DE69534418D1 - Bioarraychip-reaktionsapparatur und ihre herstellung - Google Patents
Bioarraychip-reaktionsapparatur und ihre herstellungInfo
- Publication number
- DE69534418D1 DE69534418D1 DE69534418T DE69534418T DE69534418D1 DE 69534418 D1 DE69534418 D1 DE 69534418D1 DE 69534418 T DE69534418 T DE 69534418T DE 69534418 T DE69534418 T DE 69534418T DE 69534418 D1 DE69534418 D1 DE 69534418D1
- Authority
- DE
- Germany
- Prior art keywords
- bioarraychip
- preparation
- reaction apparatus
- reaction
- bioarraychip reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00364—Pipettes
- B01J2219/00371—Pipettes comprising electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00427—Means for dispensing and evacuation of reagents using masks
- B01J2219/00432—Photolithographic masks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
- B01J2219/00529—DNA chips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
- B01J2219/00531—Sheets essentially square
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
- B01J2219/00536—Sheets in the shape of disks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00547—Bar codes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/0059—Sequential processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00608—DNA chips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/00626—Covalent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
- B01J2219/00662—Two-dimensional arrays within two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B01J2219/00689—Automatic using computers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00695—Synthesis control routines, e.g. using computer programs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00709—Type of synthesis
- B01J2219/00711—Light-directed synthesis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00731—Saccharides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0689—Sealing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0825—Test strips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/12—Libraries containing saccharides or polysaccharides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00158—Elements containing microarrays, i.e. "biochip"
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/97—Test strip or test slide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/973—Simultaneous determination of more than one analyte
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/809—Multifield plates or multicontainer arrays
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/112499—Automated chemical analysis with sample on test slide
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25568294A | 1994-06-08 | 1994-06-08 | |
US255682 | 1994-06-08 | ||
PCT/US1995/007377 WO1995033846A1 (en) | 1994-06-08 | 1995-06-08 | Bioarray chip reaction apparatus and its manufacture |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69534418D1 true DE69534418D1 (de) | 2005-10-06 |
DE69534418T2 DE69534418T2 (de) | 2006-06-22 |
Family
ID=22969439
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69527585T Expired - Lifetime DE69527585T2 (de) | 1994-06-08 | 1995-05-19 | Verfahren und Vorrichtung zum Verpacken von Chips |
DE69534418T Expired - Lifetime DE69534418T2 (de) | 1994-06-08 | 1995-06-08 | Bioarraychip-reaktionsapparatur und ihre herstellung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69527585T Expired - Lifetime DE69527585T2 (de) | 1994-06-08 | 1995-05-19 | Verfahren und Vorrichtung zum Verpacken von Chips |
Country Status (6)
Country | Link |
---|---|
US (4) | US5945334A (de) |
EP (3) | EP0695941B1 (de) |
JP (4) | JPH10505410A (de) |
AU (1) | AU2943695A (de) |
DE (2) | DE69527585T2 (de) |
WO (1) | WO1995033846A1 (de) |
Families Citing this family (402)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6905882B2 (en) | 1992-05-21 | 2005-06-14 | Biosite, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
US6156270A (en) | 1992-05-21 | 2000-12-05 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
US7524456B1 (en) | 1992-05-21 | 2009-04-28 | Biosite Incorporated | Diagnostic devices for the controlled movement of reagents without membranes |
US6767510B1 (en) | 1992-05-21 | 2004-07-27 | Biosite, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
US20060229824A1 (en) | 1993-10-26 | 2006-10-12 | Affymetrix, Inc. | Arrays of nucleic acid probes for analyzing biotransformation genes |
US6090555A (en) * | 1997-12-11 | 2000-07-18 | Affymetrix, Inc. | Scanned image alignment systems and methods |
US5631734A (en) | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
US6741344B1 (en) * | 1994-02-10 | 2004-05-25 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
US6287850B1 (en) * | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
DE69527585T2 (de) * | 1994-06-08 | 2003-04-03 | Affymetrix Inc | Verfahren und Vorrichtung zum Verpacken von Chips |
US5959098A (en) * | 1996-04-17 | 1999-09-28 | Affymetrix, Inc. | Substrate preparation process |
US6239273B1 (en) | 1995-02-27 | 2001-05-29 | Affymetrix, Inc. | Printing molecular library arrays |
US6720149B1 (en) * | 1995-06-07 | 2004-04-13 | Affymetrix, Inc. | Methods for concurrently processing multiple biological chip assays |
US6953663B1 (en) | 1995-11-29 | 2005-10-11 | Affymetrix, Inc. | Polymorphism detection |
US6300063B1 (en) | 1995-11-29 | 2001-10-09 | Affymetrix, Inc. | Polymorphism detection |
US6660233B1 (en) * | 1996-01-16 | 2003-12-09 | Beckman Coulter, Inc. | Analytical biochemistry system with robotically carried bioarray |
US6114122A (en) | 1996-03-26 | 2000-09-05 | Affymetrix, Inc. | Fluidics station with a mounting system and method of using |
US5942443A (en) * | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
US5885470A (en) * | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
US6706875B1 (en) | 1996-04-17 | 2004-03-16 | Affyemtrix, Inc. | Substrate preparation process |
FR2748156B1 (fr) * | 1996-04-26 | 1998-08-07 | Suisse Electronique Microtech | Dispositif comprenant deux substrats destines a former un microsysteme ou une partie d'un microsysteme et procede d'assemblage de deux substrats micro-usines |
JP2000512744A (ja) | 1996-05-16 | 2000-09-26 | アフィメトリックス,インコーポレイテッド | 標識材料を検出するシステムおよび方法 |
NZ333346A (en) | 1996-06-28 | 2000-03-27 | Caliper Techn Corp | High-throughput screening assay systems in microscale fluidic devices |
US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
US6875620B1 (en) * | 1996-10-31 | 2005-04-05 | Agilent Technologies, Inc. | Tiling process for constructing a chemical array |
EP0946287B1 (de) * | 1996-11-18 | 2004-08-18 | Novartis AG | Vorrichtung zur polymersynthese |
US6083763A (en) * | 1996-12-31 | 2000-07-04 | Genometrix Inc. | Multiplexed molecular analysis apparatus and method |
US6425972B1 (en) * | 1997-06-18 | 2002-07-30 | Calipher Technologies Corp. | Methods of manufacturing microfabricated substrates |
DE19734706A1 (de) * | 1997-08-11 | 1999-02-18 | Fraunhofer Ges Forschung | Piezoelektrischer Resonator, Verfahren zur Herstellung des Resonators sowie dessen Einsatz als Sensorelement zum Erfassen der Konzentration eines in einem Fluid enthaltenen Stoffes und/oder der Bestimmung physikalischer Eigenschaften des Fluids |
US6440725B1 (en) * | 1997-12-24 | 2002-08-27 | Cepheid | Integrated fluid manipulation cartridge |
US6540895B1 (en) | 1997-09-23 | 2003-04-01 | California Institute Of Technology | Microfabricated cell sorter for chemical and biological materials |
US20100105572A1 (en) * | 1997-12-19 | 2010-04-29 | Kris Richard M | High throughput assay system |
US20030039967A1 (en) * | 1997-12-19 | 2003-02-27 | Kris Richard M. | High throughput assay system using mass spectrometry |
US20030096232A1 (en) * | 1997-12-19 | 2003-05-22 | Kris Richard M. | High throughput assay system |
US6050719A (en) * | 1998-01-30 | 2000-04-18 | Affymetrix, Inc. | Rotational mixing method using a cartridge having a narrow interior |
EP2189791A3 (de) | 1998-02-04 | 2011-03-09 | Life Technologies Corporation | Mikroarrays und Verwendungen dafür |
AU2586799A (en) | 1998-02-06 | 1999-08-23 | Affymetrix, Inc. | Method of quality control in manufacturing processes |
US6150147A (en) * | 1998-02-06 | 2000-11-21 | Affymetrix, Inc. | Biological array fabrication methods with reduction of static charge |
US7095032B2 (en) * | 1998-03-20 | 2006-08-22 | Montagu Jean I | Focusing of microscopes and reading of microarrays |
US6472671B1 (en) * | 2000-02-09 | 2002-10-29 | Jean I. Montagu | Quantified fluorescence microscopy |
CA2320296A1 (en) * | 1998-05-18 | 1999-11-25 | University Of Washington | Liquid analysis cartridge |
US6830729B1 (en) | 1998-05-18 | 2004-12-14 | University Of Washington | Sample analysis instrument |
US6761816B1 (en) * | 1998-06-23 | 2004-07-13 | Clinical Micro Systems, Inc. | Printed circuit boards with monolayers and capture ligands |
US6908770B1 (en) * | 1998-07-16 | 2005-06-21 | Board Of Regents, The University Of Texas System | Fluid based analysis of multiple analytes by a sensor array |
US6132685A (en) * | 1998-08-10 | 2000-10-17 | Caliper Technologies Corporation | High throughput microfluidic systems and methods |
US6759014B2 (en) * | 2001-01-26 | 2004-07-06 | Symyx Technologies, Inc. | Apparatus and methods for parallel processing of multiple reaction mixtures |
US6913934B2 (en) * | 1998-08-13 | 2005-07-05 | Symyx Technologies, Inc. | Apparatus and methods for parallel processing of multiple reaction mixtures |
US6186659B1 (en) | 1998-08-21 | 2001-02-13 | Agilent Technologies Inc. | Apparatus and method for mixing a film of fluid |
DE69916421T2 (de) * | 1998-09-09 | 2005-03-24 | Hitachi Software Engineering Co., Ltd., Yokohama | Biochip und verfahren zur verwendung des biochips |
FR2784751B1 (fr) * | 1998-10-20 | 2001-02-02 | Mesatronic | Boitier de logement d'une puce electronique a sondes biologiques |
DE19853640C2 (de) * | 1998-11-20 | 2002-01-31 | Molecular Machines & Ind Gmbh | Mehrgefäßanordnung mit verbesserter Empfindlichkeit für die optische Analytik, Verfahren zu ihrer Herstellung sowie ihre Verwendung in optischen Analyseverfahren |
US6130745A (en) * | 1999-01-07 | 2000-10-10 | Biometric Imaging, Inc. | Optical autofocus for use with microtiter plates |
US20020177135A1 (en) * | 1999-07-27 | 2002-11-28 | Doung Hau H. | Devices and methods for biochip multiplexing |
US20040053290A1 (en) * | 2000-01-11 | 2004-03-18 | Terbrueggen Robert Henry | Devices and methods for biochip multiplexing |
US7312087B2 (en) * | 2000-01-11 | 2007-12-25 | Clinical Micro Sensors, Inc. | Devices and methods for biochip multiplexing |
US6518056B2 (en) * | 1999-04-27 | 2003-02-11 | Agilent Technologies Inc. | Apparatus, systems and method for assaying biological materials using an annular format |
US20040203047A1 (en) * | 1999-04-30 | 2004-10-14 | Caren Michael P. | Polynucleotide array fabrication |
US7276336B1 (en) | 1999-07-22 | 2007-10-02 | Agilent Technologies, Inc. | Methods of fabricating an addressable array of biopolymer probes |
US6225109B1 (en) * | 1999-05-27 | 2001-05-01 | Orchid Biosciences, Inc. | Genetic analysis device |
FR2795476B1 (fr) * | 1999-06-22 | 2001-07-27 | Biomerieux Sa | Vanne permettant de diriger un fluide dans une carte d'analyse |
EP1360992A3 (de) * | 1999-06-22 | 2004-05-19 | Caliper Life Sciences, Inc. | Apparat zur Bedienung eines mikrofluidischen Gerätes |
US6811668B1 (en) | 1999-06-22 | 2004-11-02 | Caliper Life Sciences, Inc. | Apparatus for the operation of a microfluidic device |
US6258593B1 (en) | 1999-06-30 | 2001-07-10 | Agilent Technologies Inc. | Apparatus for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber |
IL147227A0 (en) | 1999-07-02 | 2002-08-14 | Clondiag Chip Tech Gmbh | Microchip matrix device for duplicating and characterizing nucleic acids |
JP3471664B2 (ja) | 1999-07-08 | 2003-12-02 | Nec液晶テクノロジー株式会社 | 液晶セル用貼り合わせ基板の分断装置 |
FR2796571B1 (fr) * | 1999-07-19 | 2001-09-14 | Bio Merieux | Dispositif d'analyse avec une biopuce |
US6864050B2 (en) | 1999-07-30 | 2005-03-08 | Affymetrix, Inc. | Single-phase amplification of nucleic acids |
US6653151B2 (en) | 1999-07-30 | 2003-11-25 | Large Scale Proteomics Corporation | Dry deposition of materials for microarrays using matrix displacement |
US6713309B1 (en) | 1999-07-30 | 2004-03-30 | Large Scale Proteomics Corporation | Microarrays and their manufacture |
US7179638B2 (en) | 1999-07-30 | 2007-02-20 | Large Scale Biology Corporation | Microarrays and their manufacture by slicing |
US6495104B1 (en) * | 1999-08-19 | 2002-12-17 | Caliper Technologies Corp. | Indicator components for microfluidic systems |
US6784982B1 (en) | 1999-11-04 | 2004-08-31 | Regents Of The University Of Minnesota | Direct mapping of DNA chips to detector arrays |
US6867851B2 (en) * | 1999-11-04 | 2005-03-15 | Regents Of The University Of Minnesota | Scanning of biological samples |
US6569674B1 (en) | 1999-12-15 | 2003-05-27 | Amersham Biosciences Ab | Method and apparatus for performing biological reactions on a substrate surface |
US6589778B1 (en) | 1999-12-15 | 2003-07-08 | Amersham Biosciences Ab | Method and apparatus for performing biological reactions on a substrate surface |
US6642046B1 (en) * | 1999-12-09 | 2003-11-04 | Motorola, Inc. | Method and apparatus for performing biological reactions on a substrate surface |
US6420114B1 (en) * | 1999-12-06 | 2002-07-16 | Incyte Genomics, Inc. | Microarray hybridization chamber |
CA2394275A1 (en) * | 1999-12-15 | 2001-06-21 | Motorola, Inc. | Apparatus for performing biological reactions |
US20030091477A1 (en) * | 1999-12-22 | 2003-05-15 | Paul Eric A. | Flow-thru chip cartridge, chip holder, system & method thereof |
FR2803225B1 (fr) * | 1999-12-29 | 2002-06-14 | Biomerieux Sa | Appareil d'analyse a compartiment reactionnel a geometrie variable, procede de mixage et de guidage de liquides |
DE10002920A1 (de) * | 2000-01-19 | 2001-07-26 | Epigenomics Ag | Kontaktierungsvorrichtung |
US6587579B1 (en) | 2000-01-26 | 2003-07-01 | Agilent Technologies Inc. | Feature quality in array fabrication |
US6458526B1 (en) | 2000-01-28 | 2002-10-01 | Agilent Technologies, Inc. | Method and apparatus to inhibit bubble formation in a fluid |
AU2001238011A1 (en) * | 2000-01-31 | 2001-08-07 | Board Of Regents, The University Of Texas System | System for transferring fluid samples through a sensor array |
FR2806009B1 (fr) | 2000-03-07 | 2002-05-31 | Bio Merieux | Procede de mise en oeuvre d'une carte d'analyse |
WO2001083827A1 (en) | 2000-05-04 | 2001-11-08 | Yale University | High density protein arrays for screening of protein activity |
SG91870A1 (en) * | 2000-05-26 | 2002-10-15 | Casem Asia Pte Ltd | Method and device for bleed out control in solder bonding |
DE10026647A1 (de) * | 2000-05-29 | 2001-12-06 | Merck Patent Gmbh | Positioniervorrichtung |
JP4644914B2 (ja) * | 2000-06-02 | 2011-03-09 | 株式会社村田製作所 | プローブアレイ用固相基材、およびプローブアレイ |
DE10027524A1 (de) * | 2000-06-02 | 2001-12-13 | Max Planck Gesellschaft | Vorrichtung und Verfahren zur Bearbeitung von substratgebundenen Proben |
US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
EP1161984A1 (de) * | 2000-06-08 | 2001-12-12 | F. Hoffmann-La Roche Ag | Vorrichtung zum Verpacken eines chipförmigen Trägers und Verfahren zum Zusammenbau einer Vielzahl derartiger Träger |
EP1161989B8 (de) * | 2000-06-08 | 2007-11-07 | F.Hoffmann-La Roche Ag | Vorrichtung zum Verpacken eines chipförmigen Trägers und Montageverfahren für eine Vielzahl solcher Träger |
US7158224B2 (en) * | 2000-06-25 | 2007-01-02 | Affymetrix, Inc. | Optically active substrates |
AU7166201A (en) * | 2000-06-28 | 2002-01-08 | Illumina Inc | Composite arrays utilizing microspheres with a hybridization chamber |
CN1137999C (zh) * | 2000-07-04 | 2004-02-11 | 清华大学 | 集成式微阵列装置 |
US6511277B1 (en) * | 2000-07-10 | 2003-01-28 | Affymetrix, Inc. | Cartridge loader and methods |
US6833920B2 (en) * | 2000-07-11 | 2004-12-21 | Maven Technologies Llc | Apparatus and method for imaging |
US6594011B1 (en) | 2000-07-11 | 2003-07-15 | Maven Technologies, Llc | Imaging apparatus and method |
US7193711B2 (en) * | 2000-07-11 | 2007-03-20 | Maven Technologies, Llc | Imaging method and apparatus |
US7518724B2 (en) * | 2000-07-11 | 2009-04-14 | Maven Technologies | Image acquisition, processing, and display |
US7023547B2 (en) | 2000-07-11 | 2006-04-04 | Maven Technologies, Llc | Apparatus including a biochip for imaging of biological samples and method |
US7126688B2 (en) * | 2000-07-11 | 2006-10-24 | Maven Technologies, Llc | Microarray scanning |
DE10037687A1 (de) * | 2000-08-01 | 2002-02-14 | Trace Biotech Ag | Verfahren zur Herstellung von Oligonucleotid-Arrays und zur Durchführung von Hybridisierungs-Assays sowie Anlagen zur Durchführung dieser Verfahren |
US6422249B1 (en) | 2000-08-10 | 2002-07-23 | Affymetrix Inc. | Cartridge washing system and methods |
US20040185464A1 (en) * | 2000-09-15 | 2004-09-23 | Kris Richard M. | High throughput assay system |
GB0022978D0 (en) | 2000-09-19 | 2000-11-01 | Oxford Glycosciences Uk Ltd | Detection of peptides |
US6864097B1 (en) * | 2000-09-27 | 2005-03-08 | Agilent Technologies, Inc. | Arrays and their reading |
US20060141507A1 (en) * | 2000-09-27 | 2006-06-29 | Kronick Mel N | Manufacture and use of non-standard size microarray slides |
DE60125312T2 (de) * | 2000-10-26 | 2007-06-06 | Agilent Technologies, Inc. (n.d. Ges. d. Staates Delaware), Santa Clara | Mikroarray |
JP3921047B2 (ja) * | 2000-12-11 | 2007-05-30 | 日立ソフトウエアエンジニアリング株式会社 | ハイブリダイゼーション反応装置及びハイブリダイゼーション方法 |
WO2002051537A2 (en) * | 2000-12-22 | 2002-07-04 | Burstein Technologies, Inc. | Optical bio-discs and methods relating thereto |
ATE281232T1 (de) | 2000-12-28 | 2004-11-15 | Hoffmann La Roche | Verfahren zur behandlung von nukleinsaüreproben mittels schwingung eines teiles einer kartuschenwandung, system und kartusche zur durchführung desselben |
ATE337093T1 (de) * | 2000-12-28 | 2006-09-15 | Hoffmann La Roche | Verfahren, system und patrone zur verarbeitung einer nukleinsäure-probe durch oszillation der patrone |
DE20100345U1 (de) * | 2001-01-09 | 2002-05-23 | Evotec Biosystems Ag | Probenträger |
US6746649B2 (en) * | 2001-01-31 | 2004-06-08 | Agilent Technologies, Inc. | Reaction chamber roll pump |
US6879915B2 (en) | 2001-01-31 | 2005-04-12 | Agilent Technologies, Inc. | Chemical array fabrication and use |
US20030170148A1 (en) * | 2001-01-31 | 2003-09-11 | Mcentee John F. | Reaction chamber roll pump |
US7112305B2 (en) * | 2001-01-31 | 2006-09-26 | Agilent Technologies, Inc. | Automation-optimized microarray package |
WO2002063270A2 (en) * | 2001-02-05 | 2002-08-15 | Board Of Regents, The University Of Texas System | The use of mesoscale self-assembly and recognition to effect delivery of sensing reagent for arrayed sensors |
JP4148778B2 (ja) | 2001-03-09 | 2008-09-10 | バイオミクロ システムズ インコーポレイティッド | アレイとのミクロ流体的インターフェース機器 |
AU2002307152A1 (en) | 2001-04-06 | 2002-10-21 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
US6943036B2 (en) * | 2001-04-30 | 2005-09-13 | Agilent Technologies, Inc. | Error detection in chemical array fabrication |
DE10122457A1 (de) * | 2001-05-09 | 2002-11-21 | Bosch Gmbh Robert | Behälter für einen Analyse-Chip |
US20050009101A1 (en) * | 2001-05-17 | 2005-01-13 | Motorola, Inc. | Microfluidic devices comprising biochannels |
DE50202157D1 (de) | 2001-05-25 | 2005-03-10 | Tecan Trading Ag Maennedorf | System mit Verfahrenseinheit zum Hybridisieren von Nukleinsäureproben, Proteinen und Gewebeschnitten |
US20030008310A1 (en) * | 2001-05-29 | 2003-01-09 | Williams Jeffrey S. | Method and apparatus for facilitating the creation and analysis of microarrays |
US7294478B1 (en) | 2001-06-06 | 2007-11-13 | Rosetta Inpharmatics Llc | Microarray reaction cartridge |
US6485918B1 (en) | 2001-07-02 | 2002-11-26 | Packard Bioscience Corporation | Method and apparatus for incubation of a liquid reagent and target spots on a microarray substrate |
US7297553B2 (en) * | 2002-05-28 | 2007-11-20 | Nanosphere, Inc. | Method for attachment of silylated molecules to glass surfaces |
US7687437B2 (en) | 2001-07-13 | 2010-03-30 | Nanosphere, Inc. | Method for immobilizing molecules onto surfaces |
EP1439910A2 (de) * | 2001-07-26 | 2004-07-28 | Motorola, Inc. | System und verfahren zum mischen in einer mikrofluiden vorrichtung |
EP1281439A1 (de) * | 2001-07-30 | 2003-02-05 | F. Hoffmann-La Roche Ag | Vorrichtung zur Aufnahme eines chipförmigen Trägers und Verfahren zum Zusammenbau mehrerer solcher Vorrichtungen |
EP1281966A3 (de) * | 2001-07-30 | 2003-06-18 | Fuji Photo Film Co., Ltd. | Verfahren und Vorrichtung zur Durchführung einer Rezeptor-Ligand-Reaktion |
JP2003057236A (ja) * | 2001-08-10 | 2003-02-26 | Inst Of Physical & Chemical Res | 生体分子マイクロアレイの製造方法及びスポット装置 |
EP1425090A2 (de) * | 2001-09-07 | 2004-06-09 | Corning Incorporated | Mikrosäulenbasierte anordnung zur hochdurchsatz analyse |
WO2003027221A1 (en) * | 2001-09-23 | 2003-04-03 | Irm Llc | Closed cell washer |
US6767733B1 (en) | 2001-10-10 | 2004-07-27 | Pritest, Inc. | Portable biosensor apparatus with controlled flow |
US20030087289A1 (en) * | 2001-10-12 | 2003-05-08 | Harry Zuzan | Image analysis of high-density synthetic DNA microarrays |
US20030113724A1 (en) * | 2001-10-12 | 2003-06-19 | Schembri Carol T. | Packaged microarray apparatus and a method of bonding a microarray into a package |
WO2003033128A2 (en) * | 2001-10-12 | 2003-04-24 | Duke University | Methods for image analysis of high-density synthetic dna microarrays |
US7691333B2 (en) | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
WO2003048295A1 (en) | 2001-11-30 | 2003-06-12 | Fluidigm Corporation | Microfluidic device and methods of using same |
US20040038388A1 (en) * | 2001-12-19 | 2004-02-26 | Affymetrix, Inc. | Manufacturing process for array plate assembly |
US7335153B2 (en) | 2001-12-28 | 2008-02-26 | Bio Array Solutions Ltd. | Arrays of microparticles and methods of preparation thereof |
US20040020993A1 (en) * | 2001-12-28 | 2004-02-05 | Green Larry R. | Method for luminescent identification and calibration |
DE10201463B4 (de) | 2002-01-16 | 2005-07-21 | Clondiag Chip Technologies Gmbh | Reaktionsgefäß zur Durchführung von Array-Verfahren |
JP3818926B2 (ja) * | 2002-02-04 | 2006-09-06 | 富士写真フイルム株式会社 | リセプター・リガンド会合反応方法 |
CA2422224A1 (en) | 2002-03-15 | 2003-09-15 | Affymetrix, Inc. | System, method, and product for scanning of biological materials |
US6916621B2 (en) | 2002-03-27 | 2005-07-12 | Spectral Genomics, Inc. | Methods for array-based comparitive binding assays |
AU2003224817B2 (en) | 2002-04-01 | 2008-11-06 | Fluidigm Corporation | Microfluidic particle-analysis systems |
US8257967B2 (en) * | 2002-04-26 | 2012-09-04 | Board Of Regents, The University Of Texas System | Method and system for the detection of cardiac risk factors |
US20040060987A1 (en) * | 2002-05-07 | 2004-04-01 | Green Larry R. | Digital image analysis method for enhanced and optimized signals in fluorophore detection |
US20030208936A1 (en) * | 2002-05-09 | 2003-11-13 | Lee Charles Hee | Method for manufacturing embroidery decorated cards and envelopes |
JP4409426B2 (ja) * | 2002-05-28 | 2010-02-03 | オウトジエノミクス・インコーポレーテツド | マイクロアレイ検出器および方法 |
US6939673B2 (en) * | 2002-06-14 | 2005-09-06 | Agilent Technologies, Inc. | Manufacture of arrays with reduced error impact |
US20030232427A1 (en) * | 2002-06-18 | 2003-12-18 | Montagu Jean I. | Optically active substrates for examination of biological materials |
US20030235518A1 (en) * | 2002-06-21 | 2003-12-25 | Shea Laurence R. | Array assay devices and methods of using the same |
US7223592B2 (en) * | 2002-06-21 | 2007-05-29 | Agilent Technologies, Inc. | Devices and methods for performing array based assays |
US7220573B2 (en) * | 2002-06-21 | 2007-05-22 | Agilent Technologies, Inc. | Array assay devices and methods of using the same |
US7080766B2 (en) * | 2002-07-01 | 2006-07-25 | Agilent Technologies, Inc. | Manufacture of singulated supports comprising arrays |
US7154598B2 (en) * | 2002-07-12 | 2006-12-26 | Decision Biomarkers, Inc. | Excitation and imaging of fluorescent arrays |
US20040101444A1 (en) * | 2002-07-15 | 2004-05-27 | Xeotron Corporation | Apparatus and method for fluid delivery to a hybridization station |
EP1385006A3 (de) * | 2002-07-24 | 2004-09-01 | F. Hoffmann-La Roche Ag | System und Patrone zur Verarbeitung einer biologischen Probe |
US7452712B2 (en) | 2002-07-30 | 2008-11-18 | Applied Biosystems Inc. | Sample block apparatus and method of maintaining a microcard on a sample block |
JP4057967B2 (ja) * | 2002-07-31 | 2008-03-05 | 株式会社東芝 | 塩基配列自動解析装置 |
US7745203B2 (en) | 2002-07-31 | 2010-06-29 | Kabushiki Kaisha Toshiba | Base sequence detection apparatus and base sequence automatic analyzing apparatus |
US20060127946A1 (en) * | 2002-08-16 | 2006-06-15 | Montagu Jean I | Reading of fluorescent arrays |
US7384742B2 (en) * | 2002-08-16 | 2008-06-10 | Decision Biomarkers, Inc. | Substrates for isolating reacting and microscopically analyzing materials |
US20040043494A1 (en) * | 2002-08-30 | 2004-03-04 | Amorese Douglas A. | Apparatus for studying arrays |
US20060147924A1 (en) * | 2002-09-11 | 2006-07-06 | Ramsing Neils B | Population of nucleic acids including a subpopulation of lna oligomers |
EP2298448A3 (de) | 2002-09-25 | 2012-05-30 | California Institute of Technology | Hochintegriertes mikrofluidisches Netzwerk |
WO2004040001A2 (en) | 2002-10-02 | 2004-05-13 | California Institute Of Technology | Microfluidic nucleic acid analysis |
US6913931B2 (en) * | 2002-10-03 | 2005-07-05 | 3M Innovative Properties Company | Devices, methods and systems for low volume microarray processing |
US20040120861A1 (en) * | 2002-10-11 | 2004-06-24 | Affymetrix, Inc. | System and method for high-throughput processing of biological probe arrays |
US20040219565A1 (en) * | 2002-10-21 | 2004-11-04 | Sakari Kauppinen | Oligonucleotides useful for detecting and analyzing nucleic acids of interest |
JP3883951B2 (ja) * | 2002-10-24 | 2007-02-21 | 富士フイルムホールディングス株式会社 | 生化学解析用ユニットを利用したアッセイ法および生化学解析装置 |
EP1419821A1 (de) * | 2002-11-14 | 2004-05-19 | F. Hoffmann-La Roche Ag | Verfahren, Vorrichtung und Reaktionsbehälter zur Bearbeitung von biologischen Proben |
EP1419820A1 (de) * | 2002-11-14 | 2004-05-19 | F. Hoffmann-La Roche Ag | Verfahren, Vorrichtung und Reaktionbehälter zur Bearbeitung von biologischen Proben |
US20040101861A1 (en) * | 2002-11-27 | 2004-05-27 | Little Roger G. | Resonant cavity photodiode array for rapid DNA microarray readout |
JP3969651B2 (ja) * | 2002-11-28 | 2007-09-05 | 住友ベークライト株式会社 | マイクロアレイ用プラスチック基板 |
US20040259111A1 (en) * | 2002-12-10 | 2004-12-23 | Rosetta Inpharmatics Llc | Automated system and method for preparing an assay ready biological sample |
US20040126766A1 (en) * | 2002-12-26 | 2004-07-01 | Amorese Douglas A. | Breakaway seal for processing a subarray of an array |
US7041481B2 (en) | 2003-03-14 | 2006-05-09 | The Regents Of The University Of California | Chemical amplification based on fluid partitioning |
US8828663B2 (en) | 2005-03-18 | 2014-09-09 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US7604965B2 (en) | 2003-04-03 | 2009-10-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US7476363B2 (en) | 2003-04-03 | 2009-01-13 | Fluidigm Corporation | Microfluidic devices and methods of using same |
US20050145496A1 (en) | 2003-04-03 | 2005-07-07 | Federico Goodsaid | Thermal reaction device and method for using the same |
DE10316723A1 (de) * | 2003-04-09 | 2004-11-18 | Siemens Ag | Probenplatte zum Einbau in eine Gehäusestruktur |
US8652774B2 (en) * | 2003-04-16 | 2014-02-18 | Affymetrix, Inc. | Automated method of manufacturing polyer arrays |
DE10318219A1 (de) * | 2003-04-22 | 2004-11-11 | Febit Ag | Handhabungs- und Schutzgehäuse für einen Biochip, insbesondere für einen mikrofluidischen Reaktionsträger |
WO2004097371A2 (en) * | 2003-04-25 | 2004-11-11 | Board Of Regents, The University Of Texas System | System and method for the detection of analytes |
DE10319712A1 (de) * | 2003-05-02 | 2004-11-25 | Sirs-Lab Gmbh | Vorrichtung zur Aufnahme von Proben bei Vervielfältigungsreaktionen |
WO2004104922A2 (en) * | 2003-05-16 | 2004-12-02 | Board Of Regents, The University Of Texas System | Image and part recognition technology |
US9317922B2 (en) | 2003-05-16 | 2016-04-19 | Board Of Regents The University Of Texas System | Image and part recognition technology |
US20040235147A1 (en) * | 2003-05-21 | 2004-11-25 | Affymetrix, Inc. | System, method, and encased probe array product |
DE10323197B4 (de) * | 2003-05-22 | 2008-10-02 | Clondiag Chip Technologies Gmbh | Vorrichtung zur Halterung und Detektion von Substanzbibliotheken |
US20040241659A1 (en) * | 2003-05-30 | 2004-12-02 | Applera Corporation | Apparatus and method for hybridization and SPR detection |
EP1629285A2 (de) * | 2003-06-05 | 2006-03-01 | Bioprocessors Corporation | System und verfahren zur prozessautomatisierung |
EP1628754A2 (de) * | 2003-06-05 | 2006-03-01 | Bioprocessors Corporation | Vorrichtung und verfahren zur behandlung von substraten |
US20040248323A1 (en) | 2003-06-09 | 2004-12-09 | Protometrix, Inc. | Methods for conducting assays for enzyme activity on protein microarrays |
EP2402089A1 (de) | 2003-07-31 | 2012-01-04 | Handylab, Inc. | Verarbeitung partikelhaltiger Proben |
DE10336375A1 (de) * | 2003-08-06 | 2004-12-02 | Infineon Technologies Ag | Verfahren zum Bestücken von Probenhaltern mit Biochips und Vorrichtungen zur Durchführung des Verfahrens |
US7317415B2 (en) | 2003-08-08 | 2008-01-08 | Affymetrix, Inc. | System, method, and product for scanning of biological materials employing dual analog integrators |
DE10336849A1 (de) | 2003-08-11 | 2005-03-10 | Thinxxs Gmbh | Flusszelle |
US7998435B2 (en) | 2003-09-19 | 2011-08-16 | Life Technologies Corporation | High density plate filler |
US9492820B2 (en) | 2003-09-19 | 2016-11-15 | Applied Biosystems, Llc | High density plate filler |
US7695688B2 (en) * | 2003-09-19 | 2010-04-13 | Applied Biosystems, Llc | High density plate filler |
US8277760B2 (en) | 2003-09-19 | 2012-10-02 | Applied Biosystems, Llc | High density plate filler |
US7407630B2 (en) | 2003-09-19 | 2008-08-05 | Applera Corporation | High density plate filler |
CA2544178A1 (en) * | 2003-10-30 | 2005-05-19 | Tufts-New England Medical Center | Prenatal diagnosis using cell-free fetal dna in amniotic fluid |
EP1682902A2 (de) * | 2003-11-04 | 2006-07-26 | Roche Diagnostics GmbH | Methode zur unterscheidung von mll-ptd positiven aml von anderen aml subtypen |
WO2005043161A2 (en) * | 2003-11-04 | 2005-05-12 | Roche Diagnostics Gmbh | Method for distinguishing leukemia subtypes |
US20070105118A1 (en) * | 2003-11-04 | 2007-05-10 | Martin Dugas | Method for distinguishing aml subtypes with recurring genetic aberrations |
EP1530046A1 (de) * | 2003-11-04 | 2005-05-11 | Ludwig-Maximilians-Universität München | Methode zur Unterscheidung von AML Subtypen mit verändertem Karyotyp mit mittelmässiger Prognose |
US20070128607A1 (en) * | 2003-11-04 | 2007-06-07 | Martin Dugas | Method for distinguishing aml subtypes with different gene dosages |
EP1682903A2 (de) * | 2003-11-04 | 2006-07-26 | Roche Diagnostics GmbH | Methode zur unterscheidung zwischen aml-spezifischen flt3 längenmutationen und tkd mutationen |
US20070212688A1 (en) * | 2003-11-04 | 2007-09-13 | Martin Dugas | Method For Distinguishing Cbf-Positive Aml Subtypes From Cbf-Negative Aml Subtypes |
WO2005045435A2 (en) * | 2003-11-04 | 2005-05-19 | Roche Diagnostics Gmbh | METHOD FOR DISTINGUISHING T(11q23)/MLL-POSITIVE LEUKEMIAS FROM T(11q23)MLL NEGATIVE LEUKEMIAS |
US20070207459A1 (en) * | 2003-11-04 | 2007-09-06 | Martin Dugas | Method For Distinguishing Immunologically Defined All Subtype |
EP1533618A1 (de) * | 2003-11-04 | 2005-05-25 | Ludwig-Maximilians-Universität München | Methode zur Unterscheidung prognostisch definierbarer AML |
DE10352716A1 (de) * | 2003-11-05 | 2005-06-16 | Einsle, Xaver | Plattform |
KR100695123B1 (ko) | 2003-12-03 | 2007-03-14 | 삼성전자주식회사 | Tm에 따라 기판상에 고정화된 프로브 폴리뉴클레오티드군을 2이상 포함하는 폴리뉴클레오티드 어레이 및 그를이용하는 표적 핵산 검출 방법 |
AU2004300168A1 (en) * | 2003-12-11 | 2005-06-30 | Board Of Regents, The University Of Texas System | Method and system for the analysis of saliva using a sensor array |
KR100601936B1 (ko) * | 2003-12-17 | 2006-07-14 | 삼성전자주식회사 | 접착부 지지체와 2이상의 접착물질을 갖는 마이크로어레이반응 챔버용 패취 |
US20080233564A1 (en) * | 2004-01-08 | 2008-09-25 | The Ohio State University | Methods of Using Databases to Greate Gene-Expression Microarrays, Microarrays Greated Thereby, and Uses of the Microarrays |
US20050180894A1 (en) * | 2004-02-13 | 2005-08-18 | Affymetrix, Inc. | System, method, and product for efficient fluid transfer using and addressable adaptor |
US8101431B2 (en) | 2004-02-27 | 2012-01-24 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems |
US8105849B2 (en) | 2004-02-27 | 2012-01-31 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
WO2005113834A2 (en) * | 2004-05-20 | 2005-12-01 | Quest Diagnostics Investments Incorporated | Single label comparative hybridization |
EP1612561A1 (de) * | 2004-07-02 | 2006-01-04 | Roche Diagnostics GmbH | Instrument zur leistungsfähigen Verarbeitung von Analysevorrichtungen |
DE202004011272U1 (de) * | 2004-07-17 | 2004-09-09 | Tecan Trading Ag | Vorrichtung zum Bereitstellen einer Hybridisierkammer und zum Beeinflussen von Luftblasen in derselben |
KR100668304B1 (ko) * | 2004-09-16 | 2007-01-12 | 삼성전자주식회사 | Pcr 혼합액을 pcr 칩의 각 pcr 채널에 주입하기위한 장치 및 상기 장치를 포함하는 pcr 칩 유니트 |
WO2007018563A2 (en) * | 2004-10-05 | 2007-02-15 | Wyeth | Probe arrays for detecting multiple strains of different species |
KR100601966B1 (ko) * | 2004-10-07 | 2006-07-18 | 삼성전자주식회사 | 마이크로 칩 유니트 및 상기 마이크로 칩 유니트를이용하여 생화학 반응을 수행하는 방법 |
US7682782B2 (en) | 2004-10-29 | 2010-03-23 | Affymetrix, Inc. | System, method, and product for multiple wavelength detection using single source excitation |
CA2524964A1 (en) * | 2004-10-29 | 2006-04-29 | Affymetrix, Inc. | Automated method of manufacturing polymer arrays |
US20090118132A1 (en) * | 2004-11-04 | 2009-05-07 | Roche Molecular Systems, Inc. | Classification of Acute Myeloid Leukemia |
DE102004056735A1 (de) | 2004-11-09 | 2006-07-20 | Clondiag Chip Technologies Gmbh | Vorrichtung für die Durchführung und Analyse von Mikroarray-Experimenten |
JP4761241B2 (ja) * | 2004-11-18 | 2011-08-31 | 独立行政法人理化学研究所 | 生体分子の相互作用試験装置、生体分子の相互作用試験方法、生体分子の融解温度測定方法、核酸の配列検知方法 |
US20100256004A1 (en) * | 2004-11-18 | 2010-10-07 | Riken | Device of Testing Interaction Between Biomolecules, Method of Testing Interaction Between Biomolecules,Method of Measuring Melting Temperature of Biomolecule,Method of Sequencing Nucleic Acid,Method of Causing Interaction Between Biomolecules,and Method of Causing Migration of Biomolecule |
JP4610309B2 (ja) * | 2004-11-19 | 2011-01-12 | 独立行政法人理化学研究所 | 生体分子を相互作用させる方法、および、生体分子を移動させる方法 |
EP1842045A4 (de) * | 2005-01-18 | 2009-04-15 | Solus Biosystems Inc | Screening mehrerer proben mittels ir-spektroskopie |
WO2006081353A2 (en) * | 2005-01-27 | 2006-08-03 | Quest Diagnostics Investments Incorporated | Rapid comparative genome hybridization |
US7405831B2 (en) | 2005-02-01 | 2008-07-29 | Purdue Research Foundation | Laser scanning interferometric surface metrology |
US7910356B2 (en) | 2005-02-01 | 2011-03-22 | Purdue Research Foundation | Multiplexed biological analyzer planar array apparatus and methods |
US20070023643A1 (en) | 2005-02-01 | 2007-02-01 | Nolte David D | Differentially encoded biological analyzer planar array apparatus and methods |
KR100624464B1 (ko) * | 2005-03-29 | 2006-09-19 | 삼성전자주식회사 | 반자동 마이크로 칩 개폐장치 |
US20060246576A1 (en) * | 2005-04-06 | 2006-11-02 | Affymetrix, Inc. | Fluidic system and method for processing biological microarrays in personal instrumentation |
AU2006309284B2 (en) | 2005-05-31 | 2012-08-02 | Board Of Regents, The University Of Texas System | Methods and compositions related to determination and use of white blood cell counts |
CA2610875A1 (en) * | 2005-06-06 | 2006-12-14 | Decision Biomarkers, Inc. | Assays based on liquid flow over arrays |
WO2006132324A1 (ja) * | 2005-06-10 | 2006-12-14 | Olympus Corporation | 反応容器およびそれを用いる反応装置 |
US20060292576A1 (en) * | 2005-06-23 | 2006-12-28 | Quest Diagnostics Investments Incorporated | Non-in situ hybridization method for detecting chromosomal abnormalities |
US8288151B2 (en) * | 2005-06-29 | 2012-10-16 | Canon Kabushiki Kaisha | Biochemical reaction cassette |
EP1937850B1 (de) | 2005-10-27 | 2019-05-29 | The President and Fellows of Harvard College | Verfahren und zusammensetzungen zur markierung von nukleinsäuren |
US8075852B2 (en) | 2005-11-02 | 2011-12-13 | Affymetrix, Inc. | System and method for bubble removal |
US8076074B2 (en) | 2005-11-29 | 2011-12-13 | Quest Diagnostics Investments Incorporated | Balanced translocation in comparative hybridization |
US20070122848A1 (en) | 2005-11-29 | 2007-05-31 | Canon Kabushiki Kaisha | Biochemical reaction cassette and detection apparatus for biochemical reaction cassette |
HU227586B1 (en) * | 2005-12-23 | 2011-08-29 | Thales Rt | Method for forming sealed channel of microfluidical reactor and microfluidical reactor containing the same |
US20090305238A1 (en) * | 2006-01-23 | 2009-12-10 | Applera Corporation | Microarray Microcard |
US8055098B2 (en) | 2006-01-27 | 2011-11-08 | Affymetrix, Inc. | System, method, and product for imaging probe arrays with small feature sizes |
US9445025B2 (en) | 2006-01-27 | 2016-09-13 | Affymetrix, Inc. | System, method, and product for imaging probe arrays with small feature sizes |
US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
EP2001990B1 (de) | 2006-03-24 | 2016-06-29 | Handylab, Inc. | Integriertes system zur verarbeitung von mikrofluidischen proben und verwendungsverfahren |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
WO2007113895A1 (ja) * | 2006-04-03 | 2007-10-11 | Shimadzu Corporation | 微量液体試料用光学測定装置 |
US10522240B2 (en) | 2006-05-03 | 2019-12-31 | Population Bio, Inc. | Evaluating genetic disorders |
US7702468B2 (en) | 2006-05-03 | 2010-04-20 | Population Diagnostics, Inc. | Evaluating genetic disorders |
EP3406736B1 (de) | 2006-06-14 | 2022-09-07 | Verinata Health, Inc. | Verfahren zur diagnose fötaler anomalitäten |
EP4108780A1 (de) | 2006-06-14 | 2022-12-28 | Verinata Health, Inc. | Analyse seltener zellen mittels probentrennung und dna-etiketten |
EP2589668A1 (de) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten |
EP2043785A2 (de) * | 2006-06-29 | 2009-04-08 | GE Healthcare Bio-Sciences AB | Kammergerät |
US20080026373A1 (en) * | 2006-07-26 | 2008-01-31 | Rodionova Natalia A | Assays Based On Light Emission From Analyte Complexes Within A Cassette |
EP1900824A1 (de) * | 2006-09-14 | 2008-03-19 | Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts | Genexpressionsprofile zur Prognose, Diagnose und Therapie von Prostatakrebs und deren Verwendung |
US7522282B2 (en) | 2006-11-30 | 2009-04-21 | Purdue Research Foundation | Molecular interferometric imaging process and apparatus |
US7807359B2 (en) * | 2006-12-01 | 2010-10-05 | Quest Diagnostics Investments Incorporated | Methods of detecting TPMT mutations |
KR100834745B1 (ko) * | 2006-12-20 | 2008-06-09 | 삼성전자주식회사 | 분석 친화적 레이아웃에 기반한 올리고머 프로브 어레이칩, 이의 제조에 사용되는 마스크 및 이의 혼성화 분석방법 |
US8930178B2 (en) | 2007-01-04 | 2015-01-06 | Children's Hospital Medical Center | Processing text with domain-specific spreading activation methods |
US7659968B2 (en) * | 2007-01-19 | 2010-02-09 | Purdue Research Foundation | System with extended range of molecular sensing through integrated multi-modal data acquisition |
SG193026A1 (en) | 2007-02-07 | 2013-09-30 | Decode Genetics Ehf | Genetic variants contributing to risk of prostate cancer |
US7867783B2 (en) | 2007-02-22 | 2011-01-11 | Maven Technologies, Llc | Apparatus and method for performing ligand binding assays on microarrays in multiwell plates |
WO2008118934A1 (en) * | 2007-03-26 | 2008-10-02 | Purdue Research Foundation | Method and apparatus for conjugate quadrature interferometric detection of an immunoassay |
JP2008249439A (ja) * | 2007-03-30 | 2008-10-16 | Sumitomo Bakelite Co Ltd | マイクロアレイ用基板及びその使用方法 |
US7863037B1 (en) | 2007-04-04 | 2011-01-04 | Maven Technologies, Llc | Ligand binding assays on microarrays in closed multiwell plates |
EP2142659A4 (de) | 2007-04-30 | 2010-06-09 | Univ Ohio State Res Found | Verfahren zur unterscheidung von bauchspeicheldrüsenkrebs von normalen bauchspeicheldrüsenfunktionen und chronischer bauchspeicheldrüsenentzündung |
US20090041633A1 (en) * | 2007-05-14 | 2009-02-12 | Dultz Shane C | Apparatus and method for performing ligand binding assays on microarrays in multiwell plates |
US7799558B1 (en) | 2007-05-22 | 2010-09-21 | Dultz Shane C | Ligand binding assays on microarrays in closed multiwell plates |
WO2008146309A2 (en) | 2007-05-25 | 2008-12-04 | Decode Genetics Ehf. | Genetic variants on chr 5pl2 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment |
WO2009012185A1 (en) | 2007-07-13 | 2009-01-22 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US7507539B2 (en) * | 2007-07-30 | 2009-03-24 | Quest Diagnostics Investments Incorporated | Substractive single label comparative hybridization |
KR101414232B1 (ko) * | 2007-08-02 | 2014-08-06 | 삼성전자 주식회사 | 바이오 칩 패키지 및 바이오 칩 패키지 기판 |
HK1129808A2 (en) * | 2007-10-03 | 2009-12-04 | Diagcor Bioscience Inc Ltd | Reversed flow through platform for rapid analysis of target analytes with increased sensitivity and specificity and the device thereof |
US20100216655A1 (en) * | 2007-10-12 | 2010-08-26 | Patrick Sulem | Sequence variants for inferring human pigmentation patterns |
EP2056114A1 (de) * | 2007-10-29 | 2009-05-06 | Koninklijke Philips Electronics N.V. | Automatische Erkennung von Infektionserkrankungen |
US8093063B2 (en) * | 2007-11-29 | 2012-01-10 | Quest Diagnostics Investments Incorporated | Assay for detecting genetic abnormalities in genomic nucleic acids |
US8697360B2 (en) | 2007-11-30 | 2014-04-15 | Decode Genetics Ehf. | Genetic variants on CHR 11Q and 6Q as markers for prostate and colorectal cancer predisposition |
US8304255B1 (en) | 2008-02-11 | 2012-11-06 | Access Medical Systems, Ltd. | Immunoassay cuvettes |
NZ587903A (en) * | 2008-02-14 | 2013-05-31 | Decode Genetics Ehf | Susceptibility for lung cancer using the polymorphic marker rs1051730 |
EP2107125A1 (de) | 2008-03-31 | 2009-10-07 | Eppendorf Array Technologies SA (EAT) | Echtzeit-PCR von Targets auf einem Mikroarray |
EP2274450A2 (de) | 2008-04-01 | 2011-01-19 | Decode Genetics EHF | Suszeptibilitätsvarianten bei peripherer arterienkrankheit und bauchschlagader-aneurysma |
JP5040777B2 (ja) * | 2008-04-03 | 2012-10-03 | 住友ベークライト株式会社 | マイクロアレイ用プラスチック基板 |
WO2009137369A1 (en) * | 2008-05-03 | 2009-11-12 | Tufts Medical Center, Inc. | Neonatal salivary genomics |
US8039817B2 (en) | 2008-05-05 | 2011-10-18 | Illumina, Inc. | Compensator for multiple surface imaging |
US8039270B2 (en) * | 2008-05-22 | 2011-10-18 | Maven Technologies, Llc | Apparatus and method for performing ligand binding assays on microarrays in multiwell plates |
US7981664B1 (en) | 2008-05-22 | 2011-07-19 | Maven Technologies, Llc | Apparatus and method for performing ligand binding assays on microarrays in multiwell plates |
AU2009265105A1 (en) * | 2008-07-04 | 2010-01-07 | Decode Genetics Ehf | Copy number variations predictive of risk of schizophrenia |
JP4687756B2 (ja) | 2008-07-07 | 2011-05-25 | 株式会社村田製作所 | プローブアレイおよびその製造方法 |
EP2313525A2 (de) | 2008-07-07 | 2011-04-27 | Decode Genetics EHF | Genetische varianten zur beurteilung des brustkrebsrisikos |
EP2153892A1 (de) * | 2008-07-23 | 2010-02-17 | ETH Zurich | Mikroreaktorsystem und Verfahren zum Betrieb eines solchen Mikroreaktorsystems |
US20110230366A1 (en) * | 2008-08-12 | 2011-09-22 | Decode Genetics Ehf. | Genetic Variants Useful for Risk Assessment of Thyroid Cancer |
US20110212855A1 (en) * | 2008-08-15 | 2011-09-01 | Decode Genetics Ehf. | Genetic Variants Predictive of Cancer Risk |
KR101523727B1 (ko) * | 2008-09-16 | 2015-05-29 | 삼성전자주식회사 | 바이오 칩 패키지 바디, 상기 바이오 칩 패키지 바디의 형성방법 및 상기 바이오 칩 패키지 바디를 포함하는 바이오 칩 패키지 |
US9764322B2 (en) | 2008-09-23 | 2017-09-19 | Bio-Rad Laboratories, Inc. | System for generating droplets with pressure monitoring |
US9598725B2 (en) | 2010-03-02 | 2017-03-21 | Bio-Rad Laboratories, Inc. | Emulsion chemistry for encapsulated droplets |
US9417190B2 (en) | 2008-09-23 | 2016-08-16 | Bio-Rad Laboratories, Inc. | Calibrations and controls for droplet-based assays |
US9132394B2 (en) | 2008-09-23 | 2015-09-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
US10512910B2 (en) | 2008-09-23 | 2019-12-24 | Bio-Rad Laboratories, Inc. | Droplet-based analysis method |
US8633015B2 (en) | 2008-09-23 | 2014-01-21 | Bio-Rad Laboratories, Inc. | Flow-based thermocycling system with thermoelectric cooler |
US8951939B2 (en) | 2011-07-12 | 2015-02-10 | Bio-Rad Laboratories, Inc. | Digital assays with multiplexed detection of two or more targets in the same optical channel |
US8709762B2 (en) | 2010-03-02 | 2014-04-29 | Bio-Rad Laboratories, Inc. | System for hot-start amplification via a multiple emulsion |
US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
US11130128B2 (en) | 2008-09-23 | 2021-09-28 | Bio-Rad Laboratories, Inc. | Detection method for a target nucleic acid |
US9492797B2 (en) | 2008-09-23 | 2016-11-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
CH699853A1 (de) * | 2008-11-13 | 2010-05-14 | Tecan Trading Ag | Messgerät und Verfahren zum Bestimmen von durch ein Laborsystem bereitgestellten Fluidparametern. |
US8039794B2 (en) | 2008-12-16 | 2011-10-18 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby |
US8374818B2 (en) * | 2008-12-19 | 2013-02-12 | Affymetrix, Inc. | System, method and apparatus for calibrating inspection tools |
EP2414543B1 (de) | 2009-04-03 | 2016-10-12 | Decode Genetics EHF | Genetische marker zur risikobewertung von vorhofflimmern und apoplexie |
RU2549443C2 (ru) | 2009-04-14 | 2015-04-27 | Биокартис Нв | Индуцированная высокоинтенсивным фокусированным ультразвуком кавитация с уменьшенным порогом мощности |
ES2677010T3 (es) | 2009-04-15 | 2018-07-27 | Biocartis Nv | Protección de cámaras de muestras bioanalíticas |
AU2010237532B2 (en) | 2009-04-15 | 2014-11-20 | Biocartis Nv | Optical detection system for monitoring rtPCR reaction |
WO2010127464A1 (en) | 2009-05-06 | 2010-11-11 | Biocartis Sa | Device for cutting a sample carrier |
CA2759851A1 (en) * | 2009-05-08 | 2010-11-11 | Decode Genetics Ehf. | Genetic variants contributing to risk of prostate cancer |
US9767342B2 (en) | 2009-05-22 | 2017-09-19 | Affymetrix, Inc. | Methods and devices for reading microarrays |
EP2437887B1 (de) | 2009-06-04 | 2016-05-11 | Lockheed Martin Corporation | Mikrofluidischer chip für dna analyse von mehrfachen proben |
AU2010269841A1 (en) | 2009-07-10 | 2012-02-23 | Decode Genetics Ehf | Genetic markers associated with risk of diabetes mellitus |
US8445201B2 (en) * | 2009-07-31 | 2013-05-21 | Affymetrix, Inc. | Hybridization device, methods, and system using mixing beads |
EP2473618B1 (de) | 2009-09-02 | 2015-03-04 | Bio-Rad Laboratories, Inc. | System zum mischen von flüssigkeiten durch gerinnung mehrerer emulsionen |
CN102630250A (zh) | 2009-09-25 | 2012-08-08 | 基因诊断测试公司 | 用于检测与癌症和其他疾病相关的染色体异常的多重(+/-)链阵列和测试 |
US8501122B2 (en) | 2009-12-08 | 2013-08-06 | Affymetrix, Inc. | Manufacturing and processing polymer arrays |
US8355133B2 (en) | 2009-12-30 | 2013-01-15 | Maven Technologies, Llc | Biological testing with sawtooth-shaped prisms |
KR20110106684A (ko) * | 2010-03-23 | 2011-09-29 | 삼성전자주식회사 | 마이크로어레이 패키지 장치 및 이를 제조하는 방법 |
CN102200536B (zh) * | 2010-03-25 | 2015-05-27 | 艾博生物医药(杭州)有限公司 | 测试液体样本中被分析物的检测装置 |
JP6155419B2 (ja) | 2010-03-25 | 2017-07-05 | バイオ−ラッド・ラボラトリーズ・インコーポレーテッド | 検出用の液滴輸送システム |
CA2767182C (en) | 2010-03-25 | 2020-03-24 | Bio-Rad Laboratories, Inc. | Droplet generation for droplet-based assays |
CA2767113A1 (en) | 2010-03-25 | 2011-09-29 | Bio-Rad Laboratories, Inc. | Detection system for droplet-based assays |
DK2601609T3 (en) | 2010-08-02 | 2017-06-06 | Population Bio Inc | COMPOSITIONS AND METHODS FOR DISCOVERING MUTATIONS CAUSING GENETIC DISORDERS |
KR200476469Y1 (ko) * | 2010-08-24 | 2015-03-06 | 주식회사 파나진 | 교잡챔버와 바이오칩을 정확하게 부착하기 위한 장치 |
AU2011315951B2 (en) | 2010-10-15 | 2015-03-19 | Lockheed Martin Corporation | Micro fluidic optic design |
DE202011110979U1 (de) | 2010-11-01 | 2017-12-04 | Bio-Rad Laboratories, Inc. | System zum Bilden von Emulsionen |
WO2012095872A1 (en) | 2011-01-13 | 2012-07-19 | Decode Genetics Ehf | Genetic variants as markers for use in urinary bladder cancer risk assessment, diagnosis, prognosis and treatment |
US8309045B2 (en) | 2011-02-11 | 2012-11-13 | General Electric Company | System and method for controlling emissions in a combustion system |
CA2830443C (en) | 2011-03-18 | 2021-11-16 | Bio-Rad Laboratories, Inc. | Multiplexed digital assays with combinatorial use of signals |
BR112013026451B1 (pt) | 2011-04-15 | 2021-02-09 | Becton, Dickinson And Company | sistema e método para realizar ensaios de diagnóstico molecular em várias amostras em paralelo e simultaneamente amplificação em tempo real em pluralidade de câmaras de reação de amplificação |
CA2834291A1 (en) | 2011-04-25 | 2012-11-01 | Biorad Laboratories, Inc. | Methods and compositions for nucleic acid analysis |
EP2737089B1 (de) | 2011-07-29 | 2017-09-06 | Bio-rad Laboratories, Inc. | Bibliothekscharakterisierung durch digitalen test |
EP2766483B1 (de) | 2011-10-10 | 2022-03-23 | The Hospital For Sick Children | Verfahren und zusammensetzungen zum screening und zur behandlung von entwicklungsstörungen |
US9599561B2 (en) | 2011-10-13 | 2017-03-21 | Affymetrix, Inc. | Methods, systems and apparatuses for testing and calibrating fluorescent scanners |
EP2773892B1 (de) | 2011-11-04 | 2020-10-07 | Handylab, Inc. | Vorrichtung zur vorbereitung von polynukleotidproben |
DK2773779T3 (da) | 2011-11-04 | 2020-11-23 | Population Bio Inc | Fremgangsmåder og sammensætninger til diagnosticering, prognose og forebyggelse af neurologiske tilstande |
US9212381B2 (en) | 2011-11-10 | 2015-12-15 | President And Fellows Of Harvard College | Methods and compositions for labeling polypeptides |
EP3483288B1 (de) | 2011-11-30 | 2022-03-16 | Children's Hospital Medical Center | Personalisiertes schmerzmanagement und anästhesie: präventive risikoidentifizierung |
US10407724B2 (en) | 2012-02-09 | 2019-09-10 | The Hospital For Sick Children | Methods and compositions for screening and treating developmental disorders |
US9322054B2 (en) | 2012-02-22 | 2016-04-26 | Lockheed Martin Corporation | Microfluidic cartridge |
WO2013155531A2 (en) | 2012-04-13 | 2013-10-17 | Bio-Rad Laboratories, Inc. | Sample holder with a well having a wicking promoter |
DK2895621T3 (da) | 2012-09-14 | 2020-11-30 | Population Bio Inc | Fremgangsmåder og sammensætning til diagnosticering, prognose og behandling af neurologiske tilstande |
WO2014052855A1 (en) | 2012-09-27 | 2014-04-03 | Population Diagnostics, Inc. | Methods and compositions for screening and treating developmental disorders |
WO2014074942A1 (en) | 2012-11-08 | 2014-05-15 | Illumina, Inc. | Risk variants of alzheimer's disease |
US20140274749A1 (en) | 2013-03-15 | 2014-09-18 | Affymetrix, Inc. | Systems and Methods for SNP Characterization and Identifying off Target Variants |
WO2014142330A1 (ja) * | 2013-03-15 | 2014-09-18 | 株式会社ニコン | バイオチップ固定方法、バイオチップ固定装置及び生体分子アレイのスクリーニング方法 |
JPWO2015016315A1 (ja) * | 2013-08-02 | 2017-03-02 | 株式会社ニコン | プレート、プレートの製造方法、バイオチップの観察方法、及びスクリーニング方法 |
EP3040723A4 (de) * | 2013-08-30 | 2017-07-12 | Nikon Corporation | Biochipträgerelement, verfahren zur herstellung des biochipträgerelements, biochipverpackung, screening-vorrichtung und screening-verfahren |
US9352315B2 (en) | 2013-09-27 | 2016-05-31 | Taiwan Semiconductor Manufacturing Company, Ltd. | Method to produce chemical pattern in micro-fluidic structure |
EP2891722B1 (de) | 2013-11-12 | 2018-10-10 | Population Bio, Inc. | Verfahren und Zusammensetzungen zur Diagnose, Prognose und Behandlung von Endometriose |
WO2015079998A1 (ja) * | 2013-11-29 | 2015-06-04 | 三菱レイヨン株式会社 | バイオチップ保持具、バイオチップ保持具の製造方法、バイオチップ押さえ具、およびバイオチップ保持具キット |
WO2015085066A1 (en) * | 2013-12-06 | 2015-06-11 | BacterioScan Inc. | Optical measurement cuvette having sample chambers |
CN103640211A (zh) * | 2013-12-23 | 2014-03-19 | 中国石油大学(华东) | 一种柔性材料辅助聚合物微结构超声波键合封装方法 |
CA2940422A1 (en) | 2014-02-24 | 2015-08-27 | Children's Hospital Medical Center | Methods and compositions for personalized pain management |
US10634590B2 (en) * | 2014-03-11 | 2020-04-28 | Emd Millipore Corporation | IHC, tissue slide fluid exchange disposable and system |
JP2015194379A (ja) * | 2014-03-31 | 2015-11-05 | 株式会社ニコン | バイオチップ及びバイオチップにおけるアライメントマークの検出方法 |
WO2015189390A1 (en) | 2014-06-13 | 2015-12-17 | Q-Linea Ab | Method for detecting and characterising a microorganism |
EP3177738B1 (de) | 2014-08-08 | 2019-10-09 | Children's Hospital Medical Center | Diagnoseverfahren zur unterscheidung von formen von ösophagealer eosinophilie |
US10724096B2 (en) | 2014-09-05 | 2020-07-28 | Population Bio, Inc. | Methods and compositions for inhibiting and treating neurological conditions |
GB201507026D0 (en) | 2015-04-24 | 2015-06-10 | Linea Ab Q | Medical sample transportation container |
TWI553796B (zh) * | 2015-08-18 | 2016-10-11 | 姜崇義 | 溫測晶片封裝方法及其系統 |
US9754836B2 (en) | 2015-11-17 | 2017-09-05 | Pacific Biosciences Of California, Inc. | Packaging methods for fabrication of analytical device packages and analytical device packages made thereof |
EP3402572B1 (de) | 2016-01-13 | 2022-03-16 | Children's Hospital Medical Center | Zusammensetzungen und verfahren zur behandlung von allergischen entzündungserkrankungen |
US9659838B1 (en) * | 2016-03-28 | 2017-05-23 | Lockheed Martin Corporation | Integration of chip level micro-fluidic cooling in chip packages for heat flux removal |
GB2554767A (en) | 2016-04-21 | 2018-04-11 | Q Linea Ab | Detecting and characterising a microorganism |
EP3571309A4 (de) | 2017-01-20 | 2020-11-25 | Children's Hospital Medical Center | Verfahren und zusammensetzungen in bezug auf die oprm1-dns-methylierung für personalisiertes schmerzmanagement |
US10240205B2 (en) | 2017-02-03 | 2019-03-26 | Population Bio, Inc. | Methods for assessing risk of developing a viral disease using a genetic test |
US11859250B1 (en) | 2018-02-23 | 2024-01-02 | Children's Hospital Medical Center | Methods for treating eosinophilic esophagitis |
JP2018124289A (ja) * | 2018-04-10 | 2018-08-09 | 株式会社ニコン | バイオチップ及びバイオチップにおけるアライメントマークの検出方法 |
EP3625368B8 (de) | 2018-08-08 | 2022-12-14 | PML Screening, LLC | Verfahren zur beurteilung des risikos der entwicklung von durch john-cunningham-virus verursachter progressiver multifokaler leukenzephalopathie durch genetisches testen |
DE102020213471A1 (de) | 2020-10-27 | 2022-04-28 | Robert Bosch Gesellschaft mit beschränkter Haftung | Prozessierungseinrichtung zum Prozessieren einer Probenflüssigkeit, Verfahren zum Herstellen einer Prozessierungseinrichtung und Verfahren zum Betreiben einer Prozessierungseinrichtung |
JP2024029793A (ja) * | 2022-08-23 | 2024-03-07 | 東洋製罐グループホールディングス株式会社 | マイクロ流体デバイス、マイクロ流体デバイスの製造方法、及び検査システム |
Family Cites Families (108)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1617732C2 (de) * | 1966-03-01 | 1972-12-21 | Promoveo-Sobioda & Cie, Seyssinet (Frankreich) | Vorrichtung zur Untersuchung lebender Zellen von Mikroorganismen |
US3802966A (en) * | 1969-08-22 | 1974-04-09 | Ethyl Corp | Apparatus for delivering a fluid suspension to a forming unit clear reactor power plant |
GB1320426A (en) * | 1971-07-06 | 1973-06-13 | Pfizer | Multiple solution testing device |
BE793185A (fr) * | 1971-12-23 | 1973-04-16 | Atomic Energy Commission | Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques |
JPS6112373B2 (de) * | 1974-09-04 | 1986-04-08 | Hitachi Ltd | |
US4204929A (en) * | 1978-04-18 | 1980-05-27 | University Patents, Inc. | Isoelectric focusing method |
US4190040A (en) * | 1978-07-03 | 1980-02-26 | American Hospital Supply Corporation | Resealable puncture housing for surgical implantation |
US4500707A (en) * | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
FI76888C (fi) * | 1981-04-29 | 1988-12-12 | Ciba Geigy Ag | Nya medel och foerpackningar foer immunologiska analyser. |
US4373071A (en) * | 1981-04-30 | 1983-02-08 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
US4447140A (en) * | 1982-09-29 | 1984-05-08 | Campbell Jeptha E | Microscope slides |
FI71768C (fi) * | 1984-02-17 | 1987-02-09 | Orion Yhtymae Oy | Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning. |
DE3565986D1 (en) * | 1984-05-02 | 1988-12-08 | Brendan James Hamill | An apparatus for the chemical synthesis of oligonucleotides |
GB8429212D0 (en) * | 1984-11-19 | 1984-12-27 | Vincent Patents Ltd | Exhaust systems for ic engines |
FR2584090B1 (fr) * | 1985-06-27 | 1987-08-28 | Roussel Uclaf | Nouveaux supports, leur preparation et les intermediaires obtenus, leur application a la synthese d'oligonucleotides et les nouveaux nucleosides et oligonucleotides relies aux supports ainsi obtenus |
US4963498A (en) * | 1985-08-05 | 1990-10-16 | Biotrack | Capillary flow device |
US5164598A (en) * | 1985-08-05 | 1992-11-17 | Biotrack | Capillary flow device |
US4912035A (en) * | 1987-06-11 | 1990-03-27 | Eastman Kodak Company | Method for minimizing interference by reductants when detecting cells in biological fluids |
US5714380A (en) * | 1986-10-23 | 1998-02-03 | Amoco Corporation | Closed vessel for isolating target molecules and for performing amplification |
JPH0750094B2 (ja) * | 1987-01-28 | 1995-05-31 | 富士写真フイルム株式会社 | 化学分析スライドの連続製造方法 |
US4965725B1 (en) * | 1988-04-08 | 1996-05-07 | Neuromedical Systems Inc | Neural network based automated cytological specimen classification system and method |
US5700637A (en) * | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
US5188963A (en) * | 1989-11-17 | 1993-02-23 | Gene Tec Corporation | Device for processing biological specimens for analysis of nucleic acids |
US5320808A (en) * | 1988-08-02 | 1994-06-14 | Abbott Laboratories | Reaction cartridge and carousel for biological sample analyzer |
US5382511A (en) * | 1988-08-02 | 1995-01-17 | Gene Tec Corporation | Method for studying nucleic acids within immobilized specimens |
US5281540A (en) * | 1988-08-02 | 1994-01-25 | Abbott Laboratories | Test array for performing assays |
US5281516A (en) * | 1988-08-02 | 1994-01-25 | Gene Tec Corporation | Temperature control apparatus and method |
US4992383A (en) * | 1988-08-05 | 1991-02-12 | Porton Instruments, Inc. | Method for protein and peptide sequencing using derivatized glass supports |
US5200051A (en) * | 1988-11-14 | 1993-04-06 | I-Stat Corporation | Wholly microfabricated biosensors and process for the manufacture and use thereof |
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US6955915B2 (en) * | 1989-06-07 | 2005-10-18 | Affymetrix, Inc. | Apparatus comprising polymers |
US5800992A (en) * | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5196305A (en) * | 1989-09-12 | 1993-03-23 | Eastman Kodak Company | Diagnostic and amplification methods using primers having thymine at 3' end to overcome primer-target mismatch at the 3' end |
US5346672A (en) * | 1989-11-17 | 1994-09-13 | Gene Tec Corporation | Devices for containing biological specimens for thermal processing |
US5091652A (en) * | 1990-01-12 | 1992-02-25 | The Regents Of The University Of California | Laser excited confocal microscope fluorescence scanner and method |
US5192503A (en) * | 1990-05-23 | 1993-03-09 | Mcgrath Charles M | Probe clip in situ assay apparatus |
US5100626A (en) * | 1990-05-24 | 1992-03-31 | Levin Andrew E | Binding assay device with removable cassette and manifold |
US5204253A (en) * | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
JPH06504997A (ja) * | 1990-12-06 | 1994-06-09 | アフィメトリックス, インコーポレイテッド | 非常に大きい規模の固定化されたポリマーの合成 |
US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
US5846708A (en) * | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
US5384261A (en) * | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
US5412087A (en) * | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
EP0916396B1 (de) * | 1991-11-22 | 2005-04-13 | Affymetrix, Inc. (a Delaware Corporation) | Kombinatorische Strategien für die Polymersynthese |
US5310469A (en) * | 1991-12-31 | 1994-05-10 | Abbott Laboratories | Biosensor with a membrane containing biologically active material |
US5486335A (en) * | 1992-05-01 | 1996-01-23 | Trustees Of The University Of Pennsylvania | Analysis based on flow restriction |
US5637469A (en) * | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
US5498392A (en) * | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
US5304487A (en) * | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
JP2673078B2 (ja) * | 1992-05-27 | 1997-11-05 | 東芝電池株式会社 | アルカリ二次電池用のペースト式電極 |
FI923220A (fi) * | 1992-07-14 | 1994-01-15 | Wallac Oy | Foerfarande och apparatur foer hantering av prov samt provuppsamlingssystem |
US5288514A (en) * | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
US5508200A (en) * | 1992-10-19 | 1996-04-16 | Tiffany; Thomas | Method and apparatus for conducting multiple chemical assays |
US5482591A (en) * | 1992-10-30 | 1996-01-09 | Specialty Silicone Products, Inc. | Laminated seals and method of production |
US5314829A (en) * | 1992-12-18 | 1994-05-24 | California Institute Of Technology | Method for imaging informational biological molecules on a semiconductor substrate |
US6258325B1 (en) * | 1993-04-19 | 2001-07-10 | Ashok Ramesh Sanadi | Method and apparatus for preventing cross-contamination of multi-well test plates |
DE4313253A1 (de) * | 1993-04-23 | 1994-10-27 | Boehringer Mannheim Gmbh | System zur Analyse von Inhaltsstoffen flüssiger Proben |
IL110298A (en) * | 1993-07-13 | 1999-04-11 | Brann Mark Robert | Identification of ligands by selective amplification of cells transfected with receptors |
US5382512A (en) * | 1993-08-23 | 1995-01-17 | Chiron Corporation | Assay device with captured particle reagent |
US5494124A (en) * | 1993-10-08 | 1996-02-27 | Vortexx Group, Inc. | Negative pressure vortex nozzle |
FR2714061B1 (fr) * | 1993-12-16 | 1996-03-08 | Genset Sa | Procédé de préparation de polynucléotides sur support solide et appareil permettant sa mise en Óoeuvre. |
US5631734A (en) * | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
US5571639A (en) * | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
DE69527585T2 (de) * | 1994-06-08 | 2003-04-03 | Affymetrix Inc | Verfahren und Vorrichtung zum Verpacken von Chips |
US6287850B1 (en) * | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
US5485277A (en) * | 1994-07-26 | 1996-01-16 | Physical Optics Corporation | Surface plasmon resonance sensor and methods for the utilization thereof |
US5599668A (en) * | 1994-09-22 | 1997-02-04 | Abbott Laboratories | Light scattering optical waveguide method for detecting specific binding events |
US5585069A (en) * | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
US5545531A (en) * | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
US6720149B1 (en) * | 1995-06-07 | 2004-04-13 | Affymetrix, Inc. | Methods for concurrently processing multiple biological chip assays |
US5856174A (en) * | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US5843655A (en) * | 1995-09-18 | 1998-12-01 | Affymetrix, Inc. | Methods for testing oligonucleotide arrays |
US5605653A (en) * | 1995-11-09 | 1997-02-25 | Devos; Jerry | Liquid circulation apparatus |
US6660233B1 (en) * | 1996-01-16 | 2003-12-09 | Beckman Coulter, Inc. | Analytical biochemistry system with robotically carried bioarray |
US6114122A (en) * | 1996-03-26 | 2000-09-05 | Affymetrix, Inc. | Fluidics station with a mounting system and method of using |
EP1007966A4 (de) * | 1996-08-21 | 2001-10-17 | Smithkline Beecham Corp | Schnellverfahren zum gruppieren und synthesieren von wulstbasierenden kombinatorischen bibliotheken |
US6054100A (en) * | 1996-11-18 | 2000-04-25 | Robbins Scientific Corporation | Apparatus for multi-well microscale synthesis |
US6008892A (en) * | 1997-05-23 | 1999-12-28 | Molecular Dynamics, Inc. | Optical substrate for enhanced detectability of fluorescence |
US5948685A (en) * | 1998-02-10 | 1999-09-07 | Angros; Lee | Analytic plate with containment border and method of use |
US6713304B2 (en) * | 1998-02-10 | 2004-03-30 | Lee H. Angros | Method of forming a containment border on an analytic plate |
US6030582A (en) * | 1998-03-06 | 2000-02-29 | Levy; Abner | Self-resealing, puncturable container cap |
US6376619B1 (en) * | 1998-04-13 | 2002-04-23 | 3M Innovative Properties Company | High density, miniaturized arrays and methods of manufacturing same |
DE69935230T2 (de) * | 1998-08-10 | 2007-12-20 | Genomic Solutions, Inc., Ann Arbor | Vorrichtung für thermische und flüssige zirkulation zur hybridierung von nukleinsäuren |
US6186659B1 (en) * | 1998-08-21 | 2001-02-13 | Agilent Technologies Inc. | Apparatus and method for mixing a film of fluid |
US7612020B2 (en) * | 1998-12-28 | 2009-11-03 | Illumina, Inc. | Composite arrays utilizing microspheres with a hybridization chamber |
US6215894B1 (en) * | 1999-02-26 | 2001-04-10 | General Scanning, Incorporated | Automatic imaging and analysis of microarray biochips |
US6555361B1 (en) * | 1999-03-24 | 2003-04-29 | Corning Incorporated | Hybridization chamber for high density nucleic acid arrays |
US6355431B1 (en) * | 1999-04-20 | 2002-03-12 | Illumina, Inc. | Detection of nucleic acid amplification reactions using bead arrays |
US6323043B1 (en) * | 1999-04-30 | 2001-11-27 | Agilent Technologies, Inc. | Fabricating biopolymer arrays |
EP1190233B1 (de) * | 1999-05-20 | 2006-08-30 | Illumina, Inc. | Vorrichtung zur halterung und präsentation von mindestens einer mikrokugelmatrix zu lösungen und/oder zu optischen abbildungssystemen |
US6544732B1 (en) * | 1999-05-20 | 2003-04-08 | Illumina, Inc. | Encoding and decoding of array sensors utilizing nanocrystals |
US6180351B1 (en) * | 1999-07-22 | 2001-01-30 | Agilent Technologies Inc. | Chemical array fabrication with identifier |
US6395483B1 (en) * | 1999-09-02 | 2002-05-28 | 3M Innovative Properties Company | Arrays with mask layers |
US6232072B1 (en) * | 1999-10-15 | 2001-05-15 | Agilent Technologies, Inc. | Biopolymer array inspection |
DE59913714D1 (de) * | 1999-12-21 | 2006-09-07 | Tecan Trading Ag | Klemmvorrichtung zur Aufnahme und genauer Positionierung eines Gegenstandes, vorzüglich einer Mikrotiterplatte, sowie Verfahren zu ihrem Betrieb |
US6545758B1 (en) * | 2000-08-17 | 2003-04-08 | Perry Sandstrom | Microarray detector and synthesizer |
US20030096239A1 (en) * | 2000-08-25 | 2003-05-22 | Kevin Gunderson | Probes and decoder oligonucleotides |
US6864097B1 (en) * | 2000-09-27 | 2005-03-08 | Agilent Technologies, Inc. | Arrays and their reading |
JP2002222858A (ja) * | 2001-01-25 | 2002-08-09 | Mitsubishi Electric Corp | 半導体装置およびその製造方法 |
US6991939B2 (en) * | 2001-07-19 | 2006-01-31 | Tufts University | Optical array device and methods of use thereof for screening, analysis and manipulation of particles |
US20030040129A1 (en) * | 2001-08-20 | 2003-02-27 | Shah Haresh P. | Binding assays using magnetically immobilized arrays |
US6682702B2 (en) * | 2001-08-24 | 2004-01-27 | Agilent Technologies, Inc. | Apparatus and method for simultaneously conducting multiple chemical reactions |
US20030087292A1 (en) * | 2001-10-04 | 2003-05-08 | Shiping Chen | Methods and systems for promoting interactions between probes and target molecules in fluid in microarrays |
US7018842B2 (en) * | 2002-02-28 | 2006-03-28 | Agilent Technologies, Inc. | Reading dry chemical arrays through the substrate |
US20030235520A1 (en) * | 2002-06-21 | 2003-12-25 | Shea Laurence R. | Array assay devices and methods of using the same |
US20040086868A1 (en) * | 2002-10-30 | 2004-05-06 | Parker Russell A. | Enclosed arrays and their reading |
US20050026299A1 (en) * | 2003-07-31 | 2005-02-03 | Arindam Bhattacharjee | Chemical arrays on a common carrier |
US7223609B2 (en) * | 2003-08-14 | 2007-05-29 | Agilent Technologies, Inc. | Arrays for multiplexed surface plasmon resonance detection of biological molecules |
-
1995
- 1995-05-19 DE DE69527585T patent/DE69527585T2/de not_active Expired - Lifetime
- 1995-05-19 EP EP95303356A patent/EP0695941B1/de not_active Expired - Lifetime
- 1995-06-07 US US08/485,452 patent/US5945334A/en not_active Expired - Lifetime
- 1995-06-08 EP EP95925244A patent/EP0764214B1/de not_active Revoked
- 1995-06-08 JP JP8501333A patent/JPH10505410A/ja not_active Withdrawn
- 1995-06-08 JP JP14219595A patent/JP3790280B2/ja not_active Expired - Fee Related
- 1995-06-08 AU AU29436/95A patent/AU2943695A/en not_active Abandoned
- 1995-06-08 EP EP05009507A patent/EP1562045A3/de not_active Withdrawn
- 1995-06-08 WO PCT/US1995/007377 patent/WO1995033846A1/en active IP Right Grant
- 1995-06-08 DE DE69534418T patent/DE69534418T2/de not_active Expired - Lifetime
- 1995-09-14 US US08/528,173 patent/US6140044A/en not_active Expired - Lifetime
-
2005
- 2005-08-04 JP JP2005227258A patent/JP3884048B2/ja not_active Expired - Fee Related
- 2005-11-21 JP JP2005336411A patent/JP2006153877A/ja not_active Withdrawn
-
2008
- 2008-11-05 US US12/265,048 patent/US20090143249A1/en not_active Abandoned
-
2010
- 2010-07-23 US US12/842,977 patent/US20100298165A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US5945334A (en) | 1999-08-31 |
WO1995033846A1 (en) | 1995-12-14 |
EP0764214B1 (de) | 2005-08-31 |
US20090143249A1 (en) | 2009-06-04 |
JPH08166387A (ja) | 1996-06-25 |
JP2006153877A (ja) | 2006-06-15 |
AU2943695A (en) | 1996-01-04 |
US6140044A (en) | 2000-10-31 |
JP3790280B2 (ja) | 2006-06-28 |
EP1562045A3 (de) | 2005-11-02 |
EP0695941B1 (de) | 2002-07-31 |
EP0764214A4 (de) | 1997-05-07 |
DE69527585D1 (de) | 2002-09-05 |
EP0695941A2 (de) | 1996-02-07 |
JP3884048B2 (ja) | 2007-02-21 |
US20100298165A1 (en) | 2010-11-25 |
JPH10505410A (ja) | 1998-05-26 |
DE69527585T2 (de) | 2003-04-03 |
EP0764214A1 (de) | 1997-03-26 |
EP1562045A2 (de) | 2005-08-10 |
EP0695941A3 (de) | 1996-12-27 |
DE69534418T2 (de) | 2006-06-22 |
JP2005345481A (ja) | 2005-12-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69534418D1 (de) | Bioarraychip-reaktionsapparatur und ihre herstellung | |
DK0674888T3 (da) | Blandeindretning | |
DE69501574T2 (de) | Halteband | |
DE69725136D1 (de) | Atemmaske | |
NO961006L (no) | Fosfonomononukleinsyrer, fremgangsmåter for fremstilling derav og anvendelse av forbindelsene | |
ZA956007B (en) | Oxidation catalyst its preparation and oxidation using the oxidation catalyst | |
ATE258549T1 (de) | Oxazolidindion-derivate, ihre herstellung und verwendung | |
DE69723398T2 (de) | Polyalkylphenoxyaminoalkane und diese enthaltende freibstoffzusammensetzungen | |
DE69524807T2 (de) | Gasmischer | |
FI972245A0 (fi) | Meso-monojodisubstituoidut tetramakrosykliset yhdisteet sekä niiden valmistus- ja käyttömenetelmät | |
DE69532131D1 (de) | Heizvorrichtung und ihre herstellung | |
DE69521972D1 (de) | Umrichtergerät | |
DE59510397D1 (de) | Halogenierte Biphenyl-2,2'diyl-bis-diphenylphosphine, ihre Herstellung und ihre Verwendung | |
DE69519913D1 (de) | Dauerwellenzusammensetzung | |
DK0770101T3 (da) | Katalytiske sammensætninger og bestrygninger fremstillet deraf | |
NO971143L (no) | Ultralyd-stempelomformer | |
FR2728485B1 (fr) | Melangeur | |
DE59501950D1 (de) | Isolongifolanol-Derivate, ihre Herstellung und ihre Verwendung | |
NO307080B1 (no) | Fremgangsmåte for fremstilling av katalysatorer og anvendelse derav | |
DE69513265T2 (de) | Katalysatorzusammensetzung | |
FI970269A0 (fi) | 1,3-diolipohjaisten esterien seokset, menetelmä 1,3-diolipohjaisten esterien valmistamiseksi sekä esterien käyttö | |
DE29706104U1 (de) | Ozonisator | |
KR960020260U (ko) | 가열믹서 구조체 | |
DE9405878U1 (de) | Rhenchodepressive Substanz | |
ITRE940062A0 (it) | Apparecchio ozonizzatore |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |