DE69532133D1 - Geräte und verfahren, die strukturfelder zum binden von analyten verwenden - Google Patents

Geräte und verfahren, die strukturfelder zum binden von analyten verwenden

Info

Publication number
DE69532133D1
DE69532133D1 DE69532133T DE69532133T DE69532133D1 DE 69532133 D1 DE69532133 D1 DE 69532133D1 DE 69532133 T DE69532133 T DE 69532133T DE 69532133 T DE69532133 T DE 69532133T DE 69532133 D1 DE69532133 D1 DE 69532133D1
Authority
DE
Germany
Prior art keywords
methods
devices
analyte
structures
use structural
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69532133T
Other languages
English (en)
Other versions
DE69532133T2 (de
Inventor
D Hansmann
P Grace
G Lowery
M Oosta
W Loomis
B Shain
G Schapira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of DE69532133D1 publication Critical patent/DE69532133D1/de
Application granted granted Critical
Publication of DE69532133T2 publication Critical patent/DE69532133T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G01N33/5304—Reaction vessels, e.g. agglutination plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/0838—Manufacture of polymers in the presence of non-reactive compounds
    • C08G18/0842—Manufacture of polymers in the presence of non-reactive compounds in the presence of liquid diluents
    • C08G18/0861—Manufacture of polymers in the presence of non-reactive compounds in the presence of liquid diluents in the presence of a dispersing phase for the polymers or a phase dispersed in the polymers
    • C08G18/0866—Manufacture of polymers in the presence of non-reactive compounds in the presence of liquid diluents in the presence of a dispersing phase for the polymers or a phase dispersed in the polymers the dispersing or dispersed phase being an aqueous medium
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809—Multifield plates or multicontainer arrays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick
DE69532133T 1994-09-30 1995-09-29 Geräte und verfahren, die strukturfelder zum binden von analyten verwenden Expired - Lifetime DE69532133T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US315364 1989-02-23
US08/315,364 US5707799A (en) 1994-09-30 1994-09-30 Devices and methods utilizing arrays of structures for analyte capture
PCT/US1995/012462 WO1996010747A1 (en) 1994-09-30 1995-09-29 Devices and methods utilizing arrays of structures for analyte capture

Publications (2)

Publication Number Publication Date
DE69532133D1 true DE69532133D1 (de) 2003-12-18
DE69532133T2 DE69532133T2 (de) 2004-07-22

Family

ID=23224059

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69532133T Expired - Lifetime DE69532133T2 (de) 1994-09-30 1995-09-29 Geräte und verfahren, die strukturfelder zum binden von analyten verwenden

Country Status (8)

Country Link
US (2) US5707799A (de)
EP (2) EP1369691A1 (de)
JP (1) JP4086896B2 (de)
AT (1) ATE254285T1 (de)
CA (1) CA2195875C (de)
DE (1) DE69532133T2 (de)
ES (1) ES2212799T3 (de)
WO (1) WO1996010747A1 (de)

Families Citing this family (194)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6767510B1 (en) 1992-05-21 2004-07-27 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6156270A (en) * 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6905882B2 (en) * 1992-05-21 2005-06-14 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
JP4015187B2 (ja) * 1994-10-22 2007-11-28 ブリティッシュ ニュークリア フュエルズ パブリック リミティド カンパニー 不混和性流体間の拡散移動のための方法及び装置
US20030027216A1 (en) * 2001-07-02 2003-02-06 Kiernan Urban A. Analysis of proteins from biological fluids using mass spectrometric immunoassay
US6454945B1 (en) * 1995-06-16 2002-09-24 University Of Washington Microfabricated devices and methods
US5932100A (en) * 1995-06-16 1999-08-03 University Of Washington Microfabricated differential extraction device and method
US6168948B1 (en) * 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US20020068357A1 (en) * 1995-09-28 2002-06-06 Mathies Richard A. Miniaturized integrated nucleic acid processing and analysis device and method
JP2000512541A (ja) * 1996-06-14 2000-09-26 ユニバーシティ オブ ワシントン 吸収力が向上した差違抽出装置
AU4164597A (en) 1996-08-26 1998-03-19 Princeton University Reversibly sealable microstructure sorting devices
US6009339A (en) 1997-02-27 1999-12-28 Terumo Cardiovascular Systems Corporation Blood parameter measurement device
US5997818A (en) * 1997-02-27 1999-12-07 Minnesota Mining And Manufacturing Company Cassette for tonometric calibration
WO1998037801A1 (en) 1997-02-27 1998-09-03 Minnesota Mining And Manufacturing Company Cassette for measuring parameters of blood
US5822137A (en) * 1997-02-27 1998-10-13 Minnesota Mining & Manufacturing Co. Assembly for retaining optical components
US6391578B2 (en) 1997-04-09 2002-05-21 3M Innovative Properties Company Method and devices for partitioning biological sample liquids into microvolumes
US6696286B1 (en) 1997-04-09 2004-02-24 3M Innovative Properties Company Method and devices for detecting and enumerating microorganisms
WO1998049344A1 (en) * 1997-04-28 1998-11-05 Lockheed Martin Energy Research Corporation Method and apparatus for analyzing nucleic acids
US6969488B2 (en) * 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
EP0985142A4 (de) 1997-05-23 2006-09-13 Lynx Therapeutics Inc System und gerät zur sequentiellen behandlung von analyten
US6290685B1 (en) 1998-06-18 2001-09-18 3M Innovative Properties Company Microchanneled active fluid transport devices
US6431695B1 (en) 1998-06-18 2002-08-13 3M Innovative Properties Company Microstructure liquid dispenser
US6375871B1 (en) 1998-06-18 2002-04-23 3M Innovative Properties Company Methods of manufacturing microfluidic articles
US6368871B1 (en) * 1997-08-13 2002-04-09 Cepheid Non-planar microstructures for manipulation of fluid samples
WO1999009042A2 (en) * 1997-08-13 1999-02-25 Cepheid Microstructures for the manipulation of fluid samples
US6007775A (en) 1997-09-26 1999-12-28 University Of Washington Multiple analyte diffusion based chemical sensor
EP1018012A4 (de) 1997-09-26 2002-10-09 Univ Washington Simultan ablaufende partikeltrennung und chemische reaktion
US6136272A (en) * 1997-09-26 2000-10-24 University Of Washington Device for rapidly joining and splitting fluid layers
AU758407B2 (en) * 1997-12-24 2003-03-20 Cepheid Integrated fluid manipulation cartridge
US7713703B1 (en) 2000-11-13 2010-05-11 Biosite, Inc. Methods for monitoring the status of assays and immunoassays
US6830729B1 (en) 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument
EP1046032A4 (de) 1998-05-18 2002-05-29 Univ Washington Patrone zur flüssigkeitsanalyse
US6197599B1 (en) * 1998-07-30 2001-03-06 Guorong Chin Method to detect proteins
WO2000013018A2 (de) * 1998-08-28 2000-03-09 Febit Ferrarius Biotechnology Gmbh Träger für analytbestimmungsverfahren und verfahren zur herstellung des trägers
US7914994B2 (en) 1998-12-24 2011-03-29 Cepheid Method for separating an analyte from a sample
US6431476B1 (en) 1999-12-21 2002-08-13 Cepheid Apparatus and method for rapid ultrasonic disruption of cells or viruses
US6887693B2 (en) 1998-12-24 2005-05-03 Cepheid Device and method for lysing cells, spores, or microorganisms
US6174699B1 (en) 1999-03-09 2001-01-16 3M Innovative Properties Company Disc assay device with inoculation pad and methods of use
EP1177441A1 (de) * 1999-05-10 2002-02-06 Prolinx, Inc. Vorrichtung zur zelltrennung und verfahren zur anwendung
US9073053B2 (en) 1999-05-28 2015-07-07 Cepheid Apparatus and method for cell disruption
US20040200909A1 (en) * 1999-05-28 2004-10-14 Cepheid Apparatus and method for cell disruption
WO2000073413A2 (en) 1999-05-28 2000-12-07 Cepheid Apparatus and method for cell disruption
US8815521B2 (en) 2000-05-30 2014-08-26 Cepheid Apparatus and method for cell disruption
US6635163B1 (en) * 1999-06-01 2003-10-21 Cornell Research Foundation, Inc. Entropic trapping and sieving of molecules
US20030124509A1 (en) * 1999-06-03 2003-07-03 Kenis Paul J.A. Laminar flow patterning and articles made thereby
US7223364B1 (en) 1999-07-07 2007-05-29 3M Innovative Properties Company Detection article having fluid control film
EP1196243B2 (de) † 1999-07-07 2009-12-16 3M Innovative Properties Company Nachweisgerät mit einer fluid-kontroll-filmschicht mit kapillarkanälen
JP4212189B2 (ja) * 1999-07-12 2009-01-21 富士フイルム株式会社 乾式分析方法及び乾式分析要素
US6372895B1 (en) 2000-07-07 2002-04-16 3M Innovative Properties Company Fluorogenic compounds
US6613581B1 (en) * 1999-08-26 2003-09-02 Caliper Technologies Corp. Microfluidic analytic detection assays, devices, and integrated systems
US6692952B1 (en) * 1999-11-10 2004-02-17 Massachusetts Institute Of Technology Cell analysis and sorting apparatus for manipulation of cells
US6406672B1 (en) * 2000-01-28 2002-06-18 Roche Diagnostics Plasma retention structure providing internal flow
AU774638B2 (en) 2000-02-16 2004-07-01 Wisconsin Alumni Research Foundation Method and apparatus for detection of microscopic pathogens
JP4519247B2 (ja) * 2000-03-09 2010-08-04 シスメックス株式会社 核酸の抽出精製用試薬
US6571651B1 (en) * 2000-03-27 2003-06-03 Lifescan, Inc. Method of preventing short sampling of a capillary or wicking fill device
US6605451B1 (en) 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
US7087414B2 (en) * 2000-06-06 2006-08-08 Applera Corporation Methods and devices for multiplexing amplification reactions
US6610499B1 (en) 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
EP1320752A2 (de) 2000-09-18 2003-06-25 President And Fellows of Harvard College Unterschiedliche behandlung von ausgewählten bereichen einer einzelnen zelle mit hilfe unterschiedlicher flüssigkeitszusammensetzungen
US6599475B1 (en) * 2000-09-27 2003-07-29 Becton, Dickinson And Company Apparatus for producing thin liquid samples for microscopic analysis
US6706479B2 (en) 2000-10-05 2004-03-16 Virginia Tech Intellectual Properties, Inc. Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips
DE10051396A1 (de) 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh Verfahren und Vorrichtung zur integrierten Synthese und Analytbestimmung an einem Träger
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
US7316769B2 (en) * 2001-03-19 2008-01-08 Cornell Research Foundation, Inc. Length-dependent recoil separation of long molecules
DE10120035B4 (de) * 2001-04-24 2005-07-07 Advalytix Ag Verfahren und Vorrichtung zur Manipulation kleiner Flüssigkeitsmengen auf Oberflächen
US7723123B1 (en) 2001-06-05 2010-05-25 Caliper Life Sciences, Inc. Western blot by incorporating an affinity purification zone
US6881315B2 (en) 2001-08-03 2005-04-19 Nec Corporation Fractionating apparatus having colonies of pillars arranged in migration passage at interval and process for fabricating pillars
US20030059344A1 (en) * 2001-09-24 2003-03-27 Brady Michael D. Pin plate for use in array printing and method for making the pin plate
US6755949B1 (en) * 2001-10-09 2004-06-29 Roche Diagnostics Corporation Biosensor
US6723500B2 (en) * 2001-12-05 2004-04-20 Lifescan, Inc. Test strips having reaction zones and channels defined by a thermally transferred hydrophobic barrier
KR100408871B1 (ko) * 2001-12-20 2003-12-11 삼성전자주식회사 바이오칩 상에서 탄소나노튜브를 이용한 시료의 분리 또는여과 방법
EP1466008A2 (de) * 2002-01-15 2004-10-13 Agamatrix, Inc. Verfahren und vorrichtung zur verarbeitung von elektrochemischen signalen
WO2003066191A1 (en) * 2002-02-04 2003-08-14 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
US20030203504A1 (en) * 2002-04-26 2003-10-30 John Hefti Diffusion-based system and method for detecting and monitoring activity of biologic and chemical species
ES2375724T3 (es) * 2002-09-27 2012-03-05 The General Hospital Corporation Dispositivo microflu�?dico para seperación de células y sus usos.
JP3866183B2 (ja) * 2002-11-01 2007-01-10 Ａｓｔｉ株式会社 バイオチップ
US20060211055A1 (en) * 2002-11-12 2006-09-21 Caliper Life Sciences, Inc. Capture and release assay system and method
CN1720438A (zh) * 2002-11-29 2006-01-11 日本电气株式会社 分离设备和分离方法
JP2004354364A (ja) 2002-12-02 2004-12-16 Nec Corp 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法
AU2003298706A1 (en) 2002-12-04 2004-06-23 Applera Corporation Multiplex amplification of polynucleotides
US6983177B2 (en) * 2003-01-06 2006-01-03 Optiscan Biomedical Corporation Layered spectroscopic sample element with microporous membrane
US20040131088A1 (en) * 2003-01-08 2004-07-08 Adtran, Inc. Shared T1/E1 signaling bit processor
EP1604184A4 (de) * 2003-02-27 2010-10-27 Stephen A Lesko Standardisierte bewertung von therapeutischer wirksamkeit auf basis zellulärer biomarker
AU2004250131A1 (en) * 2003-06-13 2004-12-29 The General Hospital Corporation Microfluidic systems for size based removal of red blood cells and platelets from blood
DE10326607A1 (de) * 2003-06-13 2005-01-05 Steag Microparts Gmbh Vorrichtung zum Handhaben von Flüssigkeiten
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
US20040265172A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method and apparatus for entry and storage of specimens into a microfluidic device
US7541166B2 (en) * 2003-09-19 2009-06-02 Microfluidic Systems, Inc. Sonication to selectively lyse different cell types
US7491527B2 (en) * 2003-09-19 2009-02-17 Microfluidic Systems, Inc. Microfluidic differential extraction cartridge
US20060046305A1 (en) * 2003-10-15 2006-03-02 National University Of Singapore Method and apparatus for detecting analyte with filter
JP4581380B2 (ja) * 2003-11-17 2010-11-17 パナソニック株式会社 核酸増幅反応容器およびその製造方法
WO2005071056A1 (ja) * 2004-01-23 2005-08-04 Kitakyushu Foundation For The Advancement Of Industry, Science And Technology バイオチップ及びそれを用いた試料溶液の機能性検査方法
EP1564556A1 (de) 2004-02-17 2005-08-17 DST Diagnostic Science & Technology GmbH Verfahren und Vorrichtung zur Bestimmung mehrerer Analyten mit simultaner interner Kontrolle
US20050266433A1 (en) * 2004-03-03 2005-12-01 Ravi Kapur Magnetic device for isolation of cells and biomolecules in a microfluidic environment
JP2005257337A (ja) * 2004-03-09 2005-09-22 Brother Ind Ltd 検査対象受体、検査装置、及び検査方法
SE0400662D0 (sv) * 2004-03-24 2004-03-24 Aamic Ab Assay device and method
US7887750B2 (en) * 2004-05-05 2011-02-15 Bayer Healthcare Llc Analytical systems, devices, and cartridges therefor
EP1604733A1 (de) * 2004-06-11 2005-12-14 Corning Incorporated Mikrostrukturentwurf zur Optimisierung der Mischung und des Druckabfalls
WO2005123242A1 (ja) * 2004-06-15 2005-12-29 Nec Corporation 構造体ならびにこれを用いたチップ、および親／疎液性の制御方法
US20060024815A1 (en) * 2004-07-30 2006-02-02 Allman Steve L High sensitivity array-based detection system
US8053214B2 (en) * 2004-09-09 2011-11-08 Microfluidic Systems, Inc. Apparatus and method of extracting and optically analyzing an analyte from a fluid-based sample
US7988935B2 (en) * 2004-09-09 2011-08-02 Microfluidic Systems, Inc. Handheld and portable microfluidic device to automatically prepare nucleic acids for analysis
US7442557B1 (en) 2004-10-22 2008-10-28 Idexx Laboratories, Inc. Bi-directional flow assay device with reagent bridge
US7785868B2 (en) * 2004-12-02 2010-08-31 Microfluidic Systems, Inc. Apparatus to automatically lyse a sample
US20060171846A1 (en) * 2005-01-10 2006-08-03 Marr David W M Microfluidic systems incorporating integrated optical waveguides
US20090136982A1 (en) 2005-01-18 2009-05-28 Biocept, Inc. Cell separation using microchannel having patterned posts
KR20070116585A (ko) 2005-01-18 2007-12-10 바이오셉트 인코포레이티드 패턴화된 포스트를 갖는 마이크로채널을 이용하는 세포분리법
JP4646204B2 (ja) * 2005-01-27 2011-03-09 ブラザー工業株式会社 検査対象受体、分取装置、及び分取方法
US20070026414A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026415A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US20070026417A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026413A1 (en) * 2005-07-29 2007-02-01 Mehmet Toner Devices and methods for enrichment and alteration of circulating tumor cells and other particles
EP1712284B1 (de) * 2005-04-15 2012-10-10 Samsung Electronics Co., Ltd. Methode zur Zelltrennung mit Benutzung hydrophober fester Träger
US20070059680A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for cell enrichment
US20090181421A1 (en) * 2005-07-29 2009-07-16 Ravi Kapur Diagnosis of fetal abnormalities using nucleated red blood cells
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026416A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
KR100714988B1 (ko) * 2005-08-09 2007-05-09 삼성전자주식회사 산화막이 표면에 형성된 실리콘 구조물 표면을 이용한ｄｎａ 정제 방법 및 정제장치
US7618588B2 (en) * 2005-08-10 2009-11-17 Microfluidic Systems, Inc. Disposable integrated heater and tube assembly for thermally-driven chemical reactions
US20070059683A1 (en) * 2005-09-15 2007-03-15 Tom Barber Veterinary diagnostic system
US20070059781A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for size based separation and analysis
US20070059719A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Business methods for prenatal Diagnosis
US20070059716A1 (en) * 2005-09-15 2007-03-15 Ulysses Balis Methods for detecting fetal abnormality
US20070059718A1 (en) * 2005-09-15 2007-03-15 Mehmet Toner Systems and methods for enrichment of analytes
US20070059774A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Kits for Prenatal Testing
KR100700090B1 (ko) * 2005-09-23 2007-03-28 삼성전자주식회사 이온투과성 폴리머로 코팅된 전극을 이용한 핵산 정제 방법및 그 장치
US20080038714A1 (en) * 2005-11-02 2008-02-14 Affymetrix, Inc. Instrument to Pneumatically Control Lab Cards and Method Thereof
US8075852B2 (en) 2005-11-02 2011-12-13 Affymetrix, Inc. System and method for bubble removal
US20080311585A1 (en) * 2005-11-02 2008-12-18 Affymetrix, Inc. System and method for multiplex liquid handling
US8007267B2 (en) * 2005-11-02 2011-08-30 Affymetrix, Inc. System and method for making lab card by embossing
US20070099288A1 (en) * 2005-11-02 2007-05-03 Affymetrix, Inc. Microfluidic Methods, Devices, and Systems for Fluid Handling
EP1957532A4 (de) * 2005-11-21 2009-11-11 Univ Oregon Health & Science Verfahren und reagentien zur eliminierung oder reduktion von falsch positiven resultaten bei der analyse einer probe
WO2007081902A2 (en) * 2006-01-09 2007-07-19 Massachusetts Institute Of Technology Method and apparatus for high throughput diagnosis of diseased cells with microchannel devices
US8119976B2 (en) * 2007-07-03 2012-02-21 Colorado School Of Mines Optical-based cell deformability
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US9878326B2 (en) * 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
US7735652B2 (en) * 2006-06-01 2010-06-15 The Trustees Of Princeton University Apparatus and method for continuous particle separation
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
EP2029779A4 (de) 2006-06-14 2010-01-20 Living Microsystems Inc Verwendung hoch paralleler snp-genotypisierung zur fötalen diagnose
US20080050739A1 (en) * 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US20080007838A1 (en) * 2006-07-07 2008-01-10 Omnitech Partners, Inc. Field-of-view indicator, and optical system and associated method employing the same
US7919278B2 (en) * 2006-08-21 2011-04-05 Samsung Electronics Co., Ltd. Method of amplifying nucleic acid from a cell using a nonplanar solid substrate
US8158411B2 (en) 2006-08-21 2012-04-17 Samsung Electronics Co., Ltd. Method of separating microorganism using nonplanar solid substrate and device for separating microorganism using the same
US20100139383A1 (en) * 2006-11-17 2010-06-10 Treadcheck Limited Apparatus and method for monitoring tyre wear
MX2009012655A (es) * 2007-05-23 2009-12-14 Entegris Inc Articulos que presentan superficies estructuradas humectables.
EP2716656B1 (de) 2007-06-15 2016-10-12 Xiamen University An Hämagglutinin des Vogelgrippevirus Subtyp H5 bindende monoklonale Antikörper und Verwendung dafür
US20090062828A1 (en) * 2007-09-04 2009-03-05 Colorado School Of Mines Magnetic field-based colloidal atherectomy
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
CA2701069C (en) 2007-11-29 2016-03-15 International Business Machines Corporation Apparatus and method for detection of an analyte in a sample
EP2072101A1 (de) * 2007-12-21 2009-06-24 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Mehrfach angeschlossener Kanalmikroverdampfer
US8008032B2 (en) 2008-02-25 2011-08-30 Cellective Dx Corporation Tagged ligands for enrichment of rare analytes from a mixed sample
WO2009128294A1 (ja) * 2008-04-19 2009-10-22 ブラザー工業株式会社 検査対象受体及び当該検査対象受体を備えた検査装置
FI120818B (fi) * 2008-05-28 2010-03-31 Thermo Fisher Scientific Oy Reaktioastia ja menetelmä sen käsittelemiseksi
EP2321055A4 (de) * 2008-07-10 2012-01-18 Steven H Reichenbach Verfahren und vorrichtung zum sortieren von partikeln unter verwendung von asymmetrischer partikelverschiebung
ES2628181T3 (es) 2008-07-24 2017-08-02 The Trustees Of Princeton University Dispositivo de matriz de choque que tiene espacios de separación asimétricos para la segregación de partículas
US8715590B2 (en) * 2008-08-15 2014-05-06 Prognosys LLC Multiplexed lateral flow assay arrays
US8133451B2 (en) * 2008-08-28 2012-03-13 Microfluidic Systems, Inc. Sample preparation apparatus
EP2334812B1 (de) 2008-09-20 2016-12-21 The Board of Trustees of The Leland Stanford Junior University Nichtinvasive diagnose von fötaler aneuploidie mittels sequenzieren
US20100104485A1 (en) * 2008-10-28 2010-04-29 Microfluidic Systems, Inc. Flow-through thermal cycling device
US8435465B2 (en) * 2008-11-03 2013-05-07 Cfd Research Corporation Microfluidic biological extraction chip
JP4993632B2 (ja) * 2009-06-16 2012-08-08 朝日インテック株式会社 医療用ガイドワイヤ
US8187979B2 (en) * 2009-12-23 2012-05-29 Varian Semiconductor Equipment Associates, Inc. Workpiece patterning with plasma sheath modulation
JP5618556B2 (ja) * 2010-01-28 2014-11-05 株式会社日立ハイテクノロジーズ 核酸分析装置，核酸分析反応デバイス、および核酸分析用反応デバイス用基板
WO2011149526A2 (en) 2010-05-25 2011-12-01 Arryx, Inc. Methods and apparatuses for detection of positional freedom of particles in biological and chemical analyses and applications in immunodiagnostics
EP2596347B1 (de) 2010-07-22 2017-09-06 Hach Company Alkalinitätsanalyse mittels lab-on-chip
WO2012051386A2 (en) 2010-10-14 2012-04-19 Meso Scale Technologies, Llc Reagent storage in an assay device
FR2967497B1 (fr) * 2010-11-17 2014-12-12 Biomerieux Sa Dispositif et procede pour immunoessais
WO2012138701A1 (en) * 2011-04-06 2012-10-11 Ortho-Clinical Diagnostics, Inc Assay device having rhombus-shaped projections
US9541480B2 (en) 2011-06-29 2017-01-10 Academia Sinica Capture, purification, and release of biological substances using a surface coating
US10073012B2 (en) 2011-09-04 2018-09-11 Agilent Technologies, Inc. Debris filter for fluidic measurement with recess size decreasing in fluid flow direction
US9180449B2 (en) 2012-06-12 2015-11-10 Hach Company Mobile water analysis
US9494500B2 (en) 2012-10-29 2016-11-15 Academia Sinica Collection and concentration system for biologic substance of interest and use thereof
USD768872S1 (en) 2012-12-12 2016-10-11 Hach Company Cuvette for a water analysis instrument
BE1022314B1 (nl) * 2013-02-05 2016-03-15 PharmaFluidics N.V. Chemische reactor inrichting
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
WO2014145152A2 (en) 2013-03-15 2014-09-18 Gpb Scientific, Llc On-chip microfluidic processing of particles
EP3608022A1 (de) 2013-03-15 2020-02-12 The Trustees of Princeton University Verfahren und vorrichtungen für reinigung mit hohem durchsatz
JP6055922B2 (ja) * 2013-08-08 2016-12-27 パナソニック株式会社 マイクロ流体デバイス
CA2930430A1 (en) * 2013-11-22 2015-05-28 The General Hospital Corporation Microfluidic methods and systems for isolating particle clusters
WO2015153816A2 (en) 2014-04-01 2015-10-08 Academia Sinica Methods and systems for cancer diagnosis and prognosis
US10112198B2 (en) 2014-08-26 2018-10-30 Academia Sinica Collector architecture layout design
KR101605518B1 (ko) * 2014-10-24 2016-03-22 주식회사 센플러스 미소입자의 자기 배열을 위한 장치 및 방법
US10976232B2 (en) * 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
US10844353B2 (en) 2017-09-01 2020-11-24 Gpb Scientific, Inc. Methods for preparing therapeutically active cells using microfluidics
GB201820413D0 (en) 2018-12-14 2019-01-30 Osler Diagnostics Ltd Multiplexed Assay
GB201902810D0 (en) * 2019-03-01 2019-04-17 Vidya Holdings Ltd Disposition of reagents in assay device
CN113811769A (zh) * 2019-05-15 2021-12-17 电化株式会社 膜载体和检测试剂盒

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789628A (en) * 1986-06-16 1988-12-06 Vxr, Inc. Devices for carrying out ligand/anti-ligand assays, methods of using such devices and diagnostic reagents and kits incorporating such devices
CA2109924A1 (en) * 1991-05-30 1992-12-10 Janina Adamczyk Reagents containing a nonspecific binding blocker in ion-capture binding assays
EP0586605B1 (de) * 1991-05-30 1998-08-05 Abbott Laboratories Reagenzien und verfahren zur ausführung eines zweistufigen ioneneinfang-assay
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
JP3558294B2 (ja) * 1992-05-01 2004-08-25 トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア 微細加工装置を用いたポリヌクレオチド増幅分析
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5458852A (en) * 1992-05-21 1995-10-17 Biosite Diagnostics, Inc. Diagnostic devices for the controlled movement of reagents without membranes

Also Published As

Publication number Publication date
JP4086896B2 (ja) 2008-05-14
CA2195875A1 (en) 1996-04-11
ATE254285T1 (de) 2003-11-15
DE69532133T2 (de) 2004-07-22
JPH10506991A (ja) 1998-07-07
WO1996010747A1 (en) 1996-04-11
EP0783694A1 (de) 1997-07-16
US5952173A (en) 1999-09-14
EP0783694B1 (de) 2003-11-12
ES2212799T3 (es) 2004-08-01
US5707799A (en) 1998-01-13
EP1369691A1 (de) 2003-12-10
CA2195875C (en) 2008-02-05

Similar Documents

Publication Publication Date Title
DE69532133D1 (de) Geräte und verfahren, die strukturfelder zum binden von analyten verwenden
CA2252912A1 (en) Assay method, kit and assay device
DE68920176D1 (de) Festphasenanalytische Vorrichtung und Verfahren zum Gebrauch derselben.
EP0853129A3 (de) Vorrichtungen und Verfahren zur Erkennung von Nukleinsäureanalyten in Proben
DE69942314D1 (de) Versuchsanordnung zum nachweis von bindungspartnern
CA2383262A1 (en) Analytical test device with substrate having oriented through going channels and improved methods and apparatus for using same
EP0846776A3 (de) Vorrichtungen und Verfahren zur Erkennung von mehreren Analyten Proben
EP1376130A3 (de) Testvorrichtung mit opponierbaren Elementen
ATE269160T1 (de) Miniaturisierte probenvorbereitungsvorrichtungen sowie systeme zur feststellung und behandlung von analyten
DE69928747D1 (de) Verfahen und Zusammensetzungen zur Vermehrung von feststellbaren Signalen in spezifischen Bindungstests
ATE386934T1 (de) Methode und vorrichtung zum nachweis oder zur quantifizierung von kohlenhydrate enthaltenden verbindungen
ATE191566T1 (de) Testvorrichtung mit gefangenem teilchen-reagens
ATE175025T1 (de) Verfahren, reagenzien und testkits zum nachweis von subpopulationen biologischer substanzen
NO170825C (no) Fastfasesystem og apparat for detektering av en eller flere analytter i en vaeskeproeve, samt anvendelse av apparatetfor immunoanalyse
ATE461450T1 (de) Verwendung von kontrollflächen zur detektion von störproben in einem nachweisverfahren
ATE81208T1 (de) Verfahren zum nachweis und zur quantitativbestimmung von immunologischen stoffen.
ATE133257T1 (de) Ermittlung und quantifizierung mehrerer analyten unter verwendung von markierungstechniken
DE3786388T2 (de) Analytisches Gerät und Verfahren zum Nachweis von Chlamydia Trachomatis und Neisseria Gonorrhoeae.
DE69223651T2 (de) Vorrichtungen zur ausführung von ioneneinfangassays
ATE524737T1 (de) Verfahren und vorrichtung zur bestimmung mehrerer analyten mit simultaner internen kontrolle in einer grafischen kombination
WO2000026409A8 (en) Amplified array analysis method and system
ATE232981T1 (de) Differenziertes timingsverfahren zum nachweiss multiple analyte in eine testprobe
EP1892518A3 (de) Markierungsfreies optisches Verfahren mit hohem Durchsatz für den Nachweis biomolekularer Wechselwirkungen
DE50011831D1 (de) Dynamische bestimmung von analyten durch arrays auf inneren oberflächen
WO2000029619A3 (en) Multielement analytical device for assay of nucleic acid sequences and uses therefore

Legal Events

Date Code Title Description
8364 No opposition during term of opposition