DE69529409T2 - Funktionalisierte hydrophile akridinium ester - Google Patents
Funktionalisierte hydrophile akridinium esterInfo
- Publication number
- DE69529409T2 DE69529409T2 DE69529409T DE69529409T DE69529409T2 DE 69529409 T2 DE69529409 T2 DE 69529409T2 DE 69529409 T DE69529409 T DE 69529409T DE 69529409 T DE69529409 T DE 69529409T DE 69529409 T2 DE69529409 T2 DE 69529409T2
- Authority
- DE
- Germany
- Prior art keywords
- assays
- akridinium
- hydrophile
- functionalized
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/64—Acridine or hydrogenated acridine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/586—Liposomes, microcapsules or cells
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/225,165 US5656426A (en) | 1988-08-01 | 1994-04-08 | Functionaized hydrophilic acridinium esters |
PCT/IB1995/000244 WO1995027702A1 (en) | 1994-04-08 | 1995-04-06 | Novel functionalized hydrophilic acridinium esters |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69529409D1 DE69529409D1 (de) | 2003-02-20 |
DE69529409T2 true DE69529409T2 (de) | 2003-08-14 |
Family
ID=22843803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69529409T Expired - Lifetime DE69529409T2 (de) | 1994-04-08 | 1995-04-06 | Funktionalisierte hydrophile akridinium ester |
Country Status (11)
Country | Link |
---|---|
US (1) | US5656426A (de) |
EP (2) | EP0982298A1 (de) |
JP (1) | JP3844358B2 (de) |
AT (1) | ATE231130T1 (de) |
AU (1) | AU703436B2 (de) |
BR (1) | BR9507307A (de) |
CA (1) | CA2186463A1 (de) |
DE (1) | DE69529409T2 (de) |
ES (1) | ES2188654T3 (de) |
PL (1) | PL316794A1 (de) |
WO (1) | WO1995027702A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6514987B1 (en) * | 1997-01-06 | 2003-02-04 | Cerus Corporation | Frangible compounds for pathogen inactivation |
DE69837155T2 (de) | 1997-09-22 | 2007-06-21 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Verfahren zum nachweiss von antikörpern in einer probe |
AU9498098A (en) | 1997-09-22 | 1999-04-12 | Chiron Corporation | Buffers for stabilizing antigens |
WO2000009487A1 (en) | 1998-08-11 | 2000-02-24 | Bayer Corporation | Near infrared chemiluminescent acridinium compounds and uses thereof |
US6673560B1 (en) | 1998-11-25 | 2004-01-06 | Bayer Corporation | Measurement of hydride using chemiluminescent acridinium compounds and applications thereof |
DE69927240T2 (de) * | 1998-11-25 | 2006-06-22 | Bayer Corp. | Messung von hydriden mit hilfe chemilumineszierender acridiniumverbindungen |
US6783948B1 (en) * | 1999-07-30 | 2004-08-31 | Bayer Corporation | Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes |
ATE291096T1 (de) * | 1999-07-30 | 2005-04-15 | Bayer Ag | Chemilumineszenz-substrate von hydrolytischen enzymen wie phosphatasen |
US6348317B1 (en) * | 1999-11-18 | 2002-02-19 | The Arizona Board Of Regents | Fluorescent and DNA cleavage properties of peptide/dye conjugates |
EP1352086B1 (de) * | 2000-05-01 | 2008-11-12 | Gen-Probe Incorporated | Polynukleotid-proben zum nachweis und zur quantifizierung von candida spezies |
US6664043B2 (en) * | 2001-07-03 | 2003-12-16 | Bayer Corporation | Acridinium ester labels having hydrophilic modifiers |
US6723851B2 (en) | 2001-10-31 | 2004-04-20 | Quest Diagnostics Investment Incorporated | Chemiluminescent compounds and use thereof |
US20030232386A1 (en) * | 2002-06-17 | 2003-12-18 | Shah Dinesh O. | Assay conjugate and uses thereof |
US6924154B2 (en) * | 2002-08-20 | 2005-08-02 | Quest Diagnostics Investments Incorporated | Hydrophilic chemilumescent acridinium labeling reagents |
ATE553089T1 (de) * | 2002-08-20 | 2012-04-15 | Quest Diagnostics Invest Inc | Hydrophile, chemilumineszente acridiniummarkierungsreagenzien |
US7319041B2 (en) * | 2002-09-27 | 2008-01-15 | Siemens Medical Solutions Diagnostic | Applications of acridinium compounds and derivatives in homogeneous assays |
US7309615B2 (en) * | 2002-09-27 | 2007-12-18 | Siemens Medical Solutions Diagnostic | High quantum yield acridinium compounds and their uses in improving assay sensitivity |
US20090068635A1 (en) * | 2007-09-06 | 2009-03-12 | Muerhoff Anthony S | Indirectly labelled assay conjugates and methods of preparing and using same |
JP5395803B2 (ja) * | 2007-11-20 | 2014-01-22 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド | イオン液体中でのアクリジン化合物の容易なn−アルキル化 |
BRPI1009804A2 (pt) | 2009-03-27 | 2015-08-25 | Protea Biopharma N V | Métodos para detecção e tratamento de doença de príon aberrante |
US8778624B2 (en) | 2009-11-16 | 2014-07-15 | Siemens Healthcare Diagnostics Inc. | Zwitterion-containing acridinium compounds |
JP2013534909A (ja) | 2010-05-21 | 2013-09-09 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド | 両性イオン性試薬 |
ES2618042T3 (es) * | 2012-07-10 | 2017-06-20 | Siemens Healthcare Diagnostics Inc. | Síntesis de compuestos de acridinio mediante n-alquilación de acridanos |
CN105264377B (zh) | 2013-05-14 | 2017-09-08 | 西门子医疗保健诊断公司 | 可降解的阳离子型表面活性剂及其在增强化学发光中的用途 |
CN112521335A (zh) | 2013-07-08 | 2021-03-19 | 西门子医疗保健诊断公司 | 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯 |
CN104262250A (zh) * | 2014-09-01 | 2015-01-07 | 深圳市美凯特科技有限公司 | 三碘代甲状腺素半抗原发光标记物及合成方法 |
CN106749185A (zh) * | 2016-11-29 | 2017-05-31 | 湖南师范大学 | 吖啶酯类化学发光底物dmae·nhs的合成 |
WO2018156925A1 (en) * | 2017-02-23 | 2018-08-30 | Siemens Healthcare Diagnostics Inc. | Chemiluminescent androstenedione conjugates |
WO2019116234A1 (en) | 2017-12-12 | 2019-06-20 | Nestec S.A. | Methods for determining microbiome ribosomal rna composition changes |
WO2020005920A1 (en) | 2018-06-25 | 2020-01-02 | Siemens Healthcare Diagnostics Inc. | N-alkylation of acridans |
US11237170B2 (en) | 2018-12-04 | 2022-02-01 | Aat Bioquest, Inc. | Styryl phenols, derivatives and their use in methods of analyte detection |
EP4115183A4 (de) * | 2020-03-04 | 2023-12-27 | Siemens Healthcare Diagnostics, Inc. | Verfahren zur verstärkung von immuntestsignalen |
EP4114968A4 (de) * | 2020-03-04 | 2023-07-19 | Siemens Healthcare Diagnostics, Inc. | Zusammensetzungen und verfahren zur verwendung modifizierter liposome |
CN112684163B (zh) * | 2021-01-29 | 2022-08-09 | 安邦(厦门)生物科技有限公司 | 一种吖啶类化合物标记原料工作液及制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4031117A (en) * | 1975-09-22 | 1977-06-21 | Becton, Dickinson And Company | Testosterone derivatives |
US4197286A (en) * | 1977-09-27 | 1980-04-08 | Southwest Research Institute | Testosterone derivatives and assay method |
GB2112779B (en) * | 1981-12-11 | 1986-10-15 | Welsh Nat School Med | Aryl acridinium esters as luminescent labelling materials |
US4745181A (en) * | 1986-10-06 | 1988-05-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
ATE111083T1 (de) * | 1986-10-22 | 1994-09-15 | Abbott Lab | Chemilumineszierende acridinium- und phenantridiniumsalze. |
NZ227506A (en) * | 1987-12-31 | 1992-06-25 | London Diagnostics Inc | Specific binding assays using chemiluminescent compounds |
US5321136A (en) * | 1987-12-31 | 1994-06-14 | London Diagnostics, Inc. | Peri substituted fused ring chemiluminescent labels and their conjugates, and assays therefrom |
US5283334A (en) * | 1987-12-31 | 1994-02-01 | London Diagnostics, Inc. | Side-chain functional chemiluminescent labels and their conjugates, and assays therefrom |
AU634716B2 (en) * | 1988-08-01 | 1993-03-04 | Ciba Corning Diagnostics Corp. | Method for detection of an analyte using acridinium esters and liposomes |
US5241070A (en) * | 1988-09-26 | 1993-08-31 | Ciba Corning Diagnostics Corp. | Nucleophilic polysubstituted aryl acridinium esters and uses thereof |
CA1339491C (en) * | 1988-09-26 | 1997-10-07 | Say-Jong Law | Nucleophilic polysubstituted aryl acridinium ester and uses thereof |
JP3584379B2 (ja) * | 1993-02-04 | 2004-11-04 | 持田製薬株式会社 | アクリジニウム化合物およびアクリジニウム化合物複合体 |
-
1994
- 1994-04-08 US US08/225,165 patent/US5656426A/en not_active Expired - Lifetime
-
1995
- 1995-04-06 ES ES95913298T patent/ES2188654T3/es not_active Expired - Lifetime
- 1995-04-06 WO PCT/IB1995/000244 patent/WO1995027702A1/en active IP Right Grant
- 1995-04-06 AT AT95913298T patent/ATE231130T1/de not_active IP Right Cessation
- 1995-04-06 CA CA002186463A patent/CA2186463A1/en not_active Abandoned
- 1995-04-06 DE DE69529409T patent/DE69529409T2/de not_active Expired - Lifetime
- 1995-04-06 EP EP99203889A patent/EP0982298A1/de not_active Withdrawn
- 1995-04-06 EP EP95913298A patent/EP0754178B1/de not_active Expired - Lifetime
- 1995-04-06 AU AU20816/95A patent/AU703436B2/en not_active Expired
- 1995-04-06 BR BR9507307A patent/BR9507307A/pt not_active Application Discontinuation
- 1995-04-06 JP JP52621695A patent/JP3844358B2/ja not_active Expired - Lifetime
- 1995-04-06 PL PL95316794A patent/PL316794A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JPH10503169A (ja) | 1998-03-24 |
EP0754178A1 (de) | 1997-01-22 |
WO1995027702A1 (en) | 1995-10-19 |
DE69529409D1 (de) | 2003-02-20 |
JP3844358B2 (ja) | 2006-11-08 |
EP0754178B1 (de) | 2003-01-15 |
CA2186463A1 (en) | 1995-10-19 |
PL316794A1 (en) | 1997-02-17 |
ATE231130T1 (de) | 2003-02-15 |
AU703436B2 (en) | 1999-03-25 |
US5656426A (en) | 1997-08-12 |
BR9507307A (pt) | 1997-09-02 |
ES2188654T3 (es) | 2003-07-01 |
AU2081695A (en) | 1995-10-30 |
EP0982298A1 (de) | 2000-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: SIEMENS HEALTHCARE DIAGNOSTICS INC. (N.D.GES.D, US |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: MAIER, D., DIPL.-ING. UNIV., PAT.-ASS., 81739 MUEN |