DE69533043D1 - Acrylamid-derivate und verfahren zu deren herstellung - Google Patents

Acrylamid-derivate und verfahren zu deren herstellung

Info

Publication number: DE69533043D1
Authority: DE; Germany
Prior art keywords: acrylamide derivatives; general formula; production; derivatives represented; eüindole
Prior art date: 1994-11-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69533043T

Other languages

English (en)

Other versions

DE69533043T2 (de

Inventor

Yasumichi Fukuda

Shigeki Seto

Yasuo Oomori

Hiroyuki Ebisu

Shiro Terashima

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kyorin Pharmaceutical Co Ltd

Sagami Chemical Research Institute

Original Assignee

Kyorin Pharmaceutical Co Ltd

Sagami Chemical Research Institute

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-29

Filing date

1995-11-28

Publication date

2004-06-17

1995-11-28 Application filed by Kyorin Pharmaceutical Co Ltd, Sagami Chemical Research Institute filed Critical Kyorin Pharmaceutical Co Ltd

2004-06-17 Application granted granted Critical

2004-06-17 Publication of DE69533043D1 publication Critical patent/DE69533043D1/de

2005-04-07 Publication of DE69533043T2 publication Critical patent/DE69533043T2/de

2015-11-29 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical class NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 2
150000003926 acrylamides Chemical class 0.000 abstract 2
201000011510 cancer Diseases 0.000 abstract 1
231100001231 less toxic Toxicity 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

DE69533043T 1994-11-29 1995-11-28 Acrylamid-derivate und verfahren zu deren herstellung Expired - Fee Related DE69533043T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP29527494		1994-11-29
JP29527494		1994-11-29
PCT/JP1995/002413 WO1996016965A1 (fr)	1994-11-29	1995-11-28	Derives d'acrylamide et leur procede de production

Publications (2)

Publication Number	Publication Date
DE69533043D1 true DE69533043D1 (de)	2004-06-17
DE69533043T2 DE69533043T2 (de)	2005-04-07

Family

ID=17818480

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69533043T Expired - Fee Related DE69533043T2 (de)	1994-11-29	1995-11-28	Acrylamid-derivate und verfahren zu deren herstellung

Country Status (12)

Country	Link
US (1)	US5786486A (de)
EP (1)	EP0799827B1 (de)
KR (1)	KR100395083B1 (de)
CN (1)	CN1051552C (de)
AT (1)	ATE266663T1 (de)
AU (1)	AU693283B2 (de)
CA (1)	CA2205872A1 (de)
DE (1)	DE69533043T2 (de)
FI (1)	FI972074A0 (de)
HU (1)	HUT77654A (de)
MX (1)	MX9703917A (de)
WO (1)	WO1996016965A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2216533C2 (ru)	1998-01-28	2003-11-20	Шионоги Энд Ко., Лтд.	Новые трициклические производные (варианты), фармацевтическая композиция (варианты), способ подавления иммуной реакции или лечения и/или предупреждения аллергических заболеваний (варианты)
KR20030033007A (ko) *	2001-05-31	2003-04-26	코울터 파머수티컬, 인코포레이티드	세포독소, 약물전구체, 링커 및 이에 유용한 안정화제
AU2005244980B2 (en) *	2004-05-19	2011-09-15	E. R. Squibb & Sons, L.L.C.	Chemical linkers and conjugates thereof
US7691962B2 (en) *	2004-05-19	2010-04-06	Medarex, Inc.	Chemical linkers and conjugates thereof
EP1851250B1 (de) *	2005-02-18	2012-06-06	Medarex, Inc.	Menschlicher monoklonaler antikörper gegen ein prostataspezifisches membranantigen
US7714016B2 (en) *	2005-04-08	2010-05-11	Medarex, Inc.	Cytotoxic compounds and conjugates with cleavable substrates
EP1940789B1 (de)	2005-10-26	2011-11-23	Medarex, Inc.	Verfahren und verbindungen zur herstellung von cc-1065-analoga
WO2007059404A2 (en)	2005-11-10	2007-05-24	Medarex, Inc.	Duocarmycin derivatives as novel cytotoxic compounds and conjugates
TWI412367B (zh)	2006-12-28	2013-10-21	Medarex Llc	化學鏈接劑與可裂解基質以及其之綴合物
JP2010519310A (ja)	2007-02-21	2010-06-03	メダレックスインコーポレイテッド	単一のアミノ酸を有する化学リンカーおよびその複合体
US10131682B2 (en)	2012-11-24	2018-11-20	Hangzhou Dac Biotech Co., Ltd.	Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
AU2014384434B2 (en)	2014-02-28	2016-11-03	Hangzhou Dac Biotech Co., Ltd	Charged linkers and their uses for conjugation
CN108449940B (zh)	2015-07-12	2021-06-08	杭州多禧生物科技有限公司	与细胞结合分子的共轭偶联的桥连接体
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
KR20220147721A (ko)	2016-11-14	2022-11-03	항저우 디에이씨 바이오테크 씨오, 엘티디	결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1238907A (en) *	1984-02-21	1988-07-05	Robert C. Kelly	1,2,8,8a-tetrahydrocyclopropa¬c\|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
MX9203200A (es) *	1986-12-19	1992-09-01	Upjohn Co	Analogos de cc. 1065 novedosos.
US5258383A (en) *	1991-06-28	1993-11-02	Kyowa Hakko Kogyo Co., Ltd.	DC-89 derivatives
JP2502005B2 (ja)	1992-04-27	1996-05-29	オンキヨー株式会社	バイオフィ―ドバックシステム
JP3514490B2 (ja) *	1992-08-21	2004-03-31	杏林製薬株式会社	トリフルオロメチルピロロインドールカルボン酸エステル誘導体及びその製造方法

1995
- 1995-11-28 EP EP95937194A patent/EP0799827B1/de not_active Expired - Lifetime
- 1995-11-28 US US08/849,160 patent/US5786486A/en not_active Expired - Fee Related
- 1995-11-28 WO PCT/JP1995/002413 patent/WO1996016965A1/ja active IP Right Grant
- 1995-11-28 AU AU39370/95A patent/AU693283B2/en not_active Ceased
- 1995-11-28 AT AT95937194T patent/ATE266663T1/de not_active IP Right Cessation
- 1995-11-28 HU HU9800067A patent/HUT77654A/hu not_active Application Discontinuation
- 1995-11-28 KR KR1019970703468A patent/KR100395083B1/ko not_active IP Right Cessation
- 1995-11-28 DE DE69533043T patent/DE69533043T2/de not_active Expired - Fee Related
- 1995-11-28 MX MX9703917A patent/MX9703917A/es not_active IP Right Cessation
- 1995-11-28 CA CA002205872A patent/CA2205872A1/en not_active Abandoned
- 1995-11-28 CN CN95197472A patent/CN1051552C/zh not_active Expired - Fee Related
1997
- 1997-05-14 FI FI972074A patent/FI972074A0/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUT77654A (hu)	1998-07-28
FI972074A0 (fi)	1997-05-14
AU693283B2 (en)	1998-06-25
CN1051552C (zh)	2000-04-19
EP0799827A1 (de)	1997-10-08
MX9703917A (es)	1998-05-31
CN1174553A (zh)	1998-02-25
WO1996016965A1 (fr)	1996-06-06
EP0799827A4 (de)	1998-01-28
EP0799827B1 (de)	2004-05-12
KR100395083B1 (ko)	2004-02-05
ATE266663T1 (de)	2004-05-15
DE69533043T2 (de)	2005-04-07
AU3937095A (en)	1996-06-19
US5786486A (en)	1998-07-28
CA2205872A1 (en)	1996-06-06

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Legal Events

Date	Code	Title	Description
2006-05-18	8364	No opposition during term of opposition
2007-09-13	8339	Ceased/non-payment of the annual fee