DE69532855D1 - Lichtwellenleiter-verfahren zur detektion spezifischer bindungsreaktionen nach der streulichtmethode - Google Patents

Lichtwellenleiter-verfahren zur detektion spezifischer bindungsreaktionen nach der streulichtmethode

Info

Publication number
DE69532855D1
DE69532855D1 DE69532855T DE69532855T DE69532855D1 DE 69532855 D1 DE69532855 D1 DE 69532855D1 DE 69532855 T DE69532855 T DE 69532855T DE 69532855 T DE69532855 T DE 69532855T DE 69532855 D1 DE69532855 D1 DE 69532855D1
Authority
DE
Germany
Prior art keywords
waveguide
scattering
binding
specific binding
real
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69532855T
Other languages
English (en)
Other versions
DE69532855T2 (de
Inventor
I Stimpson
Julian Gordon
V Hoijer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of DE69532855D1 publication Critical patent/DE69532855D1/de
Publication of DE69532855T2 publication Critical patent/DE69532855T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
DE69532855T 1994-09-22 1995-09-20 Lichtwellenleiter-verfahren zur detektion spezifischer bindungsreaktionen nach der streulichtmethode Expired - Lifetime DE69532855T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US311462 1994-09-22
US08/311,462 US5599668A (en) 1994-09-22 1994-09-22 Light scattering optical waveguide method for detecting specific binding events
PCT/US1995/011922 WO1996009532A1 (en) 1994-09-22 1995-09-20 Optical waveguide method for detecting specific binding events by light scattering

Publications (2)

Publication Number Publication Date
DE69532855D1 true DE69532855D1 (de) 2004-05-13
DE69532855T2 DE69532855T2 (de) 2005-03-24

Family

ID=23206973

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69532855T Expired - Lifetime DE69532855T2 (de) 1994-09-22 1995-09-20 Lichtwellenleiter-verfahren zur detektion spezifischer bindungsreaktionen nach der streulichtmethode
DE69536137T Expired - Lifetime DE69536137D1 (de) 1994-09-22 1995-09-20 Lichtwellenleiter-Verfahren zur Detektion spezifischer Bindungsreaktionen nach der Streulichtmethode

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69536137T Expired - Lifetime DE69536137D1 (de) 1994-09-22 1995-09-20 Lichtwellenleiter-Verfahren zur Detektion spezifischer Bindungsreaktionen nach der Streulichtmethode

Country Status (9)

Country Link
US (2) US5599668A (de)
EP (2) EP0783683B1 (de)
JP (1) JP3608665B2 (de)
AT (2) ATE263967T1 (de)
AU (1) AU3636295A (de)
CA (1) CA2197321C (de)
DE (2) DE69532855T2 (de)
ES (2) ES2221930T3 (de)
WO (1) WO1996009532A1 (de)

Families Citing this family (271)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120643A (en) * 1987-07-13 1992-06-09 Abbott Laboratories Process for immunochromatography with colloidal particles
US6955915B2 (en) * 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US6315953B1 (en) * 1993-11-01 2001-11-13 Nanogen, Inc. Devices for molecular biological analysis and diagnostics including waveguides
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
GB9326450D0 (en) * 1993-12-24 1994-02-23 Multilyte Ltd Binding assay
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
EP0695941B1 (de) * 1994-06-08 2002-07-31 Affymetrix, Inc. Verfahren und Vorrichtung zum Verpacken von Chips
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
CA2207629A1 (en) * 1994-12-22 1996-06-27 Abbott Laboratories Methods of immobilizing oligonucleotides to solid support materials and methods of using support bound oligonucleotides
US5633724A (en) * 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
ATE229081T1 (de) * 1996-01-26 2002-12-15 Abbott Lab Verfahren zur analyse von nukleinsäure- wiederholungssequenzen
WO1997032212A1 (en) * 1996-03-01 1997-09-04 Beckman Instruments, Inc. System for simultaneously conducting multiple ligand binding assays
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
BR9710836A (pt) 1996-04-25 2000-10-24 Spectrametrix Inc Ensaio de analitos usando marcas em partìculas
DE19628002C1 (de) * 1996-07-11 1997-12-18 Inst Chemo Biosensorik Vorrichtung und Verfahren zur Durchführung von Fluoreszenzimmunotests
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20020172953A1 (en) * 1996-07-29 2002-11-21 Mirkin Chad A. Movement of biomolecule-coated nanoparticles in an electric field
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
ES2287956T3 (es) 1996-07-29 2007-12-16 Nanosphere Inc. Nanoparticulas que tienen oligonucleotidos unidos a las mismas y usos de las mismas.
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
AUPO229596A0 (en) * 1996-09-12 1996-10-03 Varian Australia Pty Ltd Method for analysis of DNA
US6180415B1 (en) 1997-02-20 2001-01-30 The Regents Of The University Of California Plasmon resonant particles, methods and apparatus
US6344272B1 (en) 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
US6852252B2 (en) 1997-03-12 2005-02-08 William Marsh Rice University Use of metalnanoshells to impede the photo-oxidation of conjugated polymer
EP0985142A4 (de) 1997-05-23 2006-09-13 Lynx Therapeutics Inc System und gerät zur sequentiellen behandlung von analyten
JP3120453B2 (ja) * 1997-06-19 2000-12-25 トヨタ自動車株式会社 微小液滴の保持方法、反応方法
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
DE19730359A1 (de) * 1997-07-15 1999-01-21 Boehringer Mannheim Gmbh Integriertes Verfahren und System zur Amplifizierung und zum Nachweis von Nukleinsäuren
US6974669B2 (en) * 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US6294327B1 (en) 1997-09-08 2001-09-25 Affymetrix, Inc. Apparatus and method for detecting samples labeled with material having strong light scattering properties, using reflection mode light and diffuse scattering
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
FR2773218B1 (fr) * 1997-12-31 2000-03-10 Stago International Dispositif, procede et appareil de mise en oeuvre du procede, pour effectuer un dosage d'au moins un composant particulier dans un echantillon de produit
GB9800378D0 (en) * 1998-01-08 1998-03-04 Univ Liverpool Proteome analysis
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
US6338968B1 (en) * 1998-02-02 2002-01-15 Signature Bioscience, Inc. Method and apparatus for detecting molecular binding events
US6485905B2 (en) * 1998-02-02 2002-11-26 Signature Bioscience, Inc. Bio-assay device
US6368795B1 (en) * 1998-02-02 2002-04-09 Signature Bioscience, Inc. Bio-assay device and test system for detecting molecular binding events
US6395480B1 (en) 1999-02-01 2002-05-28 Signature Bioscience, Inc. Computer program and database structure for detecting molecular binding events
US6428811B1 (en) 1998-03-11 2002-08-06 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
US6699724B1 (en) 1998-03-11 2004-03-02 Wm. Marsh Rice University Metal nanoshells for biosensing applications
US20030153023A1 (en) * 1999-05-13 2003-08-14 Starzl Timothy W. Enumeration method of analyte detection
US6346376B1 (en) * 1998-06-03 2002-02-12 Centre Suisse D'electronique Et De Mictotechnique Sa Optical sensor unit and procedure for the ultrasensitive detection of chemical or biochemical analytes
EP1090293B2 (de) 1998-06-24 2019-01-23 Illumina, Inc. Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel
US6171794B1 (en) 1998-07-13 2001-01-09 Rosetta Inpharmatics, Inc. Methods for determining cross-hybridization
AU6151699A (en) 1998-09-21 2000-04-10 Ramot University Authority For Applied Research And Industrial Development Ltd. Method, chip, device and system for effecting and monitoring nucleic acid accumulation
US6187540B1 (en) 1998-11-09 2001-02-13 Identigene, Inc. Method of newborn identification and tracking
DE69936534T2 (de) 1998-11-30 2008-03-13 Nanosphere, Inc., Northbrook Nanopartikel mit polymerschalen
US6221579B1 (en) * 1998-12-11 2001-04-24 Kimberly-Clark Worldwide, Inc. Patterned binding of functionalized microspheres for optical diffraction-based biosensors
US6934022B1 (en) * 1998-12-17 2005-08-23 Leica Microsystems Heidelberg Gmbh Method for differentiated investigation of diverse structures in preferably biological preparations
US6579673B2 (en) * 1998-12-17 2003-06-17 Kimberly-Clark Worldwide, Inc. Patterned deposition of antibody binding protein for optical diffraction-based biosensors
US20050026209A1 (en) * 1999-01-08 2005-02-03 Vann Charles S. Optical fiber bundle for detecting binding of chemical species
US7595189B2 (en) * 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
JP4454155B2 (ja) 1999-01-08 2010-04-21 アプライド バイオシステムズ， エルエルシー 化学種を接触させるためのファイバーアレイならびにファイバーアレイを使用および作製する方法
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
ATE490777T1 (de) 1999-06-01 2010-12-15 Baylor College Medicine Zusammensetzungen und verfahren zur therapeutischen anwendung einer mit dem gen atonal assoziierten sequenz
US7205155B1 (en) 1999-08-20 2007-04-17 Stiftung Fur Diagnostische Forschung Method for the determination of substances using the evanescence field method
DE19943704C1 (de) * 1999-09-08 2001-05-10 Inst Physikalische Hochtech Ev Affinitätssensor zum Nachweis biologischer und/oder chemischer Spezies und dessen Verwendung
DE19947616C2 (de) * 1999-10-01 2003-05-28 Fraunhofer Ges Forschung Verfahren zur Bestimmung von Substanzen, wie z.B. DNA-Sequenzen, in einer Probe und Vorrichtung zur Durchführung des Verfahrens
CA2396113C (en) * 2000-01-13 2009-04-07 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
DE10002566A1 (de) * 2000-01-21 2001-08-02 Fraunhofer Ges Forschung Verfahren und Einrichtung zur Bestimmung des Schmelzpunktes und/oder der Bindungskonstante von Substanzen, wie z. B. DNA-Sequenzen, in einer Probe
US6235483B1 (en) 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
EP1266207B1 (de) * 2000-03-22 2010-10-27 Axela Inc. Verfahren und vorrichtung zur bestimmung mehrerer analyten
JP4606543B2 (ja) * 2000-04-13 2011-01-05 パナソニック株式会社 光学特性計測装置における被検溶液量確認方法および計測系制御方法
AU2001275475A1 (en) * 2000-06-12 2001-12-24 Genicon Sciences Corporation Assay for genetic polymorphisms using scattered light detectable labels
JP2004501667A (ja) * 2000-07-01 2004-01-22 クロンディアグ　チップ　テヒノロギーズ　ゲーエムベーハー プローブ・アレイ上での分子相互作用の定性的および／または定量的検出方法
AU2006235770B2 (en) * 2000-07-01 2009-12-24 Clondiag Chip Technologies Gmbh Method for the qualitative and/or quantitative detection of molecular interactions on probe arrays
ATE324465T1 (de) * 2000-07-11 2006-05-15 Univ Northwestern Nachweismethode mittels verstärkter silberfärbung
DE10036457A1 (de) * 2000-07-26 2002-02-14 Giesing Michael Verwendung eines bildgebenden photoelektrischen Flächensensors zur Auswertung von Biochips und Bildgebungsverfahren hierfür
DE10062244A1 (de) * 2000-12-14 2002-07-04 Infineon Technologies Ag Sensor zur Detektion von makromolekularen Biopolymeren, Sensoranordnung, Verfahren zur Detektion von makromolekularen Biopolymeren und Verfahren zum Herstellen eines Sensors zur Detektion von makromolekularen Biopolymeren
WO2002066965A2 (en) * 2001-02-19 2002-08-29 Scientific Generics Limited Assay apparatus, assay method and probe array for use in same
WO2002068932A2 (en) 2001-02-23 2002-09-06 Genicon Sciences Corporation Methods for providing extended dynamic range in analyte assays
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US20040121350A1 (en) * 2002-12-24 2004-06-24 Biosite Incorporated System and method for identifying a panel of indicators
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US20040126767A1 (en) * 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
AU2002245988A1 (en) * 2001-04-18 2002-10-28 Ulrich J. Krull Gradient resolved hybridisation platform
US20030113740A1 (en) * 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7238472B2 (en) 2001-05-25 2007-07-03 Nanosphere, Inc. Non-alloying core shell nanoparticles
JP2004537721A (ja) * 2001-07-30 2004-12-16 日本板硝子株式会社 光学式液滴検出装置およびそれを用いた制御装置
US20040146917A1 (en) * 2001-08-03 2004-07-29 Nanosphere, Inc. Nanoparticle imaging system and method
EP1412536B1 (de) * 2001-08-03 2009-02-25 Nanosphere, Inc. Nanopartikelabbildungssystem und -verfahren
US20060073530A1 (en) * 2001-08-15 2006-04-06 Olaf Schneewind Methods and compositions involving sortase B
WO2003021853A2 (en) 2001-09-05 2003-03-13 Genicon Sciences Corporation Apparatus for reading signals generated from resonance light scattered particle labels
US20030049866A1 (en) * 2001-09-05 2003-03-13 Genicon Sciences Corporation Sample device preservation
FR2829580B1 (fr) * 2001-09-07 2004-02-13 Bio Merieux Procede de lecture, de detection ou de quantification, hybrides ou complexes utilises dans ce procede et biopuce mettant en oeuvre ledit procede
JP4554205B2 (ja) * 2001-09-13 2010-09-29 アクセラ インコーポレーテッド 光の回折に基づく検定のための方法および装置
US20040241699A1 (en) * 2001-10-04 2004-12-02 Giovanni Zocchi Detection of polynucleotide hybridization
GB0124338D0 (en) * 2001-10-10 2001-11-28 Randox Lab Ltd Biochips
US6867005B2 (en) 2001-10-24 2005-03-15 Beckman Coulter, Inc. Method and apparatus for increasing the dynamic range and accuracy of binding assays
US7186814B2 (en) * 2001-11-09 2007-03-06 Nanosphere, Inc. Bioconjugate-nanoparticle probes
US7098041B2 (en) * 2001-12-11 2006-08-29 Kimberly-Clark Worldwide, Inc. Methods to view and analyze the results from diffraction-based diagnostics
US7102752B2 (en) * 2001-12-11 2006-09-05 Kimberly-Clark Worldwide, Inc. Systems to view and analyze the results from diffraction-based diagnostics
US8367013B2 (en) * 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US20030119203A1 (en) * 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
EP1476575A4 (de) * 2002-01-18 2007-01-10 Univ Utah Res Found Nachweis von einzelnukleotidpolymorphismen mittels planarer wellenleiter
US20030166282A1 (en) 2002-02-01 2003-09-04 David Brown High potency siRNAS for reducing the expression of target genes
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
CA2475003A1 (en) 2002-02-01 2003-08-07 Sequitur, Inc. Double-stranded oligonucleotides
US7083975B2 (en) * 2002-02-01 2006-08-01 Roland Green Microarray synthesis instrument and method
US7018842B2 (en) * 2002-02-28 2006-03-28 Agilent Technologies, Inc. Reading dry chemical arrays through the substrate
JP3960084B2 (ja) * 2002-03-06 2007-08-15 セイコーエプソン株式会社 ヘッド駆動装置及び方法、液滴吐出装置、ヘッド駆動プログラム、並びにデバイス製造方法及びデバイス
US7094537B2 (en) * 2002-04-30 2006-08-22 Agilent Technologies, Inc. Micro arrays with structured and unstructured probes
US7118855B2 (en) * 2002-05-03 2006-10-10 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7771922B2 (en) * 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US7223534B2 (en) * 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7214530B2 (en) * 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
US7485453B2 (en) * 2002-05-03 2009-02-03 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7223368B2 (en) * 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US20030211488A1 (en) * 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
JP4628095B2 (ja) * 2002-05-29 2011-02-09 オウトジエノミクス・インコーポレーテツド 統合されたマイクロアレイシステムおよびその製造方法
US20030224370A1 (en) * 2002-05-31 2003-12-04 William Rassman Method and apparatus for recognizing molecular compounds
US6790632B2 (en) * 2002-06-17 2004-09-14 Stephen Eliot Zweig Membrane receptor reagent and assay
US7091049B2 (en) * 2002-06-26 2006-08-15 Kimberly-Clark Worldwide, Inc. Enhanced diffraction-based biosensor devices
AU2003247788B2 (en) * 2002-07-02 2007-04-19 Nanosphere Inc. Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes
KR101170653B1 (ko) 2002-08-12 2012-08-03 제네렉스, 인코포레이티드 폭스바이러스 및 암과 관련된 방법 및 조성물
US7314763B2 (en) * 2002-08-27 2008-01-01 Kimberly-Clark Worldwide, Inc. Fluidics-based assay devices
US7432105B2 (en) * 2002-08-27 2008-10-07 Kimberly-Clark Worldwide, Inc. Self-calibration system for a magnetic binding assay
US7285424B2 (en) * 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
DE10241093A1 (de) * 2002-09-02 2004-03-18 Siemens Ag Mikroreaktor
EP1561109A1 (de) * 2002-09-03 2005-08-10 Zeptosens AG Analytische plattform und nachweisverfahren mit den in einer probe nachzuweisenden analyten als immobilisierten spezifischen bindungspartnern
US7169550B2 (en) * 2002-09-26 2007-01-30 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
AU2002334118B2 (en) * 2002-10-07 2007-05-17 The Secretary Of State For Defence A waveguide structure
US7781172B2 (en) * 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US20040106190A1 (en) * 2002-12-03 2004-06-03 Kimberly-Clark Worldwide, Inc. Flow-through assay devices
WO2004053105A2 (en) * 2002-12-12 2004-06-24 Nanosphere, Inc. Direct snp detection with unamplified dna
CN100386620C (zh) * 2002-12-16 2008-05-07 吴世法 激励和接收均用隐失光的拉曼散射近场增强方法
US7247500B2 (en) * 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US20040121334A1 (en) * 2002-12-19 2004-06-24 Kimberly-Clark Worldwide, Inc. Self-calibrated flow-through assay devices
EP1587955A4 (de) * 2002-12-24 2007-03-14 Biosite Inc Differenzialdiagnose-marker und verfahren zu ihrer verwendung
AU2003300433A1 (en) * 2003-01-08 2004-08-10 Maven Technologies, Llc Strong-absorber-mediated array ellipsometer
US7981694B2 (en) * 2003-01-28 2011-07-19 The Regents Of The University Of California Solid phase isolation of proteins, nucleic acids and other macromolecules
US20040157220A1 (en) 2003-02-10 2004-08-12 Purnima Kurnool Methods and apparatus for sample tracking
WO2005001143A2 (en) * 2003-02-27 2005-01-06 Nanosphere, Inc. Label-free gene expression profiling with universal nanoparticle probes in microarray assay format
US20040197819A1 (en) * 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US7851209B2 (en) * 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US7910064B2 (en) * 2003-06-03 2011-03-22 Nanosys, Inc. Nanowire-based sensor configurations
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
JP4773348B2 (ja) 2003-07-12 2011-09-14 アクセラー８ テクノロジー コーポレイション 高感度かつ迅速なバイオ検出法
CA2477991C (en) * 2003-08-20 2014-04-08 Seikagaku Corporation Stabilizing agent and blocking agent
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7943395B2 (en) * 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US7713748B2 (en) * 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943089B2 (en) * 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US20050136550A1 (en) * 2003-12-19 2005-06-23 Kimberly-Clark Worldwide, Inc. Flow control of electrochemical-based assay devices
US20050141843A1 (en) * 2003-12-31 2005-06-30 Invitrogen Corporation Waveguide comprising scattered light detectable particles
US7283245B2 (en) * 2004-01-20 2007-10-16 General Electric Company Handheld device with a disposable element for chemical analysis of multiple analytes
KR101170853B1 (ko) 2004-01-20 2012-08-03 제너럴 일렉트릭 캄파니 화학적 또는 생물학적 물질의 분석 대상물 농도 측정시스템 및 방법
US7796266B2 (en) * 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US20050244953A1 (en) * 2004-04-30 2005-11-03 Kimberly-Clark Worldwide, Inc. Techniques for controlling the optical properties of assay devices
US7815854B2 (en) 2004-04-30 2010-10-19 Kimberly-Clark Worldwide, Inc. Electroluminescent illumination source for optical detection systems
US20060019265A1 (en) * 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US7521226B2 (en) * 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
EP1771583A2 (de) * 2004-07-26 2007-04-11 Nanosphere, Inc. Verfahren zur unterscheidung von methicillin-resistentem s. aureus von methicillin-sensitivem s. aureus in einer mischkultur
ES2345993T3 (es) 2004-09-14 2010-10-07 The Regents Of The University Of Colorado, A Body Corporate Metodo para el tratamiento con bucindolol basado en direccionamiento genetico.
US7429923B2 (en) * 2004-10-22 2008-09-30 Honeywell International Inc. Neuronal sensor networks
US20060088844A1 (en) * 2004-10-22 2006-04-27 Honeywell International Inc. Real-time PCR microarray based on evanescent wave biosensor
US20070121113A1 (en) * 2004-12-22 2007-05-31 Cohen David S Transmission-based optical detection systems
US20070154903A1 (en) * 2005-06-23 2007-07-05 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
US8597576B2 (en) * 2005-06-23 2013-12-03 National Institute Of Advanced Industrial Science And Technology Analyzer for glycan or complex carbohydrate
JP2009505106A (ja) * 2005-08-19 2009-02-05 ナノスフェアー インコーポレイテッド Ｄｎａ及び抗体を含むハイブリッド基板を調製するための方法及びその使用
JP2007064943A (ja) * 2005-09-02 2007-03-15 Fujifilm Corp 全反射減衰を利用した測定方法及び装置
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
CA2621982C (en) 2005-09-07 2017-11-28 Jennerex Biotherapeutics Ulc Systemic treatment of metastatic and/or systemically-disseminated cancers using gm-csf-expressing poxviruses
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US7951583B2 (en) 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
US8288157B2 (en) 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US20070235397A1 (en) * 2006-03-30 2007-10-11 Wannop George M Storage bin and frame system
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
EP2489745B1 (de) * 2006-06-05 2017-01-11 California Institute Of Technology Echtzeit-Mikroarrays
US8637436B2 (en) 2006-08-24 2014-01-28 California Institute Of Technology Integrated semiconductor bioarray
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US8529837B2 (en) * 2006-08-07 2013-09-10 Biomag Corp. System and method for detecting specific binding reactions using magnetic labels
WO2008082713A2 (en) * 2006-08-24 2008-07-10 California Institute Of Technology Integrated semiconductor bioarray
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
US8481023B2 (en) 2006-09-15 2013-07-09 Ottawa Hospital Research Institute Oncolytic rhabdovirus
WO2008083323A1 (en) * 2006-12-29 2008-07-10 Invitrogen Corporation Detection apparatus
CN101589303B (zh) * 2007-01-17 2012-01-11 霍尼韦尔国际公司 基于倏逝波检测的微阵列读取器和读取微阵列的方法
US20080200342A1 (en) * 2007-02-15 2008-08-21 Rao Rupa S Device, Array, And Methods For Disease Detection And Analysis
US7796843B2 (en) * 2007-03-21 2010-09-14 University Of Houston Design and performance of a Fiber Bragg grating displacement sensor for measurement of movement
US20100143905A1 (en) * 2007-03-29 2010-06-10 Lane Michael J Methods and compositions for multivalent binding and methods for manufacture of rapid diagnostic tests
JP5283364B2 (ja) * 2007-10-22 2013-09-04 富士フイルム株式会社 センシング装置
US20090124024A1 (en) 2007-11-07 2009-05-14 Shingo Kasai Optical-waveguide sensor chip, method of manufacturing the same, method of measuring substance, substance-measuring kit and optical-waveguide sensor
JP4970217B2 (ja) * 2007-11-07 2012-07-04 株式会社東芝 物質の測定方法
JP5424610B2 (ja) * 2007-11-07 2014-02-26 株式会社東芝 光導波路型センサチップ、光導波路型センサチップの製造方法、物質の測定方法、物質測定用キットおよび光導波路型センサ
DE102007055386B4 (de) * 2007-11-20 2015-07-16 Boehringer Ingelheim Vetmedica Gmbh Verfahren zur Kalibrierung eines Sensorelements
WO2009103339A1 (en) * 2008-02-21 2009-08-27 Valtion Teknillinen Tutkimuskeskus Biosensor and a related manufacturing method
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
GB2461026B (en) 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
WO2013154750A1 (en) 2012-04-10 2013-10-17 The Trustees Of Columbia Unversity In The City Of New York Systems and methods for biological ion channel interfaces
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US8300993B2 (en) * 2009-03-02 2012-10-30 Mbio Diagnostics, Inc. Waveguide with integrated lens
US8331751B2 (en) * 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
GB0904934D0 (en) 2009-03-23 2009-05-06 Geneseqe As Method and apparatus for detecting molecules
CN102460254B (zh) 2009-04-29 2015-05-06 Plc诊断股份有限公司 具有扫描光源的基于波导的检测系统
US8977489B2 (en) * 2009-05-18 2015-03-10 GM Global Technology Operations LLC Turn by turn graphical navigation on full windshield head-up display
WO2011008530A2 (en) 2009-06-29 2011-01-20 Luminex Corporation Chimeric primers with hairpin conformations and methods of using same
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
US9512481B2 (en) 2009-09-11 2016-12-06 The Regents Of The University Of Colorado, A Body Corporate Polymorphisms in the PDE3A gene
KR101838472B1 (ko) 2009-09-14 2018-03-15 신라젠(주) 종양 용해 백시니아 바이러스 병용 암 치료요법
EP2483688B1 (de) 2009-09-28 2016-04-20 Koninklijke Philips N.V. Verfahren zur kennzeichnung biologischer bindungen
MX365946B (es) 2009-12-10 2019-06-19 Turnstone Lp Rabdovirus oncolitico.
EP2515899B1 (de) 2009-12-23 2016-05-25 ARCA biopharma, Inc. Verfahren und zusammensetzungen für herz-kreislauf-erkrankungen und -leiden
EP2369325A1 (de) * 2010-03-12 2011-09-28 Eppendorf Ag Arrayanalyse für Online-Detektion
US8809810B2 (en) 2010-05-20 2014-08-19 Honeywell International Inc. Microarray reader based on evanescent wave detection
WO2011149526A2 (en) 2010-05-25 2011-12-01 Arryx, Inc. Methods and apparatuses for detection of positional freedom of particles in biological and chemical analyses and applications in immunodiagnostics
US11022573B2 (en) 2010-08-31 2021-06-01 Canon U.S.A., Inc. Positive controls
WO2012031050A1 (en) * 2010-08-31 2012-03-08 Canon U.S. Life Sciences, Inc. Thermal calibration
WO2012037369A1 (en) 2010-09-15 2012-03-22 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
GB201016484D0 (en) 2010-09-30 2010-11-17 Geneseque As Method
JP6121910B2 (ja) 2011-01-04 2017-04-26 シラジェン バイオセラピューティクス インコーポレイテッド 腫瘍溶解性ワクシニアウイルスの投与による腫瘍抗原に対する抗体の生成および腫瘍特異的補体依存性細胞傷害の生成
EP2663862A4 (de) 2011-01-11 2015-01-21 Univ Columbia Systeme und verfahren zur einzelmolekülerkennung mithilfe von nanoröhrchen
WO2012116161A1 (en) 2011-02-23 2012-08-30 The Trustees Of Columbia University In The City Of New York Systems and methods for single-molecule detection using nanopores
WO2012158238A2 (en) 2011-02-28 2012-11-22 University Of Iowa Research Foundation Anti-müllerian hormone changes in pregnancy and prediction ofadverse pregnancy outcomes and gender
ES2551922T3 (es) 2011-03-07 2015-11-24 Accelerate Diagnostics, Inc. Sistemas rápidos de purificación celular
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
EP2683835B1 (de) 2011-03-08 2017-01-11 King Abdullah University Of Science And Technology Molekulares biomarker-set zur früherkennung von eierstockkrebs
US9364532B2 (en) 2011-06-08 2016-06-14 Children's Hospital Of Eastern Ontario Research Institute Inc. Compositions and methods for glioblastoma treatment
US9194801B2 (en) * 2011-08-26 2015-11-24 The Trustees Of Columbia University In The City Of New York Systems and methods for a DNA-based thermometer
WO2013036799A2 (en) 2011-09-09 2013-03-14 Fred Hutchinson Cancer Research Center Methods and compositions involving nkg2d inhibitors and cancer
EP2594942A1 (de) 2011-11-16 2013-05-22 Koninklijke Philips Electronics N.V. Lange starre Abstandshalter zur Verbesserung der Bindekinetik in Immuntests
EP2780705B1 (de) 2011-11-16 2018-09-19 Becton, Dickinson and Company Verfahren und systeme zum nachweis eines analyts in einer probe
WO2013158280A1 (en) 2012-04-20 2013-10-24 The Trustees Of Columbia University In The City Of New York Systems and methods for single-molecule nucleic-acid assay platforms
EP2741074A1 (de) 2012-12-04 2014-06-11 F. Hoffmann-La Roche AG Vorrichtung zur Verwendung bei der Bindeaffinitätserkennung
BR112015010695B1 (pt) 2013-01-11 2023-03-07 Becton, Dickinson And Company Dispositivo microfluídico e método para realizar um ensaio de uma amostra líquida, método para formar um dispositivo microfluídico, sistema e kit
WO2014116721A1 (en) 2013-01-22 2014-07-31 The Arizona Board Of Regents For And On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
RU2684211C2 (ru) 2013-02-21 2019-04-04 Тёрнстоун Лимитед Партнершип Композиция вакцины
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
JP2015072249A (ja) * 2013-03-29 2015-04-16 富士フイルム株式会社 被検物質の測定方法、被検物質測定キット及び被検物質測定試薬
BR112016007391A2 (pt) 2013-10-03 2017-08-01 Oklahoma Med Res Found biomarcadores da atividade, da intensidade e da fase aguda da doença lúpus eritematoso sistêmico
ES2856191T3 (es) 2013-11-06 2021-09-27 Becton Dickinson Co Dispositivos microfluídicos y métodos de uso de los mismos
BR112016010721B1 (pt) 2013-11-13 2021-06-01 Becton, Dickinson And Company Método e sistema de análise de uma amostra para um analito
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
JP6074624B2 (ja) * 2014-04-16 2017-02-08 学校法人北里研究所 生体試料中の個別多種及び／又は混合多種の疾患関連自己抗体の検出方法、キット及び検出装置
GB201413929D0 (en) 2014-08-06 2014-09-17 Geneseque As Method
BR112017007534B1 (pt) 2014-10-14 2022-09-27 Becton, Dickinson And Company Dispositivo de transferência de espécime, sistema de transferência e teste de espécime compreendendo referido dispositivo e dispositivo de lanceta e transferência de espécime
SG11201606297UA (en) 2014-10-14 2016-08-30 Becton Dickinson Co Blood sample management using open cell foam
DE102014221734A1 (de) * 2014-10-24 2016-04-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Messvorrichtung und System zur Schmelzkurvenanalyse eines DNA Microarrays, sowie Verwendung eines Fluoreszenzdetektorarrays zur Analyse
WO2016086227A2 (en) 2014-11-26 2016-06-02 The Regents Of The University Of California Therapeutic compositions comprising transcription factors and methods of making and using the same
CN107430123B (zh) * 2014-11-28 2020-04-14 通用电气健康护理生物科学股份公司 用于在传感器表面上检测分析物-配体结合的方法
US11181479B2 (en) 2015-02-27 2021-11-23 Ldip, Llc Waveguide-based detection system with scanning light source
EP3154697B1 (de) 2015-03-10 2018-06-20 Becton, Dickinson and Company Vorrichtung zur bearbeitung biologischer flüssigproben
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
KR20170132856A (ko) 2015-03-30 2017-12-04 액셀러레이트 다이어그노스틱스, 아이엔씨. 신속한 미생물 동정 및 항균제 감수성 시험을 위한 기기 및 시스템
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
CA2996863C (en) 2015-09-01 2021-04-13 Becton, Dickinson And Company Depth filtration device for separating specimen phases
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
US20170160187A1 (en) * 2015-12-08 2017-06-08 Tdk Corporation Laser Scanner Particle Counter and Imager
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
EP3574114B1 (de) 2017-01-26 2022-06-29 Oklahoma Medical Research Foundation Biomarker für die krankheitsaktivität, die intensität und das auftreten von systemischem lupus erythematodes
US10260033B1 (en) * 2017-10-06 2019-04-16 Wyatt Technology Corporation Method and apparatus to mitigate evaporation in high throughput measurements
WO2019200326A1 (en) 2018-04-13 2019-10-17 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
WO2020014296A1 (en) 2018-07-12 2020-01-16 Luminex Corporation Systems and methods for performing variable sample preparation and analysis processes
WO2020081204A1 (en) 2018-10-18 2020-04-23 Oklahoma Medical Research Foundation Biomarkers for a systemic lupus erythematosus (sle) disease activity immune index that characterizes disease activity
JP2022509018A (ja) 2018-10-31 2022-01-20 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ 放射線誘発肺障害のためのバイオマーカー及び使用方法
CN113924041A (zh) 2019-03-14 2022-01-11 因斯利克萨公司 基于时间门控的荧光检测的方法和系统

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975084A (en) * 1973-09-27 1976-08-17 Block Engineering, Inc. Particle detecting system
US4577109A (en) * 1980-10-06 1986-03-18 Regents Of The University Of California Remote multi-position information gathering system and method
US4608344A (en) * 1981-09-18 1986-08-26 Battelle Memorial Institute Method for the determination of species in solution with an optical wave-guide
US4582809A (en) * 1982-06-14 1986-04-15 Myron J. Block Apparatus including optical fiber for fluorescence immunoassay
US4447546A (en) * 1982-08-23 1984-05-08 Myron J. Block Fluorescent immunoassay employing optical fiber in capillary tube
US4680275A (en) * 1985-02-11 1987-07-14 Becton, Dickinson And Company Homogeneous fluorescence immunoassay using a light absorbing material
US4654532A (en) * 1985-09-09 1987-03-31 Ord, Inc. Apparatus for improving the numerical aperture at the input of a fiber optics device
US4716121A (en) * 1985-09-09 1987-12-29 Ord, Inc. Fluorescent assays, including immunoassays, with feature of flowing sample
US5017009A (en) * 1986-06-26 1991-05-21 Ortho Diagnostic Systems, Inc. Scattered total internal reflectance immunoassay system
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US4979821A (en) * 1988-01-27 1990-12-25 Ortho Diagnostic Systems Inc. Cuvette for receiving liquid sample
GB8807488D0 (en) * 1988-03-29 1988-05-05 Ares Serono Res & Dev Ltd Method of assay
GB8827853D0 (en) * 1988-11-29 1988-12-29 Ares Serono Res & Dev Ltd Sensor for optical assay
GB8911462D0 (en) * 1989-05-18 1989-07-05 Ares Serono Res & Dev Ltd Devices for use in chemical test procedures
US5350697A (en) * 1990-08-28 1994-09-27 Akzo N.V. Scattered light detection apparatus
USH1344H (en) * 1990-10-09 1994-08-02 The United States Of America As Represented By The Secretary Of The Army Portable automatic sensor for toxic gases
EP0834576B1 (de) * 1990-12-06 2002-01-16 Affymetrix, Inc. (a Delaware Corporation) Detektion von Nukleinsäuresequenzen
ES2155822T3 (es) * 1990-12-06 2001-06-01 Affymetrix Inc Compuestos y su utilizacion en una estrategia de sintesis binaria.
US5192510A (en) * 1991-01-30 1993-03-09 E. I. Du Pont De Nemours And Company Apparatus for performing fluorescent assays which separates bulk and evanescent fluorescence
GB9119735D0 (en) * 1991-09-16 1991-10-30 Secr Defence Gene probe biosensor method
JPH07505297A (ja) * 1992-04-06 1995-06-15 アボツト・ラボラトリーズ 内面全反射を使用して核酸または被分析物質を検出する方法及び装置
WO1994000763A1 (en) * 1992-06-24 1994-01-06 Akzo Nobel N.V. Method for determining multiple immunocomplexes on one surface using spectroscopy
US5359681A (en) * 1993-01-11 1994-10-25 University Of Washington Fiber optic sensor and methods and apparatus relating thereto
DE69429262T2 (de) * 1993-05-18 2002-07-25 Univ Utah Res Found Vorrichtung und verfahren fuer homogene multianalyt-immuno-assays

Also Published As

Publication number Publication date
ATE263967T1 (de) 2004-04-15
US5843651A (en) 1998-12-01
JP3608665B2 (ja) 2005-01-12
DE69536137D1 (de) 2011-03-24
ATE498123T1 (de) 2011-02-15
EP1441217B1 (de) 2011-02-09
JPH10506190A (ja) 1998-06-16
ES2358508T3 (es) 2011-05-11
CA2197321C (en) 2009-01-27
CA2197321A1 (en) 1996-03-28
US5599668A (en) 1997-02-04
EP1441217A3 (de) 2007-07-04
DE69532855T2 (de) 2005-03-24
WO1996009532A1 (en) 1996-03-28
EP0783683B1 (de) 2004-04-07
AU3636295A (en) 1996-04-09
EP1441217A2 (de) 2004-07-28
ES2221930T3 (es) 2005-01-16
EP0783683A1 (de) 1997-07-16

Similar Documents

Publication Publication Date Title
DE69532855D1 (de) Lichtwellenleiter-verfahren zur detektion spezifischer bindungsreaktionen nach der streulichtmethode
TW240291B (de)
WO2000036398A8 (de) Verfahren und vorrichtungen zur erfassung optischer eigenschaften, insbesondere von lumineszenz-reaktionen und brechungsverhalten, von auf einem träger direkt oder indirekt gebundenen molekülen
DE69429262D1 (de) Vorrichtung und verfahren fuer homogene multianalyt-immuno-assays
DE59711999D1 (de) Vorrichtung und verfahren zur durchführung von quantitativen fluoreszenz markierten affinitätstests
DE50104692D1 (de) Vorrichtung und verfahren zum übertragen von licht über eine lichtleitfaser
DE3871768T2 (de) Kuevette und apparat zur ausfuehrung biologischer nachweise.
DE69917785D1 (de) Verfahren und vorrichtung für die durchführung senkrechter photometrie mit fester optischer weglänge
DE69931503D1 (de) Vorrichtung und verfahren zur diffusen beleuchtung einer oberfläche
EP0317239A3 (de) Verfahren und Vorrichtung zum Nachweis von Restriktionsfragmentlängenpolymorphien
DE59813485D1 (de) Verfahren und Vorrichtung zur Extraktion von Signalen aus einer Glasfaser
ATE381011T1 (de) Verfahren und vorrichtung zum nachweis von mastitis mittels sichtbarem und/oder nahinfrarot- licht
ATE138816T1 (de) Vorrichtung zum applizieren mit licht
DE69611995T2 (de) Verfahren und vorrichtung zur übertragung von signalen in optischen fasern
DE3789505T2 (de) Vorrichtung und Verfahren zum Feststellen der Richtung von einfallendem Licht.
ES1009119U (es) Dispositivo de accionamiento automatico del limpiaparabrisas de un vehiculo, ante la presencia de gotas de agua en el cristal correspon diente.
DE69419482D1 (de) Vorrichtung zum optischen Koppeln einer optischen Faser mit einer elektro-optischen Vorrichtung
DE3783179T2 (de) Optische vorrichtung und verfahren zur strahlenkopplung, verwendbar zur steuerung von lichtstrahlen und raeumlichen lichtmodulation.
JPS6488338A (en) Apparatus and method for irradiating sample with light to gather light radiated from sample
DE69931330D1 (de) Vorrichtung zur Bestrahlung mit schräg-einfallendem Licht
Stimpson et al. Light scattering optical waveguide method for detecting specific binding events
DE59010854D1 (de) Vorrichtung zum Umwandeln von Lichtsignalen in Videosignale
DE59307666D1 (de) Licht leitendes Analyseelement zur Bestimmung eines Analyts
DE59107509D1 (de) Verfahren und Vorrichtung zum quantitativen Auswerten von Agglutinationsreaktionen
ATE201792T1 (de) Verfahren und vorrichtung zum herstellen von linsen mikrooptischer systeme

Legal Events

Date Code Title Description
8364 No opposition during term of opposition