DE69616770T2 - Thrombin inhibitore mit einer hirudin-ähnlichen sequenz - Google Patents

Thrombin inhibitore mit einer hirudin-ähnlichen sequenz

Info

Publication number
DE69616770T2
DE69616770T2 DE69616770T DE69616770T DE69616770T2 DE 69616770 T2 DE69616770 T2 DE 69616770T2 DE 69616770 T DE69616770 T DE 69616770T DE 69616770 T DE69616770 T DE 69616770T DE 69616770 T2 DE69616770 T2 DE 69616770T2
Authority
DE
Germany
Prior art keywords
thrombin
hirudin
hydrophobic portion
bulky hydrophobic
inhibitore
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69616770T
Other languages
English (en)
Other versions
DE69616770D1 (de
Inventor
John Dimaio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NATIONAL RESEARCH COUNCIL OF CANADA, OTTAWA, ONTAR
Original Assignee
National Research Council of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Council of Canada filed Critical National Research Council of Canada
Application granted granted Critical
Publication of DE69616770D1 publication Critical patent/DE69616770D1/de
Publication of DE69616770T2 publication Critical patent/DE69616770T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69616770T 1995-03-20 1996-03-18 Thrombin inhibitore mit einer hirudin-ähnlichen sequenz Expired - Fee Related DE69616770T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/406,142 US6060451A (en) 1990-06-15 1995-03-20 Thrombin inhibitors based on the amino acid sequence of hirudin
PCT/CA1996/000164 WO1996029347A1 (en) 1995-03-20 1996-03-18 Thrombin inhibitors based on the amino acid sequence of hirudin

Publications (2)

Publication Number Publication Date
DE69616770D1 DE69616770D1 (de) 2001-12-13
DE69616770T2 true DE69616770T2 (de) 2002-08-01

Family

ID=23606707

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69616770T Expired - Fee Related DE69616770T2 (de) 1995-03-20 1996-03-18 Thrombin inhibitore mit einer hirudin-ähnlichen sequenz

Country Status (18)

Country Link
US (1) US6060451A (de)
EP (1) EP0815139B1 (de)
JP (1) JPH11502203A (de)
KR (1) KR19980703173A (de)
CN (1) CN1182436A (de)
AT (1) ATE208401T1 (de)
AU (1) AU695920B2 (de)
BR (1) BR9607839A (de)
CA (1) CA2215702A1 (de)
DE (1) DE69616770T2 (de)
EA (1) EA000088B1 (de)
ES (1) ES2168461T3 (de)
HK (1) HK1005511A1 (de)
HU (1) HUP9800727A3 (de)
IL (1) IL117526A (de)
NO (1) NO974342L (de)
WO (1) WO1996029347A1 (de)
ZA (1) ZA962267B (de)

Families Citing this family (223)

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NO974342D0 (no) 1997-09-19
EP0815139B1 (de) 2001-11-07
HK1005511A1 (en) 1999-01-15
EA000088B1 (ru) 1998-06-25
NO974342L (no) 1997-11-19
CN1182436A (zh) 1998-05-20
ZA962267B (en) 1996-09-27
AU4934996A (en) 1996-10-08
ES2168461T3 (es) 2002-06-16
EA199700239A1 (ru) 1998-02-26
KR19980703173A (ko) 1998-10-15
WO1996029347A1 (en) 1996-09-26
CA2215702A1 (en) 1996-09-26
AU695920B2 (en) 1998-08-27
BR9607839A (pt) 1998-06-16
ATE208401T1 (de) 2001-11-15
US6060451A (en) 2000-05-09
HUP9800727A2 (hu) 1998-07-28
HUP9800727A3 (en) 1998-09-28
IL117526A (en) 1999-12-31
IL117526A0 (en) 1996-07-23
JPH11502203A (ja) 1999-02-23
DE69616770D1 (de) 2001-12-13

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