DE69614105T2 - Lagerstabile hämoglobinlösungen - Google Patents
Lagerstabile hämoglobinlösungenInfo
- Publication number
- DE69614105T2 DE69614105T2 DE69614105T DE69614105T DE69614105T2 DE 69614105 T2 DE69614105 T2 DE 69614105T2 DE 69614105 T DE69614105 T DE 69614105T DE 69614105 T DE69614105 T DE 69614105T DE 69614105 T2 DE69614105 T2 DE 69614105T2
- Authority
- DE
- Germany
- Prior art keywords
- hemoglobin solutions
- storage
- solutions
- storage stable
- stable hemoglobin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/433,896 US5929031A (en) | 1995-05-02 | 1995-05-02 | Storage stable hemoglobin solutions |
PCT/US1996/006080 WO1996034889A1 (en) | 1995-05-02 | 1996-05-01 | Storage stable hemoglobin solutions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69614105D1 DE69614105D1 (de) | 2001-08-30 |
DE69614105T2 true DE69614105T2 (de) | 2002-03-21 |
Family
ID=23721974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69614105T Expired - Lifetime DE69614105T2 (de) | 1995-05-02 | 1996-05-01 | Lagerstabile hämoglobinlösungen |
Country Status (7)
Country | Link |
---|---|
US (1) | US5929031A (de) |
EP (1) | EP0826004B1 (de) |
JP (1) | JPH11507016A (de) |
AT (1) | ATE203546T1 (de) |
CA (1) | CA2216382A1 (de) |
DE (1) | DE69614105T2 (de) |
WO (1) | WO1996034889A1 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6242417B1 (en) * | 1994-03-08 | 2001-06-05 | Somatogen, Inc. | Stabilized compositions containing hemoglobin |
US6271351B1 (en) | 1995-03-23 | 2001-08-07 | Biopure Corporation | Method for preserving a hemoglobin blood substitute |
US6288027B1 (en) | 1995-03-23 | 2001-09-11 | Biopure Corporation | Preserving a hemoglobin blood substitute with a transparent overwrap |
US6610832B1 (en) | 1995-03-23 | 2003-08-26 | Biopure Corporation | Preserving a hemoglobin blood substitute with a transparent overwrap |
US5981710A (en) * | 1997-07-21 | 1999-11-09 | Baxter International, Inc. | Therapeutic hemoglobin composition having isotropically increased size |
US6018035A (en) * | 1997-07-21 | 2000-01-25 | Baxter International Inc. | Reagents for isotropic size enhancement of a peptide, protein, nucleotide or other substrate |
US6204254B1 (en) | 1997-09-12 | 2001-03-20 | Baxter International, Inc. | Biocompatible surfaces and a method for their preparation |
ATE305013T1 (de) * | 1999-07-01 | 2005-10-15 | Int Reagents Corp | Mittel zur stabilisierung von hämoglobinen |
JP3466516B2 (ja) * | 1999-09-07 | 2003-11-10 | 科学技術振興事業団 | 安定保存可能な酸素輸液剤 |
US6894150B1 (en) * | 1999-10-01 | 2005-05-17 | Ross Walden Tye | Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin |
US7449339B2 (en) * | 1999-11-23 | 2008-11-11 | Nir Diagnostics Inc. | Spectroscopic method and apparatus for total hemoglobin measurement |
US6949384B2 (en) * | 2001-12-21 | 2005-09-27 | Spectromedical Inc. | Method for monitoring degradation of Hb-based blood substitutes |
FR2809624B1 (fr) * | 2000-05-31 | 2002-08-02 | Centre Nat Rech Scient | Utilisation comme substitut sanguin d'une hemoglobine extracellulaire de poids moleculaire eleve |
US6974447B2 (en) * | 2001-04-17 | 2005-12-13 | Baxter International Inc. | High gas barrier receptacle and closure assembly |
MXPA03009555A (es) * | 2001-04-18 | 2004-12-06 | Northfield Lab | Sistema de recipiente flexible para almacenamiento de soluciones de hemoglobina estabilizadas. |
US7747315B2 (en) * | 2002-01-15 | 2010-06-29 | Board Of Regents, The University Of Texas System | Methods and compositions to reduce scattering of light during therapeutic and diagnostic imaging procedures |
US20050260259A1 (en) * | 2004-04-23 | 2005-11-24 | Bolotin Elijah M | Compositions for treatment with glucagon-like peptide, and methods of making and using the same |
US7138105B2 (en) * | 2002-02-27 | 2006-11-21 | Pharmain | Compositions for delivery of therapeutics and other materials, and methods of making and using the same |
US7635463B2 (en) | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
JP2006502116A (ja) * | 2002-07-12 | 2006-01-19 | メダレックス, インク. | タンパク質の酸化分解を防ぐ方法及び組成物 |
US7223604B1 (en) * | 2002-09-27 | 2007-05-29 | Science & Technology Corporation @ Unm | Methods and kits for the detection of erythrocytes |
EP1592437A4 (de) * | 2003-01-29 | 2007-12-26 | Northfield Lab | Polymerisierte hämoglobin-lösungen mit verringerter tetramer-menge und herstellungsverfahren |
JP2006164312A (ja) * | 2004-12-02 | 2006-06-22 | Hitachi Ltd | 半導体装置およびそれを用いた磁気記録再生装置 |
WO2006096774A2 (en) | 2005-03-07 | 2006-09-14 | Sangart, Inc. | Composition and methods for delivering carbon monoxide (co) and nitric ozide (no) co to tissue using heme proteins as carriers |
US20090004159A1 (en) * | 2006-01-24 | 2009-01-01 | The Board Of Trustees Of The University Of Illinoi | Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells |
JP2009524436A (ja) * | 2006-01-24 | 2009-07-02 | ノースフィールド ラボラトリーズ、インコーポレイテッド | 重合したヘモグロビンの培地、並びに島細胞の単離及び移植におけるその使用 |
US7494974B2 (en) * | 2006-10-24 | 2009-02-24 | Ikor, Inc. | Carboxymethylated cross-linked tetrameric hemoglobin |
US7504377B2 (en) * | 2006-10-23 | 2009-03-17 | Ikor, Inc. | Nitric oxide-blocked cross-linked tetrameric hemoglobin |
JP2008195656A (ja) * | 2007-02-14 | 2008-08-28 | Nipro Corp | 人工酸素運搬体製剤 |
US8609815B2 (en) | 2010-09-02 | 2013-12-17 | Sangart, Inc. | Methods for preparing stable deoxygenated PEG-hemoglobin conjugate solutions comprising an antioxidant |
US9199026B2 (en) * | 2011-01-07 | 2015-12-01 | Somerset Group Enterprises, Inc. | Modular extracorporeal systems and methods for treating blood-borne diseases |
WO2013106443A1 (en) | 2012-01-09 | 2013-07-18 | Somerset Group Enterprises, Inc. | Modular extracorporeal systems and methods for treating blood-borne diseases |
US9763889B2 (en) * | 2015-06-29 | 2017-09-19 | Billion King International Ltd. | Oral delivery system for hemoglobin based oxygen carriers |
US10052290B2 (en) * | 2016-02-04 | 2018-08-21 | Billion King International Ltd. | Enteric-coated hemoglobin multiparticulate for oral delivery of hemoglobin based oxygen carriers |
WO2021204948A1 (en) * | 2020-04-09 | 2021-10-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions to determine the quality of red blood cell units |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3144705C2 (de) * | 1981-11-11 | 1983-12-08 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat |
US4727027A (en) * | 1983-05-02 | 1988-02-23 | Diamond Scientific Co. | Photochemical decontamination treatment of whole blood or blood components |
US4861867A (en) * | 1988-02-03 | 1989-08-29 | Baxter International, Inc. | Purified hemoglobin solutions and method for making same |
US5234903A (en) * | 1989-11-22 | 1993-08-10 | Enzon, Inc. | Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute |
WO1992002239A1 (en) * | 1990-08-06 | 1992-02-20 | Baxter International Inc. | Stable hemoglobin based composition and method to store same |
US5352773A (en) * | 1990-08-06 | 1994-10-04 | Baxter International Inc. | Stable hemoglobin based composition and method to store same |
AU9067791A (en) * | 1990-11-20 | 1992-06-11 | Enzon, Inc. | Method of enhancing long-term storage stability of hemoglobin products |
SE9301581D0 (sv) * | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Protein formulation |
-
1995
- 1995-05-02 US US08/433,896 patent/US5929031A/en not_active Expired - Lifetime
-
1996
- 1996-05-01 JP JP8533458A patent/JPH11507016A/ja active Pending
- 1996-05-01 WO PCT/US1996/006080 patent/WO1996034889A1/en active IP Right Grant
- 1996-05-01 AT AT96920119T patent/ATE203546T1/de not_active IP Right Cessation
- 1996-05-01 CA CA002216382A patent/CA2216382A1/en not_active Abandoned
- 1996-05-01 DE DE69614105T patent/DE69614105T2/de not_active Expired - Lifetime
- 1996-05-01 EP EP96920119A patent/EP0826004B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU708264B2 (en) | 1999-07-29 |
EP0826004B1 (de) | 2001-07-25 |
US5929031A (en) | 1999-07-27 |
EP0826004A1 (de) | 1998-03-04 |
AU5852096A (en) | 1996-11-21 |
ATE203546T1 (de) | 2001-08-15 |
CA2216382A1 (en) | 1996-11-07 |
JPH11507016A (ja) | 1999-06-22 |
DE69614105D1 (de) | 2001-08-30 |
WO1996034889A1 (en) | 1996-11-07 |
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