DE69535176D1 - Miniaturisierte, flache kolonnen zur anwendung in einer vorrichtung zur trennung von flüssigen phasen - Google Patents

Miniaturisierte, flache kolonnen zur anwendung in einer vorrichtung zur trennung von flüssigen phasen

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Publication number
DE69535176D1
DE69535176D1 DE69535176T DE69535176T DE69535176D1 DE 69535176 D1 DE69535176 D1 DE 69535176D1 DE 69535176 T DE69535176 T DE 69535176T DE 69535176 T DE69535176 T DE 69535176T DE 69535176 D1 DE69535176 D1 DE 69535176D1
Authority
DE
Germany
Prior art keywords
colons
miniaturized
flat
application
liquid phases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69535176T
Other languages
English (en)
Other versions
DE69535176T2 (de
Inventor
Patrick Kaltenbach
A Swedberg
E Witt
Fritz Bek
S Mittelstadt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agilent Technologies Inc
Original Assignee
Agilent Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/326,111 external-priority patent/US5500071A/en
Application filed by Agilent Technologies Inc filed Critical Agilent Technologies Inc
Application granted granted Critical
Publication of DE69535176D1 publication Critical patent/DE69535176D1/de
Publication of DE69535176T2 publication Critical patent/DE69535176T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/54—Heating or cooling apparatus; Heat insulating devices using spatial temperature gradients
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44708—Cooling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44773—Multi-stage electrophoresis, e.g. two-dimensional electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
    • B01L3/5055—Hinged, e.g. opposable surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • B29C66/549—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles said hollow-preforms being interconnected during their moulding process, e.g. by a hinge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/756—Microarticles, nanoarticles
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N2030/285—Control of physical parameters of the fluid carrier electrically driven carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/30—Control of physical parameters of the fluid carrier of temperature
    • G01N2030/3007—Control of physical parameters of the fluid carrier of temperature same temperature for whole column
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/30—Control of physical parameters of the fluid carrier of temperature
    • G01N2030/3015—Control of physical parameters of the fluid carrier of temperature temperature gradients along column
    • G—PHYSICS
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    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/30—Control of physical parameters of the fluid carrier of temperature
    • G01N2030/303—Control of physical parameters of the fluid carrier of temperature using peltier elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • G01N30/606—Construction of the column body with fluid access or exit ports
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
    • Y10T156/1062—Prior to assembly
    • Y10T156/1064—Partial cutting [e.g., grooving or incising]
DE69535176T 1994-10-19 1995-10-16 Miniaturisierte, flache kolonnen zur anwendung in einer vorrichtung zur trennung von flüssigen phasen Expired - Lifetime DE69535176T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US326111 1994-10-19
US08/326,111 US5500071A (en) 1994-10-19 1994-10-19 Miniaturized planar columns in novel support media for liquid phase analysis
US08/482,245 US5658413A (en) 1994-10-19 1995-06-07 Miniaturized planar columns in novel support media for liquid phase analysis
US482245 1995-06-07
PCT/US1995/013365 WO1996012546A1 (en) 1994-10-19 1995-10-16 Miniaturized planar columns for use in a liquid phase separation apparatus

Publications (2)

Publication Number Publication Date
DE69535176D1 true DE69535176D1 (de) 2006-09-28
DE69535176T2 DE69535176T2 (de) 2007-08-23

Family

ID=26985246

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69535176T Expired - Lifetime DE69535176T2 (de) 1994-10-19 1995-10-16 Miniaturisierte, flache kolonnen zur anwendung in einer vorrichtung zur trennung von flüssigen phasen
DE69535259T Expired - Lifetime DE69535259T2 (de) 1994-10-19 1995-10-19 Miniaturisierte, flache kolonnen in neuen trägermedien für flüssigphase-analyse

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69535259T Expired - Lifetime DE69535259T2 (de) 1994-10-19 1995-10-19 Miniaturisierte, flache kolonnen in neuen trägermedien für flüssigphase-analyse

Country Status (5)

Country Link
US (6) US5658413A (de)
EP (2) EP0734282B1 (de)
JP (1) JP3631758B2 (de)
DE (2) DE69535176T2 (de)
WO (2) WO1996012546A1 (de)

Families Citing this family (234)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935401A (en) * 1996-09-18 1999-08-10 Aclara Biosciences Surface modified electrophoretic chambers
US5770029A (en) * 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5658413A (en) * 1994-10-19 1997-08-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US6613560B1 (en) * 1994-10-19 2003-09-02 Agilent Technologies, Inc. PCR microreactor for amplifying DNA using microquantities of sample fluid
US5567868A (en) * 1995-01-23 1996-10-22 Hewlett-Packard Company Planar manifold assembly
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US5800784A (en) * 1996-07-09 1998-09-01 Horn; Marcus J. Chemical sample treatment system and cassette, and methods for effecting multistep treatment process
US6074827A (en) 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US5997708A (en) * 1997-04-30 1999-12-07 Hewlett-Packard Company Multilayer integrated assembly having specialized intermediary substrate
US6431695B1 (en) 1998-06-18 2002-08-13 3M Innovative Properties Company Microstructure liquid dispenser
US6290685B1 (en) 1998-06-18 2001-09-18 3M Innovative Properties Company Microchanneled active fluid transport devices
US6375871B1 (en) 1998-06-18 2002-04-23 3M Innovative Properties Company Methods of manufacturing microfluidic articles
US6068684A (en) * 1997-09-11 2000-05-30 Board Of Supervisors Of Louisiana State University And Agricultural & Mechanical College Microstructure chromatograph with rectangular column
US6803019B1 (en) 1997-10-15 2004-10-12 Aclara Biosciences, Inc. Laminate microstructure device and method for making same
DE19746581A1 (de) * 1997-10-22 1999-04-29 Merck Patent Gmbh Mikromischer
JP2001523001A (ja) * 1997-11-12 2001-11-20 ピーイー コーポレイション （エヌワイ） 自己修正ベンドをもつ蛇行電気泳動チャネル
US6224830B1 (en) 1998-01-30 2001-05-01 The Governors Of The University Of Alberta Absorbance cell for microfluid devices
US6830729B1 (en) 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument
CA2320296A1 (en) 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
US6706161B1 (en) 1998-06-10 2004-03-16 Agilent Technologies, Inc. Methods and compositions for modifying the surface of a polymeric substrate
US6459080B1 (en) * 1998-06-12 2002-10-01 Agilent Technologies, Inc. Miniaturized device for separating the constituents of a sample and delivering the constituents of the separated sample to a mass spectrometer
US6194900B1 (en) * 1998-06-19 2001-02-27 Agilent Technologies, Inc. Integrated miniaturized device for processing and NMR detection of liquid phase samples
US7799521B2 (en) * 1998-06-24 2010-09-21 Chen & Chen, Llc Thermal cycling
US6780617B2 (en) * 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
US6375901B1 (en) 1998-06-29 2002-04-23 Agilent Technologies, Inc. Chemico-mechanical microvalve and devices comprising the same
WO2000011477A1 (de) * 1998-08-20 2000-03-02 Siemens Aktiengesellschaft Trennsäulen-einheit für einen gaschromatograph und verfahren zu ihrer herstellung
US6919162B1 (en) 1998-08-28 2005-07-19 Agilent Technologies, Inc. Method for producing high-structure area texturing of a substrate, substrates prepared thereby and masks for use therein
US6759013B2 (en) 1998-09-17 2004-07-06 Agilent Technologies, Inc. Modular apparatus for chemical microanalysis
CN100435900C (zh) * 1998-09-17 2008-11-26 阿德文生物科学公司 液相色谱系统，化学分离装置及质谱分析装置和方法
US6158712A (en) * 1998-10-16 2000-12-12 Agilent Technologies, Inc. Multilayer integrated assembly having an integral microminiature valve
US6240790B1 (en) 1998-11-09 2001-06-05 Agilent Technologies, Inc. Device for high throughout sample processing, analysis and collection, and methods of use thereof
US6320295B1 (en) * 1998-11-18 2001-11-20 Mcgill Robert Andrew Diamond or diamond like carbon coated chemical sensors and a method of making same
US20020006359A1 (en) * 1998-11-25 2002-01-17 Affymetrix, Inc. Microplate sample and reagent loading system
US6913679B1 (en) * 1999-02-11 2005-07-05 The Regents Of The University Of California Apparatus and methods for high resolution separation of sample components on microfabricated channel devices
US6633031B1 (en) 1999-03-02 2003-10-14 Advion Biosciences, Inc. Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method
US6749814B1 (en) * 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
US6367847B1 (en) * 1999-03-05 2002-04-09 Waters Investments Limited Coupler for placing two or more fluid streams in communication
JP2000289166A (ja) * 1999-04-09 2000-10-17 E I Du Pont De Nemours & Co 封入された構造を含む一体式ポリイミド積層体および該積層体の製造方法
US6703120B1 (en) 1999-05-05 2004-03-09 3M Innovative Properties Company Silicone adhesives, articles, and methods
DE19919608A1 (de) * 1999-05-27 2000-11-30 Roche Diagnostics Gmbh Probenträger für die IR-Spetktroskopie von Probenflüssigkeiten
DE19927533B4 (de) * 1999-06-16 2004-03-04 Merck Patent Gmbh Miniaturisiertes Analysensystem
US6369384B1 (en) 1999-06-23 2002-04-09 Agilent Technologies, Inc. Time-of-flight mass spectrometer with post-deflector filter assembly
US7223364B1 (en) 1999-07-07 2007-05-29 3M Innovative Properties Company Detection article having fluid control film
US6489774B1 (en) 1999-07-08 2002-12-03 Agilent Technologies, Inc. Miniaturized device for ion analysis, and methods of use thereof
ATE415620T1 (de) * 1999-08-06 2008-12-15 Chempaq As Teilchenbestimmungsvorrichtung
US6495104B1 (en) * 1999-08-19 2002-12-17 Caliper Technologies Corp. Indicator components for microfluidic systems
US6258263B1 (en) * 1999-09-17 2001-07-10 The University Of Cincinnati Liquid chromatograph on a chip
DE19964337B4 (de) * 1999-10-01 2004-09-16 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Mikrofluidischer Mikrochip mit abbiegbarem Ansaugrohr
US7157284B2 (en) * 1999-10-29 2007-01-02 The United States Of America As Represented By The Environmental Protection Agency Vacuum distillation automatic sampler
JP5057318B2 (ja) 1999-12-30 2012-10-24 アドビオン インコーポレイテッド 多重電気噴霧装置、システム、および方法
EP1248949B1 (de) 2000-01-18 2013-05-22 Advion, Inc. Elektrosprayvorrichtung mit array von trennsäulen sowie verfahren zur trennung von fluidproben
US7485454B1 (en) * 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
US6561208B1 (en) 2000-04-14 2003-05-13 Nanostream, Inc. Fluidic impedances in microfluidic system
US6632400B1 (en) 2000-06-22 2003-10-14 Agilent Technologies, Inc. Integrated microfluidic and electronic components
IL137625A0 (en) * 2000-08-01 2001-10-31 Sensis Ltd Detector for an electrophoresis apparatus
US20020037130A1 (en) * 2000-08-02 2002-03-28 Sarnoff Corporation Microfluidic optical switch
US6890093B2 (en) 2000-08-07 2005-05-10 Nanostream, Inc. Multi-stream microfludic mixers
WO2002011888A2 (en) * 2000-08-07 2002-02-14 Nanostream, Inc. Fluidic mixer in microfluidic system
US7027683B2 (en) * 2000-08-15 2006-04-11 Nanostream, Inc. Optical devices with fluidic systems
US6508988B1 (en) * 2000-10-03 2003-01-21 California Institute Of Technology Combinatorial synthesis system
US7097809B2 (en) * 2000-10-03 2006-08-29 California Institute Of Technology Combinatorial synthesis system
WO2002037079A2 (en) * 2000-11-06 2002-05-10 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services Sample delivery system with laminar mixing for microvolume biosensing
US20020079220A1 (en) * 2000-11-09 2002-06-27 Pawliszyn Janusz B. Micromachining using printing technology
US6783992B2 (en) 2001-01-03 2004-08-31 Agilent Technologies, Inc. Methods and using chemico-mechanical microvalve devices for the selective separation of components from multi-component fluid samples
US6887429B1 (en) * 2001-01-26 2005-05-03 Global Fia Apparatus and method for automated medical diagnostic tests
JP4148778B2 (ja) * 2001-03-09 2008-09-10 バイオミクロ システムズ インコーポレイティッド アレイとのミクロ流体的インターフェース機器
US6610978B2 (en) 2001-03-27 2003-08-26 Agilent Technologies, Inc. Integrated sample preparation, separation and introduction microdevice for inductively coupled plasma mass spectrometry
JP2002292275A (ja) * 2001-03-29 2002-10-08 Kanagawa Acad Of Sci & Technol マイクロチップパイルアップ型化学反応システム
JP4362987B2 (ja) * 2001-04-09 2009-11-11 株式会社島津製作所 マイクロチップ電気泳動におけるサンプル導入方法
EP1409712A4 (de) * 2001-04-10 2008-05-14 Bioprocessors Corp Mikrofermentervorrichtung und screeningverfahren auf zellbasis
US20030040119A1 (en) * 2001-04-11 2003-02-27 The Regents Of The University Of Michigan Separation devices and methods for separating particles
US6814938B2 (en) * 2001-05-23 2004-11-09 Nanostream, Inc. Non-planar microfluidic devices and methods for their manufacture
US20020186263A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic fraction collectors
DE60118533T2 (de) * 2001-06-07 2006-08-24 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Analytischer Mikrochip mit Eingabe- und Ausgabeleitungen zwischen Wanne und Behälter
US6919046B2 (en) * 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
GB2376644A (en) * 2001-06-18 2002-12-24 Univ Hull Micro-reactor with separable electrodes on support members
US7128876B2 (en) * 2001-07-17 2006-10-31 Agilent Technologies, Inc. Microdevice and method for component separation in a fluid
EP1427531B1 (de) * 2001-09-11 2016-10-19 Iquum, Inc. Probenbehälter
SE0103110D0 (sv) * 2001-09-18 2001-09-18 Aamic Ab Microscale fluid handling system
US6803568B2 (en) 2001-09-19 2004-10-12 Predicant Biosciences, Inc. Multi-channel microfluidic chip for electrospray ionization
US6966880B2 (en) * 2001-10-16 2005-11-22 Agilent Technologies, Inc. Universal diagnostic platform
US7275562B2 (en) * 2001-10-17 2007-10-02 Agilent Technologies, Inc. Extensible spiral for flex circuit
US6627076B2 (en) * 2001-10-19 2003-09-30 Sandia National Laboratories Compact microchannel system
US20030124592A1 (en) * 2001-10-24 2003-07-03 Bioprofile, Llc Methods for detecting genetic haplotypes by interaction with probes
US6939032B2 (en) * 2001-10-25 2005-09-06 Erie Scientific Company Cover slip mixing apparatus
US20040028559A1 (en) * 2001-11-06 2004-02-12 Peter Schuck Sample delivery system with laminar mixing for microvolume biosensing
GB0128350D0 (en) 2001-11-27 2002-01-16 Lab901 Ltd Non-rigid apparatus for microfluidic applications
JP3852327B2 (ja) * 2001-11-30 2006-11-29 株式会社島津製作所 電気泳動部材用リザーバ部材及び電気泳動部材
US7105810B2 (en) * 2001-12-21 2006-09-12 Cornell Research Foundation, Inc. Electrospray emitter for microfluidic channel
EP1466162A1 (de) * 2002-01-10 2004-10-13 Board Of Regents The University Of Texas System Durchfluss-sortiersystem und seine verwendung
US6877892B2 (en) * 2002-01-11 2005-04-12 Nanostream, Inc. Multi-stream microfluidic aperture mixers
US6538207B1 (en) 2002-01-18 2003-03-25 Agilent Technologies, Inc. Strain relief structures for lead connections
US6666907B1 (en) * 2002-01-31 2003-12-23 Sandia Corporation Temperature programmable microfabricated gas chromatography column
JP3740528B2 (ja) * 2002-02-05 2006-02-01 独立行政法人産業技術総合研究所 微細粒子製造方法
US20030148291A1 (en) * 2002-02-05 2003-08-07 Karla Robotti Method of immobilizing biologically active molecules for assay purposes in a microfluidic format
US7261812B1 (en) 2002-02-13 2007-08-28 Nanostream, Inc. Multi-column separation devices and methods
WO2003068402A1 (en) * 2002-02-13 2003-08-21 Nanostream, Inc. Microfluidic separation column devices and fabrication methods
US7033542B2 (en) * 2002-02-14 2006-04-25 Archibald William B High throughput screening with parallel vibrational spectroscopy
US20050211555A1 (en) * 2002-02-14 2005-09-29 Solus Biosystems, Inc. Method for multiple sample screening using IR spectroscopy
FR2836071B1 (fr) * 2002-02-21 2005-02-04 Commissariat Energie Atomique Composant pour microsysteme d'analyse biologique ou biochimique
US6958119B2 (en) 2002-02-26 2005-10-25 Agilent Technologies, Inc. Mobile phase gradient generation microfluidic device
US20040017078A1 (en) * 2002-04-02 2004-01-29 Karp Christoph D. Connectors for microfluidic devices
GB0208766D0 (en) * 2002-04-02 2002-05-29 Univ Surrey Liquid-liquid separation
US6621076B1 (en) 2002-04-30 2003-09-16 Agilent Technologies, Inc. Flexible assembly for transporting sample fluids into a mass spectrometer
US20030224531A1 (en) * 2002-05-29 2003-12-04 Brennen Reid A. Microplate with an integrated microfluidic system for parallel processing minute volumes of fluids
US6859050B2 (en) 2002-05-31 2005-02-22 Agilent Technologies, Inc. High frequency contactless heating with temperature and/or conductivity monitoring
US7771658B2 (en) * 2002-06-11 2010-08-10 Chempaq A/S Disposable cartridge for characterizing particles suspended in a liquid
US20050238506A1 (en) * 2002-06-21 2005-10-27 The Charles Stark Draper Laboratory, Inc. Electromagnetically-actuated microfluidic flow regulators and related applications
US7867193B2 (en) * 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
AU2003281588A1 (en) * 2002-07-18 2004-02-09 Canon Kabushiki Kaisha Process for producing mass transfer device and apparatus for production thereof
US7470533B2 (en) * 2002-12-20 2008-12-30 Acea Biosciences Impedance based devices and methods for use in assays
US7560269B2 (en) 2002-12-20 2009-07-14 Acea Biosciences, Inc. Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US7214320B1 (en) 2002-08-08 2007-05-08 Nanostream, Inc. Systems and methods for high throughput sample analysis
AU2003259722A1 (en) * 2002-08-08 2004-02-25 Nanostream, Inc. Systems and methods for high-throughput microfluidic sample analysis
AU2003304163A1 (en) * 2002-08-21 2005-01-21 Shell Oil Company Method for measuring fluid chemistry in drilling and production operations
JP3824160B2 (ja) * 2002-08-28 2006-09-20 株式会社島津製作所 高速液体クロマトグラフ用混合装置
US6900133B2 (en) * 2002-09-18 2005-05-31 Applied Materials, Inc Method of etching variable depth features in a crystalline substrate
JP3725109B2 (ja) * 2002-09-19 2005-12-07 財団法人生産技術研究奨励会 マイクロ流体デバイス
US6774337B2 (en) * 2002-10-21 2004-08-10 Lockheed Martin Corporation Method for protecting the diaphragm and extending the life of SiC and/or Si MEMS microvalves
WO2004040295A1 (en) * 2002-10-31 2004-05-13 Nanostream, Inc. Parallel detection chromatography systems
US20050048669A1 (en) * 2003-08-26 2005-03-03 Nanostream, Inc. Gasketless microfluidic device interface
US7010964B2 (en) * 2002-10-31 2006-03-14 Nanostream, Inc. Pressurized microfluidic devices with optical detection regions
US6936167B2 (en) * 2002-10-31 2005-08-30 Nanostream, Inc. System and method for performing multiple parallel chromatographic separations
JP2006507504A (ja) * 2002-11-22 2006-03-02 ソルス バイオシステムズ インコーポレーテッド 並列振動分光法による高スループットのスクリーニング
CN1217188C (zh) * 2002-12-05 2005-08-31 清华大学 微型气相色谱柱、气相色谱系统以及在样品中分析组分的方法
EP1585594A1 (de) * 2002-12-11 2005-10-19 Inverness Medical Switzerland GmbH Mikrofluidisches bauelement, verfahren und vorrichtung zu dessen herstellung und verwendung des bauelements
US6987263B2 (en) * 2002-12-13 2006-01-17 Nanostream, Inc. High throughput systems and methods for parallel sample analysis
US20060076482A1 (en) * 2002-12-13 2006-04-13 Hobbs Steven E High throughput systems and methods for parallel sample analysis
US7147695B2 (en) * 2002-12-13 2006-12-12 New Jersey Institute Of Technology Microfabricated microconcentrator for sensors and gas chromatography
US6706091B1 (en) * 2002-12-17 2004-03-16 Sandia Corporation Sub-to super-ambient temperature programmable microfabricated gas chromatography column
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US9612234B2 (en) 2008-05-05 2017-04-04 Acea Biosciences, Inc. Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments
EP1603674B1 (de) 2003-02-05 2016-01-06 Iquum, Inc. Probenverarbeitung
SE0300454D0 (sv) * 2003-02-19 2003-02-19 Aamic Ab Nozzles for electrospray ionization and methods of fabricating them
US7007710B2 (en) * 2003-04-21 2006-03-07 Predicant Biosciences, Inc. Microfluidic devices and methods
US7074327B2 (en) * 2003-05-08 2006-07-11 Nanostream, Inc. Sample preparation for parallel chromatography
EP1628754A2 (de) 2003-06-05 2006-03-01 Bioprocessors Corporation Vorrichtung und verfahren zur behandlung von substraten
JP2005007529A (ja) * 2003-06-19 2005-01-13 Dainippon Screen Mfg Co Ltd マイクロ流体デバイスおよびマイクロ流体デバイスの製造方法
US20090088982A1 (en) * 2003-07-31 2009-04-02 Fukushima Noelle H Co-detection of single polypeptide and polynucleotide molecules
WO2005015162A2 (en) 2003-08-06 2005-02-17 Waters Investment Limited Fluidic terminal
US20050032238A1 (en) * 2003-08-07 2005-02-10 Nanostream, Inc. Vented microfluidic separation devices and methods
US7028536B2 (en) * 2004-06-29 2006-04-18 Nanostream, Inc. Sealing interface for microfluidic device
DE10336849A1 (de) * 2003-08-11 2005-03-10 Thinxxs Gmbh Flusszelle
US20060266649A1 (en) * 2003-09-22 2006-11-30 Electrophoretic Member Electrophoretic member, electrophoretic device, electrophoretic method and sample dispensing probe
GB2439233B (en) * 2003-09-22 2008-04-23 Shimadzu Corp An electrophoretic separation method
US7537807B2 (en) 2003-09-26 2009-05-26 Cornell University Scanned source oriented nanofiber formation
US20080021674A1 (en) * 2003-09-30 2008-01-24 Robert Puskas Methods for Enhancing the Analysis of Particle Detection
CA2550274A1 (en) 2003-11-12 2005-05-26 Acea Biosciences, Inc. Real time electronic cell sensing systems and applications for cell-based assays
KR20050062897A (ko) * 2003-12-19 2005-06-28 한국기계연구원 계면 교차방향 초음파 방사형 마이크로믹서 및 이를이용한 혼합시료 제조방법
US7867194B2 (en) 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US7422905B2 (en) * 2004-02-27 2008-09-09 Medtronic, Inc. Blood coagulation test cartridge, system, and method
US7439069B2 (en) * 2004-02-27 2008-10-21 Nippoldt Douglas D Blood coagulation test cartridge, system, and method
US7399637B2 (en) * 2004-04-19 2008-07-15 Medtronic, Inc. Blood coagulation test cartridge, system, and method
JP3952036B2 (ja) * 2004-05-13 2007-08-01 コニカミノルタセンシング株式会社 マイクロ流体デバイス並びに試液の試験方法および試験システム
US20050257885A1 (en) * 2004-05-24 2005-11-24 Nanostream, Inc. Capillary multi-channel optical flow cell
DE102004030619A1 (de) * 2004-06-24 2006-01-12 Forschungszentrum Karlsruhe Gmbh Verfahren zum Verbinden von Werkstücken aus Kunststoff
US20060011547A1 (en) * 2004-07-13 2006-01-19 Bell Stephen A Methods of separating components in treatment fluids
US20060015039A1 (en) * 2004-07-19 2006-01-19 Cassidy Kenneth T Guidewire bearing markings simplifying catheter selection
US20060022130A1 (en) * 2004-07-29 2006-02-02 Predicant Biosciences, Inc., A Delaware Corporation Microfluidic devices and methods with integrated electrical contact
US20060060769A1 (en) * 2004-09-21 2006-03-23 Predicant Biosciences, Inc. Electrospray apparatus with an integrated electrode
US7591883B2 (en) * 2004-09-27 2009-09-22 Cornell Research Foundation, Inc. Microfiber supported nanofiber membrane
US7572640B2 (en) * 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
EP1805500A4 (de) * 2004-09-28 2008-05-07 Singulex Inc System und verfahren zur spektroskopischen analyse einzelner partikel
US8685711B2 (en) 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
US9040305B2 (en) * 2004-09-28 2015-05-26 Singulex, Inc. Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry
KR20060058830A (ko) * 2004-11-26 2006-06-01 한국표준과학연구원 개별시료 주입구가 없는 다중채널 전기영동장치에 의한분리방법
EP1842045A4 (de) * 2005-01-18 2009-04-15 Solus Biosystems Inc Screening mehrerer proben mittels ir-spektroskopie
US8028566B2 (en) * 2005-02-10 2011-10-04 Chempaq A/S Dual sample cartridge and method for characterizing particles in liquid
JP5096170B2 (ja) 2005-02-10 2012-12-12 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ デュアルサンプルカートリッジ及び液体中の粒子を特徴付ける方法
US8178046B2 (en) * 2005-02-23 2012-05-15 Sierra Sensors Gmbh Microfluidic devices with SPR sensing capabilities
US20060219637A1 (en) * 2005-03-29 2006-10-05 Killeen Kevin P Devices, systems and methods for liquid chromatography
US20060231494A1 (en) * 2005-04-15 2006-10-19 Lu Jennifer Q Carbon nanotube stationary phases for chromatography
US7462280B2 (en) * 2005-07-22 2008-12-09 Agilent Technologies, Inc. Liquid chromatography chip with flexible interface
US7968052B2 (en) * 2005-09-22 2011-06-28 Chempaq A/S Detection and subsequent removal of an aperture blockage
US7790007B2 (en) * 2005-11-29 2010-09-07 Nec Corporation Electrophoresis chip, electrophoresis apparatus, and method for analyzing a sample
US20070140918A1 (en) * 2005-12-19 2007-06-21 Hongfeng Yin Fluidic separation devices and methods with reduced sample broadening
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US8647590B2 (en) 2006-03-16 2014-02-11 Agilent Technologies, Inc. Optical detection cell with micro-fluidic chip
US20070218454A1 (en) * 2006-03-16 2007-09-20 Brennen Reid A Optical detection cell for micro-fluidics
EP3156799B1 (de) 2006-04-04 2024-01-24 Novilux, LLC Analysator und verfahren zur hochempfindlichen detektion von analyten
EP3168618B1 (de) 2006-04-04 2018-11-21 Singulex, Inc. Hochempfindliche verfahren zur troponinanalyse
US7838250B1 (en) * 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
US20070246106A1 (en) 2006-04-25 2007-10-25 Velocys Inc. Flow Distribution Channels To Control Flow in Process Channels
WO2007140537A1 (en) * 2006-06-07 2007-12-13 Mycrolab Diagnostics Pty Ltd Production of microfluidic devices using laser-induced shockwaves
EP2087981A4 (de) * 2006-10-31 2013-01-02 Konica Minolta Opto Inc Master und mikroreaktor
BRPI0717991A2 (pt) * 2006-10-31 2013-12-03 Corning Inc Placa de eletrólito microusinada, dispositivos de célula a combustível utilizando a mesma, e método de microusinagem para produção de dispositivos de célula a combustível.
US20100038825A1 (en) * 2006-12-21 2010-02-18 Mcdonald Joel P Methods of forming microchannels by ultrafast pulsed laser direct-write processing
GB2445738A (en) * 2007-01-16 2008-07-23 Lab901 Ltd Microfluidic device
GB2445739A (en) * 2007-01-16 2008-07-23 Lab901 Ltd Polymeric laminates containing heat seals
WO2008094672A2 (en) * 2007-01-31 2008-08-07 Charles Stark Draper Laboratory, Inc. Membrane-based fluid control in microfluidic devices
US20080318334A1 (en) 2007-06-20 2008-12-25 Robotti Karla M Microfluidic devices comprising fluid flow paths having a monolithic chromatographic material
US8206025B2 (en) 2007-08-07 2012-06-26 International Business Machines Corporation Microfluid mixer, methods of use and methods of manufacture thereof
US20090087860A1 (en) * 2007-08-24 2009-04-02 Todd John A Highly sensitive system and methods for analysis of prostate specific antigen (psa)
JP2009128229A (ja) * 2007-11-26 2009-06-11 Rohm Co Ltd マイクロチップ
JP2011508219A (ja) 2007-12-19 2011-03-10 シンギュレックス・インコーポレイテッド 単一分子検出走査分析器およびその使用方法
JP2011513753A (ja) * 2008-03-05 2011-04-28 シンギュレックス・インコーポレイテッド 分子の高感度検出の方法および組成物
US20090250345A1 (en) * 2008-04-03 2009-10-08 Protea Biosciences, Inc. Microfluidic electroelution devices & processes
US20090250347A1 (en) * 2008-04-03 2009-10-08 Protea Biosciences, Inc. Microfluidic devices & processes for electrokinetic transport
CA2723223C (en) 2008-05-05 2017-06-06 Acea Biosciences, Inc. Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
US8715590B2 (en) * 2008-08-15 2014-05-06 Prognosys LLC Multiplexed lateral flow assay arrays
US8377362B2 (en) * 2008-08-20 2013-02-19 Konica Minolta Opto, Inc. Method for manufacturing micro-channel, die for molding micro-channel chip, and micro-channel chip
GB2464183A (en) * 2008-09-19 2010-04-14 Singulex Inc Sandwich assay
US8377643B2 (en) * 2009-03-16 2013-02-19 Abaxis, Inc. Split flow device for analyses of specific-binding partners
US8815178B2 (en) * 2009-03-26 2014-08-26 Arizona Board Of Regents On Behalf Of Arizona State University Integrated device for surface-contact sampling, extraction and electrochemical measurements
WO2010144358A1 (en) 2009-06-08 2010-12-16 Singulex, Inc. Highly sensitive biomarker panels
DE102009025072A1 (de) * 2009-06-16 2010-12-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zum Erzeugen eines Bereiches mit erhöhtem Brechungsindex und ein Substrat mit örtlich variablem Brechungsindex
JP2011045981A (ja) * 2009-08-28 2011-03-10 Ritsumeikan Ｍｅｍｓ、及びその製造方法
CA2798149A1 (en) 2010-05-06 2011-11-10 Singulex, Inc Methods for diagnosing, staging, predicting risk for developing and identifying treatment responders for rheumatoid arthritis
WO2011149829A1 (en) * 2010-05-27 2011-12-01 3M Innovative Properties Company Integrated systems and assemblies for sample processing
DE102010042824A1 (de) * 2010-10-22 2012-04-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mikrofluidikmodul und Verfahren zur Herstellung desselben
CN103442809B (zh) * 2010-12-03 2016-09-14 美艾利尔技术公司 通过激光照射把材料转换成光学调制状态
DE102010053749B4 (de) * 2010-12-08 2015-02-19 Airbus Defence and Space GmbH Vorrichtung zum Identifizieren biotischer Partikel
JP6162047B2 (ja) 2011-02-02 2017-07-12 ザ チャールズ スターク ドレイパー ラボラトリー インク 薬物送達装置
DE202011102073U1 (de) 2011-06-20 2011-10-10 Agilent Technologies, Inc. - A Delaware Corporation - Atmosphärendruck-Ionisationsvorrichtung
US8502162B2 (en) 2011-06-20 2013-08-06 Agilent Technologies, Inc. Atmospheric pressure ionization apparatus and method
US10024826B2 (en) 2011-08-22 2018-07-17 Waters Technologies Corporation Analysis of dried blood spot samples in a microfluidic system with dilution of extracted samples
DE102011054659A1 (de) * 2011-10-20 2013-04-25 AeroMegt GmbH Verfahren und Vorrichtung zum Messen von Aerosolen in einem großen Volumenstrom
US20130188296A1 (en) * 2012-01-19 2013-07-25 Ford Global Technologies, Llc Material And Coating For Interconnector Busbars
US9782692B2 (en) 2012-04-25 2017-10-10 Agilent Technologies, Inc. Prevention of phase separation upon proportioning and mixing fluids
CN104620099B (zh) * 2012-07-16 2018-01-02 吉恩弗路迪克斯公司 用于在样本的动电处理中使用的参数的样本相关选择
US8952326B1 (en) 2013-11-04 2015-02-10 Agilent Technologies, Inc. Atmospheric pressure interface with improved ion transfer for spectrometry, and related systems and methods
JP6310327B2 (ja) * 2014-05-27 2018-04-11 株式会社エンプラス 流体取扱装置
JP6731216B2 (ja) * 2014-10-24 2020-07-29 京都府公立大学法人 検体用ホルダ
CN110582569B (zh) 2017-03-03 2024-04-02 安捷伦科技有限公司 用于iPSC和ESC衍生的心肌细胞的功能成熟的方法和系统
DE102017108120A1 (de) * 2017-04-13 2018-10-18 Laser-Laboratorium Göttingen e.V. Analysevorrichtung
WO2021144396A1 (en) 2020-01-17 2021-07-22 F. Hoffmann-La Roche Ag Microfluidic device and method for automated split-pool synthesis
JP2023510961A (ja) 2020-01-22 2023-03-15 エフ． ホフマン－ラ ロシュ アーゲー マイクロ流体ビーズトラッピング装置および次世代配列決定ライブラリ調製のための方法
USD941488S1 (en) 2020-02-07 2022-01-18 Agilent Technologies, Inc. Instrument for analyzing biological cells
EP4228793A1 (de) 2020-10-15 2023-08-23 Kapa Biosystems, Inc. Elektrophoretische vorrichtungen und verfahren zur vorbereitung einer sequenzierungsbibliothek der nächsten generation
JP2022159961A (ja) * 2021-04-05 2022-10-18 Ckd株式会社 配管溶接構造

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770529A (en) * 1970-08-25 1973-11-06 Ibm Method of fabricating multilayer circuits
US3953056A (en) * 1972-06-09 1976-04-27 Bookwrights, Inc. Bookbinding with plastic covers
US3919768A (en) * 1973-01-02 1975-11-18 Northrop Corp Method of tunnel containing structures
US3925166A (en) * 1974-09-06 1975-12-09 Us Health Automated system for the determination of bacterial antibiotic susceptibilities
US4059009A (en) * 1976-09-10 1977-11-22 Micromeritics Instrument Corporation Liquid chromatography system
JPS5385498A (en) * 1977-01-05 1978-07-27 Hitachi Ltd Coulumn for chromatography and production of the same
US4285901A (en) * 1978-07-06 1981-08-25 Akira Yotsutsuji Method of making an insulated metal mold
DE3011919A1 (de) * 1979-03-27 1980-10-09 Canon Kk Verfahren zur herstellung eines aufzeichnungskopfes
DK429682A (da) * 1982-09-28 1984-03-29 Inflow Aps Integrerede mikroroersystemer til kontinuerlig gennemstroemningsanalyse
JPS60230058A (ja) * 1984-04-27 1985-11-15 Sord Comput Corp ポータブルキャピラリーガスクロマトグラフ装置用シリコンウエハ
JPS60230056A (ja) * 1984-04-27 1985-11-15 Sord Comput Corp キヤピラリ−クロマトグラフ装置のカラム用基板及びその製法
JPH0726948B2 (ja) * 1985-02-20 1995-03-29 株式会社東芝 クロマトグラフイ用カラム及びその製造方法
US4668607A (en) * 1985-03-26 1987-05-26 E. I. Du Pont De Nemours And Company Multilevel imaging of photopolymer relief layer for the preparation of casting molds
JPS6287858A (ja) * 1985-10-14 1987-04-22 Fujikura Ltd キヤピラリ−カラム基板
US4865729A (en) * 1985-11-04 1989-09-12 Sepragen Corporation Radial thin layer chromatography
GB2191110B (en) * 1986-06-06 1989-12-06 Plessey Co Plc Chromatographic separation device
US4713963A (en) * 1986-06-26 1987-12-22 Daryl Sharp Method and device for vacuum chromatography
JPS63271159A (ja) * 1987-04-28 1988-11-09 Seiko Instr & Electronics Ltd 高速液体クロマトグラフに用いるエンプテイカラム
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5037544A (en) * 1988-06-17 1991-08-06 Snyder Thomas A Keyed column chromatography apparatus
US5132012A (en) * 1988-06-24 1992-07-21 Hitachi, Ltd. Liquid chromatograph
JPH0652913B2 (ja) * 1988-09-26 1994-07-06 株式会社テイ・アイ・シイ・シチズン 二線式表示装置
JP2722667B2 (ja) * 1989-05-26 1998-03-04 横河電機株式会社 クロマトグラフィ用カラム
US5126022A (en) * 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
GB2244135B (en) * 1990-05-04 1994-07-13 Gen Electric Co Plc Sensor devices
SE470347B (sv) * 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
US5305015A (en) * 1990-08-16 1994-04-19 Hewlett-Packard Company Laser ablated nozzle member for inkjet printhead
US5291226A (en) * 1990-08-16 1994-03-01 Hewlett-Packard Company Nozzle member including ink flow channels
DE4112528C2 (de) * 1991-04-17 1995-04-06 Kernforschungsz Karlsruhe Spektralfotometer
SE501380C2 (sv) * 1993-06-15 1995-01-30 Pharmacia Lkb Biotech Sätt att tillverka mikrokanal/mikrokavitetsstrukturer
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5688355A (en) * 1994-10-03 1997-11-18 Xerox Corporation Process for fabricating flexible belts using laser ablation
US5571410A (en) * 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5658413A (en) * 1994-10-19 1997-08-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5641400A (en) * 1994-10-19 1997-06-24 Hewlett-Packard Company Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems
US5500071A (en) * 1994-10-19 1996-03-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5645702A (en) * 1995-06-07 1997-07-08 Hewlett-Packard Company Low voltage miniaturized column analytical apparatus and method
US5669997A (en) * 1995-07-13 1997-09-23 Hughes Danbury Optical Systems, Inc. Method of bonding optical members together

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US6093362A (en) 2000-07-25
EP0734282A1 (de) 1996-10-02
US5658413A (en) 1997-08-19
EP0734282A4 (de) 1996-11-20
DE69535259T2 (de) 2007-01-25
JPH09508706A (ja) 1997-09-02
EP0734281B1 (de) 2006-10-11
EP0734281A1 (de) 1996-10-02
DE69535259D1 (de) 2006-11-23
EP0734282B1 (de) 2006-08-16
US6264892B1 (en) 2001-07-24
US6033628A (en) 2000-03-07
US5804022A (en) 1998-09-08
DE69535176T2 (de) 2007-08-23
WO1996012545A1 (en) 1996-05-02
WO1996012546A1 (en) 1996-05-02
US5882571A (en) 1999-03-16
JP3631758B2 (ja) 2005-03-23
EP0734281A4 (de) 1996-11-20

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