DE69533043D1 - Acrylamid-derivate und verfahren zu deren herstellung - Google Patents

Acrylamid-derivate und verfahren zu deren herstellung

Info

Publication number: DE69533043D1
Authority: DE; Germany
Prior art keywords: acrylamide derivatives; general formula; production; derivatives represented; eüindole
Prior art date: 1994-11-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69533043T

Other languages

English (en)

Other versions

DE69533043T2 (de

Inventor

Yasumichi Fukuda

Shigeki Seto

Yasuo Oomori

Hiroyuki Ebisu

Shiro Terashima

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kyorin Pharmaceutical Co Ltd

Sagami Chemical Research Institute

Original Assignee

Kyorin Pharmaceutical Co Ltd

Sagami Chemical Research Institute

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-29

Filing date

1995-11-28

Publication date

2004-06-17

1995-11-28 Application filed by Kyorin Pharmaceutical Co Ltd, Sagami Chemical Research Institute filed Critical Kyorin Pharmaceutical Co Ltd

2004-06-17 Publication of DE69533043D1 publication Critical patent/DE69533043D1/de

2005-04-07 Application granted granted Critical

2005-04-07 Publication of DE69533043T2 publication Critical patent/DE69533043T2/de

2015-11-29 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical class NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 2
150000003926 acrylamides Chemical class 0.000 abstract 2
201000011510 cancer Diseases 0.000 abstract 1
231100001231 less toxic Toxicity 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

DE69533043T 1994-11-29 1995-11-28 Acrylamid-derivate und verfahren zu deren herstellung Expired - Fee Related DE69533043T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP29527494		1994-11-29
JP29527494		1994-11-29
PCT/JP1995/002413 WO1996016965A1 (fr)	1994-11-29	1995-11-28	Derives d'acrylamide et leur procede de production

Publications (2)

Publication Number	Publication Date
DE69533043D1 true DE69533043D1 (de)	2004-06-17
DE69533043T2 DE69533043T2 (de)	2005-04-07

Family

ID=17818480

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69533043T Expired - Fee Related DE69533043T2 (de)	1994-11-29	1995-11-28	Acrylamid-derivate und verfahren zu deren herstellung

Country Status (12)

Country	Link
US (1)	US5786486A (de)
EP (1)	EP0799827B1 (de)
KR (1)	KR100395083B1 (de)
CN (1)	CN1051552C (de)
AT (1)	ATE266663T1 (de)
AU (1)	AU693283B2 (de)
CA (1)	CA2205872A1 (de)
DE (1)	DE69533043T2 (de)
FI (1)	FI972074A0 (de)
HU (1)	HUT77654A (de)
MX (1)	MX9703917A (de)
WO (1)	WO1996016965A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ506101A (en)	1998-01-28	2003-06-30	Shionogi & Co	Tricyclic immunosupressant, anti-allergic and IgE production suppressant compounds
WO2002096910A1 (en) *	2001-05-31	2002-12-05	Medarex, Inc.	Cytotoxins, prodrugs, linkers and stabilizers useful therefor
US7517903B2 (en) *	2004-05-19	2009-04-14	Medarex, Inc.	Cytotoxic compounds and conjugates
RU2402548C2 (ru) *	2004-05-19	2010-10-27	Медарекс, Инк.	Химические линкеры и их конъюгаты
US20090297438A1 (en) *	2005-02-18	2009-12-03	Haichun Huang	Human Monoclonal Antibodies to Prostate Specific Membrane Antigen (PSMA)
US7714016B2 (en) *	2005-04-08	2010-05-11	Medarex, Inc.	Cytotoxic compounds and conjugates with cleavable substrates
DK1940789T3 (da)	2005-10-26	2012-03-19	Medarex Inc	Fremgangsmåder og forbindelser til fremstilling af CC-1065-analoger
CA2627190A1 (en)	2005-11-10	2007-05-24	Medarex, Inc.	Duocarmycin derivatives as novel cytotoxic compounds and conjugates
TWI412367B (zh)	2006-12-28	2013-10-21	Medarex Llc	化學鏈接劑與可裂解基質以及其之綴合物
AR065404A1 (es)	2007-02-21	2009-06-03	Medarex Inc	Conjugados farmaco-ligando, los que se unen a citotoxinas potentes, composicion farmaceutica que los contienen y su uso para retardar o detener el crecimiento de un tumor en un mamifero
JP6133431B2 (ja)	2012-11-24	2017-05-24	ハンジョウディーエーシーバイオテックシーオー．，エルティディ．ＨａｎｇｚｈｏｕＤａｃＢｉｏｔｅｃｈＣｏ．，Ｌｔｄ．	親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用
PT3122757T (pt)	2014-02-28	2023-11-03	Hangzhou Dac Biotech Co Ltd	Ligantes carregados e as suas utilizações em conjugação
CN113350518A (zh)	2015-07-12	2021-09-07	杭州多禧生物科技有限公司	与细胞结合分子的共轭偶联的桥连接体
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
CN116143678A (zh)	2016-11-14	2023-05-23	杭州多禧生物科技有限公司	偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1238907A (en) *	1984-02-21	1988-07-05	Robert C. Kelly	1,2,8,8a-tetrahydrocyclopropa¬c\|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
WO1988004659A2 (en) *	1986-12-19	1988-06-30	The Upjohn Company	Novel cc-1065 analogs
US5258383A (en) *	1991-06-28	1993-11-02	Kyowa Hakko Kogyo Co., Ltd.	DC-89 derivatives
JP2502005B2 (ja)	1992-04-27	1996-05-29	オンキヨー株式会社	バイオフィ―ドバックシステム
JP3514490B2 (ja) *	1992-08-21	2004-03-31	杏林製薬株式会社	トリフルオロメチルピロロインドールカルボン酸エステル誘導体及びその製造方法

1995
- 1995-11-28 AU AU39370/95A patent/AU693283B2/en not_active Ceased
- 1995-11-28 WO PCT/JP1995/002413 patent/WO1996016965A1/ja active IP Right Grant
- 1995-11-28 AT AT95937194T patent/ATE266663T1/de not_active IP Right Cessation
- 1995-11-28 CN CN95197472A patent/CN1051552C/zh not_active Expired - Fee Related
- 1995-11-28 US US08/849,160 patent/US5786486A/en not_active Expired - Fee Related
- 1995-11-28 CA CA002205872A patent/CA2205872A1/en not_active Abandoned
- 1995-11-28 KR KR1019970703468A patent/KR100395083B1/ko not_active IP Right Cessation
- 1995-11-28 DE DE69533043T patent/DE69533043T2/de not_active Expired - Fee Related
- 1995-11-28 HU HU9800067A patent/HUT77654A/hu not_active Application Discontinuation
- 1995-11-28 MX MX9703917A patent/MX9703917A/es not_active IP Right Cessation
- 1995-11-28 EP EP95937194A patent/EP0799827B1/de not_active Expired - Lifetime
1997
- 1997-05-14 FI FI972074A patent/FI972074A0/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUT77654A (hu)	1998-07-28
ATE266663T1 (de)	2004-05-15
EP0799827B1 (de)	2004-05-12
DE69533043T2 (de)	2005-04-07
FI972074A0 (fi)	1997-05-14
CN1174553A (zh)	1998-02-25
EP0799827A1 (de)	1997-10-08
KR100395083B1 (ko)	2004-02-05
AU3937095A (en)	1996-06-19
US5786486A (en)	1998-07-28
CN1051552C (zh)	2000-04-19
CA2205872A1 (en)	1996-06-06
AU693283B2 (en)	1998-06-25
MX9703917A (es)	1998-05-31
WO1996016965A1 (fr)	1996-06-06
EP0799827A4 (de)	1998-01-28

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Legal Events

Date	Code	Title	Description
2006-05-18	8364	No opposition during term of opposition
2007-09-13	8339	Ceased/non-payment of the annual fee