DE69528714T2 - Propofol und disodium edta enthaltende öl-in-wasser emulsionen - Google Patents

Propofol und disodium edta enthaltende öl-in-wasser emulsionen

Info

Publication number: DE69528714T2
Authority: DE; Germany
Prior art keywords: propofol; water emulsions; containing oil; disodium edta; water
Prior art date: 1994-03-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69528714T

Other languages

English (en)

Other versions

DE69528714D1 (de

Inventor

Christopher Buchan Jones

John Henry Platt

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

AstraZeneca AB

Original Assignee

AstraZeneca AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-22

Filing date

1995-03-17

Publication date

2003-06-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48793621&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69528714(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-03-17 Application filed by AstraZeneca AB filed Critical AstraZeneca AB

2002-12-05 Application granted granted Critical

2002-12-05 Publication of DE69528714D1 publication Critical patent/DE69528714D1/de

2003-06-12 Publication of DE69528714T2 publication Critical patent/DE69528714T2/de

2015-03-18 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 title abstract 3
239000000839 emulsion Substances 0.000 title abstract 2
229960004134 propofol Drugs 0.000 title abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 title 1
ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 title 1
235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 title 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
238000011109 contamination Methods 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
239000007764 o/w emulsion Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
239000008177 pharmaceutical agent Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

DE69528714T 1994-03-22 1995-03-17 Propofol und disodium edta enthaltende öl-in-wasser emulsionen Expired - Lifetime DE69528714T2 (de)

Applications Claiming Priority (19)

Application Number	Priority Date	Filing Date	Title
GB9405593A GB9405593D0 (en)	1994-03-22	1994-03-22	Pharmaceutical compositions
NZ282005A NZ282005A (en)	1994-03-22	1995-03-17	Oil in water emulsions containing propofol (2,6 diisopropylphenol) and edetate
BR9510452A BR9510452A (pt)	1994-03-22	1995-03-17	Composição farmacêutica e aquosa estéril para a administração parenteral processos para limitar o potencial de crescimento microbiano em composição farmacêutica estéril para a administração parenteral para produzir anestesia em um animal de sangue quente e para aperfeiçoar o tempo de administração e/ou o tempo entre as trocas de conjuntos
CH01282/04A CH694423A5 (de)	1994-03-22	1995-03-17	Verwendung von Edetat zur Stabilisierung von pharmzeutischen Zusammensetzungen.
PCT/GB1995/000579 WO1996029064A1 (en)	1994-03-22	1995-03-17	Oil in water emulsions containing propofol and edetate
NZ500588A NZ500588A (en)	1994-03-22	1995-03-17	Oil in water emulsions containing propofol and edetate for producing anaesthesia
BE9500241A BE1009198A5 (fr)	1994-03-22	1995-03-17	Compositions pharmaceutiques nouvelles contenant du propofol.
DE19509828A DE19509828A1 (de)	1994-03-22	1995-03-17	Pharmazeutische Zusammensetzungen
PL95322278A PL186354B1 (pl)	1994-03-22	1995-03-17	Jałowe kompozycje farmaceutyczne oraz sposoby ograniczania potencjału wzrostowego drobnoustrojów i poprawiania czasu stosowania emulsji
CA002212794A CA2212794C (en)	1994-03-22	1995-03-17	Oil in water emulsions containing propofol and edetate
EP95911412A EP0814787B1 (de)	1994-03-22	1995-03-17	Propofol und disodium edta enthaltende öl-in-wasser emulsionen
HU9702180A HU227951B1 (en)	1994-03-22	1995-03-17	Oil in water emulsions containing propofol and disodium edetate
FR9503128A FR2731617B1 (fr)	1994-03-22	1995-03-17	Compositions pharmaceutiques nouvelles contenant du propofol
CH02011/97A CH693764A5 (de)	1994-03-22	1995-03-17	Pharmazeutische Zusammensetzung enthaltend Propofol und Edetat.
CH00393/03A CH693762A5 (de)	1994-03-22	1995-03-17	Wässrige Zusammensetzungen enthaltend eine Öl-in-Wasser-Emulsion
ZA952239A ZA952239B (en)	1994-03-22	1995-03-17	Pharmaceutical compositions
NO19974278A NO320007B1 (no)	1994-03-22	1997-09-16	Steril farmasoytisk blanding inneholdende propofol og edetat for parenteral administrering, fremgangsmate for a begrense potensialet for mikrobevekst i blandingen, samt anvendelse derav.
JP00624199A JP4012328B2 (ja)	1994-03-22	1999-01-13	エデテートを含有する水中油滴エマルジョン
FI20085586A FI120641B (fi)	1994-03-22	2008-06-13	Ruuansulatuskanavan ulkopuolisesti annettavat rasvaemulsiot, jotka sisältävät edetaattia säilöntäaineena

Publications (2)

Publication Number	Publication Date
DE69528714D1 DE69528714D1 (de)	2002-12-05
DE69528714T2 true DE69528714T2 (de)	2003-06-12

Family

ID=48793621

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE69528714T Expired - Lifetime DE69528714T2 (de)	1994-03-22	1995-03-17	Propofol und disodium edta enthaltende öl-in-wasser emulsionen
DE19509828A Ceased DE19509828A1 (de)	1994-03-22	1995-03-17	Pharmazeutische Zusammensetzungen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE19509828A Ceased DE19509828A1 (de)	1994-03-22	1995-03-17	Pharmazeutische Zusammensetzungen

Country Status (33)

Country	Link
US (1)	US5714520A (de)
EP (2)	EP1238677B1 (de)
JP (2)	JP3067806B2 (de)
AT (2)	ATE312625T1 (de)
AU (1)	AU710143B2 (de)
BE (1)	BE1009198A5 (de)
BR (1)	BR9510452A (de)
CA (1)	CA2212794C (de)
CH (4)	CH694423A5 (de)
CZ (1)	CZ297549B6 (de)
DE (2)	DE69528714T2 (de)
DK (3)	DK1238677T3 (de)
ES (2)	ES2183869T3 (de)
FI (2)	FI120640B (de)
FR (1)	FR2731617B1 (de)
GB (2)	GB9405593D0 (de)
HK (1)	HK1008927A1 (de)
HU (1)	HU227951B1 (de)
IL (1)	IL113021A (de)
IT (1)	IT1281193B1 (de)
LU (1)	LU90136B1 (de)
MX (1)	MX9707005A (de)
NO (2)	NO320007B1 (de)
NZ (2)	NZ282005A (de)
PL (1)	PL186354B1 (de)
PT (1)	PT814787E (de)
RU (1)	RU2147432C1 (de)
SE (2)	SE523909C2 (de)
SI (1)	SI0814787T1 (de)
SK (1)	SK286375B6 (de)
TW (1)	TW458781B (de)
WO (1)	WO1996029064A1 (de)
ZA (1)	ZA952239B (de)

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1994
- 1994-03-22 GB GB9405593A patent/GB9405593D0/en active Pending
1995
- 1995-03-17 ZA ZA952239A patent/ZA952239B/xx unknown
- 1995-03-17 CZ CZ0290497A patent/CZ297549B6/cs not_active IP Right Cessation
- 1995-03-17 CH CH01282/04A patent/CH694423A5/de not_active IP Right Cessation
- 1995-03-17 JP JP08528148A patent/JP3067806B2/ja not_active Expired - Lifetime
- 1995-03-17 NZ NZ282005A patent/NZ282005A/xx not_active IP Right Cessation
- 1995-03-17 CA CA002212794A patent/CA2212794C/en not_active Expired - Fee Related
- 1995-03-17 TW TW084102594A patent/TW458781B/zh not_active IP Right Cessation
- 1995-03-17 HU HU9702180A patent/HU227951B1/hu unknown
- 1995-03-17 BR BR9510452A patent/BR9510452A/pt not_active IP Right Cessation
- 1995-03-17 PL PL95322278A patent/PL186354B1/pl unknown
- 1995-03-17 EP EP02009330A patent/EP1238677B1/de not_active Expired - Lifetime
- 1995-03-17 BE BE9500241A patent/BE1009198A5/fr active
- 1995-03-17 GB GB9505405A patent/GB2298789B/en not_active Expired - Lifetime
- 1995-03-17 SK SK1247-97A patent/SK286375B6/sk not_active IP Right Cessation
- 1995-03-17 AT AT02009330T patent/ATE312625T1/de active
- 1995-03-17 IL IL11302195A patent/IL113021A/en not_active IP Right Cessation
- 1995-03-17 ES ES95911412T patent/ES2183869T3/es not_active Expired - Lifetime
- 1995-03-17 WO PCT/GB1995/000579 patent/WO1996029064A1/en active Application Filing
- 1995-03-17 MX MX9707005A patent/MX9707005A/es unknown
- 1995-03-17 PT PT95911412T patent/PT814787E/pt unknown
- 1995-03-17 SI SI9530628T patent/SI0814787T1/xx unknown
- 1995-03-17 DE DE69528714T patent/DE69528714T2/de not_active Expired - Lifetime
- 1995-03-17 DE DE19509828A patent/DE19509828A1/de not_active Ceased
- 1995-03-17 FR FR9503128A patent/FR2731617B1/fr not_active Expired - Lifetime
- 1995-03-17 RU RU97117100A patent/RU2147432C1/ru active
- 1995-03-17 EP EP95911412A patent/EP0814787B1/de not_active Expired - Lifetime
- 1995-03-17 DK DK02009330T patent/DK1238677T3/da active
- 1995-03-17 ES ES02009330T patent/ES2253469T3/es not_active Expired - Lifetime
- 1995-03-17 CH CH00393/03A patent/CH693762A5/de not_active IP Right Cessation
- 1995-03-17 AT AT95911412T patent/ATE226817T1/de active
- 1995-03-17 DK DK95911412T patent/DK0814787T3/da active
- 1995-03-17 CH CH02053/03A patent/CH694396A5/de not_active IP Right Cessation
- 1995-03-17 IT IT95MI000529A patent/IT1281193B1/it active IP Right Grant
- 1995-03-17 AU AU18988/95A patent/AU710143B2/en not_active Expired
- 1995-03-17 CH CH02011/97A patent/CH693764A5/de not_active IP Right Cessation
- 1995-03-17 NZ NZ500588A patent/NZ500588A/en not_active IP Right Cessation
- 1995-03-22 US US08/408,707 patent/US5714520A/en not_active Expired - Lifetime
1997
- 1997-09-10 LU LU90136A patent/LU90136B1/de active
- 1997-09-10 SE SE9703274A patent/SE523909C2/sv not_active IP Right Cessation
- 1997-09-16 FI FI973702A patent/FI120640B/fi not_active IP Right Cessation
- 1997-09-16 NO NO19974278A patent/NO320007B1/no not_active IP Right Cessation
- 1997-09-17 DK DK106697A patent/DK106697A/da not_active Application Discontinuation
1998
- 1998-08-04 HK HK98109677A patent/HK1008927A1/xx not_active IP Right Cessation
1999
- 1999-01-13 JP JP00624199A patent/JP4012328B2/ja not_active Expired - Lifetime
2004
- 2004-01-21 SE SE0400115A patent/SE527123C2/sv not_active IP Right Cessation
- 2004-05-04 NO NO20041838A patent/NO334956B1/no not_active IP Right Cessation
2008
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Also Published As

Publication number	Publication date
ITMI950529A1 (it)	1996-09-17
JPH11500737A (ja)	1999-01-19
EP1238677A2 (de)	2002-09-11
GB2298789A (en)	1996-09-18
IL113021A0 (en)	1995-12-08
PL322278A1 (en)	1998-01-19
DK106697A (da)	1997-09-17
FI120640B (fi)	2010-01-15
SE523909C2 (sv)	2004-06-01
GB9505405D0 (en)	1995-05-03
US5714520A (en)	1998-02-03
NO334956B1 (no)	2014-08-04
ES2253469T3 (es)	2006-06-01
FI973702A0 (fi)	1997-09-16
FI973702A (fi)	1997-09-16
HU227951B1 (en)	2012-07-30
SE9703274L (sv)	1997-09-10
AU710143B2 (en)	1999-09-16
SI0814787T1 (en)	2003-04-30
CH693762A5 (de)	2004-01-30
SE0400115D0 (sv)	2004-01-21
JPH11263725A (ja)	1999-09-28
NO320007B1 (no)	2005-10-10
PT814787E (pt)	2003-02-28
BE1009198A5 (fr)	1996-12-03
ITMI950529A0 (it)	1995-03-17
IT1281193B1 (it)	1998-02-17
CA2212794A1 (en)	1996-09-26
CZ290497A3 (en)	1997-12-17
ZA952239B (en)	1996-09-17
EP1238677B1 (de)	2005-12-14
IL113021A (en)	2001-04-30
NO20041838L (no)	1997-09-16
HK1008927A1 (en)	1999-07-16
GB2298789B (en)	1999-12-08
CH693764A5 (de)	2004-01-30
MX9707005A (es)	1997-11-29
NZ500588A (en)	2001-04-27
FI120641B (fi)	2010-01-15
NO974278L (no)	1997-09-16
ES2183869T3 (es)	2003-04-01
SE9703274D0 (sv)	1997-09-10
FR2731617B1 (fr)	1997-05-30
RU2147432C1 (ru)	2000-04-20
PL186354B1 (pl)	2003-12-31
JP3067806B2 (ja)	2000-07-24
FI20085586A (fi)	2008-06-13
CA2212794C (en)	2000-09-12
WO1996029064A1 (en)	1996-09-26
NZ282005A (en)	2000-01-28
ATE226817T1 (de)	2002-11-15
CZ297549B6 (cs)	2007-02-07
EP0814787B1 (de)	2002-10-30
BR9510452A (pt)	1998-05-19
CH694423A5 (de)	2005-01-14
CH694396A5 (de)	2004-12-31
GB9405593D0 (en)	1994-05-11
TW458781B (en)	2001-10-11
DK0814787T3 (da)	2003-01-06
AU1898895A (en)	1996-10-08
SK286375B6 (sk)	2008-08-05
SE0400115L (sv)	2004-01-21
LU90136B1 (de)	1997-11-27
NO974278D0 (no)	1997-09-16
SK124797A3 (en)	1998-01-14
SE527123C2 (sv)	2005-12-27
FR2731617A1 (fr)	1996-09-20
DK1238677T3 (da)	2006-03-06
JP4012328B2 (ja)	2007-11-21
ATE312625T1 (de)	2005-12-15
EP0814787A1 (de)	1998-01-07
HUT77358A (hu)	1998-03-30
EP1238677A3 (de)	2003-01-22
DE19509828A1 (de)	1996-09-19
DE69528714D1 (de)	2002-12-05

Legal Events

Date	Code	Title	Description
2003-10-30	8363	Opposition against the patent

Publication	Publication Date	Title
DE69528714T2 (de)	2003-06-12	Propofol und disodium edta enthaltende öl-in-wasser emulsionen
IL114212A (en)	1999-07-14	Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same
DE69016749D1 (de)	1995-03-23	Emulsion.
DE69011922D1 (de)	1994-10-06	Arzneiemulsionen.
GR3024405T3 (en)	1997-11-28	Preparations comprising a fluorocarbon and a lipophilic/fluorophilic organic compound, and their use
DE69625213T2 (de)	2003-08-28	Mikroemulsionen zur verwendung als träger zur verabreichung von wirkstoffen
ES431706A1 (es)	1976-11-16	Un procedimiento de preparacion de emulsiones de compuestosfluorados en agua o en soluciones salinas.
KR870002835A (ko)	1987-04-13	이온화성 소수성약제의 약제학적 제조방법
ES2114931T3 (es)	1998-06-16	Nuevos esteres esteroidales.
ES2053897T3 (es)	1994-08-01	Un metodo para estabilizar factores de coagulacion de la sangre.
MX9300674A (es)	1993-10-01	Biorreactor de hepatocitos, metodo para hacerlo, metodo para usarlos y sistema de asistencia para el mismo.
SE8705064D0 (sv)	1987-12-18	Emulsion for parenteral administrering
KR940008678A (ko)	1994-05-16	주사용 메스나 액제
ES2084657T3 (es)	1996-05-16	Agente para el tratamiento de los trastornos del sistema de transmision cerebro-neural.
BR0111094A (pt)	2003-04-08	Composição farmacêutica, uso de uma composição farmacêutica estéril, e, método para melhorar a sobrevida em um paciente criticamente doente