27 | 2016-12-01 | Pharmakea, Inc. | Autotaxin inhibitors and uses thereof |
WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3644384A (en) * | 1969-06-09 | 1972-02-22 | Sterling Drug Inc | Certain 2-(alpha-haloacetyl) - 1 2 3 4-tetrahydro - 9h - pyrido(3 4-b)indole-3-carboxylates and derivatives |
US3717638A (en) * | 1971-03-11 | 1973-02-20 | Sterling Drug Inc | 1,2,3,4,6,7,12,12A-OCTAHYDRO-2-PHENYLPYRAZINO[2',1':6,1]PYRIDO[3,4-b]INDOLES AND INTERMEDIATES THEREFOR |
US3917599A (en) * | 1973-03-30 | 1975-11-04 | Council Scient Ind Res | 2-Substituted-1,2,3,4,6,7,12,12A-octahydropyrazino(2{40 ,1{40 :6,1)pyrido(3,4-B)indoles |
GB1454171A (en) * | 1973-10-19 | 1976-10-27 | Council Scient Ind Res | Tetracyclic compounds |
US4188390A (en) * | 1977-11-05 | 1980-02-12 | Pfizer Inc. | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines |
GR79603B (de) * | 1982-07-24 | 1984-10-31 | Pfizer | |
US4801587A (en) * | 1987-03-02 | 1989-01-31 | Gene Voss | Impotence ointment |
IT1217190B (it) * | 1988-04-22 | 1990-03-14 | Recordati Chem Pharm | Composti utili per il trattamento e diagnosi di disfunzioni frettili |
EP0357122A3 (de) * | 1988-08-29 | 1991-10-23 | Duphar International Research B.V | Verwendung von Beta-Carbolinen und deren bio-isosterischen Benzofuran- und Benzothiophenanalogen zur Herstellung eines Arzneimittels mit cytostatischer Wirkung |
DE3830096A1 (de) * | 1988-09-03 | 1990-03-15 | Hoechst Ag | Piperazindione mit psychotroper wirkung |
FR2649613B1 (fr) * | 1989-07-11 | 1991-09-27 | Virag Ronald | Medicament vaso-actif |
JPH0344324A (ja) * | 1989-07-13 | 1991-02-26 | Kazuoki Tsuchiya | 性機能賦活剤 |
US5270323A (en) * | 1990-05-31 | 1993-12-14 | Pfizer Inc. | Method of treating impotence |
ATE113839T1 (de) * | 1990-05-31 | 1994-11-15 | Pfizer | Arzneimittel gegen impotenz. |
GB9013750D0 (en) * | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
GB9114760D0 (en) * | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
GB9218322D0 (en) * | 1992-08-28 | 1992-10-14 | Pfizer Ltd | Therapeutic agents |
GB9301192D0 (en) * | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
GB9401090D0 (en) * | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
GB9514465D0 (en) * | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
ATE312609T1 (de) * | 1994-04-22 | 2005-12-15 | Pentech Pharmaceuticals Inc | Sublinguale zusammensetzung enthaltend apomorphine zur diagnose der funktionellen impotenz |
US5874437A (en) * | 1996-11-01 | 1999-02-23 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
-
1995
- 1995-07-14 GB GBGB9514473.9A patent/GB9514473D0/en active Pending
-
1996
- 1996-07-11 MX MX9800415A patent/MX9800415A/es unknown
- 1996-07-11 AT AT96925709T patent/ATE211139T1/de not_active IP Right Cessation
- 1996-07-11 BR BR9609503-2A patent/BR9609503A/pt not_active IP Right Cessation
- 1996-07-11 EP EP96925709A patent/EP0859778B1/de not_active Expired - Lifetime
- 1996-07-11 US US08/981,966 patent/US6001847A/en not_active Expired - Lifetime
- 1996-07-11 DE DE69618231T patent/DE69618231T2/de not_active Expired - Fee Related
- 1996-07-11 ES ES96925709T patent/ES2170252T3/es not_active Expired - Lifetime
- 1996-07-11 CA CA002226759A patent/CA2226759A1/en not_active Abandoned
- 1996-07-11 JP JP53072796A patent/JP4012246B2/ja not_active Expired - Fee Related
- 1996-07-11 CN CN96196779A patent/CN1095841C/zh not_active Expired - Fee Related
- 1996-07-11 AU AU66138/96A patent/AU702548B2/en not_active Ceased
- 1996-07-11 WO PCT/EP1996/003023 patent/WO1996032003A2/en active IP Right Grant
-
1998
- 1998-09-16 US US09/154,619 patent/US6143757A/en not_active Expired - Fee Related
-
1999
- 1999-08-24 US US09/382,240 patent/US6218400B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2170252T3 (es) | 2002-08-01 |
JP4012246B2 (ja) | 2007-11-21 |
JPH11509517A (ja) | 1999-08-24 |
CN1095841C (zh) | 2002-12-11 |
AU6613896A (en) | 1996-10-30 |
GB9514473D0 (en) | 1995-09-13 |
ATE211139T1 (de) | 2002-01-15 |
EP0859778B1 (de) | 2001-12-19 |
CA2226759A1 (en) | 1996-10-17 |
EP0859778A2 (de) | 1998-08-26 |
US6218400B1 (en) | 2001-04-17 |
WO1996032003A3 (en) | 1997-01-03 |
CN1195350A (zh) | 1998-10-07 |
WO1996032003A2 (en) | 1996-10-17 |
US6143757A (en) | 2000-11-07 |
US6001847A (en) | 1999-12-14 |
BR9609503A (pt) | 2000-03-08 |
MX9800415A (es) | 1998-04-30 |
DE69618231D1 (de) | 2002-01-31 |
AU702548B2 (en) | 1999-02-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |