DE69536137D1 - Lichtwellenleiter-Verfahren zur Detektion spezifischer Bindungsreaktionen nach der Streulichtmethode - Google Patents

Lichtwellenleiter-Verfahren zur Detektion spezifischer Bindungsreaktionen nach der Streulichtmethode

Info

Publication number
DE69536137D1
DE69536137D1 DE69536137T DE69536137T DE69536137D1 DE 69536137 D1 DE69536137 D1 DE 69536137D1 DE 69536137 T DE69536137 T DE 69536137T DE 69536137 T DE69536137 T DE 69536137T DE 69536137 D1 DE69536137 D1 DE 69536137D1
Authority
DE
Germany
Prior art keywords
waveguide
scattering
binding
detection
optical waveguide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69536137T
Other languages
English (en)
Inventor
Donald I Stimpson
Julian Gordon
Joanell V Hoijer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of DE69536137D1 publication Critical patent/DE69536137D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
DE69536137T 1994-09-22 1995-09-20 Lichtwellenleiter-Verfahren zur Detektion spezifischer Bindungsreaktionen nach der Streulichtmethode Expired - Lifetime DE69536137D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/311,462 US5599668A (en) 1994-09-22 1994-09-22 Light scattering optical waveguide method for detecting specific binding events

Publications (1)

Publication Number Publication Date
DE69536137D1 true DE69536137D1 (de) 2011-03-24

Family

ID=23206973

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69532855T Expired - Lifetime DE69532855T2 (de) 1994-09-22 1995-09-20 Lichtwellenleiter-verfahren zur detektion spezifischer bindungsreaktionen nach der streulichtmethode
DE69536137T Expired - Lifetime DE69536137D1 (de) 1994-09-22 1995-09-20 Lichtwellenleiter-Verfahren zur Detektion spezifischer Bindungsreaktionen nach der Streulichtmethode

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69532855T Expired - Lifetime DE69532855T2 (de) 1994-09-22 1995-09-20 Lichtwellenleiter-verfahren zur detektion spezifischer bindungsreaktionen nach der streulichtmethode

Country Status (9)

Country Link
US (2) US5599668A (de)
EP (2) EP1441217B1 (de)
JP (1) JP3608665B2 (de)
AT (2) ATE498123T1 (de)
AU (1) AU3636295A (de)
CA (1) CA2197321C (de)
DE (2) DE69532855T2 (de)
ES (2) ES2358508T3 (de)
WO (1) WO1996009532A1 (de)

Families Citing this family (271)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120643A (en) * 1987-07-13 1992-06-09 Abbott Laboratories Process for immunochromatography with colloidal particles
US6955915B2 (en) * 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US6315953B1 (en) * 1993-11-01 2001-11-13 Nanogen, Inc. Devices for molecular biological analysis and diagnostics including waveguides
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
GB9326450D0 (en) * 1993-12-24 1994-02-23 Multilyte Ltd Binding assay
EP0695941B1 (de) * 1994-06-08 2002-07-31 Affymetrix, Inc. Verfahren und Vorrichtung zum Verpacken von Chips
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
EP0795032A2 (de) * 1994-12-22 1997-09-17 Abbott Laboratories Verfahren zur immobilisierung von oligonukleotiden auf festen trägermaterial und verfahren zur anwendung träger gebundener oligonukleotiden
US5633724A (en) * 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
ATE229081T1 (de) * 1996-01-26 2002-12-15 Abbott Lab Verfahren zur analyse von nukleinsäure- wiederholungssequenzen
WO1997032212A1 (en) * 1996-03-01 1997-09-04 Beckman Instruments, Inc. System for simultaneously conducting multiple ligand binding assays
US6586193B2 (en) 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
JP2000510582A (ja) 1996-04-25 2000-08-15 ゼニコン・サイエンシーズ・コーポレーション 微粒子標識を使用した分析物アッセイ
DE19628002C1 (de) * 1996-07-11 1997-12-18 Inst Chemo Biosensorik Vorrichtung und Verfahren zur Durchführung von Fluoreszenzimmunotests
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20020172953A1 (en) * 1996-07-29 2002-11-21 Mirkin Chad A. Movement of biomolecule-coated nanoparticles in an electric field
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) * 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
AU4043497A (en) 1996-07-29 1998-02-20 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
AUPO229596A0 (en) * 1996-09-12 1996-10-03 Varian Australia Pty Ltd Method for analysis of DNA
US6180415B1 (en) * 1997-02-20 2001-01-30 The Regents Of The University Of California Plasmon resonant particles, methods and apparatus
US6852252B2 (en) 1997-03-12 2005-02-08 William Marsh Rice University Use of metalnanoshells to impede the photo-oxidation of conjugated polymer
US6344272B1 (en) * 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
EP0985142A4 (de) * 1997-05-23 2006-09-13 Lynx Therapeutics Inc System und gerät zur sequentiellen behandlung von analyten
JP3120453B2 (ja) * 1997-06-19 2000-12-25 トヨタ自動車株式会社 微小液滴の保持方法、反応方法
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
DE19730359A1 (de) * 1997-07-15 1999-01-21 Boehringer Mannheim Gmbh Integriertes Verfahren und System zur Amplifizierung und zum Nachweis von Nukleinsäuren
US6974669B2 (en) * 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US6294327B1 (en) * 1997-09-08 2001-09-25 Affymetrix, Inc. Apparatus and method for detecting samples labeled with material having strong light scattering properties, using reflection mode light and diffuse scattering
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
FR2773218B1 (fr) * 1997-12-31 2000-03-10 Stago International Dispositif, procede et appareil de mise en oeuvre du procede, pour effectuer un dosage d'au moins un composant particulier dans un echantillon de produit
GB9800378D0 (en) * 1998-01-08 1998-03-04 Univ Liverpool Proteome analysis
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
US6485905B2 (en) * 1998-02-02 2002-11-26 Signature Bioscience, Inc. Bio-assay device
DE69918389T2 (de) * 1998-02-02 2005-10-06 Mds Sciex, Concord Verfahren und Vorrichtung zur Erkennung von Molekülbindungsreaktionen
US6395480B1 (en) 1999-02-01 2002-05-28 Signature Bioscience, Inc. Computer program and database structure for detecting molecular binding events
US6338968B1 (en) * 1998-02-02 2002-01-15 Signature Bioscience, Inc. Method and apparatus for detecting molecular binding events
US6428811B1 (en) 1998-03-11 2002-08-06 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
US6699724B1 (en) * 1998-03-11 2004-03-02 Wm. Marsh Rice University Metal nanoshells for biosensing applications
US20030153023A1 (en) * 1999-05-13 2003-08-14 Starzl Timothy W. Enumeration method of analyte detection
US6346376B1 (en) * 1998-06-03 2002-02-12 Centre Suisse D'electronique Et De Mictotechnique Sa Optical sensor unit and procedure for the ultrasensitive detection of chemical or biochemical analytes
EP2360271A1 (de) 1998-06-24 2011-08-24 Illumina, Inc. Dekodierung von Arraysensoren mit Mikrosphären
US6171794B1 (en) 1998-07-13 2001-01-09 Rosetta Inpharmatics, Inc. Methods for determining cross-hybridization
US7640083B2 (en) * 2002-11-22 2009-12-29 Monroe David A Record and playback system for aircraft
AU6151699A (en) 1998-09-21 2000-04-10 Ramot University Authority For Applied Research And Industrial Development Ltd. Method, chip, device and system for effecting and monitoring nucleic acid accumulation
US6187540B1 (en) 1998-11-09 2001-02-13 Identigene, Inc. Method of newborn identification and tracking
EP2000803A1 (de) 1998-11-30 2008-12-10 Nanosphere, Inc. Nanoteilchen mit Polymerschalen
US6221579B1 (en) * 1998-12-11 2001-04-24 Kimberly-Clark Worldwide, Inc. Patterned binding of functionalized microspheres for optical diffraction-based biosensors
JP2002532728A (ja) * 1998-12-17 2002-10-02 ライカ ミクロジュステムス ハイデルベルク ゲーエムベーハー 有利には生体試料における種々の構造体を識別検査するための方法
US6579673B2 (en) * 1998-12-17 2003-06-17 Kimberly-Clark Worldwide, Inc. Patterned deposition of antibody binding protein for optical diffraction-based biosensors
AU772719B2 (en) * 1999-01-08 2004-05-06 Applera Corporation Fiber array for contacting chemical species and methods for using and making same
US7595189B2 (en) * 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
US20050026209A1 (en) * 1999-01-08 2005-02-03 Vann Charles S. Optical fiber bundle for detecting binding of chemical species
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
WO2000073764A2 (en) 1999-06-01 2000-12-07 Baylor College Of Medicine Composition and methods for the therapeutic use of an atonal-associated sequence
EP1204856B2 (de) * 1999-08-20 2011-11-16 Stiftung für Diagnostische Forschung Verfahren zur bestimmung von substanzen mittels der evaneszenzfeldmethode
DE19943704C1 (de) * 1999-09-08 2001-05-10 Inst Physikalische Hochtech Ev Affinitätssensor zum Nachweis biologischer und/oder chemischer Spezies und dessen Verwendung
DE19947616C2 (de) * 1999-10-01 2003-05-28 Fraunhofer Ges Forschung Verfahren zur Bestimmung von Substanzen, wie z.B. DNA-Sequenzen, in einer Probe und Vorrichtung zur Durchführung des Verfahrens
AU774593C (en) 2000-01-13 2005-06-23 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
DE10002566A1 (de) * 2000-01-21 2001-08-02 Fraunhofer Ges Forschung Verfahren und Einrichtung zur Bestimmung des Schmelzpunktes und/oder der Bindungskonstante von Substanzen, wie z. B. DNA-Sequenzen, in einer Probe
US6235483B1 (en) 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
DE60143347D1 (de) * 2000-03-22 2010-12-09 Axela Inc Verfahren und vorrichtung zur bestimmung mehrerer analyten
JP4606543B2 (ja) * 2000-04-13 2011-01-05 パナソニック株式会社 光学特性計測装置における被検溶液量確認方法および計測系制御方法
AU2001275475A1 (en) * 2000-06-12 2001-12-24 Genicon Sciences Corporation Assay for genetic polymorphisms using scattered light detectable labels
AU2006235770B2 (en) * 2000-07-01 2009-12-24 Clondiag Chip Technologies Gmbh Method for the qualitative and/or quantitative detection of molecular interactions on probe arrays
AU7637601A (en) * 2000-07-01 2002-01-14 Clondiag Chip Tech Gmbh Method for qualitative and/or quantitative detecting of molecular interactions on probe arrays
AU7687001A (en) 2000-07-11 2002-01-21 Nanospherre Inc Method of detection by enhancement of silver staining
DE10036457A1 (de) * 2000-07-26 2002-02-14 Giesing Michael Verwendung eines bildgebenden photoelektrischen Flächensensors zur Auswertung von Biochips und Bildgebungsverfahren hierfür
DE10062244A1 (de) * 2000-12-14 2002-07-04 Infineon Technologies Ag Sensor zur Detektion von makromolekularen Biopolymeren, Sensoranordnung, Verfahren zur Detektion von makromolekularen Biopolymeren und Verfahren zum Herstellen eines Sensors zur Detektion von makromolekularen Biopolymeren
WO2002066965A2 (en) * 2001-02-19 2002-08-29 Scientific Generics Limited Assay apparatus, assay method and probe array for use in same
CA2439307A1 (en) 2001-02-23 2002-09-06 Genicon Sciences Corporation Methods for providing extended dynamic range in analyte assays
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US20040126767A1 (en) * 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US20040121350A1 (en) * 2002-12-24 2004-06-24 Biosite Incorporated System and method for identifying a panel of indicators
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
AU2002245988A1 (en) * 2001-04-18 2002-10-28 Ulrich J. Krull Gradient resolved hybridisation platform
US20030113740A1 (en) * 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
AU2002239726A1 (en) 2001-05-25 2002-12-09 Northwestern University Non-alloying core shell nanoparticles
WO2003012408A1 (en) * 2001-07-30 2003-02-13 Nippon Sheet Glass Co., Ltd. Optical condensation sensor and controller employing the same
US20040146917A1 (en) * 2001-08-03 2004-07-29 Nanosphere, Inc. Nanoparticle imaging system and method
WO2003053535A2 (en) * 2001-08-03 2003-07-03 Nanosphere, Inc. Nanoparticle imaging system and method
US20060073530A1 (en) * 2001-08-15 2006-04-06 Olaf Schneewind Methods and compositions involving sortase B
CA2459570A1 (en) * 2001-09-05 2003-03-13 Genicon Sciences Corporation Apparatus for reading signals generated from resonance light scattered particle labels
US20030049866A1 (en) * 2001-09-05 2003-03-13 Genicon Sciences Corporation Sample device preservation
FR2829580B1 (fr) * 2001-09-07 2004-02-13 Bio Merieux Procede de lecture, de detection ou de quantification, hybrides ou complexes utilises dans ce procede et biopuce mettant en oeuvre ledit procede
WO2003023400A2 (en) * 2001-09-13 2003-03-20 Axela Biosensors Inc. Method and apparatus for assay based on light diffraction
EP1432829A4 (de) * 2001-10-04 2005-01-19 Univ California Nachweis einer polynukleotidhybridisierung
GB0124338D0 (en) * 2001-10-10 2001-11-28 Randox Lab Ltd Biochips
US6867005B2 (en) 2001-10-24 2005-03-15 Beckman Coulter, Inc. Method and apparatus for increasing the dynamic range and accuracy of binding assays
JP4220397B2 (ja) * 2001-11-09 2009-02-04 ナノスフェアー インコーポレイテッド バイオコンジュゲート‐ナノ粒子プローブ
US7102752B2 (en) * 2001-12-11 2006-09-05 Kimberly-Clark Worldwide, Inc. Systems to view and analyze the results from diffraction-based diagnostics
US7098041B2 (en) * 2001-12-11 2006-08-29 Kimberly-Clark Worldwide, Inc. Methods to view and analyze the results from diffraction-based diagnostics
US20030119203A1 (en) * 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US8367013B2 (en) * 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
WO2003062791A2 (en) * 2002-01-18 2003-07-31 University Of Utah Research Foundation Detection of single nucleotide polymorphisms using planar waveguides
EP3415625A1 (de) 2002-02-01 2018-12-19 Life Technologies Corporation Doppelsträngige oligonukleotide
WO2003064621A2 (en) 2002-02-01 2003-08-07 Ambion, Inc. HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US7083975B2 (en) * 2002-02-01 2006-08-01 Roland Green Microarray synthesis instrument and method
US7018842B2 (en) * 2002-02-28 2006-03-28 Agilent Technologies, Inc. Reading dry chemical arrays through the substrate
JP3960084B2 (ja) * 2002-03-06 2007-08-15 セイコーエプソン株式会社 ヘッド駆動装置及び方法、液滴吐出装置、ヘッド駆動プログラム、並びにデバイス製造方法及びデバイス
US7094537B2 (en) * 2002-04-30 2006-08-22 Agilent Technologies, Inc. Micro arrays with structured and unstructured probes
US7223534B2 (en) * 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7771922B2 (en) * 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US7485453B2 (en) * 2002-05-03 2009-02-03 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7118855B2 (en) * 2002-05-03 2006-10-10 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7223368B2 (en) * 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7214530B2 (en) * 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
US20030211488A1 (en) * 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
US7666819B2 (en) * 2002-05-29 2010-02-23 Autogenomics, Inc. Integrated micro array system and methods therefor
US20030224370A1 (en) * 2002-05-31 2003-12-04 William Rassman Method and apparatus for recognizing molecular compounds
US6790632B2 (en) * 2002-06-17 2004-09-14 Stephen Eliot Zweig Membrane receptor reagent and assay
US7091049B2 (en) * 2002-06-26 2006-08-15 Kimberly-Clark Worldwide, Inc. Enhanced diffraction-based biosensor devices
CA2490413C (en) * 2002-07-02 2011-08-30 Nanosphere, Inc. Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes
EP2269618A1 (de) 2002-08-12 2011-01-05 Jennerex Biotherapeutics ULC Ein onkolytisches Vaccinia-Virus zur Verwendung in Kombination mit Chemotherapie zur Behandlung von Krebs
US7432105B2 (en) * 2002-08-27 2008-10-07 Kimberly-Clark Worldwide, Inc. Self-calibration system for a magnetic binding assay
US7285424B2 (en) * 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7314763B2 (en) * 2002-08-27 2008-01-01 Kimberly-Clark Worldwide, Inc. Fluidics-based assay devices
DE10241093A1 (de) * 2002-09-02 2004-03-18 Siemens Ag Mikroreaktor
AU2003258683A1 (en) * 2002-09-03 2004-03-29 Zeptosens Ag Analytical platform and detection method with analytes which are to be detected in a sample in the form of immobilized specific binding partners
US7169550B2 (en) * 2002-09-26 2007-01-30 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
AU2002334118B2 (en) * 2002-10-07 2007-05-17 The Secretary Of State For Defence A waveguide structure
US20040106190A1 (en) * 2002-12-03 2004-06-03 Kimberly-Clark Worldwide, Inc. Flow-through assay devices
AU2003302253B2 (en) * 2002-12-12 2007-06-28 Nanosphere, Inc. Direct SNP detection with unamplified DNA
CN100386620C (zh) * 2002-12-16 2008-05-07 吴世法 激励和接收均用隐失光的拉曼散射近场增强方法
US7247500B2 (en) * 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US20040121334A1 (en) * 2002-12-19 2004-06-24 Kimberly-Clark Worldwide, Inc. Self-calibrated flow-through assay devices
CA2511501A1 (en) * 2002-12-24 2004-07-15 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
AU2003300433A1 (en) * 2003-01-08 2004-08-10 Maven Technologies, Llc Strong-absorber-mediated array ellipsometer
US7981694B2 (en) * 2003-01-28 2011-07-19 The Regents Of The University Of California Solid phase isolation of proteins, nucleic acids and other macromolecules
US20040157220A1 (en) 2003-02-10 2004-08-12 Purnima Kurnool Methods and apparatus for sample tracking
US20050130174A1 (en) * 2003-02-27 2005-06-16 Nanosphere, Inc. Label-free gene expression profiling with universal nanoparticle probes in microarray assay format
US7851209B2 (en) * 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US20040197819A1 (en) * 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US7910064B2 (en) * 2003-06-03 2011-03-22 Nanosys, Inc. Nanowire-based sensor configurations
AU2004273783A1 (en) 2003-07-12 2005-03-31 Accelr8 Technology Corporation Sensitive and rapid biodetection
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
EP2031390B1 (de) * 2003-08-20 2014-07-16 Seikagaku Corporation Stabilisator und Blocker
US7943395B2 (en) * 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US7713748B2 (en) * 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US20050112703A1 (en) * 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7943089B2 (en) * 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US20050136550A1 (en) * 2003-12-19 2005-06-23 Kimberly-Clark Worldwide, Inc. Flow control of electrochemical-based assay devices
US20050141843A1 (en) * 2003-12-31 2005-06-30 Invitrogen Corporation Waveguide comprising scattered light detectable particles
KR101170853B1 (ko) 2004-01-20 2012-08-03 제너럴 일렉트릭 캄파니 화학적 또는 생물학적 물질의 분석 대상물 농도 측정시스템 및 방법
US7283245B2 (en) * 2004-01-20 2007-10-16 General Electric Company Handheld device with a disposable element for chemical analysis of multiple analytes
US20050244953A1 (en) * 2004-04-30 2005-11-03 Kimberly-Clark Worldwide, Inc. Techniques for controlling the optical properties of assay devices
US7815854B2 (en) 2004-04-30 2010-10-19 Kimberly-Clark Worldwide, Inc. Electroluminescent illumination source for optical detection systems
US7796266B2 (en) * 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US20060019265A1 (en) * 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US7521226B2 (en) * 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
US20060057613A1 (en) * 2004-07-26 2006-03-16 Nanosphere, Inc. Method for distinguishing methicillin resistant S. aureus from methicillin sensitive S. aureus in a mixed culture
US7678824B2 (en) 2004-09-14 2010-03-16 The Regents Of The University Of Colorado, A Body Corporate Methods for treatment with bucindolol based on genetic targeting
US7429923B2 (en) * 2004-10-22 2008-09-30 Honeywell International Inc. Neuronal sensor networks
US20060088844A1 (en) * 2004-10-22 2006-04-27 Honeywell International Inc. Real-time PCR microarray based on evanescent wave biosensor
US20070121113A1 (en) * 2004-12-22 2007-05-31 Cohen David S Transmission-based optical detection systems
WO2007002567A2 (en) * 2005-06-23 2007-01-04 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
US8597576B2 (en) * 2005-06-23 2013-12-03 National Institute Of Advanced Industrial Science And Technology Analyzer for glycan or complex carbohydrate
ATE489482T1 (de) * 2005-08-19 2010-12-15 Nanosphere Inc Verfahren zur herstellung von hybridsubstraten mit dna und antikörpern sowie verwendungen davon
JP2007064943A (ja) * 2005-09-02 2007-03-15 Fujifilm Corp 全反射減衰を利用した測定方法及び装置
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
KR20090004839A (ko) 2005-09-07 2009-01-12 제네렉스, 인코포레이티드 Ｇｍ-ｃｓｆ를 발현하는 폭스바이러스를 사용한 전이성및/또는 전신 파종성 암의 전신 치료법
US7951583B2 (en) 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US8288157B2 (en) 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US20070235397A1 (en) * 2006-03-30 2007-10-11 Wannop George M Storage bin and frame system
JP2009540299A (ja) * 2006-06-05 2009-11-19 カリフォルニア インスティテュート オブ テクノロジー リアルタイムマイクロアレイ
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
US8637436B2 (en) 2006-08-24 2014-01-28 California Institute Of Technology Integrated semiconductor bioarray
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US8529837B2 (en) * 2006-08-07 2013-09-10 Biomag Corp. System and method for detecting specific binding reactions using magnetic labels
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
WO2008082713A2 (en) * 2006-08-24 2008-07-10 California Institute Of Technology Integrated semiconductor bioarray
EP2064229B1 (de) 2006-09-15 2015-08-12 Ottawa Hospital Research Institute Onkolytisches rhabdovirus
US20100285490A1 (en) * 2006-12-29 2010-11-11 Invitrogen Corporation Detection apparatus
CN101589303B (zh) * 2007-01-17 2012-01-11 霍尼韦尔国际公司 基于倏逝波检测的微阵列读取器和读取微阵列的方法
US20080200342A1 (en) 2007-02-15 2008-08-21 Rao Rupa S Device, Array, And Methods For Disease Detection And Analysis
US7796843B2 (en) * 2007-03-21 2010-09-14 University Of Houston Design and performance of a Fiber Bragg grating displacement sensor for measurement of movement
WO2009005552A2 (en) * 2007-03-29 2009-01-08 Epitype Corporation Methods and compositions for multivalent binding and methods for manufacture of rapid diagnostic tests
JP5283364B2 (ja) * 2007-10-22 2013-09-04 富士フイルム株式会社 センシング装置
JP4970217B2 (ja) * 2007-11-07 2012-07-04 株式会社東芝 物質の測定方法
JP5424610B2 (ja) * 2007-11-07 2014-02-26 株式会社東芝 光導波路型センサチップ、光導波路型センサチップの製造方法、物質の測定方法、物質測定用キットおよび光導波路型センサ
US20090124024A1 (en) 2007-11-07 2009-05-14 Shingo Kasai Optical-waveguide sensor chip, method of manufacturing the same, method of measuring substance, substance-measuring kit and optical-waveguide sensor
DE102007055386B4 (de) * 2007-11-20 2015-07-16 Boehringer Ingelheim Vetmedica Gmbh Verfahren zur Kalibrierung eines Sensorelements
WO2009103339A1 (en) * 2008-02-21 2009-08-27 Valtion Teknillinen Tutkimuskeskus Biosensor and a related manufacturing method
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
GB2461026B (en) 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
WO2013154750A1 (en) 2012-04-10 2013-10-17 The Trustees Of Columbia Unversity In The City Of New York Systems and methods for biological ion channel interfaces
US8300993B2 (en) * 2009-03-02 2012-10-30 Mbio Diagnostics, Inc. Waveguide with integrated lens
US8331751B2 (en) * 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
GB0904934D0 (en) 2009-03-23 2009-05-06 Geneseqe As Method and apparatus for detecting molecules
EP2425286B1 (de) 2009-04-29 2020-06-24 Ldip, Llc Auf wellenleitern basierendes detektionssystem mit abtastlichtquelle
US8977489B2 (en) * 2009-05-18 2015-03-10 GM Global Technology Operations LLC Turn by turn graphical navigation on full windshield head-up display
EP2449104B1 (de) 2009-06-29 2014-06-04 Luminex Corporation Chimäre primer mit haarnadel-konformationen und verwendungsverfahren dafür
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
WO2011032088A1 (en) 2009-09-11 2011-03-17 Arca Biopharma, Inc. Polymorphisms in the pde3a gene
CN107303302A (zh) 2009-09-14 2017-10-31 希拉金股份有限公司 溶瘤牛痘病毒组合癌症疗法
EP2483688B1 (de) 2009-09-28 2016-04-20 Koninklijke Philips N.V. Verfahren zur kennzeichnung biologischer bindungen
MX337062B (es) 2009-12-10 2016-02-11 Ottawa Hospital Res Inst Rabdovirus oncolítico.
ES2587191T3 (es) 2009-12-23 2016-10-21 Arca Biopharma, Inc. Métodos y composiciones para enfermedades y afecciones cardiovasculares
EP2369325A1 (de) * 2010-03-12 2011-09-28 Eppendorf Ag Arrayanalyse für Online-Detektion
WO2011143791A1 (en) 2010-05-20 2011-11-24 Honeywell International Inc. Microarray reader based on evanescent wave detection
US9176152B2 (en) 2010-05-25 2015-11-03 Arryx, Inc Methods and apparatuses for detection of positional freedom of particles in biological and chemical analyses and applications in immunodiagnostics
WO2012031050A1 (en) * 2010-08-31 2012-03-08 Canon U.S. Life Sciences, Inc. Thermal calibration
US11022573B2 (en) 2010-08-31 2021-06-01 Canon U.S.A., Inc. Positive controls
TW201217783A (en) 2010-09-15 2012-05-01 Mbio Diagnostics Inc System and method for detecting multiple molecules in one assay
GB201016484D0 (en) 2010-09-30 2010-11-17 Geneseque As Method
KR101942237B1 (ko) 2011-01-04 2019-01-25 신라젠(주) 종양 항원에 대한 항체의 생산 및 종양용해 우두 바이러스의 투여에 의한 종양 특이적 보체 의존적 세포독성의 생산
EP3444600B1 (de) 2011-01-11 2020-05-13 The Trustees of Columbia University in the City of New York System und verfahren zur einzelmoleküldetektion mithilfe von nanoröhrchen
EP2678669A1 (de) 2011-02-23 2014-01-01 The Trustees of Columbia University in the City of New York Systeme und verfahren zur einzelmolekülerkennung mithilfe von nanoporen
EP2681566A2 (de) 2011-02-28 2014-01-08 University of Iowa Research Foundation Anti-müller-hormon-veränderungen in der schwangerschaft und vorhersage von schwangerschaftsnebenwirkungen und des geschlechts
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
ES2551922T3 (es) 2011-03-07 2015-11-24 Accelerate Diagnostics, Inc. Sistemas rápidos de purificación celular
WO2012120377A2 (en) 2011-03-08 2012-09-13 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
EP2718427B1 (de) 2011-06-08 2017-01-11 Children's Hospital of Eastern Ontario Research Institute Inc. Zusammensetzungen zur behandlung von glioblastomen
US9194801B2 (en) * 2011-08-26 2015-11-24 The Trustees Of Columbia University In The City Of New York Systems and methods for a DNA-based thermometer
US10040853B2 (en) 2011-09-09 2018-08-07 Fred Hutchinson Cancer Research Center Methods and compositions involving NKG2D inhibitors and cancer
EP3441142A1 (de) * 2011-11-16 2019-02-13 Becton, Dickinson and Company Verfahren und systeme zum nachweis eines analyts in einer probe
EP2594942A1 (de) 2011-11-16 2013-05-22 Koninklijke Philips Electronics N.V. Lange starre Abstandshalter zur Verbesserung der Bindekinetik in Immuntests
WO2013158280A1 (en) 2012-04-20 2013-10-24 The Trustees Of Columbia University In The City Of New York Systems and methods for single-molecule nucleic-acid assay platforms
EP2741074A1 (de) 2012-12-04 2014-06-11 F. Hoffmann-La Roche AG Vorrichtung zur Verwendung bei der Bindeaffinitätserkennung
US9678065B2 (en) 2013-01-11 2017-06-13 Becton, Dickinson And Company Low-cost point-of-care assay device
WO2014116721A1 (en) 2013-01-22 2014-07-31 The Arizona Board Of Regents For And On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
CA2901501C (en) 2013-02-21 2023-03-07 Children's Hospital Of Eastern Ontario Research Institute Inc. Vaccine composition
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
JP2015072249A (ja) * 2013-03-29 2015-04-16 富士フイルム株式会社 被検物質の測定方法、被検物質測定キット及び被検物質測定試薬
SG11201602540XA (en) 2013-10-03 2016-04-28 Oklahoma Med Res Found Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
CN106029863A (zh) 2013-11-06 2016-10-12 贝克顿·迪金森公司 微流体性装置和制造和使用其的方法
US10018640B2 (en) 2013-11-13 2018-07-10 Becton, Dickinson And Company Optical imaging system and methods for using the same
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
JP6074624B2 (ja) * 2014-04-16 2017-02-08 学校法人北里研究所 生体試料中の個別多種及び／又は混合多種の疾患関連自己抗体の検出方法、キット及び検出装置
GB201413929D0 (en) 2014-08-06 2014-09-17 Geneseque As Method
BR122020024283B1 (pt) 2014-10-14 2023-02-23 Becton, Dickinson And Company Dispositivo de transferência de sangue adaptado para receber uma amostra de sangue
ES2897931T3 (es) 2014-10-14 2022-03-03 Becton Dickinson Co Gestión de muestras de sangre utilizando espuma de célula abierta
DE102014221734A1 (de) * 2014-10-24 2016-04-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Messvorrichtung und System zur Schmelzkurvenanalyse eines DNA Microarrays, sowie Verwendung eines Fluoreszenzdetektorarrays zur Analyse
CA2969145A1 (en) 2014-11-26 2016-06-02 The Regents Of The University Of California Therapeutic compositions comprising transcription factors and methods of making and using the same
US10725030B2 (en) * 2014-11-28 2020-07-28 Ge Healthcare Bio-Sciences Ab Method for determining analyte-ligand binding on a sensor surface
WO2016138427A1 (en) 2015-02-27 2016-09-01 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
EP4350351A2 (de) 2015-03-10 2024-04-10 Becton, Dickinson and Company Mikroprobenverwaltungsvorrichtung für biologische flüssigkeiten
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
KR20170132856A (ko) 2015-03-30 2017-12-04 액셀러레이트 다이어그노스틱스, 아이엔씨. 신속한 미생물 동정 및 항균제 감수성 시험을 위한 기기 및 시스템
ES2857873T3 (es) 2015-09-01 2021-09-29 Becton Dickinson Co Dispositivo de filtración en profundidad para separar fases de muestras
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
US20170160187A1 (en) * 2015-12-08 2017-06-08 Tdk Corporation Laser Scanner Particle Counter and Imager
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
US20190390278A1 (en) 2017-01-26 2019-12-26 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
US10260033B1 (en) * 2017-10-06 2019-04-16 Wyatt Technology Corporation Method and apparatus to mitigate evaporation in high throughput measurements
US10871485B2 (en) 2018-04-13 2020-12-22 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
US11459604B2 (en) 2018-07-12 2022-10-04 Luminex Corporation Systems and methods for performing variable sample preparation and analysis processes
CA3116539C (en) 2018-10-18 2023-10-03 Oklahoma Medical Research Foundation Biomarkers for a systemic lupus erythematosus (sle) disease activity immune index that characterizes disease activity
US11733242B2 (en) 2018-10-31 2023-08-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Biomarkers and methods of use for radiation-induced lung injury
JP2022525322A (ja) 2019-03-14 2022-05-12 インシリクサ， インコーポレイテッド 時間ゲート蛍光ベースの検出のための方法およびシステム

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975084A (en) * 1973-09-27 1976-08-17 Block Engineering, Inc. Particle detecting system
US4577109A (en) * 1980-10-06 1986-03-18 Regents Of The University Of California Remote multi-position information gathering system and method
EP0075353B1 (de) * 1981-09-18 1987-08-19 Battelle Memorial Institute Verfahren und Vorrichtung zur Bestimmung von gelösten Stoffen mit Hilfe eines optischen Wellenleiters
US4582809A (en) * 1982-06-14 1986-04-15 Myron J. Block Apparatus including optical fiber for fluorescence immunoassay
US4447546A (en) * 1982-08-23 1984-05-08 Myron J. Block Fluorescent immunoassay employing optical fiber in capillary tube
US4680275A (en) * 1985-02-11 1987-07-14 Becton, Dickinson And Company Homogeneous fluorescence immunoassay using a light absorbing material
US4654532A (en) * 1985-09-09 1987-03-31 Ord, Inc. Apparatus for improving the numerical aperture at the input of a fiber optics device
US4716121A (en) * 1985-09-09 1987-12-29 Ord, Inc. Fluorescent assays, including immunoassays, with feature of flowing sample
US5017009A (en) * 1986-06-26 1991-05-21 Ortho Diagnostic Systems, Inc. Scattered total internal reflectance immunoassay system
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US4979821A (en) * 1988-01-27 1990-12-25 Ortho Diagnostic Systems Inc. Cuvette for receiving liquid sample
GB8807488D0 (en) * 1988-03-29 1988-05-05 Ares Serono Res & Dev Ltd Method of assay
GB8827853D0 (en) * 1988-11-29 1988-12-29 Ares Serono Res & Dev Ltd Sensor for optical assay
GB8911462D0 (en) * 1989-05-18 1989-07-05 Ares Serono Res & Dev Ltd Devices for use in chemical test procedures
US5350697A (en) * 1990-08-28 1994-09-27 Akzo N.V. Scattered light detection apparatus
USH1344H (en) * 1990-10-09 1994-08-02 The United States Of America As Represented By The Secretary Of The Army Portable automatic sensor for toxic gases
ATE244065T1 (de) * 1990-12-06 2003-07-15 Affymetrix Inc Verfahren und reagenzien für immobilisierten polymersynthese in sehr grossem masstab
DE69132843T2 (de) * 1990-12-06 2002-09-12 Affymetrix Inc N D Ges D Staat Identifizierung von Nukleinsäuren in Proben
US5192510A (en) * 1991-01-30 1993-03-09 E. I. Du Pont De Nemours And Company Apparatus for performing fluorescent assays which separates bulk and evanescent fluorescence
GB9119735D0 (en) * 1991-09-16 1991-10-30 Secr Defence Gene probe biosensor method
WO1993020240A1 (en) * 1992-04-06 1993-10-14 Abbott Laboratories Method and device for detection of nucleic acid or analyte using total internal reflectance
WO1994000763A1 (en) * 1992-06-24 1994-01-06 Akzo Nobel N.V. Method for determining multiple immunocomplexes on one surface using spectroscopy
US5359681A (en) * 1993-01-11 1994-10-25 University Of Washington Fiber optic sensor and methods and apparatus relating thereto
JP3426602B2 (ja) * 1993-05-18 2003-07-14 ユニヴァーシティ オブ ユタ リサーチ ファンデーション 多分析物均質蛍光免疫検定用の装置および方法

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EP1441217A2 (de) 2004-07-28
AU3636295A (en) 1996-04-09
ES2358508T3 (es) 2011-05-11
CA2197321A1 (en) 1996-03-28
EP0783683A1 (de) 1997-07-16
CA2197321C (en) 2009-01-27

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