DE69529409D1 - Funktionalisierte hydrophile akridinium ester - Google Patents

Funktionalisierte hydrophile akridinium ester

Info

Publication number
DE69529409D1
DE69529409D1 DE69529409T DE69529409T DE69529409D1 DE 69529409 D1 DE69529409 D1 DE 69529409D1 DE 69529409 T DE69529409 T DE 69529409T DE 69529409 T DE69529409 T DE 69529409T DE 69529409 D1 DE69529409 D1 DE 69529409D1
Authority
DE
Germany
Prior art keywords
assays
akridinium
hydrophile
functionalized
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69529409T
Other languages
English (en)
Other versions
DE69529409T2 (de
Inventor
Say-Jong Law
Chariklia Sotiriou-Leventis
Anand Natrajan
Qingping Jiang
B Connolly
P Kilroy
R Mccudden
M Tirrell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of DE69529409D1 publication Critical patent/DE69529409D1/de
Publication of DE69529409T2 publication Critical patent/DE69529409T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/64—Acridine or hydrogenated acridine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/586—Liposomes, microcapsules or cells
DE69529409T 1994-04-08 1995-04-06 Funktionalisierte hydrophile akridinium ester Expired - Lifetime DE69529409T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/225,165 US5656426A (en) 1988-08-01 1994-04-08 Functionaized hydrophilic acridinium esters
PCT/IB1995/000244 WO1995027702A1 (en) 1994-04-08 1995-04-06 Novel functionalized hydrophilic acridinium esters

Publications (2)

Publication Number Publication Date
DE69529409D1 true DE69529409D1 (de) 2003-02-20
DE69529409T2 DE69529409T2 (de) 2003-08-14

Family

ID=22843803

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69529409T Expired - Lifetime DE69529409T2 (de) 1994-04-08 1995-04-06 Funktionalisierte hydrophile akridinium ester

Country Status (11)

Country Link
US (1) US5656426A (de)
EP (2) EP0982298A1 (de)
JP (1) JP3844358B2 (de)
AT (1) ATE231130T1 (de)
AU (1) AU703436B2 (de)
BR (1) BR9507307A (de)
CA (1) CA2186463A1 (de)
DE (1) DE69529409T2 (de)
ES (1) ES2188654T3 (de)
PL (1) PL316794A1 (de)
WO (1) WO1995027702A1 (de)

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US6514987B1 (en) * 1997-01-06 2003-02-04 Cerus Corporation Frangible compounds for pathogen inactivation
DE69840334D1 (de) 1997-09-22 2009-01-22 Novartis Vaccines & Diagnostic Puffern zur stabilizierung von hcv antigenen
AU9497998A (en) 1997-09-22 1999-04-12 Chiron Corporation Method for detecting antibodies in a sample
DE69940433D1 (de) 1998-08-11 2009-04-02 Siemens Healthcare Diagnostics Im nahen infrarot chemilumineszente akridinium derivate und ihre verwendung
IL136929A0 (en) * 1998-11-25 2001-06-14 Bayer Ag Measurement of hydride using chemiluminescent acridinium compounds
US6673560B1 (en) 1998-11-25 2004-01-06 Bayer Corporation Measurement of hydride using chemiluminescent acridinium compounds and applications thereof
US6783948B1 (en) * 1999-07-30 2004-08-31 Bayer Corporation Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes
ATE291096T1 (de) * 1999-07-30 2005-04-15 Bayer Ag Chemilumineszenz-substrate von hydrolytischen enzymen wie phosphatasen
US6348317B1 (en) * 1999-11-18 2002-02-19 The Arizona Board Of Regents Fluorescent and DNA cleavage properties of peptide/dye conjugates
JP4859325B2 (ja) * 2000-05-01 2012-01-25 ジェン−プローブ・インコーポレーテッド カンジダ種の検出および定量化のためのポリヌクレオチドプローブ
US6664043B2 (en) * 2001-07-03 2003-12-16 Bayer Corporation Acridinium ester labels having hydrophilic modifiers
US6723851B2 (en) * 2001-10-31 2004-04-20 Quest Diagnostics Investment Incorporated Chemiluminescent compounds and use thereof
US20030232386A1 (en) * 2002-06-17 2003-12-18 Shah Dinesh O. Assay conjugate and uses thereof
ATE553089T1 (de) * 2002-08-20 2012-04-15 Quest Diagnostics Invest Inc Hydrophile, chemilumineszente acridiniummarkierungsreagenzien
US6924154B2 (en) * 2002-08-20 2005-08-02 Quest Diagnostics Investments Incorporated Hydrophilic chemilumescent acridinium labeling reagents
US7309615B2 (en) * 2002-09-27 2007-12-18 Siemens Medical Solutions Diagnostic High quantum yield acridinium compounds and their uses in improving assay sensitivity
US7319041B2 (en) * 2002-09-27 2008-01-15 Siemens Medical Solutions Diagnostic Applications of acridinium compounds and derivatives in homogeneous assays
US20090068635A1 (en) * 2007-09-06 2009-03-12 Muerhoff Anthony S Indirectly labelled assay conjugates and methods of preparing and using same
WO2009067417A1 (en) * 2007-11-20 2009-05-28 Siemens Heathcare Diagnostics Inc. Facile n-alkylation of acridine compounds in ionic liquids
EP2411509A1 (de) 2009-03-27 2012-02-01 Protea Biopharma N.v. Verfahren zum nachweis und zur behandlung von anomale-prionen-krankheit
US8778624B2 (en) 2009-11-16 2014-07-15 Siemens Healthcare Diagnostics Inc. Zwitterion-containing acridinium compounds
EP2571487B1 (de) 2010-05-21 2023-01-04 Siemens Healthcare Diagnostics Inc. Zwitterionische reagenzien
ES2618042T3 (es) * 2012-07-10 2017-06-20 Siemens Healthcare Diagnostics Inc. Síntesis de compuestos de acridinio mediante n-alquilación de acridanos
JP6494599B2 (ja) 2013-05-14 2019-04-03 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． 分解可能なカチオン界面活性剤および化学発光を増強するためのその利用
WO2015006174A1 (en) 2013-07-08 2015-01-15 Siemens Healthcare Diagnostics Inc. Hydrophilic high quantum yield acridinium esters with improved stability and fast light emission
CN104262250A (zh) * 2014-09-01 2015-01-07 深圳市美凯特科技有限公司 三碘代甲状腺素半抗原发光标记物及合成方法
CN106749185A (zh) * 2016-11-29 2017-05-31 湖南师范大学 吖啶酯类化学发光底物dmae·nhs的合成
WO2018156925A1 (en) * 2017-02-23 2018-08-30 Siemens Healthcare Diagnostics Inc. Chemiluminescent androstenedione conjugates
WO2019116234A1 (en) 2017-12-12 2019-06-20 Nestec S.A. Methods for determining microbiome ribosomal rna composition changes
US11203573B2 (en) 2018-06-25 2021-12-21 Siemens Healthcare Diagnostics Inc. N-alkylation of acridans
US11237170B2 (en) 2018-12-04 2022-02-01 Aat Bioquest, Inc. Styryl phenols, derivatives and their use in methods of analyte detection
CN115136006A (zh) * 2020-03-04 2022-09-30 美国西门子医学诊断股份有限公司 放大免疫测定信号的方法
EP4114968A4 (de) * 2020-03-04 2023-07-19 Siemens Healthcare Diagnostics, Inc. Zusammensetzungen und verfahren zur verwendung modifizierter liposome
CN112684163B (zh) * 2021-01-29 2022-08-09 安邦（厦门）生物科技有限公司 一种吖啶类化合物标记原料工作液及制备方法

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US4031117A (en) * 1975-09-22 1977-06-21 Becton, Dickinson And Company Testosterone derivatives
US4197286A (en) * 1977-09-27 1980-04-08 Southwest Research Institute Testosterone derivatives and assay method
GB2112779B (en) * 1981-12-11 1986-10-15 Welsh Nat School Med Aryl acridinium esters as luminescent labelling materials
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
EP0273115B1 (de) * 1986-10-22 1994-09-07 Abbott Laboratories Chemilumineszierende Acridinium- und Phenantridiniumsalze
US5284952A (en) * 1987-12-31 1994-02-08 London Diagnostics, Inc. Sulfonyl substituted chemiluminescent labels and their conjugates, and assays therefrom
US5321136A (en) * 1987-12-31 1994-06-14 London Diagnostics, Inc. Peri substituted fused ring chemiluminescent labels and their conjugates, and assays therefrom
NZ227506A (en) * 1987-12-31 1992-06-25 London Diagnostics Inc Specific binding assays using chemiluminescent compounds
AU634716B2 (en) * 1988-08-01 1993-03-04 Ciba Corning Diagnostics Corp. Method for detection of an analyte using acridinium esters and liposomes
US5241070A (en) * 1988-09-26 1993-08-31 Ciba Corning Diagnostics Corp. Nucleophilic polysubstituted aryl acridinium esters and uses thereof
CA1339491C (en) * 1988-09-26 1997-10-07 Say-Jong Law Nucleophilic polysubstituted aryl acridinium ester and uses thereof
JP3584379B2 (ja) * 1993-02-04 2004-11-04 持田製薬株式会社 アクリジニウム化合物およびアクリジニウム化合物複合体

Also Published As

Publication number Publication date
EP0754178A1 (de) 1997-01-22
CA2186463A1 (en) 1995-10-19
DE69529409T2 (de) 2003-08-14
BR9507307A (pt) 1997-09-02
ES2188654T3 (es) 2003-07-01
US5656426A (en) 1997-08-12
JPH10503169A (ja) 1998-03-24
EP0754178B1 (de) 2003-01-15
AU703436B2 (en) 1999-03-25
PL316794A1 (en) 1997-02-17
JP3844358B2 (ja) 2006-11-08
EP0982298A1 (de) 2000-03-01
WO1995027702A1 (en) 1995-10-19
AU2081695A (en) 1995-10-30
ATE231130T1 (de) 2003-02-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SIEMENS HEALTHCARE DIAGNOSTICS INC. (N.D.GES.D, US

8328 Change in the person/name/address of the agent

Representative=s name: MAIER, D., DIPL.-ING. UNIV., PAT.-ASS., 81739 MUEN