DE69534418D1 - Bioarraychip-reaktionsapparatur und ihre herstellung - Google Patents

Bioarraychip-reaktionsapparatur und ihre herstellung

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Publication number
DE69534418D1
DE69534418D1 DE69534418T DE69534418T DE69534418D1 DE 69534418 D1 DE69534418 D1 DE 69534418D1 DE 69534418 T DE69534418 T DE 69534418T DE 69534418 T DE69534418 T DE 69534418T DE 69534418 D1 DE69534418 D1 DE 69534418D1
Authority
DE
Germany
Prior art keywords
bioarraychip
preparation
reaction apparatus
reaction
bioarraychip reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69534418T
Other languages
English (en)
Other versions
DE69534418T2 (de
Inventor
M Besemer
W Goss
L Winkler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affymetrix Inc
Original Assignee
Affymetrix Inc
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Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22969439&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69534418(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Affymetrix Inc filed Critical Affymetrix Inc
Publication of DE69534418D1 publication Critical patent/DE69534418D1/de
Application granted granted Critical
Publication of DE69534418T2 publication Critical patent/DE69534418T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877Flow chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof
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    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/10Libraries containing peptides or polypeptides, or derivatives thereof
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    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/12Libraries containing saccharides or polysaccharides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
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    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099Characterised by type of test elements
    • G01N2035/00158Elements containing microarrays, i.e. "biochip"
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/97Test strip or test slide
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/973Simultaneous determination of more than one analyte
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809Multifield plates or multicontainer arrays
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • Y10T436/112499Automated chemical analysis with sample on test slide
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Families Citing this family (402)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6905882B2 (en) 1992-05-21 2005-06-14 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6156270A (en) 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US7524456B1 (en) 1992-05-21 2009-04-28 Biosite Incorporated Diagnostic devices for the controlled movement of reagents without membranes
US6767510B1 (en) 1992-05-21 2004-07-27 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US20060229824A1 (en) 1993-10-26 2006-10-12 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes
US6090555A (en) * 1997-12-11 2000-07-18 Affymetrix, Inc. Scanned image alignment systems and methods
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US6741344B1 (en) * 1994-02-10 2004-05-25 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
DE69527585T2 (de) * 1994-06-08 2003-04-03 Affymetrix Inc Verfahren und Vorrichtung zum Verpacken von Chips
US5959098A (en) * 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US6239273B1 (en) 1995-02-27 2001-05-29 Affymetrix, Inc. Printing molecular library arrays
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US6953663B1 (en) 1995-11-29 2005-10-11 Affymetrix, Inc. Polymorphism detection
US6300063B1 (en) 1995-11-29 2001-10-09 Affymetrix, Inc. Polymorphism detection
US6660233B1 (en) * 1996-01-16 2003-12-09 Beckman Coulter, Inc. Analytical biochemistry system with robotically carried bioarray
US6114122A (en) 1996-03-26 2000-09-05 Affymetrix, Inc. Fluidics station with a mounting system and method of using
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5885470A (en) * 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US6706875B1 (en) 1996-04-17 2004-03-16 Affyemtrix, Inc. Substrate preparation process
FR2748156B1 (fr) * 1996-04-26 1998-08-07 Suisse Electronique Microtech Dispositif comprenant deux substrats destines a former un microsysteme ou une partie d'un microsysteme et procede d'assemblage de deux substrats micro-usines
JP2000512744A (ja) 1996-05-16 2000-09-26 アフィメトリックス,インコーポレイテッド 標識材料を検出するシステムおよび方法
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US6875620B1 (en) * 1996-10-31 2005-04-05 Agilent Technologies, Inc. Tiling process for constructing a chemical array
EP0946287B1 (de) * 1996-11-18 2004-08-18 Novartis AG Vorrichtung zur polymersynthese
US6083763A (en) * 1996-12-31 2000-07-04 Genometrix Inc. Multiplexed molecular analysis apparatus and method
US6425972B1 (en) * 1997-06-18 2002-07-30 Calipher Technologies Corp. Methods of manufacturing microfabricated substrates
DE19734706A1 (de) * 1997-08-11 1999-02-18 Fraunhofer Ges Forschung Piezoelektrischer Resonator, Verfahren zur Herstellung des Resonators sowie dessen Einsatz als Sensorelement zum Erfassen der Konzentration eines in einem Fluid enthaltenen Stoffes und/oder der Bestimmung physikalischer Eigenschaften des Fluids
US6440725B1 (en) * 1997-12-24 2002-08-27 Cepheid Integrated fluid manipulation cartridge
US6540895B1 (en) 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US20100105572A1 (en) * 1997-12-19 2010-04-29 Kris Richard M High throughput assay system
US20030039967A1 (en) * 1997-12-19 2003-02-27 Kris Richard M. High throughput assay system using mass spectrometry
US20030096232A1 (en) * 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US6050719A (en) * 1998-01-30 2000-04-18 Affymetrix, Inc. Rotational mixing method using a cartridge having a narrow interior
EP2189791A3 (de) 1998-02-04 2011-03-09 Life Technologies Corporation Mikroarrays und Verwendungen dafür
AU2586799A (en) 1998-02-06 1999-08-23 Affymetrix, Inc. Method of quality control in manufacturing processes
US6150147A (en) * 1998-02-06 2000-11-21 Affymetrix, Inc. Biological array fabrication methods with reduction of static charge
US7095032B2 (en) * 1998-03-20 2006-08-22 Montagu Jean I Focusing of microscopes and reading of microarrays
US6472671B1 (en) * 2000-02-09 2002-10-29 Jean I. Montagu Quantified fluorescence microscopy
CA2320296A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
US6830729B1 (en) 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument
US6761816B1 (en) * 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6759014B2 (en) * 2001-01-26 2004-07-06 Symyx Technologies, Inc. Apparatus and methods for parallel processing of multiple reaction mixtures
US6913934B2 (en) * 1998-08-13 2005-07-05 Symyx Technologies, Inc. Apparatus and methods for parallel processing of multiple reaction mixtures
US6186659B1 (en) 1998-08-21 2001-02-13 Agilent Technologies Inc. Apparatus and method for mixing a film of fluid
DE69916421T2 (de) * 1998-09-09 2005-03-24 Hitachi Software Engineering Co., Ltd., Yokohama Biochip und verfahren zur verwendung des biochips
FR2784751B1 (fr) * 1998-10-20 2001-02-02 Mesatronic Boitier de logement d'une puce electronique a sondes biologiques
DE19853640C2 (de) * 1998-11-20 2002-01-31 Molecular Machines & Ind Gmbh Mehrgefäßanordnung mit verbesserter Empfindlichkeit für die optische Analytik, Verfahren zu ihrer Herstellung sowie ihre Verwendung in optischen Analyseverfahren
US6130745A (en) * 1999-01-07 2000-10-10 Biometric Imaging, Inc. Optical autofocus for use with microtiter plates
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US20040053290A1 (en) * 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
US7312087B2 (en) * 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6518056B2 (en) * 1999-04-27 2003-02-11 Agilent Technologies Inc. Apparatus, systems and method for assaying biological materials using an annular format
US20040203047A1 (en) * 1999-04-30 2004-10-14 Caren Michael P. Polynucleotide array fabrication
US7276336B1 (en) 1999-07-22 2007-10-02 Agilent Technologies, Inc. Methods of fabricating an addressable array of biopolymer probes
US6225109B1 (en) * 1999-05-27 2001-05-01 Orchid Biosciences, Inc. Genetic analysis device
FR2795476B1 (fr) * 1999-06-22 2001-07-27 Biomerieux Sa Vanne permettant de diriger un fluide dans une carte d'analyse
EP1360992A3 (de) * 1999-06-22 2004-05-19 Caliper Life Sciences, Inc. Apparat zur Bedienung eines mikrofluidischen Gerätes
US6811668B1 (en) 1999-06-22 2004-11-02 Caliper Life Sciences, Inc. Apparatus for the operation of a microfluidic device
US6258593B1 (en) 1999-06-30 2001-07-10 Agilent Technologies Inc. Apparatus for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber
IL147227A0 (en) 1999-07-02 2002-08-14 Clondiag Chip Tech Gmbh Microchip matrix device for duplicating and characterizing nucleic acids
JP3471664B2 (ja) 1999-07-08 2003-12-02 Nec液晶テクノロジー株式会社 液晶セル用貼り合わせ基板の分断装置
FR2796571B1 (fr) * 1999-07-19 2001-09-14 Bio Merieux Dispositif d'analyse avec une biopuce
US6864050B2 (en) 1999-07-30 2005-03-08 Affymetrix, Inc. Single-phase amplification of nucleic acids
US6653151B2 (en) 1999-07-30 2003-11-25 Large Scale Proteomics Corporation Dry deposition of materials for microarrays using matrix displacement
US6713309B1 (en) 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture
US7179638B2 (en) 1999-07-30 2007-02-20 Large Scale Biology Corporation Microarrays and their manufacture by slicing
US6495104B1 (en) * 1999-08-19 2002-12-17 Caliper Technologies Corp. Indicator components for microfluidic systems
US6784982B1 (en) 1999-11-04 2004-08-31 Regents Of The University Of Minnesota Direct mapping of DNA chips to detector arrays
US6867851B2 (en) * 1999-11-04 2005-03-15 Regents Of The University Of Minnesota Scanning of biological samples
US6569674B1 (en) 1999-12-15 2003-05-27 Amersham Biosciences Ab Method and apparatus for performing biological reactions on a substrate surface
US6589778B1 (en) 1999-12-15 2003-07-08 Amersham Biosciences Ab Method and apparatus for performing biological reactions on a substrate surface
US6642046B1 (en) * 1999-12-09 2003-11-04 Motorola, Inc. Method and apparatus for performing biological reactions on a substrate surface
US6420114B1 (en) * 1999-12-06 2002-07-16 Incyte Genomics, Inc. Microarray hybridization chamber
CA2394275A1 (en) * 1999-12-15 2001-06-21 Motorola, Inc. Apparatus for performing biological reactions
US20030091477A1 (en) * 1999-12-22 2003-05-15 Paul Eric A. Flow-thru chip cartridge, chip holder, system & method thereof
FR2803225B1 (fr) * 1999-12-29 2002-06-14 Biomerieux Sa Appareil d'analyse a compartiment reactionnel a geometrie variable, procede de mixage et de guidage de liquides
DE10002920A1 (de) * 2000-01-19 2001-07-26 Epigenomics Ag Kontaktierungsvorrichtung
US6587579B1 (en) 2000-01-26 2003-07-01 Agilent Technologies Inc. Feature quality in array fabrication
US6458526B1 (en) 2000-01-28 2002-10-01 Agilent Technologies, Inc. Method and apparatus to inhibit bubble formation in a fluid
AU2001238011A1 (en) * 2000-01-31 2001-08-07 Board Of Regents, The University Of Texas System System for transferring fluid samples through a sensor array
FR2806009B1 (fr) 2000-03-07 2002-05-31 Bio Merieux Procede de mise en oeuvre d'une carte d'analyse
WO2001083827A1 (en) 2000-05-04 2001-11-08 Yale University High density protein arrays for screening of protein activity
SG91870A1 (en) * 2000-05-26 2002-10-15 Casem Asia Pte Ltd Method and device for bleed out control in solder bonding
DE10026647A1 (de) * 2000-05-29 2001-12-06 Merck Patent Gmbh Positioniervorrichtung
JP4644914B2 (ja) * 2000-06-02 2011-03-09 株式会社村田製作所 プローブアレイ用固相基材、およびプローブアレイ
DE10027524A1 (de) * 2000-06-02 2001-12-13 Max Planck Gesellschaft Vorrichtung und Verfahren zur Bearbeitung von substratgebundenen Proben
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
EP1161984A1 (de) * 2000-06-08 2001-12-12 F. Hoffmann-La Roche Ag Vorrichtung zum Verpacken eines chipförmigen Trägers und Verfahren zum Zusammenbau einer Vielzahl derartiger Träger
EP1161989B8 (de) * 2000-06-08 2007-11-07 F.Hoffmann-La Roche Ag Vorrichtung zum Verpacken eines chipförmigen Trägers und Montageverfahren für eine Vielzahl solcher Träger
US7158224B2 (en) * 2000-06-25 2007-01-02 Affymetrix, Inc. Optically active substrates
AU7166201A (en) * 2000-06-28 2002-01-08 Illumina Inc Composite arrays utilizing microspheres with a hybridization chamber
CN1137999C (zh) * 2000-07-04 2004-02-11 清华大学 集成式微阵列装置
US6511277B1 (en) * 2000-07-10 2003-01-28 Affymetrix, Inc. Cartridge loader and methods
US6833920B2 (en) * 2000-07-11 2004-12-21 Maven Technologies Llc Apparatus and method for imaging
US6594011B1 (en) 2000-07-11 2003-07-15 Maven Technologies, Llc Imaging apparatus and method
US7193711B2 (en) * 2000-07-11 2007-03-20 Maven Technologies, Llc Imaging method and apparatus
US7518724B2 (en) * 2000-07-11 2009-04-14 Maven Technologies Image acquisition, processing, and display
US7023547B2 (en) 2000-07-11 2006-04-04 Maven Technologies, Llc Apparatus including a biochip for imaging of biological samples and method
US7126688B2 (en) * 2000-07-11 2006-10-24 Maven Technologies, Llc Microarray scanning
DE10037687A1 (de) * 2000-08-01 2002-02-14 Trace Biotech Ag Verfahren zur Herstellung von Oligonucleotid-Arrays und zur Durchführung von Hybridisierungs-Assays sowie Anlagen zur Durchführung dieser Verfahren
US6422249B1 (en) 2000-08-10 2002-07-23 Affymetrix Inc. Cartridge washing system and methods
US20040185464A1 (en) * 2000-09-15 2004-09-23 Kris Richard M. High throughput assay system
GB0022978D0 (en) 2000-09-19 2000-11-01 Oxford Glycosciences Uk Ltd Detection of peptides
US6864097B1 (en) * 2000-09-27 2005-03-08 Agilent Technologies, Inc. Arrays and their reading
US20060141507A1 (en) * 2000-09-27 2006-06-29 Kronick Mel N Manufacture and use of non-standard size microarray slides
DE60125312T2 (de) * 2000-10-26 2007-06-06 Agilent Technologies, Inc. (n.d. Ges. d. Staates Delaware), Santa Clara Mikroarray
JP3921047B2 (ja) * 2000-12-11 2007-05-30 日立ソフトウエアエンジニアリング株式会社 ハイブリダイゼーション反応装置及びハイブリダイゼーション方法
WO2002051537A2 (en) * 2000-12-22 2002-07-04 Burstein Technologies, Inc. Optical bio-discs and methods relating thereto
ATE281232T1 (de) 2000-12-28 2004-11-15 Hoffmann La Roche Verfahren zur behandlung von nukleinsaüreproben mittels schwingung eines teiles einer kartuschenwandung, system und kartusche zur durchführung desselben
ATE337093T1 (de) * 2000-12-28 2006-09-15 Hoffmann La Roche Verfahren, system und patrone zur verarbeitung einer nukleinsäure-probe durch oszillation der patrone
DE20100345U1 (de) * 2001-01-09 2002-05-23 Evotec Biosystems Ag Probenträger
US6746649B2 (en) * 2001-01-31 2004-06-08 Agilent Technologies, Inc. Reaction chamber roll pump
US6879915B2 (en) 2001-01-31 2005-04-12 Agilent Technologies, Inc. Chemical array fabrication and use
US20030170148A1 (en) * 2001-01-31 2003-09-11 Mcentee John F. Reaction chamber roll pump
US7112305B2 (en) * 2001-01-31 2006-09-26 Agilent Technologies, Inc. Automation-optimized microarray package
WO2002063270A2 (en) * 2001-02-05 2002-08-15 Board Of Regents, The University Of Texas System The use of mesoscale self-assembly and recognition to effect delivery of sensing reagent for arrayed sensors
JP4148778B2 (ja) 2001-03-09 2008-09-10 バイオミクロ システムズ インコーポレイティッド アレイとのミクロ流体的インターフェース機器
AU2002307152A1 (en) 2001-04-06 2002-10-21 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US6943036B2 (en) * 2001-04-30 2005-09-13 Agilent Technologies, Inc. Error detection in chemical array fabrication
DE10122457A1 (de) * 2001-05-09 2002-11-21 Bosch Gmbh Robert Behälter für einen Analyse-Chip
US20050009101A1 (en) * 2001-05-17 2005-01-13 Motorola, Inc. Microfluidic devices comprising biochannels
DE50202157D1 (de) 2001-05-25 2005-03-10 Tecan Trading Ag Maennedorf System mit Verfahrenseinheit zum Hybridisieren von Nukleinsäureproben, Proteinen und Gewebeschnitten
US20030008310A1 (en) * 2001-05-29 2003-01-09 Williams Jeffrey S. Method and apparatus for facilitating the creation and analysis of microarrays
US7294478B1 (en) 2001-06-06 2007-11-13 Rosetta Inpharmatics Llc Microarray reaction cartridge
US6485918B1 (en) 2001-07-02 2002-11-26 Packard Bioscience Corporation Method and apparatus for incubation of a liquid reagent and target spots on a microarray substrate
US7297553B2 (en) * 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
US7687437B2 (en) 2001-07-13 2010-03-30 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
EP1439910A2 (de) * 2001-07-26 2004-07-28 Motorola, Inc. System und verfahren zum mischen in einer mikrofluiden vorrichtung
EP1281439A1 (de) * 2001-07-30 2003-02-05 F. Hoffmann-La Roche Ag Vorrichtung zur Aufnahme eines chipförmigen Trägers und Verfahren zum Zusammenbau mehrerer solcher Vorrichtungen
EP1281966A3 (de) * 2001-07-30 2003-06-18 Fuji Photo Film Co., Ltd. Verfahren und Vorrichtung zur Durchführung einer Rezeptor-Ligand-Reaktion
JP2003057236A (ja) * 2001-08-10 2003-02-26 Inst Of Physical & Chemical Res 生体分子マイクロアレイの製造方法及びスポット装置
EP1425090A2 (de) * 2001-09-07 2004-06-09 Corning Incorporated Mikrosäulenbasierte anordnung zur hochdurchsatz analyse
WO2003027221A1 (en) * 2001-09-23 2003-04-03 Irm Llc Closed cell washer
US6767733B1 (en) 2001-10-10 2004-07-27 Pritest, Inc. Portable biosensor apparatus with controlled flow
US20030087289A1 (en) * 2001-10-12 2003-05-08 Harry Zuzan Image analysis of high-density synthetic DNA microarrays
US20030113724A1 (en) * 2001-10-12 2003-06-19 Schembri Carol T. Packaged microarray apparatus and a method of bonding a microarray into a package
WO2003033128A2 (en) * 2001-10-12 2003-04-24 Duke University Methods for image analysis of high-density synthetic dna microarrays
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
WO2003048295A1 (en) 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
US20040038388A1 (en) * 2001-12-19 2004-02-26 Affymetrix, Inc. Manufacturing process for array plate assembly
US7335153B2 (en) 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
US20040020993A1 (en) * 2001-12-28 2004-02-05 Green Larry R. Method for luminescent identification and calibration
DE10201463B4 (de) 2002-01-16 2005-07-21 Clondiag Chip Technologies Gmbh Reaktionsgefäß zur Durchführung von Array-Verfahren
JP3818926B2 (ja) * 2002-02-04 2006-09-06 富士写真フイルム株式会社 リセプター・リガンド会合反応方法
CA2422224A1 (en) 2002-03-15 2003-09-15 Affymetrix, Inc. System, method, and product for scanning of biological materials
US6916621B2 (en) 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
AU2003224817B2 (en) 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US8257967B2 (en) * 2002-04-26 2012-09-04 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
US20040060987A1 (en) * 2002-05-07 2004-04-01 Green Larry R. Digital image analysis method for enhanced and optimized signals in fluorophore detection
US20030208936A1 (en) * 2002-05-09 2003-11-13 Lee Charles Hee Method for manufacturing embroidery decorated cards and envelopes
JP4409426B2 (ja) * 2002-05-28 2010-02-03 オウトジエノミクス・インコーポレーテツド マイクロアレイ検出器および方法
US6939673B2 (en) * 2002-06-14 2005-09-06 Agilent Technologies, Inc. Manufacture of arrays with reduced error impact
US20030232427A1 (en) * 2002-06-18 2003-12-18 Montagu Jean I. Optically active substrates for examination of biological materials
US20030235518A1 (en) * 2002-06-21 2003-12-25 Shea Laurence R. Array assay devices and methods of using the same
US7223592B2 (en) * 2002-06-21 2007-05-29 Agilent Technologies, Inc. Devices and methods for performing array based assays
US7220573B2 (en) * 2002-06-21 2007-05-22 Agilent Technologies, Inc. Array assay devices and methods of using the same
US7080766B2 (en) * 2002-07-01 2006-07-25 Agilent Technologies, Inc. Manufacture of singulated supports comprising arrays
US7154598B2 (en) * 2002-07-12 2006-12-26 Decision Biomarkers, Inc. Excitation and imaging of fluorescent arrays
US20040101444A1 (en) * 2002-07-15 2004-05-27 Xeotron Corporation Apparatus and method for fluid delivery to a hybridization station
EP1385006A3 (de) * 2002-07-24 2004-09-01 F. Hoffmann-La Roche Ag System und Patrone zur Verarbeitung einer biologischen Probe
US7452712B2 (en) 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
JP4057967B2 (ja) * 2002-07-31 2008-03-05 株式会社東芝 塩基配列自動解析装置
US7745203B2 (en) 2002-07-31 2010-06-29 Kabushiki Kaisha Toshiba Base sequence detection apparatus and base sequence automatic analyzing apparatus
US20060127946A1 (en) * 2002-08-16 2006-06-15 Montagu Jean I Reading of fluorescent arrays
US7384742B2 (en) * 2002-08-16 2008-06-10 Decision Biomarkers, Inc. Substrates for isolating reacting and microscopically analyzing materials
US20040043494A1 (en) * 2002-08-30 2004-03-04 Amorese Douglas A. Apparatus for studying arrays
US20060147924A1 (en) * 2002-09-11 2006-07-06 Ramsing Neils B Population of nucleic acids including a subpopulation of lna oligomers
EP2298448A3 (de) 2002-09-25 2012-05-30 California Institute of Technology Hochintegriertes mikrofluidisches Netzwerk
WO2004040001A2 (en) 2002-10-02 2004-05-13 California Institute Of Technology Microfluidic nucleic acid analysis
US6913931B2 (en) * 2002-10-03 2005-07-05 3M Innovative Properties Company Devices, methods and systems for low volume microarray processing
US20040120861A1 (en) * 2002-10-11 2004-06-24 Affymetrix, Inc. System and method for high-throughput processing of biological probe arrays
US20040219565A1 (en) * 2002-10-21 2004-11-04 Sakari Kauppinen Oligonucleotides useful for detecting and analyzing nucleic acids of interest
JP3883951B2 (ja) * 2002-10-24 2007-02-21 富士フイルムホールディングス株式会社 生化学解析用ユニットを利用したアッセイ法および生化学解析装置
EP1419821A1 (de) * 2002-11-14 2004-05-19 F. Hoffmann-La Roche Ag Verfahren, Vorrichtung und Reaktionsbehälter zur Bearbeitung von biologischen Proben
EP1419820A1 (de) * 2002-11-14 2004-05-19 F. Hoffmann-La Roche Ag Verfahren, Vorrichtung und Reaktionbehälter zur Bearbeitung von biologischen Proben
US20040101861A1 (en) * 2002-11-27 2004-05-27 Little Roger G. Resonant cavity photodiode array for rapid DNA microarray readout
JP3969651B2 (ja) * 2002-11-28 2007-09-05 住友ベークライト株式会社 マイクロアレイ用プラスチック基板
US20040259111A1 (en) * 2002-12-10 2004-12-23 Rosetta Inpharmatics Llc Automated system and method for preparing an assay ready biological sample
US20040126766A1 (en) * 2002-12-26 2004-07-01 Amorese Douglas A. Breakaway seal for processing a subarray of an array
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
DE10316723A1 (de) * 2003-04-09 2004-11-18 Siemens Ag Probenplatte zum Einbau in eine Gehäusestruktur
US8652774B2 (en) * 2003-04-16 2014-02-18 Affymetrix, Inc. Automated method of manufacturing polyer arrays
DE10318219A1 (de) * 2003-04-22 2004-11-11 Febit Ag Handhabungs- und Schutzgehäuse für einen Biochip, insbesondere für einen mikrofluidischen Reaktionsträger
WO2004097371A2 (en) * 2003-04-25 2004-11-11 Board Of Regents, The University Of Texas System System and method for the detection of analytes
DE10319712A1 (de) * 2003-05-02 2004-11-25 Sirs-Lab Gmbh Vorrichtung zur Aufnahme von Proben bei Vervielfältigungsreaktionen
WO2004104922A2 (en) * 2003-05-16 2004-12-02 Board Of Regents, The University Of Texas System Image and part recognition technology
US9317922B2 (en) 2003-05-16 2016-04-19 Board Of Regents The University Of Texas System Image and part recognition technology
US20040235147A1 (en) * 2003-05-21 2004-11-25 Affymetrix, Inc. System, method, and encased probe array product
DE10323197B4 (de) * 2003-05-22 2008-10-02 Clondiag Chip Technologies Gmbh Vorrichtung zur Halterung und Detektion von Substanzbibliotheken
US20040241659A1 (en) * 2003-05-30 2004-12-02 Applera Corporation Apparatus and method for hybridization and SPR detection
EP1629285A2 (de) * 2003-06-05 2006-03-01 Bioprocessors Corporation System und verfahren zur prozessautomatisierung
EP1628754A2 (de) * 2003-06-05 2006-03-01 Bioprocessors Corporation Vorrichtung und verfahren zur behandlung von substraten
US20040248323A1 (en) 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
EP2402089A1 (de) 2003-07-31 2012-01-04 Handylab, Inc. Verarbeitung partikelhaltiger Proben
DE10336375A1 (de) * 2003-08-06 2004-12-02 Infineon Technologies Ag Verfahren zum Bestücken von Probenhaltern mit Biochips und Vorrichtungen zur Durchführung des Verfahrens
US7317415B2 (en) 2003-08-08 2008-01-08 Affymetrix, Inc. System, method, and product for scanning of biological materials employing dual analog integrators
DE10336849A1 (de) 2003-08-11 2005-03-10 Thinxxs Gmbh Flusszelle
US7998435B2 (en) 2003-09-19 2011-08-16 Life Technologies Corporation High density plate filler
US9492820B2 (en) 2003-09-19 2016-11-15 Applied Biosystems, Llc High density plate filler
US7695688B2 (en) * 2003-09-19 2010-04-13 Applied Biosystems, Llc High density plate filler
US8277760B2 (en) 2003-09-19 2012-10-02 Applied Biosystems, Llc High density plate filler
US7407630B2 (en) 2003-09-19 2008-08-05 Applera Corporation High density plate filler
CA2544178A1 (en) * 2003-10-30 2005-05-19 Tufts-New England Medical Center Prenatal diagnosis using cell-free fetal dna in amniotic fluid
EP1682902A2 (de) * 2003-11-04 2006-07-26 Roche Diagnostics GmbH Methode zur unterscheidung von mll-ptd positiven aml von anderen aml subtypen
WO2005043161A2 (en) * 2003-11-04 2005-05-12 Roche Diagnostics Gmbh Method for distinguishing leukemia subtypes
US20070105118A1 (en) * 2003-11-04 2007-05-10 Martin Dugas Method for distinguishing aml subtypes with recurring genetic aberrations
EP1530046A1 (de) * 2003-11-04 2005-05-11 Ludwig-Maximilians-Universität München Methode zur Unterscheidung von AML Subtypen mit verändertem Karyotyp mit mittelmässiger Prognose
US20070128607A1 (en) * 2003-11-04 2007-06-07 Martin Dugas Method for distinguishing aml subtypes with different gene dosages
EP1682903A2 (de) * 2003-11-04 2006-07-26 Roche Diagnostics GmbH Methode zur unterscheidung zwischen aml-spezifischen flt3 längenmutationen und tkd mutationen
US20070212688A1 (en) * 2003-11-04 2007-09-13 Martin Dugas Method For Distinguishing Cbf-Positive Aml Subtypes From Cbf-Negative Aml Subtypes
WO2005045435A2 (en) * 2003-11-04 2005-05-19 Roche Diagnostics Gmbh METHOD FOR DISTINGUISHING T(11q23)/MLL-POSITIVE LEUKEMIAS FROM T(11q23)MLL NEGATIVE LEUKEMIAS
US20070207459A1 (en) * 2003-11-04 2007-09-06 Martin Dugas Method For Distinguishing Immunologically Defined All Subtype
EP1533618A1 (de) * 2003-11-04 2005-05-25 Ludwig-Maximilians-Universität München Methode zur Unterscheidung prognostisch definierbarer AML
DE10352716A1 (de) * 2003-11-05 2005-06-16 Einsle, Xaver Plattform
KR100695123B1 (ko) 2003-12-03 2007-03-14 삼성전자주식회사 Tm에 따라 기판상에 고정화된 프로브 폴리뉴클레오티드군을 2이상 포함하는 폴리뉴클레오티드 어레이 및 그를이용하는 표적 핵산 검출 방법
AU2004300168A1 (en) * 2003-12-11 2005-06-30 Board Of Regents, The University Of Texas System Method and system for the analysis of saliva using a sensor array
KR100601936B1 (ko) * 2003-12-17 2006-07-14 삼성전자주식회사 접착부 지지체와 2이상의 접착물질을 갖는 마이크로어레이반응 챔버용 패취
US20080233564A1 (en) * 2004-01-08 2008-09-25 The Ohio State University Methods of Using Databases to Greate Gene-Expression Microarrays, Microarrays Greated Thereby, and Uses of the Microarrays
US20050180894A1 (en) * 2004-02-13 2005-08-18 Affymetrix, Inc. System, method, and product for efficient fluid transfer using and addressable adaptor
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
WO2005113834A2 (en) * 2004-05-20 2005-12-01 Quest Diagnostics Investments Incorporated Single label comparative hybridization
EP1612561A1 (de) * 2004-07-02 2006-01-04 Roche Diagnostics GmbH Instrument zur leistungsfähigen Verarbeitung von Analysevorrichtungen
DE202004011272U1 (de) * 2004-07-17 2004-09-09 Tecan Trading Ag Vorrichtung zum Bereitstellen einer Hybridisierkammer und zum Beeinflussen von Luftblasen in derselben
KR100668304B1 (ko) * 2004-09-16 2007-01-12 삼성전자주식회사 Pcr 혼합액을 pcr 칩의 각 pcr 채널에 주입하기위한 장치 및 상기 장치를 포함하는 pcr 칩 유니트
WO2007018563A2 (en) * 2004-10-05 2007-02-15 Wyeth Probe arrays for detecting multiple strains of different species
KR100601966B1 (ko) * 2004-10-07 2006-07-18 삼성전자주식회사 마이크로 칩 유니트 및 상기 마이크로 칩 유니트를이용하여 생화학 반응을 수행하는 방법
US7682782B2 (en) 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
CA2524964A1 (en) * 2004-10-29 2006-04-29 Affymetrix, Inc. Automated method of manufacturing polymer arrays
US20090118132A1 (en) * 2004-11-04 2009-05-07 Roche Molecular Systems, Inc. Classification of Acute Myeloid Leukemia
DE102004056735A1 (de) 2004-11-09 2006-07-20 Clondiag Chip Technologies Gmbh Vorrichtung für die Durchführung und Analyse von Mikroarray-Experimenten
JP4761241B2 (ja) * 2004-11-18 2011-08-31 独立行政法人理化学研究所 生体分子の相互作用試験装置、生体分子の相互作用試験方法、生体分子の融解温度測定方法、核酸の配列検知方法
US20100256004A1 (en) * 2004-11-18 2010-10-07 Riken Device of Testing Interaction Between Biomolecules, Method of Testing Interaction Between Biomolecules,Method of Measuring Melting Temperature of Biomolecule,Method of Sequencing Nucleic Acid,Method of Causing Interaction Between Biomolecules,and Method of Causing Migration of Biomolecule
JP4610309B2 (ja) * 2004-11-19 2011-01-12 独立行政法人理化学研究所 生体分子を相互作用させる方法、および、生体分子を移動させる方法
EP1842045A4 (de) * 2005-01-18 2009-04-15 Solus Biosystems Inc Screening mehrerer proben mittels ir-spektroskopie
WO2006081353A2 (en) * 2005-01-27 2006-08-03 Quest Diagnostics Investments Incorporated Rapid comparative genome hybridization
US7405831B2 (en) 2005-02-01 2008-07-29 Purdue Research Foundation Laser scanning interferometric surface metrology
US7910356B2 (en) 2005-02-01 2011-03-22 Purdue Research Foundation Multiplexed biological analyzer planar array apparatus and methods
US20070023643A1 (en) 2005-02-01 2007-02-01 Nolte David D Differentially encoded biological analyzer planar array apparatus and methods
KR100624464B1 (ko) * 2005-03-29 2006-09-19 삼성전자주식회사 반자동 마이크로 칩 개폐장치
US20060246576A1 (en) * 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
AU2006309284B2 (en) 2005-05-31 2012-08-02 Board Of Regents, The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
CA2610875A1 (en) * 2005-06-06 2006-12-14 Decision Biomarkers, Inc. Assays based on liquid flow over arrays
WO2006132324A1 (ja) * 2005-06-10 2006-12-14 Olympus Corporation 反応容器およびそれを用いる反応装置
US20060292576A1 (en) * 2005-06-23 2006-12-28 Quest Diagnostics Investments Incorporated Non-in situ hybridization method for detecting chromosomal abnormalities
US8288151B2 (en) * 2005-06-29 2012-10-16 Canon Kabushiki Kaisha Biochemical reaction cassette
EP1937850B1 (de) 2005-10-27 2019-05-29 The President and Fellows of Harvard College Verfahren und zusammensetzungen zur markierung von nukleinsäuren
US8075852B2 (en) 2005-11-02 2011-12-13 Affymetrix, Inc. System and method for bubble removal
US8076074B2 (en) 2005-11-29 2011-12-13 Quest Diagnostics Investments Incorporated Balanced translocation in comparative hybridization
US20070122848A1 (en) 2005-11-29 2007-05-31 Canon Kabushiki Kaisha Biochemical reaction cassette and detection apparatus for biochemical reaction cassette
HU227586B1 (en) * 2005-12-23 2011-08-29 Thales Rt Method for forming sealed channel of microfluidical reactor and microfluidical reactor containing the same
US20090305238A1 (en) * 2006-01-23 2009-12-10 Applera Corporation Microarray Microcard
US8055098B2 (en) 2006-01-27 2011-11-08 Affymetrix, Inc. System, method, and product for imaging probe arrays with small feature sizes
US9445025B2 (en) 2006-01-27 2016-09-13 Affymetrix, Inc. System, method, and product for imaging probe arrays with small feature sizes
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
EP2001990B1 (de) 2006-03-24 2016-06-29 Handylab, Inc. Integriertes system zur verarbeitung von mikrofluidischen proben und verwendungsverfahren
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
WO2007113895A1 (ja) * 2006-04-03 2007-10-11 Shimadzu Corporation 微量液体試料用光学測定装置
US10522240B2 (en) 2006-05-03 2019-12-31 Population Bio, Inc. Evaluating genetic disorders
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
EP3406736B1 (de) 2006-06-14 2022-09-07 Verinata Health, Inc. Verfahren zur diagnose fötaler anomalitäten
EP4108780A1 (de) 2006-06-14 2022-12-28 Verinata Health, Inc. Analyse seltener zellen mittels probentrennung und dna-etiketten
EP2589668A1 (de) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten
EP2043785A2 (de) * 2006-06-29 2009-04-08 GE Healthcare Bio-Sciences AB Kammergerät
US20080026373A1 (en) * 2006-07-26 2008-01-31 Rodionova Natalia A Assays Based On Light Emission From Analyte Complexes Within A Cassette
EP1900824A1 (de) * 2006-09-14 2008-03-19 Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts Genexpressionsprofile zur Prognose, Diagnose und Therapie von Prostatakrebs und deren Verwendung
US7522282B2 (en) 2006-11-30 2009-04-21 Purdue Research Foundation Molecular interferometric imaging process and apparatus
US7807359B2 (en) * 2006-12-01 2010-10-05 Quest Diagnostics Investments Incorporated Methods of detecting TPMT mutations
KR100834745B1 (ko) * 2006-12-20 2008-06-09 삼성전자주식회사 분석 친화적 레이아웃에 기반한 올리고머 프로브 어레이칩, 이의 제조에 사용되는 마스크 및 이의 혼성화 분석방법
US8930178B2 (en) 2007-01-04 2015-01-06 Children's Hospital Medical Center Processing text with domain-specific spreading activation methods
US7659968B2 (en) * 2007-01-19 2010-02-09 Purdue Research Foundation System with extended range of molecular sensing through integrated multi-modal data acquisition
SG193026A1 (en) 2007-02-07 2013-09-30 Decode Genetics Ehf Genetic variants contributing to risk of prostate cancer
US7867783B2 (en) 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
WO2008118934A1 (en) * 2007-03-26 2008-10-02 Purdue Research Foundation Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
JP2008249439A (ja) * 2007-03-30 2008-10-16 Sumitomo Bakelite Co Ltd マイクロアレイ用基板及びその使用方法
US7863037B1 (en) 2007-04-04 2011-01-04 Maven Technologies, Llc Ligand binding assays on microarrays in closed multiwell plates
EP2142659A4 (de) 2007-04-30 2010-06-09 Univ Ohio State Res Found Verfahren zur unterscheidung von bauchspeicheldrüsenkrebs von normalen bauchspeicheldrüsenfunktionen und chronischer bauchspeicheldrüsenentzündung
US20090041633A1 (en) * 2007-05-14 2009-02-12 Dultz Shane C Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
WO2008146309A2 (en) 2007-05-25 2008-12-04 Decode Genetics Ehf. Genetic variants on chr 5pl2 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US7507539B2 (en) * 2007-07-30 2009-03-24 Quest Diagnostics Investments Incorporated Substractive single label comparative hybridization
KR101414232B1 (ko) * 2007-08-02 2014-08-06 삼성전자 주식회사 바이오 칩 패키지 및 바이오 칩 패키지 기판
HK1129808A2 (en) * 2007-10-03 2009-12-04 Diagcor Bioscience Inc Ltd Reversed flow through platform for rapid analysis of target analytes with increased sensitivity and specificity and the device thereof
US20100216655A1 (en) * 2007-10-12 2010-08-26 Patrick Sulem Sequence variants for inferring human pigmentation patterns
EP2056114A1 (de) * 2007-10-29 2009-05-06 Koninklijke Philips Electronics N.V. Automatische Erkennung von Infektionserkrankungen
US8093063B2 (en) * 2007-11-29 2012-01-10 Quest Diagnostics Investments Incorporated Assay for detecting genetic abnormalities in genomic nucleic acids
US8697360B2 (en) 2007-11-30 2014-04-15 Decode Genetics Ehf. Genetic variants on CHR 11Q and 6Q as markers for prostate and colorectal cancer predisposition
US8304255B1 (en) 2008-02-11 2012-11-06 Access Medical Systems, Ltd. Immunoassay cuvettes
NZ587903A (en) * 2008-02-14 2013-05-31 Decode Genetics Ehf Susceptibility for lung cancer using the polymorphic marker rs1051730
EP2107125A1 (de) 2008-03-31 2009-10-07 Eppendorf Array Technologies SA (EAT) Echtzeit-PCR von Targets auf einem Mikroarray
EP2274450A2 (de) 2008-04-01 2011-01-19 Decode Genetics EHF Suszeptibilitätsvarianten bei peripherer arterienkrankheit und bauchschlagader-aneurysma
JP5040777B2 (ja) * 2008-04-03 2012-10-03 住友ベークライト株式会社 マイクロアレイ用プラスチック基板
WO2009137369A1 (en) * 2008-05-03 2009-11-12 Tufts Medical Center, Inc. Neonatal salivary genomics
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
US8039270B2 (en) * 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
AU2009265105A1 (en) * 2008-07-04 2010-01-07 Decode Genetics Ehf Copy number variations predictive of risk of schizophrenia
JP4687756B2 (ja) 2008-07-07 2011-05-25 株式会社村田製作所 プローブアレイおよびその製造方法
EP2313525A2 (de) 2008-07-07 2011-04-27 Decode Genetics EHF Genetische varianten zur beurteilung des brustkrebsrisikos
EP2153892A1 (de) * 2008-07-23 2010-02-17 ETH Zurich Mikroreaktorsystem und Verfahren zum Betrieb eines solchen Mikroreaktorsystems
US20110230366A1 (en) * 2008-08-12 2011-09-22 Decode Genetics Ehf. Genetic Variants Useful for Risk Assessment of Thyroid Cancer
US20110212855A1 (en) * 2008-08-15 2011-09-01 Decode Genetics Ehf. Genetic Variants Predictive of Cancer Risk
KR101523727B1 (ko) * 2008-09-16 2015-05-29 삼성전자주식회사 바이오 칩 패키지 바디, 상기 바이오 칩 패키지 바디의 형성방법 및 상기 바이오 칩 패키지 바디를 포함하는 바이오 칩 패키지
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US9598725B2 (en) 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
CH699853A1 (de) * 2008-11-13 2010-05-14 Tecan Trading Ag Messgerät und Verfahren zum Bestimmen von durch ein Laborsystem bereitgestellten Fluidparametern.
US8039794B2 (en) 2008-12-16 2011-10-18 Quest Diagnostics Investments Incorporated Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby
US8374818B2 (en) * 2008-12-19 2013-02-12 Affymetrix, Inc. System, method and apparatus for calibrating inspection tools
EP2414543B1 (de) 2009-04-03 2016-10-12 Decode Genetics EHF Genetische marker zur risikobewertung von vorhofflimmern und apoplexie
RU2549443C2 (ru) 2009-04-14 2015-04-27 Биокартис Нв Индуцированная высокоинтенсивным фокусированным ультразвуком кавитация с уменьшенным порогом мощности
ES2677010T3 (es) 2009-04-15 2018-07-27 Biocartis Nv Protección de cámaras de muestras bioanalíticas
AU2010237532B2 (en) 2009-04-15 2014-11-20 Biocartis Nv Optical detection system for monitoring rtPCR reaction
WO2010127464A1 (en) 2009-05-06 2010-11-11 Biocartis Sa Device for cutting a sample carrier
CA2759851A1 (en) * 2009-05-08 2010-11-11 Decode Genetics Ehf. Genetic variants contributing to risk of prostate cancer
US9767342B2 (en) 2009-05-22 2017-09-19 Affymetrix, Inc. Methods and devices for reading microarrays
EP2437887B1 (de) 2009-06-04 2016-05-11 Lockheed Martin Corporation Mikrofluidischer chip für dna analyse von mehrfachen proben
AU2010269841A1 (en) 2009-07-10 2012-02-23 Decode Genetics Ehf Genetic markers associated with risk of diabetes mellitus
US8445201B2 (en) * 2009-07-31 2013-05-21 Affymetrix, Inc. Hybridization device, methods, and system using mixing beads
EP2473618B1 (de) 2009-09-02 2015-03-04 Bio-Rad Laboratories, Inc. System zum mischen von flüssigkeiten durch gerinnung mehrerer emulsionen
CN102630250A (zh) 2009-09-25 2012-08-08 基因诊断测试公司 用于检测与癌症和其他疾病相关的染色体异常的多重(+/-)链阵列和测试
US8501122B2 (en) 2009-12-08 2013-08-06 Affymetrix, Inc. Manufacturing and processing polymer arrays
US8355133B2 (en) 2009-12-30 2013-01-15 Maven Technologies, Llc Biological testing with sawtooth-shaped prisms
KR20110106684A (ko) * 2010-03-23 2011-09-29 삼성전자주식회사 마이크로어레이 패키지 장치 및 이를 제조하는 방법
CN102200536B (zh) * 2010-03-25 2015-05-27 艾博生物医药(杭州)有限公司 测试液体样本中被分析物的检测装置
JP6155419B2 (ja) 2010-03-25 2017-07-05 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド 検出用の液滴輸送システム
CA2767182C (en) 2010-03-25 2020-03-24 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
CA2767113A1 (en) 2010-03-25 2011-09-29 Bio-Rad Laboratories, Inc. Detection system for droplet-based assays
DK2601609T3 (en) 2010-08-02 2017-06-06 Population Bio Inc COMPOSITIONS AND METHODS FOR DISCOVERING MUTATIONS CAUSING GENETIC DISORDERS
KR200476469Y1 (ko) * 2010-08-24 2015-03-06 주식회사 파나진 교잡챔버와 바이오칩을 정확하게 부착하기 위한 장치
AU2011315951B2 (en) 2010-10-15 2015-03-19 Lockheed Martin Corporation Micro fluidic optic design
DE202011110979U1 (de) 2010-11-01 2017-12-04 Bio-Rad Laboratories, Inc. System zum Bilden von Emulsionen
WO2012095872A1 (en) 2011-01-13 2012-07-19 Decode Genetics Ehf Genetic variants as markers for use in urinary bladder cancer risk assessment, diagnosis, prognosis and treatment
US8309045B2 (en) 2011-02-11 2012-11-13 General Electric Company System and method for controlling emissions in a combustion system
CA2830443C (en) 2011-03-18 2021-11-16 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
BR112013026451B1 (pt) 2011-04-15 2021-02-09 Becton, Dickinson And Company sistema e método para realizar ensaios de diagnóstico molecular em várias amostras em paralelo e simultaneamente amplificação em tempo real em pluralidade de câmaras de reação de amplificação
CA2834291A1 (en) 2011-04-25 2012-11-01 Biorad Laboratories, Inc. Methods and compositions for nucleic acid analysis
EP2737089B1 (de) 2011-07-29 2017-09-06 Bio-rad Laboratories, Inc. Bibliothekscharakterisierung durch digitalen test
EP2766483B1 (de) 2011-10-10 2022-03-23 The Hospital For Sick Children Verfahren und zusammensetzungen zum screening und zur behandlung von entwicklungsstörungen
US9599561B2 (en) 2011-10-13 2017-03-21 Affymetrix, Inc. Methods, systems and apparatuses for testing and calibrating fluorescent scanners
EP2773892B1 (de) 2011-11-04 2020-10-07 Handylab, Inc. Vorrichtung zur vorbereitung von polynukleotidproben
DK2773779T3 (da) 2011-11-04 2020-11-23 Population Bio Inc Fremgangsmåder og sammensætninger til diagnosticering, prognose og forebyggelse af neurologiske tilstande
US9212381B2 (en) 2011-11-10 2015-12-15 President And Fellows Of Harvard College Methods and compositions for labeling polypeptides
EP3483288B1 (de) 2011-11-30 2022-03-16 Children's Hospital Medical Center Personalisiertes schmerzmanagement und anästhesie: präventive risikoidentifizierung
US10407724B2 (en) 2012-02-09 2019-09-10 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
WO2013155531A2 (en) 2012-04-13 2013-10-17 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
DK2895621T3 (da) 2012-09-14 2020-11-30 Population Bio Inc Fremgangsmåder og sammensætning til diagnosticering, prognose og behandling af neurologiske tilstande
WO2014052855A1 (en) 2012-09-27 2014-04-03 Population Diagnostics, Inc. Methods and compositions for screening and treating developmental disorders
WO2014074942A1 (en) 2012-11-08 2014-05-15 Illumina, Inc. Risk variants of alzheimer's disease
US20140274749A1 (en) 2013-03-15 2014-09-18 Affymetrix, Inc. Systems and Methods for SNP Characterization and Identifying off Target Variants
WO2014142330A1 (ja) * 2013-03-15 2014-09-18 株式会社ニコン バイオチップ固定方法、バイオチップ固定装置及び生体分子アレイのスクリーニング方法
JPWO2015016315A1 (ja) * 2013-08-02 2017-03-02 株式会社ニコン プレート、プレートの製造方法、バイオチップの観察方法、及びスクリーニング方法
EP3040723A4 (de) * 2013-08-30 2017-07-12 Nikon Corporation Biochipträgerelement, verfahren zur herstellung des biochipträgerelements, biochipverpackung, screening-vorrichtung und screening-verfahren
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
EP2891722B1 (de) 2013-11-12 2018-10-10 Population Bio, Inc. Verfahren und Zusammensetzungen zur Diagnose, Prognose und Behandlung von Endometriose
WO2015079998A1 (ja) * 2013-11-29 2015-06-04 三菱レイヨン株式会社 バイオチップ保持具、バイオチップ保持具の製造方法、バイオチップ押さえ具、およびバイオチップ保持具キット
WO2015085066A1 (en) * 2013-12-06 2015-06-11 BacterioScan Inc. Optical measurement cuvette having sample chambers
CN103640211A (zh) * 2013-12-23 2014-03-19 中国石油大学(华东) 一种柔性材料辅助聚合物微结构超声波键合封装方法
CA2940422A1 (en) 2014-02-24 2015-08-27 Children's Hospital Medical Center Methods and compositions for personalized pain management
US10634590B2 (en) * 2014-03-11 2020-04-28 Emd Millipore Corporation IHC, tissue slide fluid exchange disposable and system
JP2015194379A (ja) * 2014-03-31 2015-11-05 株式会社ニコン バイオチップ及びバイオチップにおけるアライメントマークの検出方法
WO2015189390A1 (en) 2014-06-13 2015-12-17 Q-Linea Ab Method for detecting and characterising a microorganism
EP3177738B1 (de) 2014-08-08 2019-10-09 Children's Hospital Medical Center Diagnoseverfahren zur unterscheidung von formen von ösophagealer eosinophilie
US10724096B2 (en) 2014-09-05 2020-07-28 Population Bio, Inc. Methods and compositions for inhibiting and treating neurological conditions
GB201507026D0 (en) 2015-04-24 2015-06-10 Linea Ab Q Medical sample transportation container
TWI553796B (zh) * 2015-08-18 2016-10-11 姜崇義 溫測晶片封裝方法及其系統
US9754836B2 (en) 2015-11-17 2017-09-05 Pacific Biosciences Of California, Inc. Packaging methods for fabrication of analytical device packages and analytical device packages made thereof
EP3402572B1 (de) 2016-01-13 2022-03-16 Children's Hospital Medical Center Zusammensetzungen und verfahren zur behandlung von allergischen entzündungserkrankungen
US9659838B1 (en) * 2016-03-28 2017-05-23 Lockheed Martin Corporation Integration of chip level micro-fluidic cooling in chip packages for heat flux removal
GB2554767A (en) 2016-04-21 2018-04-11 Q Linea Ab Detecting and characterising a microorganism
EP3571309A4 (de) 2017-01-20 2020-11-25 Children's Hospital Medical Center Verfahren und zusammensetzungen in bezug auf die oprm1-dns-methylierung für personalisiertes schmerzmanagement
US10240205B2 (en) 2017-02-03 2019-03-26 Population Bio, Inc. Methods for assessing risk of developing a viral disease using a genetic test
US11859250B1 (en) 2018-02-23 2024-01-02 Children's Hospital Medical Center Methods for treating eosinophilic esophagitis
JP2018124289A (ja) * 2018-04-10 2018-08-09 株式会社ニコン バイオチップ及びバイオチップにおけるアライメントマークの検出方法
EP3625368B8 (de) 2018-08-08 2022-12-14 PML Screening, LLC Verfahren zur beurteilung des risikos der entwicklung von durch john-cunningham-virus verursachter progressiver multifokaler leukenzephalopathie durch genetisches testen
DE102020213471A1 (de) 2020-10-27 2022-04-28 Robert Bosch Gesellschaft mit beschränkter Haftung Prozessierungseinrichtung zum Prozessieren einer Probenflüssigkeit, Verfahren zum Herstellen einer Prozessierungseinrichtung und Verfahren zum Betreiben einer Prozessierungseinrichtung
JP2024029793A (ja) * 2022-08-23 2024-03-07 東洋製罐グループホールディングス株式会社 マイクロ流体デバイス、マイクロ流体デバイスの製造方法、及び検査システム

Family Cites Families (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1617732C2 (de) * 1966-03-01 1972-12-21 Promoveo-Sobioda & Cie, Seyssinet (Frankreich) Vorrichtung zur Untersuchung lebender Zellen von Mikroorganismen
US3802966A (en) * 1969-08-22 1974-04-09 Ethyl Corp Apparatus for delivering a fluid suspension to a forming unit clear reactor power plant
GB1320426A (en) * 1971-07-06 1973-06-13 Pfizer Multiple solution testing device
BE793185A (fr) * 1971-12-23 1973-04-16 Atomic Energy Commission Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques
JPS6112373B2 (de) * 1974-09-04 1986-04-08 Hitachi Ltd
US4204929A (en) * 1978-04-18 1980-05-27 University Patents, Inc. Isoelectric focusing method
US4190040A (en) * 1978-07-03 1980-02-26 American Hospital Supply Corporation Resealable puncture housing for surgical implantation
US4500707A (en) * 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
FI76888C (fi) * 1981-04-29 1988-12-12 Ciba Geigy Ag Nya medel och foerpackningar foer immunologiska analyser.
US4373071A (en) * 1981-04-30 1983-02-08 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US4447140A (en) * 1982-09-29 1984-05-08 Campbell Jeptha E Microscope slides
FI71768C (fi) * 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
DE3565986D1 (en) * 1984-05-02 1988-12-08 Brendan James Hamill An apparatus for the chemical synthesis of oligonucleotides
GB8429212D0 (en) * 1984-11-19 1984-12-27 Vincent Patents Ltd Exhaust systems for ic engines
FR2584090B1 (fr) * 1985-06-27 1987-08-28 Roussel Uclaf Nouveaux supports, leur preparation et les intermediaires obtenus, leur application a la synthese d'oligonucleotides et les nouveaux nucleosides et oligonucleotides relies aux supports ainsi obtenus
US4963498A (en) * 1985-08-05 1990-10-16 Biotrack Capillary flow device
US5164598A (en) * 1985-08-05 1992-11-17 Biotrack Capillary flow device
US4912035A (en) * 1987-06-11 1990-03-27 Eastman Kodak Company Method for minimizing interference by reductants when detecting cells in biological fluids
US5714380A (en) * 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
JPH0750094B2 (ja) * 1987-01-28 1995-05-31 富士写真フイルム株式会社 化学分析スライドの連続製造方法
US4965725B1 (en) * 1988-04-08 1996-05-07 Neuromedical Systems Inc Neural network based automated cytological specimen classification system and method
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
US5320808A (en) * 1988-08-02 1994-06-14 Abbott Laboratories Reaction cartridge and carousel for biological sample analyzer
US5382511A (en) * 1988-08-02 1995-01-17 Gene Tec Corporation Method for studying nucleic acids within immobilized specimens
US5281540A (en) * 1988-08-02 1994-01-25 Abbott Laboratories Test array for performing assays
US5281516A (en) * 1988-08-02 1994-01-25 Gene Tec Corporation Temperature control apparatus and method
US4992383A (en) * 1988-08-05 1991-02-12 Porton Instruments, Inc. Method for protein and peptide sequencing using derivatized glass supports
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6955915B2 (en) * 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5196305A (en) * 1989-09-12 1993-03-23 Eastman Kodak Company Diagnostic and amplification methods using primers having thymine at 3' end to overcome primer-target mismatch at the 3' end
US5346672A (en) * 1989-11-17 1994-09-13 Gene Tec Corporation Devices for containing biological specimens for thermal processing
US5091652A (en) * 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
US5192503A (en) * 1990-05-23 1993-03-09 Mcgrath Charles M Probe clip in situ assay apparatus
US5100626A (en) * 1990-05-24 1992-03-31 Levin Andrew E Binding assay device with removable cassette and manifold
US5204253A (en) * 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
JPH06504997A (ja) * 1990-12-06 1994-06-09 アフィメトリックス, インコーポレイテッド 非常に大きい規模の固定化されたポリマーの合成
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5384261A (en) * 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
EP0916396B1 (de) * 1991-11-22 2005-04-13 Affymetrix, Inc. (a Delaware Corporation) Kombinatorische Strategien für die Polymersynthese
US5310469A (en) * 1991-12-31 1994-05-10 Abbott Laboratories Biosensor with a membrane containing biologically active material
US5486335A (en) * 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
JP2673078B2 (ja) * 1992-05-27 1997-11-05 東芝電池株式会社 アルカリ二次電池用のペースト式電極
FI923220A (fi) * 1992-07-14 1994-01-15 Wallac Oy Foerfarande och apparatur foer hantering av prov samt provuppsamlingssystem
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5508200A (en) * 1992-10-19 1996-04-16 Tiffany; Thomas Method and apparatus for conducting multiple chemical assays
US5482591A (en) * 1992-10-30 1996-01-09 Specialty Silicone Products, Inc. Laminated seals and method of production
US5314829A (en) * 1992-12-18 1994-05-24 California Institute Of Technology Method for imaging informational biological molecules on a semiconductor substrate
US6258325B1 (en) * 1993-04-19 2001-07-10 Ashok Ramesh Sanadi Method and apparatus for preventing cross-contamination of multi-well test plates
DE4313253A1 (de) * 1993-04-23 1994-10-27 Boehringer Mannheim Gmbh System zur Analyse von Inhaltsstoffen flüssiger Proben
IL110298A (en) * 1993-07-13 1999-04-11 Brann Mark Robert Identification of ligands by selective amplification of cells transfected with receptors
US5382512A (en) * 1993-08-23 1995-01-17 Chiron Corporation Assay device with captured particle reagent
US5494124A (en) * 1993-10-08 1996-02-27 Vortexx Group, Inc. Negative pressure vortex nozzle
FR2714061B1 (fr) * 1993-12-16 1996-03-08 Genset Sa Procédé de préparation de polynucléotides sur support solide et appareil permettant sa mise en Óoeuvre.
US5631734A (en) * 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5571639A (en) * 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
DE69527585T2 (de) * 1994-06-08 2003-04-03 Affymetrix Inc Verfahren und Vorrichtung zum Verpacken von Chips
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
US5485277A (en) * 1994-07-26 1996-01-16 Physical Optics Corporation Surface plasmon resonance sensor and methods for the utilization thereof
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5843655A (en) * 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
US5605653A (en) * 1995-11-09 1997-02-25 Devos; Jerry Liquid circulation apparatus
US6660233B1 (en) * 1996-01-16 2003-12-09 Beckman Coulter, Inc. Analytical biochemistry system with robotically carried bioarray
US6114122A (en) * 1996-03-26 2000-09-05 Affymetrix, Inc. Fluidics station with a mounting system and method of using
EP1007966A4 (de) * 1996-08-21 2001-10-17 Smithkline Beecham Corp Schnellverfahren zum gruppieren und synthesieren von wulstbasierenden kombinatorischen bibliotheken
US6054100A (en) * 1996-11-18 2000-04-25 Robbins Scientific Corporation Apparatus for multi-well microscale synthesis
US6008892A (en) * 1997-05-23 1999-12-28 Molecular Dynamics, Inc. Optical substrate for enhanced detectability of fluorescence
US5948685A (en) * 1998-02-10 1999-09-07 Angros; Lee Analytic plate with containment border and method of use
US6713304B2 (en) * 1998-02-10 2004-03-30 Lee H. Angros Method of forming a containment border on an analytic plate
US6030582A (en) * 1998-03-06 2000-02-29 Levy; Abner Self-resealing, puncturable container cap
US6376619B1 (en) * 1998-04-13 2002-04-23 3M Innovative Properties Company High density, miniaturized arrays and methods of manufacturing same
DE69935230T2 (de) * 1998-08-10 2007-12-20 Genomic Solutions, Inc., Ann Arbor Vorrichtung für thermische und flüssige zirkulation zur hybridierung von nukleinsäuren
US6186659B1 (en) * 1998-08-21 2001-02-13 Agilent Technologies Inc. Apparatus and method for mixing a film of fluid
US7612020B2 (en) * 1998-12-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
US6215894B1 (en) * 1999-02-26 2001-04-10 General Scanning, Incorporated Automatic imaging and analysis of microarray biochips
US6555361B1 (en) * 1999-03-24 2003-04-29 Corning Incorporated Hybridization chamber for high density nucleic acid arrays
US6355431B1 (en) * 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US6323043B1 (en) * 1999-04-30 2001-11-27 Agilent Technologies, Inc. Fabricating biopolymer arrays
EP1190233B1 (de) * 1999-05-20 2006-08-30 Illumina, Inc. Vorrichtung zur halterung und präsentation von mindestens einer mikrokugelmatrix zu lösungen und/oder zu optischen abbildungssystemen
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US6180351B1 (en) * 1999-07-22 2001-01-30 Agilent Technologies Inc. Chemical array fabrication with identifier
US6395483B1 (en) * 1999-09-02 2002-05-28 3M Innovative Properties Company Arrays with mask layers
US6232072B1 (en) * 1999-10-15 2001-05-15 Agilent Technologies, Inc. Biopolymer array inspection
DE59913714D1 (de) * 1999-12-21 2006-09-07 Tecan Trading Ag Klemmvorrichtung zur Aufnahme und genauer Positionierung eines Gegenstandes, vorzüglich einer Mikrotiterplatte, sowie Verfahren zu ihrem Betrieb
US6545758B1 (en) * 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
US20030096239A1 (en) * 2000-08-25 2003-05-22 Kevin Gunderson Probes and decoder oligonucleotides
US6864097B1 (en) * 2000-09-27 2005-03-08 Agilent Technologies, Inc. Arrays and their reading
JP2002222858A (ja) * 2001-01-25 2002-08-09 Mitsubishi Electric Corp 半導体装置およびその製造方法
US6991939B2 (en) * 2001-07-19 2006-01-31 Tufts University Optical array device and methods of use thereof for screening, analysis and manipulation of particles
US20030040129A1 (en) * 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
US6682702B2 (en) * 2001-08-24 2004-01-27 Agilent Technologies, Inc. Apparatus and method for simultaneously conducting multiple chemical reactions
US20030087292A1 (en) * 2001-10-04 2003-05-08 Shiping Chen Methods and systems for promoting interactions between probes and target molecules in fluid in microarrays
US7018842B2 (en) * 2002-02-28 2006-03-28 Agilent Technologies, Inc. Reading dry chemical arrays through the substrate
US20030235520A1 (en) * 2002-06-21 2003-12-25 Shea Laurence R. Array assay devices and methods of using the same
US20040086868A1 (en) * 2002-10-30 2004-05-06 Parker Russell A. Enclosed arrays and their reading
US20050026299A1 (en) * 2003-07-31 2005-02-03 Arindam Bhattacharjee Chemical arrays on a common carrier
US7223609B2 (en) * 2003-08-14 2007-05-29 Agilent Technologies, Inc. Arrays for multiplexed surface plasmon resonance detection of biological molecules

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US5945334A (en) 1999-08-31
WO1995033846A1 (en) 1995-12-14
EP0764214B1 (de) 2005-08-31
US20090143249A1 (en) 2009-06-04
JPH08166387A (ja) 1996-06-25
JP2006153877A (ja) 2006-06-15
AU2943695A (en) 1996-01-04
US6140044A (en) 2000-10-31
JP3790280B2 (ja) 2006-06-28
EP1562045A3 (de) 2005-11-02
EP0695941B1 (de) 2002-07-31
EP0764214A4 (de) 1997-05-07
DE69527585D1 (de) 2002-09-05
EP0695941A2 (de) 1996-02-07
JP3884048B2 (ja) 2007-02-21
US20100298165A1 (en) 2010-11-25
JPH10505410A (ja) 1998-05-26
DE69527585T2 (de) 2003-04-03
EP0764214A1 (de) 1997-03-26
EP1562045A2 (de) 2005-08-10
EP0695941A3 (de) 1996-12-27
DE69534418T2 (de) 2006-06-22
JP2005345481A (ja) 2005-12-15

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